Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01796:Vmn2r118'

155365

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r118

Ensembl Gene

ENSMUSG00000091504

Gene Name

vomeronasal 2, receptor 118

Synonyms

EG383258, Vmn2r119, EG668547

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

IGL01796

Quality Score

Status

Chromosome

Chromosomal Location

55592341-55624672 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 55608585 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 455 (I455T)

Ref Sequence

ENSEMBL: ENSMUSP00000131128 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168440]

AlphaFold

E9Q1C1

Predicted Effect

probably benign
Transcript: ENSMUST00000168440
AA Change: I455T

PolyPhen 2 Score 0.297 (Sensitivity: 0.91; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000131128
Gene: ENSMUSG00000091504
AA Change: I455T

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	142	470	4.6e-27	PFAM
Pfam:NCD3G	513	566	2.6e-20	PFAM
Pfam:7tm_3	599	834	5.9e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aacs	T	C	5: 125,513,209	Y511H	probably damaging	Het
Abca7	T	G	10: 80,013,909	Y1948D	probably damaging	Het
Adgrl2	C	A	3: 148,858,975	G319V	probably damaging	Het
Adgrv1	T	A	13: 81,567,342	D909V	probably benign	Het
Anapc16	T	C	10: 59,988,757	E119G	possibly damaging	Het
C1qtnf12	T	C	4: 155,966,429	V285A	possibly damaging	Het
Cbr1	A	C	16: 93,608,231	N89T	probably damaging	Het
Cdh23	T	A	10: 60,311,137	Q2778L	probably benign	Het
Clca4c-ps	A	G	3: 144,889,579		noncoding transcript	Het
Cst9	T	C	2: 148,835,349	F47L	probably damaging	Het
Dqx1	T	C	6: 83,066,427		probably benign	Het
Dus4l	T	C	12: 31,642,795	S150G	probably benign	Het
E2f2	A	T	4: 136,180,417	K142*	probably null	Het
Eif2ak4	T	A	2: 118,446,304	H169Q	probably benign	Het
Fmo9	C	T	1: 166,663,335	A525T	probably benign	Het
Gm42878	T	C	5: 121,545,184	D6G	probably benign	Het
Igfals	A	G	17: 24,880,082	Y49C	probably damaging	Het
Iltifb	T	C	10: 118,290,164	N176S	possibly damaging	Het
Ipo7	T	C	7: 110,029,848		probably benign	Het
Itga1	T	C	13: 114,985,121	E784G	probably damaging	Het
Jcad	G	T	18: 4,672,855	E206*	probably null	Het
Kif24	A	T	4: 41,392,978		probably benign	Het
Lrrc2	T	A	9: 110,980,818		probably null	Het
Ltbp1	A	G	17: 75,227,245		probably benign	Het
Man2c1	C	T	9: 57,137,960	T451I	possibly damaging	Het
Manba	T	A	3: 135,542,389	N346K	probably damaging	Het
Nell1	T	C	7: 50,176,216		probably benign	Het
Nfat5	T	C	8: 107,367,641	V744A	probably damaging	Het
Nms	T	C	1: 38,946,111	M98T	possibly damaging	Het
Nos1	A	T	5: 117,938,274	K1120*	probably null	Het
Olfr741	C	A	14: 50,485,541	Q28K	probably benign	Het
Plekho1	C	T	3: 95,990,835	R172H	probably damaging	Het
Pot1b	A	T	17: 55,669,750	C391S	possibly damaging	Het
Scn1a	G	A	2: 66,332,301		probably benign	Het
Sgce	T	G	6: 4,711,326	N149H	probably damaging	Het
Slc45a1	A	G	4: 150,643,969	W126R	probably damaging	Het
Slc9a1	G	A	4: 133,420,093		probably benign	Het
Tmem131l	T	A	3: 83,938,055	K423*	probably null	Het
Tnrc18	C	T	5: 142,764,887	E1444K	possibly damaging	Het
Tpp1	T	C	7: 105,747,650		probably benign	Het
Trip12	A	C	1: 84,728,278	S610R	probably benign	Het
Ushbp1	G	T	8: 71,387,432	A525E	probably benign	Het
Vmn2r106	A	T	17: 20,268,052	M695K	possibly damaging	Het
Zbtb41	T	C	1: 139,442,883	F686S	probably damaging	Het

