Incidental Mutation 'IGL01796:Lrrc2'
ID 155375
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc2
Ensembl Gene ENSMUSG00000032495
Gene Name leucine rich repeat containing 2
Synonyms 2400002D05Rik, 4933431K03Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01796
Quality Score
Status
Chromosome 9
Chromosomal Location 110780613-110813134 bp(+) (GRCm39)
Type of Mutation splice site (4117 bp from exon)
DNA Base Change (assembly) T to A at 110809886 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143305 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035076] [ENSMUST00000199891]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000035076
SMART Domains Protein: ENSMUSP00000035076
Gene: ENSMUSG00000032495

DomainStartEndE-ValueType
Blast:LRR 143 165 5e-7 BLAST
LRR_TYP 166 189 4.87e-4 SMART
LRR 236 258 1.41e1 SMART
LRR 259 282 2.27e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000196598
Predicted Effect probably null
Transcript: ENSMUST00000199891
SMART Domains Protein: ENSMUSP00000143305
Gene: ENSMUSG00000066319

DomainStartEndE-ValueType
zf-3CxxC 52 164 2.13e-52 SMART
low complexity region 356 404 N/A INTRINSIC
low complexity region 458 474 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the leucine-rich repeat-containing family of proteins, which function in diverse biological pathways. This family member may possibly be a nuclear protein. Similarity to the RAS suppressor protein, as well as expression down-regulation observed in tumor cells, suggests that it may function as a tumor suppressor. The gene is located in the chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region that is commonly deleted in diverse tumors. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Sep 2011]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aacs T C 5: 125,590,273 (GRCm39) Y511H probably damaging Het
Abca7 T G 10: 79,849,743 (GRCm39) Y1948D probably damaging Het
Adgrl2 C A 3: 148,564,611 (GRCm39) G319V probably damaging Het
Adgrv1 T A 13: 81,715,461 (GRCm39) D909V probably benign Het
Anapc16 T C 10: 59,824,579 (GRCm39) E119G possibly damaging Het
C1qtnf12 T C 4: 156,050,886 (GRCm39) V285A possibly damaging Het
Cbr1 A C 16: 93,405,119 (GRCm39) N89T probably damaging Het
Cdh23 T A 10: 60,146,916 (GRCm39) Q2778L probably benign Het
Clca4c-ps A G 3: 144,595,340 (GRCm39) noncoding transcript Het
Cst9 T C 2: 148,677,269 (GRCm39) F47L probably damaging Het
Dqx1 T C 6: 83,043,408 (GRCm39) probably benign Het
Dus4l T C 12: 31,692,794 (GRCm39) S150G probably benign Het
E2f2 A T 4: 135,907,728 (GRCm39) K142* probably null Het
Eif2ak4 T A 2: 118,276,785 (GRCm39) H169Q probably benign Het
Fmo9 C T 1: 166,490,904 (GRCm39) A525T probably benign Het
Gm42878 T C 5: 121,683,247 (GRCm39) D6G probably benign Het
Igfals A G 17: 25,099,056 (GRCm39) Y49C probably damaging Het
Il22b T C 10: 118,126,069 (GRCm39) N176S possibly damaging Het
Ipo7 T C 7: 109,629,055 (GRCm39) probably benign Het
Itga1 T C 13: 115,121,657 (GRCm39) E784G probably damaging Het
Jcad G T 18: 4,672,855 (GRCm39) E206* probably null Het
Kif24 A T 4: 41,392,978 (GRCm39) probably benign Het
Ltbp1 A G 17: 75,534,240 (GRCm39) probably benign Het
Man2c1 C T 9: 57,045,244 (GRCm39) T451I possibly damaging Het
Manba T A 3: 135,248,150 (GRCm39) N346K probably damaging Het
Nell1 T C 7: 49,825,964 (GRCm39) probably benign Het
Nfat5 T C 8: 108,094,273 (GRCm39) V744A probably damaging Het
Nms T C 1: 38,985,192 (GRCm39) M98T possibly damaging Het
Nos1 A T 5: 118,076,339 (GRCm39) K1120* probably null Het
Or11g25 C A 14: 50,722,998 (GRCm39) Q28K probably benign Het
Plekho1 C T 3: 95,898,147 (GRCm39) R172H probably damaging Het
