Incidental Mutation 'IGL01789:Lipm'
ID155153
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lipm
Ensembl Gene ENSMUSG00000056078
Gene Namelipase, family member M
SynonymsLipl3, 4632427C23Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.309) question?
Stock #IGL01789
Quality Score
Status
Chromosome19
Chromosomal Location34100943-34122687 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 34118747 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 321 (D321G)
Ref Sequence ENSEMBL: ENSMUSP00000025685 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025685] [ENSMUST00000025686]
Predicted Effect probably damaging
Transcript: ENSMUST00000025685
AA Change: D321G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000025685
Gene: ENSMUSG00000056078
AA Change: D321G

DomainStartEndE-ValueType
Pfam:Abhydro_lipase 49 111 3.3e-26 PFAM
Pfam:Abhydrolase_1 92 393 2.6e-29 PFAM
Pfam:Abhydrolase_5 93 387 2.5e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000025686
SMART Domains Protein: ENSMUSP00000025686
Gene: ENSMUSG00000024774

DomainStartEndE-ValueType
ANK 39 68 1.1e-6 SMART
ANK 72 130 2.05e2 SMART
ANK 134 163 1.68e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159887
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160474
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930572O03Rik C A 5: 15,656,886 probably benign Het
Afm C T 5: 90,525,584 P232S probably benign Het
Atp11b A T 3: 35,789,592 Q81L possibly damaging Het
Cgn G A 3: 94,776,218 P413S possibly damaging Het
Eps8 C T 6: 137,539,366 M5I probably benign Het
Fam83h A T 15: 76,006,120 M143K probably damaging Het
Gzf1 G A 2: 148,684,061 A151T probably benign Het
Hmcn1 C T 1: 150,690,601 C2217Y probably damaging Het
Leo1 T C 9: 75,454,614 probably benign Het
Nos2 C T 11: 78,944,657 probably benign Het
Phtf2 T C 5: 20,794,374 Y257C probably benign Het
Rnpep T C 1: 135,268,095 K359E possibly damaging Het
Tas2r130 T A 6: 131,630,155 S226C probably damaging Het
Tpbg A T 9: 85,844,901 M308L probably benign Het
Trip11 G A 12: 101,871,831 S1715L probably benign Het
Unc13b T A 4: 43,239,462 N3508K probably damaging Het
Utp20 A T 10: 88,798,279 probably null Het
Wdhd1 A T 14: 47,274,817 M39K probably benign Het
Other mutations in Lipm
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01624:Lipm APN 19 34121145 missense probably damaging 1.00
IGL01878:Lipm APN 19 34116511 missense possibly damaging 0.63
IGL01897:Lipm APN 19 34121308 missense probably damaging 1.00
IGL02713:Lipm APN 19 34101170 start codon destroyed probably null 0.77
R0029:Lipm UTSW 19 34116548 splice site probably benign
R0352:Lipm UTSW 19 34112875 splice site probably benign
R0565:Lipm UTSW 19 34116506 missense probably benign 0.00
R0815:Lipm UTSW 19 34118761 missense probably benign 0.13
R1658:Lipm UTSW 19 34116447 missense probably benign
R2990:Lipm UTSW 19 34116486 missense probably benign 0.03
R4758:Lipm UTSW 19 34101170 start codon destroyed possibly damaging 0.59
R5446:Lipm UTSW 19 34117887 missense possibly damaging 0.92
R5468:Lipm UTSW 19 34109554 splice site probably null
R5905:Lipm UTSW 19 34111911 missense probably benign
R6066:Lipm UTSW 19 34112974 missense probably damaging 1.00
R6437:Lipm UTSW 19 34121257 missense probably damaging 1.00
R6722:Lipm UTSW 19 34121265 missense probably benign 0.00
R6927:Lipm UTSW 19 34101163 start gained probably benign
R7007:Lipm UTSW 19 34112097 missense probably damaging 1.00
R7031:Lipm UTSW 19 34116471 missense probably benign
R7081:Lipm UTSW 19 34121323 missense possibly damaging 0.90
R7092:Lipm UTSW 19 34121358 missense possibly damaging 0.75
R7419:Lipm UTSW 19 34116481 missense probably benign 0.09
R7426:Lipm UTSW 19 34116198 missense possibly damaging 0.56
R7772:Lipm UTSW 19 34117891 missense probably damaging 0.99
Posted On2014-02-04