Incidental Mutation 'IGL01837:Or6d14'
ID 154982
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or6d14
Ensembl Gene ENSMUSG00000051046
Gene Name olfactory receptor family 6 subfamily D member 14
Synonyms Olfr214, GA_x54KRFPKN04-58190962-58191900, MOR119-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.212) question?
Stock # IGL01837
Quality Score
Status
Chromosome 6
Chromosomal Location 116533388-116534350 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 116533807 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 140 (Y140*)
Ref Sequence ENSEMBL: ENSMUSP00000150737 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060204] [ENSMUST00000122096] [ENSMUST00000203867] [ENSMUST00000214699] [ENSMUST00000215846] [ENSMUST00000217313]
AlphaFold Q8VG27
Predicted Effect probably null
Transcript: ENSMUST00000060204
AA Change: Y140*
SMART Domains Protein: ENSMUSP00000052730
Gene: ENSMUSG00000051046
AA Change: Y140*

DomainStartEndE-ValueType
Pfam:7tm_4 39 316 4.7e-47 PFAM
Pfam:7tm_1 49 298 5.9e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000122096
SMART Domains Protein: ENSMUSP00000145194
Gene: ENSMUSG00000107906

DomainStartEndE-ValueType
DEXDc 57 254 2.4e-59 SMART
HELICc 291 372 6.6e-38 SMART
Predicted Effect probably null
Transcript: ENSMUST00000203867
AA Change: Y140*
SMART Domains Protein: ENSMUSP00000145465
Gene: ENSMUSG00000051046
AA Change: Y140*

DomainStartEndE-ValueType
Pfam:7tm_4 39 316 4.7e-47 PFAM
Pfam:7tm_1 49 298 5.9e-17 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000214699
AA Change: Y140*
Predicted Effect probably null
Transcript: ENSMUST00000215846
AA Change: Y140*
Predicted Effect probably null
Transcript: ENSMUST00000217313
AA Change: Y140*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 T C 17: 24,627,671 (GRCm39) F1372L probably damaging Het
Alcam T A 16: 52,073,531 (GRCm39) N339I probably benign Het
Ankrd35 A C 3: 96,587,982 (GRCm39) D141A probably damaging Het
Apc2 A G 10: 80,150,492 (GRCm39) I1820V probably benign Het
Ccp110 T A 7: 118,324,684 (GRCm39) probably null Het
Copa T A 1: 171,946,419 (GRCm39) D954E probably benign Het
Csmd2 A T 4: 128,313,363 (GRCm39) I1347F possibly damaging Het
Ddx10 A G 9: 53,140,498 (GRCm39) I301T probably benign Het
Defb23 T A 2: 152,301,294 (GRCm39) M93L probably benign Het
Dnah8 T C 17: 30,970,565 (GRCm39) probably null Het
Dok3 T C 13: 55,671,383 (GRCm39) E396G probably damaging Het
Eml6 T A 11: 29,727,055 (GRCm39) M1318L probably benign Het
Foxm1 T A 6: 128,343,167 (GRCm39) probably benign Het
Gm11992 A T 11: 9,011,266 (GRCm39) R236W probably damaging Het
Greb1 T C 12: 16,734,452 (GRCm39) I1513V probably benign Het
Hivep3 A G 4: 119,951,759 (GRCm39) E25G possibly damaging Het
Ighg2b C T 12: 113,270,065 (GRCm39) E318K unknown Het
Itga4 T C 2: 79,145,349 (GRCm39) S722P probably damaging Het
Kirrel3 G A 9: 34,946,224 (GRCm39) R617H probably damaging Het
Mboat1 A T 13: 30,425,166 (GRCm39) H409L possibly damaging Het
Naa15 A T 3: 51,351,369 (GRCm39) K180* probably null Het
Nccrp1 A G 7: 28,246,191 (GRCm39) S124P probably damaging Het
Nphp4 T C 4: 152,573,338 (GRCm39) I92T probably damaging Het
Or13a28 G A 7: 140,218,124 (GRCm39) C170Y probably damaging Het
Pkd1l3 A G 8: 110,356,798 (GRCm39) D741G possibly damaging Het
Plcb2 C T 2: 118,542,407 (GRCm39) probably null Het
Pramel19 A G 4: 101,798,650 (GRCm39) E207G probably damaging Het
Prm2 G A 16: 10,609,775 (GRCm39) probably null Het
R3hdm1 C T 1: 128,114,497 (GRCm39) Q184* probably null Het
Rgl1 A T 1: 152,424,901 (GRCm39) N359K probably damaging Het
Rnf44 A G 13: 54,829,966 (GRCm39) Y366H probably damaging Het
Rpap2 G A 5: 107,773,835 (GRCm39) probably null Het
Ryr3 T C 2: 112,631,665 (GRCm39) N2120S probably damaging Het
Samd8 A G 14: 21,825,027 (GRCm39) probably benign Het
Sipa1 G T 19: 5,702,099 (GRCm39) T937K probably damaging Het
Sos1 A T 17: 80,730,157 (GRCm39) D707E probably damaging Het
Tas2r109 T C 6: 132,957,477 (GRCm39) N151S probably benign Het
Try5 T C 6: 41,290,358 (GRCm39) N42S probably benign Het
Ttn G T 2: 76,732,338 (GRCm39) probably benign Het
Utp14b A G 1: 78,642,636 (GRCm39) E178G probably damaging Het
Other mutations in Or6d14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00951:Or6d14 APN 6 116,534,027 (GRCm39) missense probably benign
IGL02523:Or6d14 APN 6 116,534,054 (GRCm39) missense probably benign 0.03
R0027:Or6d14 UTSW 6 116,533,910 (GRCm39) missense probably damaging 0.99
R0616:Or6d14 UTSW 6 116,533,889 (GRCm39) missense probably benign 0.00
R1121:Or6d14 UTSW 6 116,534,190 (GRCm39) missense probably damaging 0.99
R1555:Or6d14 UTSW 6 116,533,787 (GRCm39) missense probably damaging 1.00
R1691:Or6d14 UTSW 6 116,533,538 (GRCm39) missense probably benign 0.00
R2196:Or6d14 UTSW 6 116,533,578 (GRCm39) missense probably damaging 0.99
R3080:Or6d14 UTSW 6 116,534,178 (GRCm39) missense probably damaging 0.98
R5416:Or6d14 UTSW 6 116,534,166 (GRCm39) missense probably damaging 1.00
R5706:Or6d14 UTSW 6 116,534,074 (GRCm39) missense probably damaging 1.00
R6848:Or6d14 UTSW 6 116,533,736 (GRCm39) missense probably damaging 0.98
R7425:Or6d14 UTSW 6 116,533,398 (GRCm39) missense possibly damaging 0.95
R8059:Or6d14 UTSW 6 116,533,434 (GRCm39) missense possibly damaging 0.47
R8349:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8449:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8551:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8552:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8553:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8555:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8988:Or6d14 UTSW 6 116,534,255 (GRCm39) missense possibly damaging 0.89
R9720:Or6d14 UTSW 6 116,534,016 (GRCm39) missense possibly damaging 0.61
Posted On 2014-02-04