Incidental Mutation 'IGL01788:Or4k15c'
ID 155112
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or4k15c
Ensembl Gene ENSMUSG00000060523
Gene Name olfactory receptor family 4 subfamily K member 15C
Synonyms MOR246-4, GA_x6K02T2PMLR-5775299-5774334, Olfr726
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # IGL01788
Quality Score
Status
Chromosome 14
Chromosomal Location 50321171-50322136 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 50321959 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 60 (Y60H)
Ref Sequence ENSEMBL: ENSMUSP00000149373 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072370] [ENSMUST00000206834] [ENSMUST00000213345] [ENSMUST00000215105] [ENSMUST00000215278] [ENSMUST00000217422] [ENSMUST00000217025] [ENSMUST00000217319]
AlphaFold E9Q8X3
Predicted Effect probably damaging
Transcript: ENSMUST00000072370
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072207
Gene: ENSMUSG00000060523
AA Change: Y60H

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 1.3e-47 PFAM
Pfam:7TM_GPCR_Srsx 36 288 5.4e-8 PFAM
Pfam:7tm_1 41 287 7.5e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205951
AA Change: Y60H
Predicted Effect probably damaging
Transcript: ENSMUST00000206834
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000213345
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000215105
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000215278
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217422
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217025
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217319
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9230009I02Rik T G 11: 50,982,542 (GRCm39) noncoding transcript Het
Acp6 A G 3: 97,073,198 (GRCm39) T80A probably damaging Het
Adamtsl5 T C 10: 80,180,757 (GRCm39) T102A probably benign Het
Adcy6 C A 15: 98,494,400 (GRCm39) E812* probably null Het
Apol6 G A 15: 76,935,216 (GRCm39) V162I possibly damaging Het
Atp6v1h T A 1: 5,220,206 (GRCm39) M396K possibly damaging Het
B3gnt8 A G 7: 25,328,613 (GRCm39) T348A probably damaging Het
Cgnl1 A G 9: 71,562,672 (GRCm39) V869A probably benign Het
Dcaf5 A T 12: 80,395,098 (GRCm39) I357N probably damaging Het
Dennd4a A G 9: 64,749,903 (GRCm39) I165V probably benign Het
Dlgap2 T A 8: 14,893,631 (GRCm39) I982K probably benign Het
Dop1a A T 9: 86,413,772 (GRCm39) H1891L probably benign Het
Fhad1 A C 4: 141,660,113 (GRCm39) S65R probably benign Het
Fn1 A G 1: 71,652,996 (GRCm39) I1331T probably damaging Het
Fto A T 8: 92,136,359 (GRCm39) Y211F probably benign Het
Gm3278 A C 14: 16,080,370 (GRCm39) R60S probably benign Het
Ifna9 A G 4: 88,510,097 (GRCm39) S176P probably damaging Het
Klk1 T C 7: 43,878,407 (GRCm39) I189T probably benign Het
Mcph1 G A 8: 18,682,419 (GRCm39) G519R probably damaging Het
Mcph1 G A 8: 18,682,420 (GRCm39) G519E probably damaging Het
N4bp1 A T 8: 87,587,624 (GRCm39) V438E probably benign Het
Ncapg T A 5: 45,828,423 (GRCm39) V58E probably damaging Het
Nid2 T A 14: 19,858,047 (GRCm39) S1054T probably damaging Het
Nlrp4a A T 7: 26,153,492 (GRCm39) Y681F probably benign Het
Or4f57 T C 2: 111,791,352 (GRCm39) D22G probably benign Het
