Incidental Mutation 'IGL01787:Gm4758'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm4758
Ensembl Gene ENSMUSG00000079595
Gene Namepredicted gene 4758
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #IGL01787
Quality Score
Chromosomal Location36308045-36312653 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 36311229 bp
Amino Acid Change Tyrosine to Asparagine at position 34 (Y34N)
Ref Sequence ENSEMBL: ENSMUSP00000110501 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114851]
Predicted Effect probably damaging
Transcript: ENSMUST00000114851
AA Change: Y34N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110501
Gene: ENSMUSG00000079595
AA Change: Y34N

CY 1 96 1.9e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157239
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232642
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahctf1 A G 1: 179,753,322 S1772P probably benign Het
Epsti1 T C 14: 77,972,612 probably null Het
Mtrr A T 13: 68,571,147 L325Q probably damaging Het
Neb T C 2: 52,296,355 K902E possibly damaging Het
Nfkbie T C 17: 45,556,263 L108P probably damaging Het
Olfr1263 A T 2: 90,015,311 Y127F probably damaging Het
Olfr136 T A 17: 38,335,579 C141S probably damaging Het
Pcdh15 A G 10: 74,450,283 D712G probably benign Het
Polr3k T C 2: 181,864,458 probably benign Het
Shkbp1 A C 7: 27,342,450 F660V possibly damaging Het
Smchd1 T C 17: 71,391,418 D1121G probably damaging Het
Srgap3 A T 6: 112,723,022 D998E probably benign Het
Stab1 T C 14: 31,139,808 D14G probably damaging Het
Tap1 T C 17: 34,196,604 S641P probably benign Het
Tgm3 C T 2: 130,047,740 S618F possibly damaging Het
Tgm6 T C 2: 130,151,434 probably benign Het
Tmco5 A T 2: 116,887,300 E194D probably damaging Het
Treml4 T A 17: 48,264,704 V45E probably damaging Het
Uggt2 A T 14: 119,081,734 M292K probably damaging Het
Usp5 A T 6: 124,824,226 D179E possibly damaging Het
Ythdf1 A G 2: 180,911,693 L216P probably damaging Het
Zfp948 C T 17: 21,587,071 A175V probably benign Het
Other mutations in Gm4758
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01141:Gm4758 APN 16 36308064 missense probably benign 0.03
IGL02114:Gm4758 APN 16 36311255 nonsense probably null
IGL02547:Gm4758 APN 16 36312526 critical splice acceptor site probably benign
R1800:Gm4758 UTSW 16 36312533 missense probably damaging 0.98
R1858:Gm4758 UTSW 16 36308087 missense probably damaging 1.00
R1958:Gm4758 UTSW 16 36312565 missense possibly damaging 0.78
R4424:Gm4758 UTSW 16 36312589 unclassified probably null 0.52
R4618:Gm4758 UTSW 16 36312590 missense possibly damaging 0.69
R5162:Gm4758 UTSW 16 36312556 missense probably damaging 1.00
R6437:Gm4758 UTSW 16 36312637 missense probably damaging 1.00
Posted On2014-02-04