Incidental Mutation 'IGL01790:Vsig10'
ID155192
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vsig10
Ensembl Gene ENSMUSG00000066894
Gene NameV-set and immunoglobulin domain containing 10
Synonyms
Accession Numbers

Genbank: NM_001033311; MGI: 2448533

Is this an essential gene? Probably non essential (E-score: 0.055) question?
Stock #IGL01790
Quality Score
Status
Chromosome5
Chromosomal Location117319083-117355005 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 117338314 bp
ZygosityHeterozygous
Amino Acid Change Tryptophan to Arginine at position 278 (W278R)
Ref Sequence ENSEMBL: ENSMUSP00000107598 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086464] [ENSMUST00000111967]
Predicted Effect probably damaging
Transcript: ENSMUST00000086464
AA Change: W251R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000083655
Gene: ENSMUSG00000066894
AA Change: W251R

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
IG 23 114 4.03e-8 SMART
IG 132 214 9.49e-5 SMART
Pfam:Ig_2 215 300 2.6e-2 PFAM
Pfam:Ig_3 216 284 3.5e-4 PFAM
IGc2 313 384 1.12e-6 SMART
transmembrane domain 403 425 N/A INTRINSIC
coiled coil region 446 481 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000111967
AA Change: W278R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000107598
Gene: ENSMUSG00000066894
AA Change: W278R

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IG 50 141 4.03e-8 SMART
IG 159 241 9.49e-5 SMART
Blast:IG_like 248 327 2e-33 BLAST
IGc2 340 411 1.12e-6 SMART
transmembrane domain 430 452 N/A INTRINSIC
coiled coil region 473 508 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145052
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147182
SMART Domains Protein: ENSMUSP00000125808
Gene: ENSMUSG00000066894

DomainStartEndE-ValueType
Blast:IG_like 1 41 3e-14 BLAST
IGc2 54 125 1.12e-6 SMART
transmembrane domain 144 166 N/A INTRINSIC
coiled coil region 187 222 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(11) : Gene trapped(11)

Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930572O03Rik C A 5: 15,656,886 probably benign Het
Arhgap8 A C 15: 84,767,214 I288L possibly damaging Het
Astn1 T C 1: 158,580,327 I618T possibly damaging Het
Bod1l T C 5: 41,832,250 S377G probably benign Het
Disp2 A T 2: 118,790,880 S698C probably damaging Het
Ehbp1l1 A G 19: 5,722,984 V43A probably damaging Het
Eml5 G T 12: 98,798,932 T1539K probably damaging Het
Fmnl2 T C 2: 53,118,368 I824T probably damaging Het
Gpr75 T G 11: 30,891,132 N12K probably damaging Het
Hap1 C T 11: 100,351,906 probably null Het
Helz2 A C 2: 181,238,481 Y481D probably benign Het
Klhl3 T C 13: 58,009,422 probably null Het
Lrcol1 A G 5: 110,354,207 S49G probably damaging Het
Magi3 A G 3: 104,085,244 M304T probably damaging Het
Med13l T C 5: 118,593,522 W88R probably damaging Het
Nfatc1 A G 18: 80,667,042 V503A probably damaging Het
Ntm C A 9: 29,411,590 V45L probably benign Het
Olfr1184 T A 2: 88,486,926 S65T possibly damaging Het
Olfr1186 A G 2: 88,526,423 N280S probably damaging Het
Olfr1313 T A 2: 112,071,921 I221L probably benign Het
Olfr1471 A G 19: 13,445,162 D50G probably damaging Het
Olfr19 T C 16: 16,673,103 R293G probably damaging Het
Pias4 T C 10: 81,157,498 Q197R probably damaging Het
Pkhd1 T A 1: 20,558,671 H684L probably damaging Het
Psmb3 T A 11: 97,712,510 M183K probably damaging Het
Rasal1 T C 5: 120,670,318 F472L possibly damaging Het
Rpl3 A T 15: 80,079,860 probably benign Het
Scin A T 12: 40,063,257 D538E probably benign Het
Sdhb T C 4: 140,973,727 S165P probably benign Het
Slc43a2 C A 11: 75,545,751 probably null Het
Sparc C T 11: 55,407,215 probably null Het
Tcf25 A G 8: 123,393,236 E382G possibly damaging Het
Tmx3 G A 18: 90,511,334 probably null Het
Trim24 C T 6: 37,945,613 P452S probably benign Het
Other mutations in Vsig10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Vsig10 APN 5 117338414 missense probably benign 0.00
IGL00340:Vsig10 APN 5 117351587 missense probably benign 0.03
IGL01082:Vsig10 APN 5 117334905 missense probably benign 0.33
IGL01285:Vsig10 APN 5 117324889 missense probably benign 0.43
IGL03004:Vsig10 APN 5 117325075 missense probably damaging 1.00
D3080:Vsig10 UTSW 5 117343819 missense probably damaging 1.00
R0101:Vsig10 UTSW 5 117335069 critical splice donor site probably null
R0403:Vsig10 UTSW 5 117338461 missense probably benign 0.05
R0674:Vsig10 UTSW 5 117343846 missense probably damaging 1.00
R1437:Vsig10 UTSW 5 117351570 missense probably damaging 0.96
R1689:Vsig10 UTSW 5 117352760 missense probably benign 0.00
R1710:Vsig10 UTSW 5 117351654 missense probably benign
R1765:Vsig10 UTSW 5 117318815 unclassified probably benign
R4422:Vsig10 UTSW 5 117324921 missense probably benign 0.00
R4541:Vsig10 UTSW 5 117352816 utr 3 prime probably benign
R4909:Vsig10 UTSW 5 117338243 missense probably benign 0.31
R4999:Vsig10 UTSW 5 117343975 missense probably damaging 1.00
R5855:Vsig10 UTSW 5 117338270 missense probably damaging 1.00
R5866:Vsig10 UTSW 5 117352749 critical splice acceptor site probably null
R6214:Vsig10 UTSW 5 117343924 missense probably damaging 1.00
R6418:Vsig10 UTSW 5 117348296 missense probably benign 0.03
R6505:Vsig10 UTSW 5 117351759 missense possibly damaging 0.95
R6854:Vsig10 UTSW 5 117338407 missense probably benign 0.36
R7121:Vsig10 UTSW 5 117343902 missense probably damaging 1.00
R7596:Vsig10 UTSW 5 117334783 missense possibly damaging 0.46
R8066:Vsig10 UTSW 5 117351784 missense probably benign 0.00
R8335:Vsig10 UTSW 5 117348370 missense probably damaging 1.00
Posted On2014-02-04