Incidental Mutation 'IGL01796:Kif24'
ID 155374
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kif24
Ensembl Gene ENSMUSG00000028438
Gene Name kinesin family member 24
Synonyms 4933425J19Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01796
Quality Score
Status
Chromosome 4
Chromosomal Location 41390745-41464887 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to T at 41392978 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000030148] [ENSMUST00000072866] [ENSMUST00000108055] [ENSMUST00000108060]
AlphaFold Q6NWW5
Predicted Effect probably benign
Transcript: ENSMUST00000030148
SMART Domains Protein: ENSMUSP00000030148
Gene: ENSMUSG00000028438

DomainStartEndE-ValueType
KISc 216 413 2.51e-29 SMART
low complexity region 481 499 N/A INTRINSIC
low complexity region 563 574 N/A INTRINSIC
low complexity region 626 644 N/A INTRINSIC
low complexity region 678 695 N/A INTRINSIC
low complexity region 1119 1130 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000072866
SMART Domains Protein: ENSMUSP00000072643
Gene: ENSMUSG00000028437

DomainStartEndE-ValueType
coiled coil region 64 95 N/A INTRINSIC
low complexity region 333 348 N/A INTRINSIC
SCOP:d1ifya_ 387 430 5e-10 SMART
PDB:4AE4|B 388 502 1e-74 PDB
Blast:UBA 392 428 7e-14 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000108055
SMART Domains Protein: ENSMUSP00000103690
Gene: ENSMUSG00000028438

DomainStartEndE-ValueType
Blast:KISc 82 205 1e-47 BLAST
KISc 216 547 3.09e-134 SMART
low complexity region 615 633 N/A INTRINSIC
low complexity region 697 708 N/A INTRINSIC
low complexity region 760 778 N/A INTRINSIC
low complexity region 812 829 N/A INTRINSIC
low complexity region 1253 1264 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108060
SMART Domains Protein: ENSMUSP00000103695
Gene: ENSMUSG00000028437

DomainStartEndE-ValueType
coiled coil region 64 95 N/A INTRINSIC
low complexity region 333 348 N/A INTRINSIC
PDB:4AE4|B 362 441 2e-50 PDB
SCOP:d1exja1 394 437 1e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000132235
SMART Domains Protein: ENSMUSP00000123491
Gene: ENSMUSG00000028437

