Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01800:Vmn2r49'

155468

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r49

Ensembl Gene

ENSMUSG00000096180

Gene Name

vomeronasal 2, receptor 49

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.108) question?

Stock #

IGL01800

Quality Score

Status

Chromosome

Chromosomal Location

9710172-9726066 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 9710601 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 710 (C710*)

Ref Sequence

ENSEMBL: ENSMUSP00000104190 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108550]

AlphaFold

D3Z6L3

Predicted Effect

probably null
Transcript: ENSMUST00000108550
AA Change: C710*

SMART Domains

Protein: ENSMUSP00000104190
Gene: ENSMUSG00000096180
AA Change: C710*

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	1.4e-33	PFAM
Pfam:NCD3G	512	565	5.1e-21	PFAM
Pfam:7tm_3	598	833	3.5e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc2	A	G	19: 43,772,734 (GRCm39)	Y48C	possibly damaging	Het
Acsm3	T	C	7: 119,373,866 (GRCm39)	S251P	possibly damaging	Het
Ano5	G	A	7: 51,222,823 (GRCm39)		probably null	Het
Ccdc65	C	T	15: 98,606,946 (GRCm39)	A51V	probably benign	Het
Cspg5	A	G	9: 110,080,218 (GRCm39)		probably benign	Het
Dhx30	A	G	9: 109,914,581 (GRCm39)	V935A	possibly damaging	Het
Disp3	T	A	4: 148,334,258 (GRCm39)	K1012*	probably null	Het
Dock2	T	C	11: 34,647,100 (GRCm39)	N18S	probably damaging	Het
Dst	A	T	1: 34,301,173 (GRCm39)	I1180F	probably damaging	Het
Elp2	A	G	18: 24,750,548 (GRCm39)	Y295C	probably benign	Het
Eml2	A	G	7: 18,935,122 (GRCm39)		probably benign	Het
Fat4	A	G	3: 39,035,878 (GRCm39)	T3177A	probably damaging	Het
Flrt2	A	T	12: 95,746,462 (GRCm39)	I267F	probably damaging	Het
Gm5611	T	G	9: 16,941,767 (GRCm39)		noncoding transcript	Het
Gstcd	A	G	3: 132,790,335 (GRCm39)		probably null	Het
Gucy1b2	T	C	14: 62,649,104 (GRCm39)	M476V	probably benign	Het
Jak2	A	G	19: 29,263,693 (GRCm39)		probably benign	Het
Kcnt1	T	C	2: 25,778,137 (GRCm39)	F85S	probably damaging	Het
Kcnu1	G	A	8: 26,427,528 (GRCm39)	V282M	probably damaging	Het
Lancl1	T	G	1: 67,060,029 (GRCm39)	E132A	probably benign	Het
Or4g7	T	C	2: 111,309,209 (GRCm39)	F27L	probably benign	Het
Or5b106	A	G	19: 13,123,993 (GRCm39)	F10S	probably damaging	Het
Pigm	G	A	1: 172,204,770 (GRCm39)	A169T	probably damaging	Het
Ppargc1a	A	G	5: 51,652,063 (GRCm39)	Y212H	probably damaging	Het
Ppp1r13l	A	T	7: 19,111,936 (GRCm39)		probably benign	Het
Pramel12	T	C	4: 143,145,650 (GRCm39)	L373P	probably damaging	Het
Rictor	T	C	15: 6,804,182 (GRCm39)	I554T	probably damaging	Het
Sbno1	G	A	5: 124,519,568 (GRCm39)		probably benign	Het
Sesn2	G	T	4: 132,226,418 (GRCm39)	L194I	probably damaging	Het
Slc26a2	A	T	18: 61,334,801 (GRCm39)	Y217*	probably null	Het
Sptbn5	G	T	2: 119,886,908 (GRCm39)		probably benign	Het
Tmem184a	A	T	5: 139,798,899 (GRCm39)	S17T	possibly damaging	Het
Trhr	T	C	15: 44,092,603 (GRCm39)	M280T	possibly damaging	Het
Ube2j1	A	T	4: 33,045,115 (GRCm39)	E129D	probably benign	Het
Ube4b	A	T	4: 149,415,951 (GRCm39)	S3T	probably damaging	Het
Vmn2r82	C	T	10: 79,192,581 (GRCm39)	R53C	probably benign	Het
Zdhhc2	T	C	8: 40,917,284 (GRCm39)	L227P	probably damaging	Het
Zfp995	A	C	17: 22,099,972 (GRCm39)	H87Q	possibly damaging	Het

Other mutations in Vmn2r49

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01892:Vmn2r49	APN	7	9,718,690 (GRCm39)	missense	probably benign	0.00
IGL02505:Vmn2r49	APN	7	9,710,378 (GRCm39)	missense	probably benign	0.27
IGL03345:Vmn2r49	APN	7	9,718,621 (GRCm39)	missense	probably damaging	1.00
PIT4434001:Vmn2r49	UTSW	7	9,710,762 (GRCm39)	missense	probably damaging	1.00
PIT4520001:Vmn2r49	UTSW	7	9,722,988 (GRCm39)	missense	probably benign	0.06
R0367:Vmn2r49	UTSW	7	9,710,357 (GRCm39)	missense	probably damaging	1.00
R0609:Vmn2r49	UTSW	7	9,710,233 (GRCm39)	missense	probably benign	0.40
R0931:Vmn2r49	UTSW	7	9,720,325 (GRCm39)	missense	possibly damaging	0.55
R1594:Vmn2r49	UTSW	7	9,710,550 (GRCm39)	missense	probably damaging	1.00
R1969:Vmn2r49	UTSW	7	9,720,235 (GRCm39)	missense	probably damaging	0.99
R4831:Vmn2r49	UTSW	7	9,720,352 (GRCm39)	missense	probably benign
R4944:Vmn2r49	UTSW	7	9,722,959 (GRCm39)	missense	probably benign
R4945:Vmn2r49	UTSW	7	9,720,214 (GRCm39)	nonsense	probably null
R5109:Vmn2r49	UTSW	7	9,710,204 (GRCm39)	missense	probably benign	0.01
R5141:Vmn2r49	UTSW	7	9,720,300 (GRCm39)	missense	probably benign	0.01
R5778:Vmn2r49	UTSW	7	9,710,274 (GRCm39)	missense	probably damaging	1.00
R6168:Vmn2r49	UTSW	7	9,718,713 (GRCm39)	missense	probably benign	0.01
R6513:Vmn2r49	UTSW	7	9,710,524 (GRCm39)	missense	probably damaging	0.99
R7347:Vmn2r49	UTSW	7	9,720,741 (GRCm39)	missense	probably benign	0.00
R7464:Vmn2r49	UTSW	7	9,722,820 (GRCm39)	missense	probably benign	0.03
R7495:Vmn2r49	UTSW	7	9,710,826 (GRCm39)	nonsense	probably null
R7750:Vmn2r49	UTSW	7	9,710,185 (GRCm39)	missense	probably damaging	1.00
R8031:Vmn2r49	UTSW	7	9,720,408 (GRCm39)	missense	possibly damaging	0.67
R9158:Vmn2r49	UTSW	7	9,722,835 (GRCm39)	missense	probably damaging	1.00
R9347:Vmn2r49	UTSW	7	9,718,674 (GRCm39)	missense	probably benign	0.00
R9553:Vmn2r49	UTSW	7	9,720,849 (GRCm39)	missense	probably benign	0.41

Posted On

2014-02-04