Incidental Mutation 'IGL01800:Disp3'
ID155498
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Disp3
Ensembl Gene ENSMUSG00000041544
Gene Namedispatched RND transporter family member 3
SynonymsPtchd2, G630052C06Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01800
Quality Score
Status
Chromosome4
Chromosomal Location148240264-148287965 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 148249801 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Stop codon at position 1012 (K1012*)
Ref Sequence ENSEMBL: ENSMUSP00000038490 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047720]
Predicted Effect probably null
Transcript: ENSMUST00000047720
AA Change: K1012*
SMART Domains Protein: ENSMUSP00000038490
Gene: ENSMUSG00000041544
AA Change: K1012*

DomainStartEndE-ValueType
transmembrane domain 68 90 N/A INTRINSIC
low complexity region 159 171 N/A INTRINSIC
low complexity region 179 195 N/A INTRINSIC
Pfam:Patched 362 735 2.2e-21 PFAM
Pfam:MMPL 366 590 3.1e-14 PFAM
Pfam:Sterol-sensing 435 588 1.1e-17 PFAM
Pfam:Patched 1121 1301 1.6e-7 PFAM
transmembrane domain 1314 1333 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc2 A G 19: 43,784,295 Y48C possibly damaging Het
Acsm3 T C 7: 119,774,643 S251P possibly damaging Het
Ano5 G A 7: 51,573,075 probably null Het
Ccdc65 C T 15: 98,709,065 A51V probably benign Het
Cspg5 A G 9: 110,251,150 probably benign Het
Dhx30 A G 9: 110,085,513 V935A possibly damaging Het
Dock2 T C 11: 34,756,273 N18S probably damaging Het
Dst A T 1: 34,262,092 I1180F probably damaging Het
Elp2 A G 18: 24,617,491 Y295C probably benign Het
Eml2 A G 7: 19,201,197 probably benign Het
Fat4 A G 3: 38,981,729 T3177A probably damaging Het
Flrt2 A T 12: 95,779,688 I267F probably damaging Het
Gm5611 T G 9: 17,030,471 noncoding transcript Het
Gstcd A G 3: 133,084,574 probably null Het
Gucy1b2 T C 14: 62,411,655 M476V probably benign Het
Jak2 A G 19: 29,286,293 probably benign Het
Kcnt1 T C 2: 25,888,125 F85S probably damaging Het
Kcnu1 G A 8: 25,937,500 V282M probably damaging Het
Lancl1 T G 1: 67,020,870 E132A probably benign Het
Olfr1288 T C 2: 111,478,864 F27L probably benign Het
Olfr1459 A G 19: 13,146,629 F10S probably damaging Het
Pigm G A 1: 172,377,203 A169T probably damaging Het
Ppargc1a A G 5: 51,494,721 Y212H probably damaging Het
Ppp1r13l A T 7: 19,378,011 probably benign Het
Pramef8 T C 4: 143,419,080 L373P probably damaging Het
Rictor T C 15: 6,774,701 I554T probably damaging Het
Sbno1 G A 5: 124,381,505 probably benign Het
Sesn2 G T 4: 132,499,107 L194I probably damaging Het
Slc26a2 A T 18: 61,201,729 Y217* probably null Het
Sptbn5 G T 2: 120,056,427 probably benign Het
Tmem184a A T 5: 139,813,144 S17T possibly damaging Het
Trhr T C 15: 44,229,207 M280T possibly damaging Het
Ube2j1 A T 4: 33,045,115 E129D probably benign Het
Ube4b A T 4: 149,331,494 S3T probably damaging Het
Vmn2r49 A T 7: 9,976,674 C710* probably null Het
Vmn2r82 C T 10: 79,356,747 R53C probably benign Het
Zdhhc2 T C 8: 40,464,243 L227P probably damaging Het