DomainStartEndE-ValueType
SCOP:d1ifya_ 68 111 2e-11 SMART
PDB:4AE4|B 69 140 2e-44 PDB
Blast:UBA 73 109 7e-15 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141951
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kinesins, such as KIF24, are microtubule-dependent ATPases that function as molecular motors. They play important roles in intracellular vesicle transport and cell division (summary by Venturelli et al., 2010 [PubMed 20670673]).[supplied by OMIM, Feb 2011]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aacs T C 5: 125,590,273 (GRCm39) Y511H probably damaging Het
Abca7 T G 10: 79,849,743 (GRCm39) Y1948D probably damaging Het
Adgrl2 C A 3: 148,564,611 (GRCm39) G319V probably damaging Het
Adgrv1 T A 13: 81,715,461 (GRCm39) D909V probably benign Het
Anapc16 T C 10: 59,824,579 (GRCm39) E119G possibly damaging Het
C1qtnf12 T C 4: 156,050,886 (GRCm39) V285A possibly damaging Het
Cbr1 A C 16: 93,405,119 (GRCm39) N89T probably damaging Het
Cdh23 T A 10: 60,146,916 (GRCm39) Q2778L probably benign Het
Clca4c-ps A G 3: 144,595,340 (GRCm39) noncoding transcript Het
Cst9 T C 2: 148,677,269 (GRCm39) F47L probably damaging Het
Dqx1 T C 6: 83,043,408 (GRCm39) probably benign Het
Dus4l T C 12: 31,692,794 (GRCm39) S150G probably benign Het
E2f2 A T 4: 135,907,728 (GRCm39) K142* probably null Het
Eif2ak4 T A 2: 118,276,785 (GRCm39) H169Q probably benign Het
Fmo9 C T 1: 166,490,904 (GRCm39) A525T probably benign Het
Gm42878 T C 5: 121,683,247 (GRCm39) D6G probably benign Het
Igfals A G 17: 25,099,056 (GRCm39) Y49C probably damaging Het
Il22b T C 10: 118,126,069 (GRCm39) N176S possibly damaging Het
Ipo7 T C 7: 109,629,055 (GRCm39) probably benign Het
Itga1 T C 13: 115,121,657 (GRCm39) E784G probably damaging Het
Jcad G T 18: 4,672,855 (GRCm39) E206* probably null Het
Lrrc2 T A 9: 110,809,886 (GRCm39) probably null Het
Ltbp1 A G 17: 75,534,240 (GRCm39) probably benign Het
Man2c1 C T 9: 57,045,244 (GRCm39) T451I possibly damaging Het
Manba T A 3: 135,248,150 (GRCm39) N346K probably damaging Het
Nell1 T C 7: 49,825,964 (GRCm39) probably benign Het
Nfat5 T C 8: 108,094,273 (GRCm39) V744A probably damaging Het
Nms T C 1: 38,985,192 (GRCm39) M98T possibly damaging Het
Nos1 A T 5: 118,076,339 (GRCm39) K1120* probably null Het
Or11g25 C A 14: 50,722,998 (GRCm39) Q28K probably benign Het
Plekho1 C T 3: 95,898,147 (GRCm39) R172H probably damaging Het
Pot1b A T 17: 55,976,750 (GRCm39) C391S possibly damaging Het
Scn1a G A 2: 66,162,645 (GRCm39) probably benign Het
Sgce T G 6: 4,711,326 (GRCm39) N149H probably damaging Het
Slc45a1 A G 4: 150,728,426 (GRCm39) W126R probably damaging Het
Slc9a1 G A 4: 133,147,404 (GRCm39) probably benign Het
Tmem131l T A 3: 83,845,362 (GRCm39) K423* probably null Het
Tnrc18 C T 5: 142,750,642 (GRCm39) E1444K possibly damaging Het
Tpp1 T C 7: 105,396,857 (GRCm39) probably benign Het
Trip12 A C 1: 84,705,999 (GRCm39) S610R probably benign Het
Ushbp1 G T 8: 71,840,076 (GRCm39) A525E probably benign Het
Vmn2r106 A T 17: 20,488,314 (GRCm39) M695K possibly damaging Het
Vmn2r118 A G 17: 55,915,585 (GRCm39) I455T probably benign Het
Zbtb41 T C 1: 139,370,621 (GRCm39) F686S probably damaging Het
Other mutations in Kif24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00509:Kif24 APN 4 41,413,826 (GRCm39) splice site probably null
IGL00787:Kif24 APN 4 41,397,583 (GRCm39) missense probably damaging 1.00
IGL01065:Kif24 APN 4 41,423,639 (GRCm39) unclassified probably benign
IGL01716:Kif24 APN 4 41,393,454 (GRCm39) missense probably benign 0.40
