Incidental Mutation 'IGL01791:Olfr657'
ID155202
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr657
Ensembl Gene ENSMUSG00000073923
Gene Nameolfactory receptor 657
SynonymsMOR40-13, GA_x6K02T2PBJ9-7263864-7264823
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.063) question?
Stock #IGL01791
Quality Score
Status
Chromosome7
Chromosomal Location104624794-104637481 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 104636475 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 267 (T267I)
Ref Sequence ENSEMBL: ENSMUSP00000150070 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098171] [ENSMUST00000213297] [ENSMUST00000215454]
Predicted Effect possibly damaging
Transcript: ENSMUST00000098171
AA Change: T267I

PolyPhen 2 Score 0.753 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000095773
Gene: ENSMUSG00000073923
AA Change: T267I

DomainStartEndE-ValueType
Pfam:7tm_4 37 315 6.2e-74 PFAM
Pfam:7TM_GPCR_Srsx 40 312 1.2e-8 PFAM
Pfam:7tm_1 47 297 9.3e-15 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213297
AA Change: T267I

PolyPhen 2 Score 0.753 (Sensitivity: 0.85; Specificity: 0.92)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215454
AA Change: T267I

PolyPhen 2 Score 0.753 (Sensitivity: 0.85; Specificity: 0.92)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930572O03Rik C A 5: 15,656,886 probably benign Het
Arhgap32 A G 9: 32,247,190 I174V probably damaging Het
Asb15 T A 6: 24,567,212 C511S probably damaging Het
Atr C T 9: 95,921,781 A1896V probably benign Het
B3gnt4 C T 5: 123,511,099 R176C probably damaging Het
Brf1 T C 12: 112,962,475 D557G probably benign Het
Catsperg2 T A 7: 29,704,665 probably null Het
Ccdc144b T C 3: 36,035,267 probably benign Het
Cdip1 A G 16: 4,768,865 I122T probably damaging Het
Ctrl C T 8: 105,932,567 E147K probably benign Het
Dennd2c T C 3: 103,166,425 V829A probably benign Het
Dync1h1 T A 12: 110,658,930 L3874Q probably damaging Het
Gm10521 T C 1: 171,896,397 S92P unknown Het
Gzf1 G A 2: 148,684,061 A151T probably benign Het
Hddc2 A G 10: 31,326,026 Y123C probably damaging Het
Hyal4 T C 6: 24,763,895 probably benign Het
Ighv16-1 T C 12: 114,068,969 N71S probably benign Het
Ing2 A T 8: 47,669,035 S159R probably benign Het
Itga1 A T 13: 114,987,661 N698K probably benign Het
Lemd2 A T 17: 27,190,728 I483N probably damaging Het
Lyst T C 13: 13,635,302 L519P probably damaging Het
Mapk10 T C 5: 102,996,648 N101S probably damaging Het
Nfatc4 A T 14: 55,832,238 E164V probably null Het
Nfkb2 T G 19: 46,309,839 probably benign Het
Nox3 A G 17: 3,682,943 V231A possibly damaging Het
Nup160 G A 2: 90,703,853 G674D probably damaging Het
Olfr364-ps1 A T 2: 37,146,536 D108V probably damaging Het
Otoa T G 7: 121,155,849 V998G probably benign Het
Pcnx3 A T 19: 5,673,267 M1300K probably benign Het
Pde4b A G 4: 102,590,930 probably benign Het
Rfc1 T A 5: 65,263,145 K1104I probably benign Het
Serpina1f G T 12: 103,693,502 Q174K probably damaging Het
Serping1 T C 2: 84,773,377 N107D possibly damaging Het
Surf6 A G 2: 26,899,747 S94P probably benign Het
Tctex1d4 T A 4: 117,128,597 S206T probably damaging Het
Tigd4 T A 3: 84,594,745 I323N probably damaging Het
Vmn2r28 T C 7: 5,488,162 D362G probably benign Het
Wdfy3 A G 5: 101,937,412 S739P probably damaging Het
Other mutations in Olfr657
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01815:Olfr657 APN 7 104636345 missense probably damaging 0.99
IGL01831:Olfr657 APN 7 104636060 missense probably damaging 0.99
IGL02285:Olfr657 APN 7 104635725 missense probably benign 0.06
R1529:Olfr657 UTSW 7 104636489 missense probably benign 0.01
R1775:Olfr657 UTSW 7 104636159 missense probably benign 0.01
R2356:Olfr657 UTSW 7 104636627 nonsense probably null
R3809:Olfr657 UTSW 7 104636333 missense possibly damaging 0.76
R4011:Olfr657 UTSW 7 104636348 missense probably benign
R4206:Olfr657 UTSW 7 104636149 missense possibly damaging 0.52
R4520:Olfr657 UTSW 7 104636169 missense probably damaging 0.99
R4551:Olfr657 UTSW 7 104636424 missense probably damaging 1.00
R6394:Olfr657 UTSW 7 104635702 missense possibly damaging 0.59
R6394:Olfr657 UTSW 7 104636027 missense possibly damaging 0.78
R6477:Olfr657 UTSW 7 104635679 missense probably benign 0.00
R6727:Olfr657 UTSW 7 104635887 missense probably damaging 0.99
R7554:Olfr657 UTSW 7 104636526 missense probably benign
X0065:Olfr657 UTSW 7 104636194 missense probably benign 0.06
Posted On2014-02-04