Incidental Mutation 'IGL01796:Fmo9'
ID |
155368 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Fmo9
|
Ensembl Gene |
ENSMUSG00000026560 |
Gene Name |
flavin containing monooxygenase 9 |
Synonyms |
4831428F09Rik |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.063)
|
Stock # |
IGL01796
|
Quality Score |
|
Status
|
|
Chromosome |
1 |
Chromosomal Location |
166489624-166509414 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to T
at 166490904 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Alanine to Threonine
at position 525
(A525T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000027843
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027843]
[ENSMUST00000148677]
|
AlphaFold |
Q8C116 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000027843
AA Change: A525T
PolyPhen 2
Score 0.311 (Sensitivity: 0.90; Specificity: 0.89)
|
SMART Domains |
Protein: ENSMUSP00000027843 Gene: ENSMUSG00000026560 AA Change: A525T
Domain | Start | End | E-Value | Type |
Pfam:FMO-like
|
3 |
535 |
1.2e-252 |
PFAM |
Pfam:Pyr_redox_2
|
4 |
262 |
2.9e-12 |
PFAM |
Pfam:Pyr_redox_3
|
7 |
221 |
2.3e-14 |
PFAM |
Pfam:NAD_binding_8
|
8 |
83 |
1.2e-6 |
PFAM |
Pfam:K_oxygenase
|
77 |
334 |
8.9e-11 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000148677
AA Change: A474T
PolyPhen 2
Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
|
SMART Domains |
Protein: ENSMUSP00000114750 Gene: ENSMUSG00000026560 AA Change: A474T
Domain | Start | End | E-Value | Type |
Pfam:FMO-like
|
1 |
484 |
1.6e-222 |
PFAM |
Pfam:Pyr_redox_3
|
3 |
170 |
1.2e-12 |
PFAM |
Pfam:K_oxygenase
|
28 |
283 |
6.2e-11 |
PFAM |
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 44 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Aacs |
T |
C |
5: 125,590,273 (GRCm39) |
Y511H |
probably damaging |
Het |
Abca7 |
T |
G |
10: 79,849,743 (GRCm39) |
Y1948D |
probably damaging |
Het |
Adgrl2 |
C |
A |
3: 148,564,611 (GRCm39) |
G319V |
probably damaging |
Het |
Adgrv1 |
T |
A |
13: 81,715,461 (GRCm39) |
D909V |
probably benign |
Het |
Anapc16 |
T |
C |
10: 59,824,579 (GRCm39) |
E119G |
possibly damaging |
Het |
C1qtnf12 |
T |
C |
4: 156,050,886 (GRCm39) |
V285A |
possibly damaging |
Het |
Cbr1 |
A |
C |
16: 93,405,119 (GRCm39) |
N89T |
probably damaging |
Het |
Cdh23 |
T |
A |
10: 60,146,916 (GRCm39) |
Q2778L |
probably benign |
Het |
Clca4c-ps |
A |
G |
3: 144,595,340 (GRCm39) |
|
noncoding transcript |
Het |
Cst9 |
T |
C |
2: 148,677,269 (GRCm39) |
F47L |
probably damaging |
Het |
Dqx1 |
T |
C |
6: 83,043,408 (GRCm39) |
|
probably benign |
Het |
Dus4l |
T |
C |
12: 31,692,794 (GRCm39) |
S150G |
probably benign |
Het |
E2f2 |
A |
T |
4: 135,907,728 (GRCm39) |
K142* |
probably null |
Het |