Other mutations in Vmn2r118

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Vmn2r118	APN	17	55592708	missense	probably damaging	1.00
IGL00976:Vmn2r118	APN	17	55593204	missense	probably damaging	1.00
IGL01419:Vmn2r118	APN	17	55593000	missense	probably benign	0.01
IGL01799:Vmn2r118	APN	17	55592990	missense	probably damaging	1.00
IGL02002:Vmn2r118	APN	17	55592619	missense	probably damaging	1.00
IGL02075:Vmn2r118	APN	17	55610517	missense	probably benign	0.18
IGL02172:Vmn2r118	APN	17	55624598	missense	probably benign	0.00
IGL02529:Vmn2r118	APN	17	55610870	missense	possibly damaging	0.58
IGL02712:Vmn2r118	APN	17	55592655	missense	probably benign	0.21
IGL03096:Vmn2r118	APN	17	55607996	missense	probably damaging	1.00
R0306:Vmn2r118	UTSW	17	55608616	missense	possibly damaging	0.89
R0329:Vmn2r118	UTSW	17	55610717	missense	probably damaging	1.00
R0330:Vmn2r118	UTSW	17	55610717	missense	probably damaging	1.00
R0396:Vmn2r118	UTSW	17	55608643	missense	probably benign	0.00
R0411:Vmn2r118	UTSW	17	55611021	splice site	probably benign
R0513:Vmn2r118	UTSW	17	55610970	nonsense	probably null
R0627:Vmn2r118	UTSW	17	55610772	missense	probably benign	0.01
R0638:Vmn2r118	UTSW	17	55608466	missense	probably benign	0.03
R1328:Vmn2r118	UTSW	17	55608620	missense	probably benign	0.01
R1366:Vmn2r118	UTSW	17	55593237	nonsense	probably null
R1465:Vmn2r118	UTSW	17	55610935	missense	probably benign	0.33
R1465:Vmn2r118	UTSW	17	55610935	missense	probably benign	0.33
R1511:Vmn2r118	UTSW	17	55608496	nonsense	probably null
R1515:Vmn2r118	UTSW	17	55610643	missense	probably benign	0.25
R1550:Vmn2r118	UTSW	17	55608083	missense	probably damaging	1.00
R1779:Vmn2r118	UTSW	17	55611530	missense	probably benign	0.03
R1834:Vmn2r118	UTSW	17	55592456	missense	probably damaging	1.00
R1840:Vmn2r118	UTSW	17	55610406	nonsense	probably null
R1854:Vmn2r118	UTSW	17	55611556	missense	possibly damaging	0.57
R1967:Vmn2r118	UTSW	17	55592882	missense	probably damaging	1.00
R1976:Vmn2r118	UTSW	17	55592925	missense	probably damaging	1.00
R2308:Vmn2r118	UTSW	17	55624650	missense	probably benign	0.33
R3700:Vmn2r118	UTSW	17	55608421	missense	possibly damaging	0.68
R4334:Vmn2r118	UTSW	17	55610347	missense	possibly damaging	0.58
R4647:Vmn2r118	UTSW	17	55610665	missense	probably damaging	1.00
R4709:Vmn2r118	UTSW	17	55610860	missense	probably damaging	1.00
R4805:Vmn2r118	UTSW	17	55592581	missense	probably damaging	1.00
R4858:Vmn2r118	UTSW	17	55592894	missense	probably damaging	0.98
R5384:Vmn2r118	UTSW	17	55611565	missense	probably benign	0.00
R5385:Vmn2r118	UTSW	17	55611565	missense	probably benign	0.00
R5664:Vmn2r118	UTSW	17	55592765	missense	possibly damaging	0.46
R5740:Vmn2r118	UTSW	17	55593103	missense	probably benign	0.00
R5927:Vmn2r118	UTSW	17	55624494	missense	probably benign	0.04
R6143:Vmn2r118	UTSW	17	55592871	missense	possibly damaging	0.92
R6513:Vmn2r118	UTSW	17	55608093	missense	probably damaging	1.00
R6573:Vmn2r118	UTSW	17	55592996	missense	probably damaging	1.00
R6760:Vmn2r118	UTSW	17	55592714	missense	possibly damaging	0.92
R6794:Vmn2r118	UTSW	17	55592348	missense	possibly damaging	0.48
R6929:Vmn2r118	UTSW	17	55610440	missense	probably benign	0.01
R7201:Vmn2r118	UTSW	17	55608496	nonsense	probably null
R7539:Vmn2r118	UTSW	17	55592853	missense	probably damaging	0.98
R7836:Vmn2r118	UTSW	17	55593242	missense	probably damaging	0.99
R8179:Vmn2r118	UTSW	17	55608484	missense	probably benign	0.36
R8248:Vmn2r118	UTSW	17	55610936	missense	probably benign	0.18
R8347:Vmn2r118	UTSW	17	55610423	missense	possibly damaging	0.94
R8415:Vmn2r118	UTSW	17	55608057	missense	probably benign	0.08
R8428:Vmn2r118	UTSW	17	55608642	missense	probably benign	0.33
R8917:Vmn2r118	UTSW	17	55610216	missense	possibly damaging	0.82
R8993:Vmn2r118	UTSW	17	55610835	missense	possibly damaging	0.72
R9038:Vmn2r118	UTSW	17	55611649	missense	probably damaging	1.00
R9155:Vmn2r118	UTSW	17	55610207	missense	probably null	0.83
R9603:Vmn2r118	UTSW	17	55592837	missense	probably damaging	1.00
R9742:Vmn2r118	UTSW	17	55611009	missense	probably damaging	0.98
R9749:Vmn2r118	UTSW	17	55608415	critical splice donor site	probably null
R9792:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
R9793:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
R9795:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
X0022:Vmn2r118	UTSW	17	55593218	missense	probably damaging	1.00
Z1176:Vmn2r118	UTSW	17	55610655	nonsense	probably null

Posted On

2014-02-04