IGL02307:Kif24 APN 4 41,395,274 (GRCm39) missense probably benign 0.02
IGL03061:Kif24 APN 4 41,394,323 (GRCm39) missense possibly damaging 0.86
IGL03080:Kif24 APN 4 41,394,417 (GRCm39) missense probably benign 0.12
IGL03100:Kif24 APN 4 41,394,446 (GRCm39) missense possibly damaging 0.59
R0226:Kif24 UTSW 4 41,414,939 (GRCm39) nonsense probably null
R0345:Kif24 UTSW 4 41,428,413 (GRCm39) missense probably benign 0.01
R0365:Kif24 UTSW 4 41,428,731 (GRCm39) missense probably benign 0.06
R0366:Kif24 UTSW 4 41,428,717 (GRCm39) missense possibly damaging 0.77
R0579:Kif24 UTSW 4 41,393,706 (GRCm39) missense probably damaging 0.97
R0682:Kif24 UTSW 4 41,428,620 (GRCm39) missense probably benign 0.01
R1611:Kif24 UTSW 4 41,423,552 (GRCm39) missense probably benign 0.02
R1634:Kif24 UTSW 4 41,393,529 (GRCm39) missense probably benign 0.02
R1772:Kif24 UTSW 4 41,409,787 (GRCm39) missense probably damaging 1.00
R1997:Kif24 UTSW 4 41,392,904 (GRCm39) missense possibly damaging 0.92
R3833:Kif24 UTSW 4 41,395,064 (GRCm39) missense probably damaging 1.00
R3849:Kif24 UTSW 4 41,404,734 (GRCm39) missense probably damaging 1.00
R4356:Kif24 UTSW 4 41,413,827 (GRCm39) critical splice donor site probably null
R4357:Kif24 UTSW 4 41,413,827 (GRCm39) critical splice donor site probably null
R4358:Kif24 UTSW 4 41,413,827 (GRCm39) critical splice donor site probably null
R4359:Kif24 UTSW 4 41,413,827 (GRCm39) critical splice donor site probably null
R4406:Kif24 UTSW 4 41,393,954 (GRCm39) missense probably damaging 1.00
R4580:Kif24 UTSW 4 41,395,287 (GRCm39) missense probably damaging 1.00
R4756:Kif24 UTSW 4 41,397,545 (GRCm39) critical splice donor site probably null
R4921:Kif24 UTSW 4 41,394,329 (GRCm39) missense probably damaging 0.99
R4935:Kif24 UTSW 4 41,394,939 (GRCm39) missense probably damaging 0.99
R5288:Kif24 UTSW 4 41,395,373 (GRCm39) missense probably benign 0.09
R5398:Kif24 UTSW 4 41,394,401 (GRCm39) missense possibly damaging 0.50
R5885:Kif24 UTSW 4 41,423,463 (GRCm39) missense probably damaging 1.00
R5901:Kif24 UTSW 4 41,428,604 (GRCm39) missense probably damaging 1.00
R5919:Kif24 UTSW 4 41,394,477 (GRCm39) missense possibly damaging 0.62
R5945:Kif24 UTSW 4 41,428,670 (GRCm39) nonsense probably null
R6278:Kif24 UTSW 4 41,423,498 (GRCm39) missense probably damaging 1.00
R6291:Kif24 UTSW 4 41,413,959 (GRCm39) missense probably damaging 1.00
R6891:Kif24 UTSW 4 41,394,168 (GRCm39) missense probably benign 0.33
R7178:Kif24 UTSW 4 41,395,085 (GRCm39) missense probably benign 0.00
R7437:Kif24 UTSW 4 41,404,687 (GRCm39) missense possibly damaging 0.70
R7453:Kif24 UTSW 4 41,394,673 (GRCm39) missense possibly damaging 0.91
R7543:Kif24 UTSW 4 41,413,993 (GRCm39) nonsense probably null
R7548:Kif24 UTSW 4 41,423,601 (GRCm39) missense possibly damaging 0.57
R8167:Kif24 UTSW 4 41,392,957 (GRCm39) missense possibly damaging 0.87
R8305:Kif24 UTSW 4 41,428,825 (GRCm39) missense probably damaging 1.00
R8407:Kif24 UTSW 4 41,394,488 (GRCm39) missense probably benign 0.05
R8722:Kif24 UTSW 4 41,394,233 (GRCm39) missense probably benign
R8916:Kif24 UTSW 4 41,394,963 (GRCm39) missense probably benign 0.23
R9093:Kif24 UTSW 4 41,428,691 (GRCm39) missense probably benign
R9172:Kif24 UTSW 4 41,400,442 (GRCm39) missense probably benign 0.44
R9468:Kif24 UTSW 4 41,404,794 (GRCm39) missense probably damaging 1.00
R9687:Kif24 UTSW 4 41,428,546 (GRCm39) missense probably damaging 0.99
Z1088:Kif24 UTSW 4 41,395,091 (GRCm39) missense probably damaging 0.99
Posted On 2014-02-04