Eif2ak4 |
T |
A |
2: 118,276,785 (GRCm39) |
H169Q |
probably benign |
Het |
Gm42878 |
T |
C |
5: 121,683,247 (GRCm39) |
D6G |
probably benign |
Het |
Igfals |
A |
G |
17: 25,099,056 (GRCm39) |
Y49C |
probably damaging |
Het |
Il22b |
T |
C |
10: 118,126,069 (GRCm39) |
N176S |
possibly damaging |
Het |
Ipo7 |
T |
C |
7: 109,629,055 (GRCm39) |
|
probably benign |
Het |
Itga1 |
T |
C |
13: 115,121,657 (GRCm39) |
E784G |
probably damaging |
Het |
Jcad |
G |
T |
18: 4,672,855 (GRCm39) |
E206* |
probably null |
Het |
Kif24 |
A |
T |
4: 41,392,978 (GRCm39) |
|
probably benign |
Het |
Lrrc2 |
T |
A |
9: 110,809,886 (GRCm39) |
|
probably null |
Het |
Ltbp1 |
A |
G |
17: 75,534,240 (GRCm39) |
|
probably benign |
Het |
Man2c1 |
C |
T |
9: 57,045,244 (GRCm39) |
T451I |
possibly damaging |
Het |
Manba |
T |
A |
3: 135,248,150 (GRCm39) |
N346K |
probably damaging |
Het |
Nell1 |
T |
C |
7: 49,825,964 (GRCm39) |
|
probably benign |
Het |
Nfat5 |
T |
C |
8: 108,094,273 (GRCm39) |
V744A |
probably damaging |
Het |
Nms |
T |
C |
1: 38,985,192 (GRCm39) |
M98T |
possibly damaging |
Het |
Nos1 |
A |
T |
5: 118,076,339 (GRCm39) |
K1120* |
probably null |
Het |
Or11g25 |
C |
A |
14: 50,722,998 (GRCm39) |
Q28K |
probably benign |
Het |
Plekho1 |
C |
T |
3: 95,898,147 (GRCm39) |
R172H |
probably damaging |
Het |
Pot1b |
A |
T |
17: 55,976,750 (GRCm39) |
C391S |
possibly damaging |
Het |
Scn1a |
G |
A |
2: 66,162,645 (GRCm39) |
|
probably benign |
Het |
Sgce |
T |
G |
6: 4,711,326 (GRCm39) |
N149H |
probably damaging |
Het |
Slc45a1 |
A |
G |
4: 150,728,426 (GRCm39) |
W126R |
probably damaging |
Het |
Slc9a1 |
G |
A |
4: 133,147,404 (GRCm39) |
|
probably benign |
Het |
Tmem131l |
T |
A |
3: 83,845,362 (GRCm39) |
K423* |
probably null |
Het |
Tnrc18 |
C |
T |
5: 142,750,642 (GRCm39) |
E1444K |
possibly damaging |
Het |
Tpp1 |
T |
C |
7: 105,396,857 (GRCm39) |
|
probably benign |
Het |
Trip12 |
A |
C |
1: 84,705,999 (GRCm39) |
S610R |
probably benign |
Het |
Ushbp1 |
G |
T |
8: 71,840,076 (GRCm39) |
A525E |
probably benign |
Het |
Vmn2r106 |
A |
T |
17: 20,488,314 (GRCm39) |
M695K |
possibly damaging |
Het |
Vmn2r118 |
A |
G |
17: 55,915,585 (GRCm39) |
I455T |
probably benign |
Het |
Zbtb41 |
T |
C |
1: 139,370,621 (GRCm39) |
F686S |
probably damaging |
Het |
|
Other mutations in Fmo9 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00886:Fmo9
|
APN |
1 |
166,507,714 (GRCm39) |
splice site |
probably null |
|
IGL03005:Fmo9
|
APN |
1 |
166,502,088 (GRCm39) |
missense |
probably benign |
0.02 |
IGL03115:Fmo9
|
APN |
1 |
166,505,220 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03163:Fmo9
|
APN |
1 |
166,502,019 (GRCm39) |
missense |
possibly damaging |
0.77 |
R0089:Fmo9
|
UTSW |
