Incidental Mutation 'IGL01796:Fmo9'
ID 155368
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fmo9
Ensembl Gene ENSMUSG00000026560
Gene Name flavin containing monooxygenase 9
Synonyms 4831428F09Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # IGL01796
Quality Score
Status
Chromosome 1
Chromosomal Location 166489624-166509414 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 166490904 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 525 (A525T)
Ref Sequence ENSEMBL: ENSMUSP00000027843 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027843] [ENSMUST00000148677]
AlphaFold Q8C116
Predicted Effect probably benign
Transcript: ENSMUST00000027843
AA Change: A525T

PolyPhen 2 Score 0.311 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000027843
Gene: ENSMUSG00000026560
AA Change: A525T

DomainStartEndE-ValueType
Pfam:FMO-like 3 535 1.2e-252 PFAM
Pfam:Pyr_redox_2 4 262 2.9e-12 PFAM
Pfam:Pyr_redox_3 7 221 2.3e-14 PFAM
Pfam:NAD_binding_8 8 83 1.2e-6 PFAM
Pfam:K_oxygenase 77 334 8.9e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000148677
AA Change: A474T

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000114750
Gene: ENSMUSG00000026560
AA Change: A474T

DomainStartEndE-ValueType
Pfam:FMO-like 1 484 1.6e-222 PFAM
Pfam:Pyr_redox_3 3 170 1.2e-12 PFAM
Pfam:K_oxygenase 28 283 6.2e-11 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aacs T C 5: 125,590,273 (GRCm39) Y511H probably damaging Het
Abca7 T G 10: 79,849,743 (GRCm39) Y1948D probably damaging Het
Adgrl2 C A 3: 148,564,611 (GRCm39) G319V probably damaging Het
Adgrv1 T A 13: 81,715,461 (GRCm39) D909V probably benign Het
Anapc16 T C 10: 59,824,579 (GRCm39) E119G possibly damaging Het
C1qtnf12 T C 4: 156,050,886 (GRCm39) V285A possibly damaging Het
Cbr1 A C 16: 93,405,119 (GRCm39) N89T probably damaging Het
Cdh23 T A 10: 60,146,916 (GRCm39) Q2778L probably benign Het
Clca4c-ps A G 3: 144,595,340 (GRCm39) noncoding transcript Het
Cst9 T C 2: 148,677,269 (GRCm39) F47L probably damaging Het
Dqx1 T C 6: 83,043,408 (GRCm39) probably benign Het
Dus4l T C 12: 31,692,794 (GRCm39) S150G probably benign Het
E2f2 A T 4: 135,907,728 (GRCm39) K142* probably null Het
Eif2ak4 T A 2: 118,276,785 (GRCm39) H169Q probably benign Het
Gm42878 T C 5: 121,683,247 (GRCm39) D6G probably benign Het
Igfals A G 17: 25,099,056 (GRCm39) Y49C probably damaging Het
Il22b T C 10: 118,126,069 (GRCm39) N176S possibly damaging Het
Ipo7 T C 7: 109,629,055 (GRCm39) probably benign Het
Itga1 T C 13: 115,121,657 (GRCm39) E784G probably damaging Het
Jcad G T 18: 4,672,855 (GRCm39) E206* probably null Het
Kif24 A T 4: 41,392,978 (GRCm39) probably benign Het
Lrrc2 T A 9: 110,809,886 (GRCm39) probably null Het
Ltbp1 A G 17: 75,534,240 (GRCm39) probably benign Het
Man2c1 C T 9: 57,045,244 (GRCm39) T451I possibly damaging Het
Manba T A 3: 135,248,150 (GRCm39) N346K probably damaging Het
Nell1 T C 7: 49,825,964 (GRCm39) probably benign Het
Nfat5 T C 8: 108,094,273 (GRCm39) V744A probably damaging Het
Nms T C 1: 38,985,192 (GRCm39) M98T possibly damaging Het
Nos1 A T 5: 118,076,339 (GRCm39) K1120* probably null Het
Or11g25 C A 14: 50,722,998 (GRCm39) Q28K probably benign Het
Plekho1 C T 3: 95,898,147 (GRCm39) R172H probably damaging Het
Pot1b A T 17: 55,976,750 (GRCm39) C391S possibly damaging Het
