Incidental Mutation 'IGL01796:Or11g25'
ID 155336
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or11g25
Ensembl Gene ENSMUSG00000095765
Gene Name olfactory receptor family 11 subfamily G member 25
Synonyms MOR106-15, MOR106-10, Olfr741, GA_x6K02T2PMLR-6197851-6198786
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # IGL01796
Quality Score
Status
Chromosome 14
Chromosomal Location 50710514-50723852 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 50722998 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 28 (Q28K)
Ref Sequence ENSEMBL: ENSMUSP00000151020 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071932] [ENSMUST00000205518] [ENSMUST00000213903]
AlphaFold L7N1Y5
Predicted Effect probably benign
Transcript: ENSMUST00000071932
AA Change: Q28K

PolyPhen 2 Score 0.276 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000071824
Gene: ENSMUSG00000095765
AA Change: Q28K

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 1.2e-55 PFAM
Pfam:7tm_1 45 294 2.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205518
AA Change: Q28K

PolyPhen 2 Score 0.276 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000213903
AA Change: Q28K

PolyPhen 2 Score 0.276 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aacs T C 5: 125,590,273 (GRCm39) Y511H probably damaging Het
Abca7 T G 10: 79,849,743 (GRCm39) Y1948D probably damaging Het
Adgrl2 C A 3: 148,564,611 (GRCm39) G319V probably damaging Het
Adgrv1 T A 13: 81,715,461 (GRCm39) D909V probably benign Het
Anapc16 T C 10: 59,824,579 (GRCm39) E119G possibly damaging Het
C1qtnf12 T C 4: 156,050,886 (GRCm39) V285A possibly damaging Het
Cbr1 A C 16: 93,405,119 (GRCm39) N89T probably damaging Het
Cdh23 T A 10: 60,146,916 (GRCm39) Q2778L probably benign Het
Clca4c-ps A G 3: 144,595,340 (GRCm39) noncoding transcript Het
Cst9 T C 2: 148,677,269 (GRCm39) F47L probably damaging Het
Dqx1 T C 6: 83,043,408 (GRCm39) probably benign Het
Dus4l T C 12: 31,692,794 (GRCm39) S150G probably benign Het
E2f2 A T 4: 135,907,728 (GRCm39) K142* probably null Het
Eif2ak4 T A 2: 118,276,785 (GRCm39) H169Q probably benign Het
Fmo9 C T 1: 166,490,904 (GRCm39) A525T probably benign Het
Gm42878 T C 5: 121,683,247 (GRCm39) D6G probably benign Het
Igfals A G 17: 25,099,056 (GRCm39) Y49C probably damaging Het
Il22b T C 10: 118,126,069 (GRCm39) N176S possibly damaging Het
Ipo7 T C 7: 109,629,055 (GRCm39) probably benign Het
Itga1 T C 13: 115,121,657 (GRCm39) E784G probably damaging Het
Jcad G T 18: 4,672,855 (GRCm39) E206* probably null Het
Kif24 A T 4: 41,392,978 (GRCm39) probably benign Het
Lrrc2 T A 9: 110,809,886 (GRCm39) probably null Het
Ltbp1 A G 17: 75,534,240 (GRCm39) probably benign Het
Man2c1 C T 9: 57,045,244 (GRCm39) T451I possibly damaging Het
Manba T A 3: 135,248,150 (GRCm39) N346K probably damaging Het
Nell1 T C 7: 49,825,964 (GRCm39) probably benign Het
Nfat5 T C 8: 108,094,273 (GRCm39) V744A probably damaging Het
Nms T C 1: 38,985,192 (GRCm39) M98T possibly damaging Het
Nos1 A T 5: 118,076,339 (GRCm39) K1120* probably null Het
Plekho1 C T 3: 95,898,147 (GRCm39) R172H probably damaging Het
Pot1b A T 17: 55,976,750 (GRCm39) C391S possibly damaging Het
Scn1a G A 2: 66,162,645 (GRCm39) probably benign Het
Sgce T G 6: 4,711,326 (GRCm39) N149H probably damaging Het
Slc45a1 A G 4: 150,728,426 (GRCm39) W126R probably damaging Het
Slc9a1 G A 4: 133,147,404 (GRCm39) probably benign Het
Tmem131l T A 3: 83,845,362 (GRCm39) K423* probably null Het
Tnrc18 C T 5: 142,750,642 (GRCm39) E1444K possibly damaging Het
Tpp1 T C 7: 105,396,857 (GRCm39) probably benign Het
Trip12 A C 1: 84,705,999 (GRCm39) S610R probably benign Het
Ushbp1 G T 8: 71,840,076 (GRCm39) A525E probably benign Het
Vmn2r106 A T 17: 20,488,314 (GRCm39) M695K possibly damaging Het
Vmn2r118 A G 17: 55,915,585 (GRCm39) I455T probably benign Het
Zbtb41 T C 1: 139,370,621 (GRCm39) F686S probably damaging Het
Other mutations in Or11g25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01773:Or11g25 APN 14 50,723,230 (GRCm39) missense probably damaging 0.98
IGL01916:Or11g25 APN 14 50,722,950 (GRCm39) missense probably benign 0.01
IGL02686:Or11g25 APN 14 50,723,426 (GRCm39) missense probably benign 0.01
IGL02874:Or11g25 APN 14 50,723,686 (GRCm39) missense possibly damaging 0.57
IGL02898:Or11g25 APN 14 50,723,643 (GRCm39) missense probably damaging 1.00
PIT4515001:Or11g25 UTSW 14 50,723,536 (GRCm39) missense probably benign 0.03
R0085:Or11g25 UTSW 14 50,723,791 (GRCm39) missense probably benign 0.16
R1777:Or11g25 UTSW 14 50,723,757 (GRCm39) missense probably benign 0.08
R1850:Or11g25 UTSW 14 50,723,055 (GRCm39) missense probably benign
R2270:Or11g25 UTSW 14 50,723,494 (GRCm39) missense probably damaging 1.00
R2338:Or11g25 UTSW 14 50,723,097 (GRCm39) missense possibly damaging 0.47
R2971:Or11g25 UTSW 14 50,723,065 (GRCm39) missense probably damaging 0.99
R4594:Or11g25 UTSW 14 50,723,619 (GRCm39) missense probably benign 0.00
R5383:Or11g25 UTSW 14 50,723,509 (GRCm39) nonsense probably null
R5708:Or11g25 UTSW 14 50,723,452 (GRCm39) missense probably damaging 1.00
R6038:Or11g25 UTSW 14 50,723,677 (GRCm39) missense probably damaging 1.00
R6038:Or11g25 UTSW 14 50,723,677 (GRCm39) missense probably damaging 1.00
R7116:Or11g25 UTSW 14 50,723,025 (GRCm39) missense probably benign 0.00
R7702:Or11g25 UTSW 14 50,723,751 (GRCm39) missense possibly damaging 0.79
R8169:Or11g25 UTSW 14 50,723,692 (GRCm39) missense probably benign 0.13
R9040:Or11g25 UTSW 14 50,722,995 (GRCm39) missense probably benign 0.00
R9139:Or11g25 UTSW 14 50,723,707 (GRCm39) missense probably damaging 0.98
Posted On 2014-02-04