Incidental Mutation 'IGL01786:Rnf32'
ID155082
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rnf32
Ensembl Gene ENSMUSG00000029130
Gene Namering finger protein 32
Synonyms2700025B22Rik, 1700009J01Rik, Lmbr2, 4930542N22Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.137) question?
Stock #IGL01786
Quality Score
Status
Chromosome5
Chromosomal Location29195992-29228457 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) T to C at 29206814 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000144394 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001247] [ENSMUST00000160246] [ENSMUST00000160383] [ENSMUST00000160888] [ENSMUST00000161398] [ENSMUST00000168460] [ENSMUST00000198669]
Predicted Effect probably benign
Transcript: ENSMUST00000001247
SMART Domains Protein: ENSMUSP00000001247
Gene: ENSMUSG00000029130

DomainStartEndE-ValueType
low complexity region 21 34 N/A INTRINSIC
low complexity region 41 55 N/A INTRINSIC
low complexity region 97 107 N/A INTRINSIC
RING 129 170 4.8e-7 SMART
IQ 187 209 1.23e-1 SMART
RING 295 357 3.84e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000160246
SMART Domains Protein: ENSMUSP00000124657
Gene: ENSMUSG00000029130

DomainStartEndE-ValueType
low complexity region 21 34 N/A INTRINSIC
low complexity region 41 55 N/A INTRINSIC
low complexity region 97 107 N/A INTRINSIC
RING 129 170 4.8e-7 SMART
IQ 187 209 1.23e-1 SMART
RING 295 357 3.84e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000160383
SMART Domains Protein: ENSMUSP00000125515
Gene: ENSMUSG00000029130

DomainStartEndE-ValueType
low complexity region 21 34 N/A INTRINSIC
low complexity region 41 55 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160887
Predicted Effect probably benign
Transcript: ENSMUST00000160888
SMART Domains Protein: ENSMUSP00000124499
Gene: ENSMUSG00000029130

DomainStartEndE-ValueType
low complexity region 21 34 N/A INTRINSIC
low complexity region 41 55 N/A INTRINSIC
low complexity region 97 107 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000161398
SMART Domains Protein: ENSMUSP00000125741
Gene: ENSMUSG00000029130

DomainStartEndE-ValueType
low complexity region 6 17 N/A INTRINSIC
low complexity region 24 38 N/A INTRINSIC
low complexity region 80 90 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162975
SMART Domains Protein: ENSMUSP00000123952
Gene: ENSMUSG00000029130

DomainStartEndE-ValueType
low complexity region 4 18 N/A INTRINSIC
low complexity region 60 70 N/A INTRINSIC
RING 92 133 4.8e-7 SMART
IQ 150 172 1.23e-1 SMART
RING 202 264 3.84e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000168460
SMART Domains Protein: ENSMUSP00000132213
Gene: ENSMUSG00000029130

DomainStartEndE-ValueType
low complexity region 21 34 N/A INTRINSIC
low complexity region 41 55 N/A INTRINSIC
low complexity region 97 107 N/A INTRINSIC
RING 129 170 4.8e-7 SMART
IQ 187 209 1.23e-1 SMART
RING 295 357 3.84e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000198669
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains two RING ring finger motifs. RING finger motifs are present in a variety of functionally distinct proteins and are known to be involved in protein-DNA or protein-protein interactions. This gene was found to be expressed during spermatogenesis, most likely in spermatocytes and/or in spermatids. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam9 T A 8: 24,996,839 H20L probably damaging Het
Ano3 T A 2: 110,682,715 Q645L probably damaging Het
Clasp1 T A 1: 118,497,736 L272Q possibly damaging Het
Corin T C 5: 72,339,876 N532S probably damaging Het
Ddx1 A T 12: 13,229,136 D468E probably benign Het
Hk2 A G 6: 82,739,553 S333P probably benign Het
Kctd19 T C 8: 105,390,304 T398A probably benign Het
Klra8 T A 6: 130,119,068 probably null Het
Mcm8 A G 2: 132,827,948 D314G probably benign Het
Mga T A 2: 119,902,912 D80E probably damaging Het
Mylk3 T C 8: 85,359,317 Q36R probably benign Het
Myom2 T C 8: 15,106,330 S726P probably damaging Het
Nuf2 T C 1: 169,510,483 S242G possibly damaging Het
Nup210l T A 3: 90,122,776 Y265* probably null Het
Olfr1445 C T 19: 12,884,277 T132I probably damaging Het
Olfr530 T A 7: 140,373,125 M162L probably benign Het
Otud3 T C 4: 138,896,897 D278G probably benign Het
Papolg A G 11: 23,874,488 V298A probably damaging Het
Phc1 T C 6: 122,319,520 D847G possibly damaging Het
Pkd2l1 A G 19: 44,191,442 F110L probably damaging Het
Plxnd1 T A 6: 115,959,935 T1638S probably damaging Het
Polr3a G A 14: 24,484,120 Q106* probably null Het
Slc30a9 A G 5: 67,346,238 probably benign Het
Slc44a2 A G 9: 21,352,486 Y650C probably damaging Het
Sv2a A T 3: 96,188,209 Y306F probably benign Het
Tmem50a T C 4: 134,898,447 E153G probably damaging Het
Tor1a A G 2: 30,963,703 probably null Het
Tusc5 G A 11: 76,680,466 V103I probably benign Het
Usp20 A G 2: 31,017,163 E594G probably benign Het
Other mutations in Rnf32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01591:Rnf32 APN 5 29224274 missense probably damaging 1.00
IGL02832:Rnf32 APN 5 29205703 critical splice donor site probably null
IGL02976:Rnf32 APN 5 29206712 unclassified probably null
R0038:Rnf32 UTSW 5 29205654 unclassified probably benign
R0038:Rnf32 UTSW 5 29205654 unclassified probably benign
R0070:Rnf32 UTSW 5 29225127 missense probably benign 0.00
R1812:Rnf32 UTSW 5 29206260 missense possibly damaging 0.88
R2279:Rnf32 UTSW 5 29225280 missense probably benign 0.36
R4903:Rnf32 UTSW 5 29198578 missense probably benign 0.00
R4964:Rnf32 UTSW 5 29198578 missense probably benign 0.00
R4966:Rnf32 UTSW 5 29198578 missense probably benign 0.00
R5155:Rnf32 UTSW 5 29203147 missense probably damaging 1.00
R5987:Rnf32 UTSW 5 29203147 missense probably damaging 1.00
R6060:Rnf32 UTSW 5 29206754 missense probably benign 0.01
R6374:Rnf32 UTSW 5 29225268 nonsense probably null
R7627:Rnf32 UTSW 5 29197950 start gained probably benign
Z1176:Rnf32 UTSW 5 29225250 missense probably damaging 0.99
Posted On2014-02-04