Scn1a G A 2: 66,162,645 (GRCm39) probably benign Het
Sgce T G 6: 4,711,326 (GRCm39) N149H probably damaging Het
Slc45a1 A G 4: 150,728,426 (GRCm39) W126R probably damaging Het
Slc9a1 G A 4: 133,147,404 (GRCm39) probably benign Het
Tmem131l T A 3: 83,845,362 (GRCm39) K423* probably null Het
Tnrc18 C T 5: 142,750,642 (GRCm39) E1444K possibly damaging Het
Tpp1 T C 7: 105,396,857 (GRCm39) probably benign Het
Trip12 A C 1: 84,705,999 (GRCm39) S610R probably benign Het
Ushbp1 G T 8: 71,840,076 (GRCm39) A525E probably benign Het
Vmn2r106 A T 17: 20,488,314 (GRCm39) M695K possibly damaging Het
Vmn2r118 A G 17: 55,915,585 (GRCm39) I455T probably benign Het
Zbtb41 T C 1: 139,370,621 (GRCm39) F686S probably damaging Het
Other mutations in Fmo9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00886:Fmo9 APN 1 166,507,714 (GRCm39) splice site probably null
IGL03005:Fmo9 APN 1 166,502,088 (GRCm39) missense probably benign 0.02
IGL03115:Fmo9 APN 1 166,505,220 (GRCm39) missense probably damaging 1.00
IGL03163:Fmo9 APN 1 166,502,019 (GRCm39) missense possibly damaging 0.77
R0089:Fmo9 UTSW 1 166,494,878 (GRCm39) missense probably benign 0.05
R0570:Fmo9 UTSW 1 166,502,031 (GRCm39) missense probably null 0.00
R1520:Fmo9 UTSW 1 166,495,024 (GRCm39) missense probably benign 0.19
R1779:Fmo9 UTSW 1 166,490,868 (GRCm39) missense probably benign 0.18
R1783:Fmo9 UTSW 1 166,501,217 (GRCm39) missense probably benign 0.01
R2858:Fmo9 UTSW 1 166,501,236 (GRCm39) missense probably damaging 1.00
R2859:Fmo9 UTSW 1 166,501,236 (GRCm39) missense probably damaging 1.00
R3851:Fmo9 UTSW 1 166,490,936 (GRCm39) missense probably benign 0.00
R3924:Fmo9 UTSW 1 166,492,221 (GRCm39) missense probably benign 0.03
R4470:Fmo9 UTSW 1 166,507,799 (GRCm39) missense probably damaging 1.00
R4728:Fmo9 UTSW 1 166,490,880 (GRCm39) missense possibly damaging 0.82
R5538:Fmo9 UTSW 1 166,501,198 (GRCm39) missense probably benign 0.01
R5650:Fmo9 UTSW 1 166,491,015 (GRCm39) missense probably damaging 1.00
R5820:Fmo9 UTSW 1 166,492,170 (GRCm39) missense possibly damaging 0.67
R6163:Fmo9 UTSW 1 166,494,962 (GRCm39) missense probably benign
R6229:Fmo9 UTSW 1 166,505,126 (GRCm39) missense possibly damaging 0.64
R6243:Fmo9 UTSW 1 166,494,938 (GRCm39) missense probably benign 0.45
R6375:Fmo9 UTSW 1 166,492,164 (GRCm39) critical splice donor site probably null
R7144:Fmo9 UTSW 1 166,505,189 (GRCm39) missense probably benign 0.40
R7236:Fmo9 UTSW 1 166,504,140 (GRCm39) missense probably damaging 1.00
R7316:Fmo9 UTSW 1 166,491,215 (GRCm39) missense probably benign 0.21
R7341:Fmo9 UTSW 1 166,504,115 (GRCm39) missense probably damaging 1.00
R7382:Fmo9 UTSW 1 166,491,229 (GRCm39) splice site probably null
R7589:Fmo9 UTSW 1 166,501,997 (GRCm39) missense possibly damaging 0.61
R7679:Fmo9 UTSW 1 166,495,058 (GRCm39) missense probably benign 0.01
R8110:Fmo9 UTSW 1 166,491,095 (GRCm39) missense probably benign 0.03
R8500:Fmo9 UTSW 1 166,502,039 (GRCm39) missense probably damaging 1.00
R9098:Fmo9 UTSW 1 166,492,199 (GRCm39) missense possibly damaging 0.48
R9301:Fmo9 UTSW 1 166,494,794 (GRCm39) missense probably damaging 1.00
R9400:Fmo9 UTSW 1 166,505,243 (GRCm39) missense probably benign 0.09
R9401:Fmo9 UTSW 1 166,505,189 (GRCm39) missense probably damaging 0.99
Z1088:Fmo9 UTSW 1 166,501,114 (GRCm39) critical splice donor site probably null
Posted On 2014-02-04