Pot1b A T 17: 55,976,750 (GRCm39) C391S possibly damaging Het
Scn1a G A 2: 66,162,645 (GRCm39) probably benign Het
Sgce T G 6: 4,711,326 (GRCm39) N149H probably damaging Het
Slc45a1 A G 4: 150,728,426 (GRCm39) W126R probably damaging Het
Slc9a1 G A 4: 133,147,404 (GRCm39) probably benign Het
Tmem131l T A 3: 83,845,362 (GRCm39) K423* probably null Het
Tnrc18 C T 5: 142,750,642 (GRCm39) E1444K possibly damaging Het
Tpp1 T C 7: 105,396,857 (GRCm39) probably benign Het
Trip12 A C 1: 84,705,999 (GRCm39) S610R probably benign Het
Ushbp1 G T 8: 71,840,076 (GRCm39) A525E probably benign Het
Vmn2r106 A T 17: 20,488,314 (GRCm39) M695K possibly damaging Het
Vmn2r118 A G 17: 55,915,585 (GRCm39) I455T probably benign Het
Zbtb41 T C 1: 139,370,621 (GRCm39) F686S probably damaging Het
Other mutations in Lrrc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02243:Lrrc2 APN 9 110,799,125 (GRCm39) missense probably damaging 1.00
IGL02715:Lrrc2 APN 9 110,799,182 (GRCm39) missense probably damaging 1.00
IGL02793:Lrrc2 APN 9 110,808,695 (GRCm39) critical splice donor site probably null
IGL02958:Lrrc2 APN 9 110,791,741 (GRCm39) critical splice donor site probably null
PIT4362001:Lrrc2 UTSW 9 110,791,608 (GRCm39) missense possibly damaging 0.91
R0255:Lrrc2 UTSW 9 110,809,966 (GRCm39) missense possibly damaging 0.87
R0472:Lrrc2 UTSW 9 110,791,685 (GRCm39) missense probably benign 0.00
R0909:Lrrc2 UTSW 9 110,791,741 (GRCm39) critical splice donor site probably null
R1575:Lrrc2 UTSW 9 110,808,555 (GRCm39) missense probably benign 0.07
R1619:Lrrc2 UTSW 9 110,790,041 (GRCm39) missense probably benign 0.00
R1669:Lrrc2 UTSW 9 110,810,718 (GRCm39) missense probably damaging 0.99
R1778:Lrrc2 UTSW 9 110,809,908 (GRCm39) missense probably benign
R1914:Lrrc2 UTSW 9 110,810,007 (GRCm39) missense probably damaging 1.00
R2165:Lrrc2 UTSW 9 110,808,645 (GRCm39) missense possibly damaging 0.78
R3792:Lrrc2 UTSW 9 110,795,585 (GRCm39) nonsense probably null
R3793:Lrrc2 UTSW 9 110,795,585 (GRCm39) nonsense probably null
R4499:Lrrc2 UTSW 9 110,791,713 (GRCm39) missense probably benign 0.11
R4683:Lrrc2 UTSW 9 110,791,614 (GRCm39) missense possibly damaging 0.95
R4693:Lrrc2 UTSW 9 110,799,161 (GRCm39) missense probably damaging 1.00
R4723:Lrrc2 UTSW 9 110,799,228 (GRCm39) critical splice donor site probably null
R5033:Lrrc2 UTSW 9 110,809,987 (GRCm39) missense probably damaging 0.98
R5935:Lrrc2 UTSW 9 110,795,629 (GRCm39) missense probably benign 0.17
R6269:Lrrc2 UTSW 9 110,810,017 (GRCm39) missense probably damaging 1.00
R6645:Lrrc2 UTSW 9 110,799,175 (GRCm39) missense probably damaging 1.00
R6855:Lrrc2 UTSW 9 110,782,250 (GRCm39) splice site probably null
R7621:Lrrc2 UTSW 9 110,809,899 (GRCm39) missense probably benign 0.00
R7748:Lrrc2 UTSW 9 110,809,999 (GRCm39) missense possibly damaging 0.63
R7827:Lrrc2 UTSW 9 110,790,049 (GRCm39) missense possibly damaging 0.93
R8169:Lrrc2 UTSW 9 110,809,954 (GRCm39) missense probably benign
R8186:Lrrc2 UTSW 9 110,789,910 (GRCm39) missense possibly damaging 0.67
R8458:Lrrc2 UTSW 9 110,799,218 (GRCm39) missense probably damaging 1.00
R9146:Lrrc2 UTSW 9 110,808,582 (GRCm39) missense probably damaging 1.00
R9198:Lrrc2 UTSW 9 110,791,722 (GRCm39) missense probably benign 0.05
R9568:Lrrc2 UTSW 9 110,799,228 (GRCm39) critical splice donor site probably null
R9680:Lrrc2 UTSW 9 110,791,710 (GRCm39) missense probably damaging 1.00
R9761:Lrrc2 UTSW 9 110,809,942 (GRCm39) missense possibly damaging 0.49
RF009:Lrrc2 UTSW 9 110,810,744 (GRCm39) makesense probably null
RF021:Lrrc2 UTSW 9 110,810,744 (GRCm39) makesense probably null
Posted On 2014-02-04