Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01837:Tas2r109'

155008

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r109

Ensembl Gene

ENSMUSG00000062528

Gene Name

taste receptor, type 2, member 109

Synonyms

mt2r62, T2R09, mGR09, Tas2r9

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.048) question?

Stock #

IGL01837

Quality Score

Status

Chromosome

Chromosomal Location

132956978-132957928 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 132957477 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 151 (N151S)

Ref Sequence

ENSEMBL: ENSMUSP00000069300 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067539]

AlphaFold

Q7M707

Predicted Effect

probably benign
Transcript: ENSMUST00000067539
AA Change: N151S

PolyPhen 2 Score 0.269 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000069300
Gene: ENSMUSG00000062528
AA Change: N151S

Domain	Start	End	E-Value	Type
Pfam:TAS2R	9	309	4.3e-81	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca3	T	C	17: 24,627,671 (GRCm39)	F1372L	probably damaging	Het
Alcam	T	A	16: 52,073,531 (GRCm39)	N339I	probably benign	Het
Ankrd35	A	C	3: 96,587,982 (GRCm39)	D141A	probably damaging	Het
Apc2	A	G	10: 80,150,492 (GRCm39)	I1820V	probably benign	Het
Ccp110	T	A	7: 118,324,684 (GRCm39)		probably null	Het
Copa	T	A	1: 171,946,419 (GRCm39)	D954E	probably benign	Het
Csmd2	A	T	4: 128,313,363 (GRCm39)	I1347F	possibly damaging	Het
Ddx10	A	G	9: 53,140,498 (GRCm39)	I301T	probably benign	Het
Defb23	T	A	2: 152,301,294 (GRCm39)	M93L	probably benign	Het
Dnah8	T	C	17: 30,970,565 (GRCm39)		probably null	Het
Dok3	T	C	13: 55,671,383 (GRCm39)	E396G	probably damaging	Het
Eml6	T	A	11: 29,727,055 (GRCm39)	M1318L	probably benign	Het
Foxm1	T	A	6: 128,343,167 (GRCm39)		probably benign	Het
Gm11992	A	T	11: 9,011,266 (GRCm39)	R236W	probably damaging	Het
Greb1	T	C	12: 16,734,452 (GRCm39)	I1513V	probably benign	Het
Hivep3	A	G	4: 119,951,759 (GRCm39)	E25G	possibly damaging	Het
Ighg2b	C	T	12: 113,270,065 (GRCm39)	E318K	unknown	Het
Itga4	T	C	2: 79,145,349 (GRCm39)	S722P	probably damaging	Het
Kirrel3	G	A	9: 34,946,224 (GRCm39)	R617H	probably damaging	Het
Mboat1	A	T	13: 30,425,166 (GRCm39)	H409L	possibly damaging	Het
Naa15	A	T	3: 51,351,369 (GRCm39)	K180*	probably null	Het
Nccrp1	A	G	7: 28,246,191 (GRCm39)	S124P	probably damaging	Het
Nphp4	T	C	4: 152,573,338 (GRCm39)	I92T	probably damaging	Het
Or13a28	G	A	7: 140,218,124 (GRCm39)	C170Y	probably damaging	Het
Or6d14	C	A	6: 116,533,807 (GRCm39)	Y140*	probably null	Het
Pkd1l3	A	G	8: 110,356,798 (GRCm39)	D741G	possibly damaging	Het
Plcb2	C	T	2: 118,542,407 (GRCm39)		probably null	Het
Pramel19	A	G	4: 101,798,650 (GRCm39)	E207G	probably damaging	Het
Prm2	G	A	16: 10,609,775 (GRCm39)		probably null	Het
R3hdm1	C	T	1: 128,114,497 (GRCm39)	Q184*	probably null	Het
Rgl1	A	T	1: 152,424,901 (GRCm39)	N359K	probably damaging	Het
Rnf44	A	G	13: 54,829,966 (GRCm39)	Y366H	probably damaging	Het
Rpap2	G	A	5: 107,773,835 (GRCm39)		probably null	Het
Ryr3	T	C	2: 112,631,665 (GRCm39)	N2120S	probably damaging	Het
Samd8	A	G	14: 21,825,027 (GRCm39)		probably benign	Het
Sipa1	G	T	19: 5,702,099 (GRCm39)	T937K	probably damaging	Het
Sos1	A	T	17: 80,730,157 (GRCm39)	D707E	probably damaging	Het
Try5	T	C	6: 41,290,358 (GRCm39)	N42S	probably benign	Het
Ttn	G	T	2: 76,732,338 (GRCm39)		probably benign	Het
Utp14b	A	G	1: 78,642,636 (GRCm39)	E178G	probably damaging	Het

Other mutations in Tas2r109

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00467:Tas2r109	APN	6	132,956,986 (GRCm39)	missense	probably benign	0.04
IGL02094:Tas2r109	APN	6	132,957,202 (GRCm39)	missense	possibly damaging	0.78
R0788:Tas2r109	UTSW	6	132,957,264 (GRCm39)	missense	probably benign	0.01
R0849:Tas2r109	UTSW	6	132,957,856 (GRCm39)	missense	probably benign	0.00
R1542:Tas2r109	UTSW	6	132,957,873 (GRCm39)	missense	possibly damaging	0.93
R1583:Tas2r109	UTSW	6	132,957,389 (GRCm39)	missense	probably benign	0.01
R2035:Tas2r109	UTSW	6	132,957,423 (GRCm39)	missense	probably benign
R3845:Tas2r109	UTSW	6	132,957,766 (GRCm39)	missense	probably damaging	0.99
R4060:Tas2r109	UTSW	6	132,957,148 (GRCm39)	missense	probably damaging	1.00
R4355:Tas2r109	UTSW	6	132,957,144 (GRCm39)	missense	probably benign
R5353:Tas2r109	UTSW	6	132,957,594 (GRCm39)	missense	possibly damaging	0.61
R5860:Tas2r109	UTSW	6	132,957,664 (GRCm39)	missense	probably benign	0.06
R6211:Tas2r109	UTSW	6	132,957,587 (GRCm39)	nonsense	probably null
R6378:Tas2r109	UTSW	6	132,957,844 (GRCm39)	missense	probably benign	0.00
R6861:Tas2r109	UTSW	6	132,957,048 (GRCm39)	missense	probably benign	0.43
R7319:Tas2r109	UTSW	6	132,957,663 (GRCm39)	missense	probably benign	0.33
R8553:Tas2r109	UTSW	6	132,957,171 (GRCm39)	missense	probably benign	0.33
R9447:Tas2r109	UTSW	6	132,957,270 (GRCm39)	missense	probably damaging	1.00
Z1088:Tas2r109	UTSW	6	132,957,264 (GRCm39)	missense	probably benign	0.07

Posted On

2014-02-04