Zfp995 A C 17: 21,880,991 H87Q possibly damaging Het
Other mutations in Disp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Disp3 APN 4 148241534 missense probably benign 0.10
IGL01065:Disp3 APN 4 148261183 missense probably damaging 1.00
IGL01947:Disp3 APN 4 148260519 missense probably damaging 1.00
IGL02510:Disp3 APN 4 148252701 missense probably benign 0.00
IGL02573:Disp3 APN 4 148271449 missense probably damaging 1.00
IGL02728:Disp3 APN 4 148272038 missense probably damaging 1.00
IGL02931:Disp3 APN 4 148249201 missense possibly damaging 0.94
R0164:Disp3 UTSW 4 148254251 missense probably damaging 0.96
R0164:Disp3 UTSW 4 148254251 missense probably damaging 0.96
R0257:Disp3 UTSW 4 148250754 missense possibly damaging 0.87
R0409:Disp3 UTSW 4 148271959 missense probably damaging 1.00
R0557:Disp3 UTSW 4 148241404 missense possibly damaging 0.64
R0576:Disp3 UTSW 4 148241590 missense possibly damaging 0.89
R1495:Disp3 UTSW 4 148249825 missense probably benign 0.00
R1526:Disp3 UTSW 4 148259916 missense probably benign 0.00
R1791:Disp3 UTSW 4 148241518 missense probably damaging 1.00
R1856:Disp3 UTSW 4 148271632 missense probably damaging 1.00
R1987:Disp3 UTSW 4 148258753 missense probably damaging 0.97
R2030:Disp3 UTSW 4 148259966 missense probably damaging 1.00
R2271:Disp3 UTSW 4 148271602 missense possibly damaging 0.87
R2373:Disp3 UTSW 4 148258795 missense probably damaging 1.00
R2566:Disp3 UTSW 4 148241423 missense probably damaging 1.00
R3731:Disp3 UTSW 4 148252827 missense probably benign 0.03
R4359:Disp3 UTSW 4 148271932 missense probably benign 0.03
R4762:Disp3 UTSW 4 148272118 missense probably damaging 1.00
R4950:Disp3 UTSW 4 148258126 missense possibly damaging 0.94
R4975:Disp3 UTSW 4 148244216 missense possibly damaging 0.79
R5218:Disp3 UTSW 4 148242876 missense possibly damaging 0.88
R5523:Disp3 UTSW 4 148258097 missense probably benign 0.14
R5556:Disp3 UTSW 4 148258157 missense probably benign 0.14
R5857:Disp3 UTSW 4 148249183 missense probably benign 0.01
R5933:Disp3 UTSW 4 148241313 nonsense probably null
R5994:Disp3 UTSW 4 148254284 missense possibly damaging 0.94
R6362:Disp3 UTSW 4 148254308 missense possibly damaging 0.95
R6813:Disp3 UTSW 4 148259930 missense probably benign 0.09
R7211:Disp3 UTSW 4 148241522 missense probably damaging 0.98
R7470:Disp3 UTSW 4 148261070 missense possibly damaging 0.88
R7535:Disp3 UTSW 4 148242866 missense probably damaging 0.99
R8093:Disp3 UTSW 4 148270516 missense possibly damaging 0.93
R8357:Disp3 UTSW 4 148261115 missense possibly damaging 0.86
R8457:Disp3 UTSW 4 148261115 missense possibly damaging 0.86
R8506:Disp3 UTSW 4 148241570 missense possibly damaging 0.77
Z1088:Disp3 UTSW 4 148271743 missense possibly damaging 0.63
Z1176:Disp3 UTSW 4 148250957 missense probably damaging 1.00
Z1177:Disp3 UTSW 4 148249746 missense probably damaging 1.00
Z1177:Disp3 UTSW 4 148249847 missense probably benign 0.01
Z1177:Disp3 UTSW 4 148250714 missense probably damaging 1.00
Z1177:Disp3 UTSW 4 148270567 nonsense probably null
Posted On2014-02-04