1 |
166,494,878 (GRCm39) |
missense |
probably benign |
0.05 |
R0570:Fmo9
|
UTSW |
1 |
166,502,031 (GRCm39) |
missense |
probably null |
0.00 |
R1520:Fmo9
|
UTSW |
1 |
166,495,024 (GRCm39) |
missense |
probably benign |
0.19 |
R1779:Fmo9
|
UTSW |
1 |
166,490,868 (GRCm39) |
missense |
probably benign |
0.18 |
R1783:Fmo9
|
UTSW |
1 |
166,501,217 (GRCm39) |
missense |
probably benign |
0.01 |
R2858:Fmo9
|
UTSW |
1 |
166,501,236 (GRCm39) |
missense |
probably damaging |
1.00 |
R2859:Fmo9
|
UTSW |
1 |
166,501,236 (GRCm39) |
missense |
probably damaging |
1.00 |
R3851:Fmo9
|
UTSW |
1 |
166,490,936 (GRCm39) |
missense |
probably benign |
0.00 |
R3924:Fmo9
|
UTSW |
1 |
166,492,221 (GRCm39) |
missense |
probably benign |
0.03 |
R4470:Fmo9
|
UTSW |
1 |
166,507,799 (GRCm39) |
missense |
probably damaging |
1.00 |
R4728:Fmo9
|
UTSW |
1 |
166,490,880 (GRCm39) |
missense |
possibly damaging |
0.82 |
R5538:Fmo9
|
UTSW |
1 |
166,501,198 (GRCm39) |
missense |
probably benign |
0.01 |
R5650:Fmo9
|
UTSW |
1 |
166,491,015 (GRCm39) |
missense |
probably damaging |
1.00 |
R5820:Fmo9
|
UTSW |
1 |
166,492,170 (GRCm39) |
missense |
possibly damaging |
0.67 |
R6163:Fmo9
|
UTSW |
1 |
166,494,962 (GRCm39) |
missense |
probably benign |
|
R6229:Fmo9
|
UTSW |
1 |
166,505,126 (GRCm39) |
missense |
possibly damaging |
0.64 |
R6243:Fmo9
|
UTSW |
1 |
166,494,938 (GRCm39) |
missense |
probably benign |
0.45 |
R6375:Fmo9
|
UTSW |
1 |
166,492,164 (GRCm39) |
critical splice donor site |
probably null |
|
R7144:Fmo9
|
UTSW |
1 |
166,505,189 (GRCm39) |
missense |
probably benign |
0.40 |
R7236:Fmo9
|
UTSW |
1 |
166,504,140 (GRCm39) |
missense |
probably damaging |
1.00 |
R7316:Fmo9
|
UTSW |
1 |
166,491,215 (GRCm39) |
missense |
probably benign |
0.21 |
R7341:Fmo9
|
UTSW |
1 |
166,504,115 (GRCm39) |
missense |
probably damaging |
1.00 |
R7382:Fmo9
|
UTSW |
1 |
166,491,229 (GRCm39) |
splice site |
probably null |
|
R7589:Fmo9
|
UTSW |
1 |
166,501,997 (GRCm39) |
missense |
possibly damaging |
0.61 |
R7679:Fmo9
|
UTSW |
1 |
166,495,058 (GRCm39) |
missense |
probably benign |
0.01 |
R8110:Fmo9
|
UTSW |
1 |
166,491,095 (GRCm39) |
missense |
probably benign |
0.03 |
R8500:Fmo9
|
UTSW |
1 |
166,502,039 (GRCm39) |
missense |
probably damaging |
1.00 |
R9098:Fmo9
|
UTSW |
1 |
166,492,199 (GRCm39) |
missense |
possibly damaging |
0.48 |
R9301:Fmo9
|
UTSW |
1 |
166,494,794 (GRCm39) |
missense |
probably damaging |
1.00 |
R9400:Fmo9
|
UTSW |
1 |
166,505,243 (GRCm39) |
missense |
probably benign |
0.09 |
R9401:Fmo9
|
UTSW |
1 |
166,505,189 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1088:Fmo9
|
UTSW |
1 |
166,501,114 (GRCm39) |
critical splice donor site |
probably null |
|
|
Posted On |
2014-02-04 |