Incidental Mutation 'IGL01837:Olfr214'
ID154982
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr214
Ensembl Gene ENSMUSG00000051046
Gene Nameolfactory receptor 214
SynonymsMOR119-1, GA_x54KRFPKN04-58190962-58191900
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.222) question?
Stock #IGL01837
Quality Score
Status
Chromosome6
Chromosomal Location116554235-116560611 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to A at 116556846 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 140 (Y140*)
Ref Sequence ENSEMBL: ENSMUSP00000150737 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060204] [ENSMUST00000122096] [ENSMUST00000203867] [ENSMUST00000214699] [ENSMUST00000215846] [ENSMUST00000217313]
Predicted Effect probably null
Transcript: ENSMUST00000060204
AA Change: Y140*
SMART Domains Protein: ENSMUSP00000052730
Gene: ENSMUSG00000051046
AA Change: Y140*

DomainStartEndE-ValueType
Pfam:7tm_4 39 316 4.7e-47 PFAM
Pfam:7tm_1 49 298 5.9e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000122096
SMART Domains Protein: ENSMUSP00000145194
Gene: ENSMUSG00000107906

DomainStartEndE-ValueType
DEXDc 57 254 2.4e-59 SMART
HELICc 291 372 6.6e-38 SMART
Predicted Effect probably null
Transcript: ENSMUST00000203867
AA Change: Y140*
SMART Domains Protein: ENSMUSP00000145465
Gene: ENSMUSG00000051046
AA Change: Y140*

DomainStartEndE-ValueType
Pfam:7tm_4 39 316 4.7e-47 PFAM
Pfam:7tm_1 49 298 5.9e-17 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000214699
AA Change: Y140*
Predicted Effect probably null
Transcript: ENSMUST00000215846
AA Change: Y140*
Predicted Effect probably null
Transcript: ENSMUST00000217313
AA Change: Y140*
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 T C 17: 24,408,697 F1372L probably damaging Het
Alcam T A 16: 52,253,168 N339I probably benign Het
Ankrd35 A C 3: 96,680,666 D141A probably damaging Het
Apc2 A G 10: 80,314,658 I1820V probably benign Het
Ccp110 T A 7: 118,725,461 probably null Het
Copa T A 1: 172,118,852 D954E probably benign Het
Csmd2 A T 4: 128,419,570 I1347F possibly damaging Het
Ddx10 A G 9: 53,229,198 I301T probably benign Het
Defb23 T A 2: 152,459,374 M93L probably benign Het
Dnah8 T C 17: 30,751,591 probably null Het
Dok3 T C 13: 55,523,570 E396G probably damaging Het
Eml6 T A 11: 29,777,055 M1318L probably benign Het
Foxm1 T A 6: 128,366,204 probably benign Het
Gm11992 A T 11: 9,061,266 R236W probably damaging Het
Gm12794 A G 4: 101,941,453 E207G probably damaging Het
Greb1 T C 12: 16,684,451 I1513V probably benign Het
Hivep3 A G 4: 120,094,562 E25G possibly damaging Het
Ighg2b C T 12: 113,306,445 E318K unknown Het
Itga4 T C 2: 79,315,005 S722P probably damaging Het
Kirrel3 G A 9: 35,034,928 R617H probably damaging Het
Mboat1 A T 13: 30,241,183 H409L possibly damaging Het
Naa15 A T 3: 51,443,948 K180* probably null Het
Nccrp1 A G 7: 28,546,766 S124P probably damaging Het
Nphp4 T C 4: 152,488,881 I92T probably damaging Het
Olfr61 G A 7: 140,638,211 C170Y probably damaging Het
Pkd1l3 A G 8: 109,630,166 D741G possibly damaging Het
Plcb2 C T 2: 118,711,926 probably null Het
Prm2 G A 16: 10,791,911 probably null Het
R3hdm1 C T 1: 128,186,760 Q184* probably null Het
Rgl1 A T 1: 152,549,150 N359K probably damaging Het
Rnf44 A G 13: 54,682,153 Y366H probably damaging Het
Rpap2 G A 5: 107,625,969 probably null Het
Ryr3 T C 2: 112,801,320 N2120S probably damaging Het
Samd8 A G 14: 21,774,959 probably benign Het
Sipa1 G T 19: 5,652,071 T937K probably damaging Het
Sos1 A T 17: 80,422,728 D707E probably damaging Het
Tas2r109 T C 6: 132,980,514 N151S probably benign Het
Try5 T C 6: 41,313,424 N42S probably benign Het
Ttn G T 2: 76,901,994 probably benign Het
Utp14b A G 1: 78,664,919 E178G probably damaging Het
Other mutations in Olfr214
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00951:Olfr214 APN 6 116557066 missense probably benign
IGL02523:Olfr214 APN 6 116557093 missense probably benign 0.03
R0027:Olfr214 UTSW 6 116556949 missense probably damaging 0.99
R0616:Olfr214 UTSW 6 116556928 missense probably benign 0.00
R1121:Olfr214 UTSW 6 116557229 missense probably damaging 0.99
R1555:Olfr214 UTSW 6 116556826 missense probably damaging 1.00
R1691:Olfr214 UTSW 6 116556577 missense probably benign 0.00
R2196:Olfr214 UTSW 6 116556617 missense probably damaging 0.99
R3080:Olfr214 UTSW 6 116557217 missense probably damaging 0.98
R5416:Olfr214 UTSW 6 116557205 missense probably damaging 1.00
R5706:Olfr214 UTSW 6 116557113 missense probably damaging 1.00
R6848:Olfr214 UTSW 6 116556775 missense probably damaging 0.98
R7425:Olfr214 UTSW 6 116556437 missense possibly damaging 0.95
R8059:Olfr214 UTSW 6 116556473 missense possibly damaging 0.47
Posted On2014-02-04