Incidental Mutation 'IGL01838:Raly'
ID 155037
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Raly
Ensembl Gene ENSMUSG00000027593
Gene Name hnRNP-associated with lethal yellow
Synonyms Merc
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01838
Quality Score
Status
Chromosome 2
Chromosomal Location 154633016-154709181 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 154701590 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000119126 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029120] [ENSMUST00000058089] [ENSMUST00000109701] [ENSMUST00000116389] [ENSMUST00000125872] [ENSMUST00000129137] [ENSMUST00000140713] [ENSMUST00000137333]
AlphaFold Q64012
Predicted Effect probably benign
Transcript: ENSMUST00000029120
SMART Domains Protein: ENSMUSP00000029120
Gene: ENSMUSG00000027593

DomainStartEndE-ValueType
RRM 22 88 4.01e-14 SMART
low complexity region 109 123 N/A INTRINSIC
low complexity region 133 160 N/A INTRINSIC
low complexity region 227 259 N/A INTRINSIC
low complexity region 287 301 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000058089
SMART Domains Protein: ENSMUSP00000058105
Gene: ENSMUSG00000027593

DomainStartEndE-ValueType
RRM 22 88 4.01e-14 SMART
low complexity region 117 144 N/A INTRINSIC
low complexity region 211 243 N/A INTRINSIC
low complexity region 271 285 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000109701
SMART Domains Protein: ENSMUSP00000105323
Gene: ENSMUSG00000027593

DomainStartEndE-ValueType
RRM 22 88 4.01e-14 SMART
low complexity region 117 144 N/A INTRINSIC
low complexity region 211 243 N/A INTRINSIC
low complexity region 271 285 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000116389
SMART Domains Protein: ENSMUSP00000112090
Gene: ENSMUSG00000027593

DomainStartEndE-ValueType
RRM 22 88 4.01e-14 SMART
low complexity region 109 123 N/A INTRINSIC
low complexity region 133 160 N/A INTRINSIC
low complexity region 227 259 N/A INTRINSIC
low complexity region 287 301 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000125872
SMART Domains Protein: ENSMUSP00000119108
Gene: ENSMUSG00000027593

DomainStartEndE-ValueType
RRM 22 88 1.6e-16 SMART
low complexity region 120 140 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000129137
SMART Domains Protein: ENSMUSP00000114185
Gene: ENSMUSG00000027593

DomainStartEndE-ValueType
RRM 22 88 1.6e-16 SMART
low complexity region 117 144 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000140713
SMART Domains Protein: ENSMUSP00000119126
Gene: ENSMUSG00000027593

DomainStartEndE-ValueType
RRM 22 88 4.01e-14 SMART
low complexity region 109 123 N/A INTRINSIC
low complexity region 133 160 N/A INTRINSIC
low complexity region 227 259 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151578
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145202
Predicted Effect probably benign
Transcript: ENSMUST00000137333
SMART Domains Protein: ENSMUSP00000122261
Gene: ENSMUSG00000027596

DomainStartEndE-ValueType
Agouti 6 70 2.53e-4 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
PHENOTYPE: Mice homozygous for a gene trap allele are viable. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c6 T C 13: 4,499,035 (GRCm39) S208P probably benign Het
Cpe G T 8: 65,047,998 (GRCm39) T422K possibly damaging Het
Dis3l C A 9: 64,215,581 (GRCm39) V888L probably benign Het
Dnah7b T A 1: 46,397,297 (GRCm39) Y3909* probably null Het
Dnajb8 G A 6: 88,200,033 (GRCm39) V190M possibly damaging Het
Grip2 A G 6: 91,741,744 (GRCm39) V927A possibly damaging Het
Hyal3 C T 9: 107,463,786 (GRCm39) R304C possibly damaging Het
Igkv8-21 A G 6: 70,292,009 (GRCm39) S78P probably damaging Het
Lrrc7 A G 3: 157,891,100 (GRCm39) S356P probably damaging Het
Meiob T C 17: 25,042,643 (GRCm39) V157A possibly damaging Het
Mrpl48 C T 7: 100,201,860 (GRCm39) V35M probably damaging Het
Myo9b T C 8: 71,787,034 (GRCm39) Y739H probably damaging Het
Nfyb A G 10: 82,586,642 (GRCm39) L174S probably benign Het
Prm2 T C 16: 10,609,672 (GRCm39) probably benign Het
Prss50 T C 9: 110,693,560 (GRCm39) L432P probably benign Het
Scn11a A T 9: 119,587,649 (GRCm39) M1365K probably damaging Het
Slc28a2b C A 2: 122,348,464 (GRCm39) F270L possibly damaging Het
Spred1 T G 2: 117,008,062 (GRCm39) S323A probably benign Het
Svep1 T C 4: 58,121,910 (GRCm39) E761G possibly damaging Het
Thbs3 A T 3: 89,126,365 (GRCm39) K229* probably null Het
Thoc1 G A 18: 9,993,386 (GRCm39) G582S possibly damaging Het
Tmpo G A 10: 90,999,104 (GRCm39) R228C probably benign Het
Vmn2r114 T C 17: 23,515,956 (GRCm39) T512A probably benign Het
Wee1 T C 7: 109,723,744 (GRCm39) S220P probably benign Het
Other mutations in Raly
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02164:Raly APN 2 154,701,849 (GRCm39) nonsense probably null
R0227:Raly UTSW 2 154,707,841 (GRCm39) missense probably damaging 0.98
R1412:Raly UTSW 2 154,699,315 (GRCm39) missense possibly damaging 0.95
R1416:Raly UTSW 2 154,699,273 (GRCm39) nonsense probably null
R2247:Raly UTSW 2 154,705,953 (GRCm39) missense possibly damaging 0.92
R4110:Raly UTSW 2 154,699,378 (GRCm39) nonsense probably null
R4533:Raly UTSW 2 154,707,853 (GRCm39) missense probably damaging 0.98
R4654:Raly UTSW 2 154,699,376 (GRCm39) missense probably damaging 1.00
R4866:Raly UTSW 2 154,703,816 (GRCm39) missense probably damaging 0.99
R5395:Raly UTSW 2 154,705,927 (GRCm39) splice site probably null
R6254:Raly UTSW 2 154,699,286 (GRCm39) missense probably damaging 1.00
R6887:Raly UTSW 2 154,703,830 (GRCm39) missense probably damaging 0.99
R7069:Raly UTSW 2 154,701,664 (GRCm39) missense possibly damaging 0.93
R7117:Raly UTSW 2 154,699,432 (GRCm39) missense probably benign 0.35
R7289:Raly UTSW 2 154,703,774 (GRCm39) missense probably damaging 1.00
R7311:Raly UTSW 2 154,699,340 (GRCm39) missense probably damaging 1.00
R8900:Raly UTSW 2 154,705,493 (GRCm39) missense probably damaging 1.00
R9117:Raly UTSW 2 154,703,785 (GRCm39) missense probably damaging 1.00
R9546:Raly UTSW 2 154,705,754 (GRCm39) small deletion probably benign
R9550:Raly UTSW 2 154,705,754 (GRCm39) small deletion probably benign
R9781:Raly UTSW 2 154,699,265 (GRCm39) missense probably damaging 1.00
Posted On 2014-02-04