Or52e19b C A 7: 103,032,770 (GRCm39) M146I probably benign Het
Or5b94 G A 19: 12,652,442 (GRCm39) R291K probably damaging Het
Papln A T 12: 83,822,236 (GRCm39) T364S probably benign Het
Pcdh18 C A 3: 49,710,371 (GRCm39) E315* probably null Het
Pmel G A 10: 128,553,701 (GRCm39) R445Q probably damaging Het
Ppp1r12b C T 1: 134,821,245 (GRCm39) V182I possibly damaging Het
Ptprn2 A G 12: 116,864,607 (GRCm39) T541A probably damaging Het
Rbl1 A T 2: 157,005,576 (GRCm39) N813K probably benign Het
Sash1 C A 10: 8,609,410 (GRCm39) R713L probably benign Het
Slc13a1 T G 6: 24,134,371 (GRCm39) T171P probably damaging Het
Slc18b1 G T 10: 23,701,899 (GRCm39) E407D probably damaging Het
Slc2a6 G A 2: 26,914,227 (GRCm39) Q297* probably null Het
Vmn1r209 T C 13: 22,989,832 (GRCm39) H286R probably damaging Het
Vmn1r28 C A 6: 58,242,522 (GRCm39) H122N probably benign Het
Wfs1 A G 5: 37,125,980 (GRCm39) Y304H probably benign Het
Zfp512b A G 2: 181,230,556 (GRCm39) S445P possibly damaging Het
Other mutations in Or4k15c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01329:Or4k15c APN 14 50,321,454 (GRCm39) missense probably benign 0.00
IGL01432:Or4k15c APN 14 50,321,404 (GRCm39) missense probably benign 0.07
IGL01957:Or4k15c APN 14 50,321,737 (GRCm39) missense probably benign 0.00
IGL02132:Or4k15c APN 14 50,321,943 (GRCm39) missense probably damaging 1.00
R0611:Or4k15c UTSW 14 50,321,310 (GRCm39) missense probably damaging 1.00
R0689:Or4k15c UTSW 14 50,321,689 (GRCm39) missense probably benign 0.01
R1556:Or4k15c UTSW 14 50,321,916 (GRCm39) missense possibly damaging 0.90
R1710:Or4k15c UTSW 14 50,321,827 (GRCm39) missense probably benign 0.01
R1791:Or4k15c UTSW 14 50,321,499 (GRCm39) missense probably benign 0.03
R1804:Or4k15c UTSW 14 50,321,359 (GRCm39) missense probably damaging 0.99
R1853:Or4k15c UTSW 14 50,321,577 (GRCm39) missense probably damaging 1.00
R2034:Or4k15c UTSW 14 50,321,440 (GRCm39) missense probably benign 0.34
R3155:Or4k15c UTSW 14 50,321,982 (GRCm39) missense probably benign 0.09
R3156:Or4k15c UTSW 14 50,321,982 (GRCm39) missense probably benign 0.09
R3939:Or4k15c UTSW 14 50,321,173 (GRCm39) makesense probably null
R4392:Or4k15c UTSW 14 50,322,060 (GRCm39) missense probably benign 0.24
R4533:Or4k15c UTSW 14 50,321,156 (GRCm39) splice site probably null
R4694:Or4k15c UTSW 14 50,321,476 (GRCm39) missense probably benign
R5183:Or4k15c UTSW 14 50,322,003 (GRCm39) missense probably damaging 0.99
R5859:Or4k15c UTSW 14 50,321,484 (GRCm39) missense probably damaging 1.00
R6186:Or4k15c UTSW 14 50,321,982 (GRCm39) missense probably damaging 0.98
R6357:Or4k15c UTSW 14 50,321,446 (GRCm39) missense probably damaging 0.99
R6771:Or4k15c UTSW 14 50,321,446 (GRCm39) missense probably damaging 0.99
R6834:Or4k15c UTSW 14 50,321,685 (GRCm39) missense probably damaging 0.99
R6924:Or4k15c UTSW 14 50,321,307 (GRCm39) missense possibly damaging 0.91
R7953:Or4k15c UTSW 14 50,321,367 (GRCm39) missense possibly damaging 0.53
R8043:Or4k15c UTSW 14 50,321,367 (GRCm39) missense possibly damaging 0.53
R8255:Or4k15c UTSW 14 50,321,329 (GRCm39) missense noncoding transcript
R9444:Or4k15c UTSW 14 50,321,869 (GRCm39) missense
Posted On 2014-02-04