Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01804:Vmn2r2'

155597

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r2

Ensembl Gene

ENSMUSG00000043897

Gene Name

vomeronasal 2, receptor 2

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.108) question?

Stock #

IGL01804

Quality Score

Status

Chromosome

Chromosomal Location

64022699-64049349 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 64041677 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 346 (V346A)

Ref Sequence

ENSEMBL: ENSMUSP00000135110 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077958] [ENSMUST00000177151]

AlphaFold

L7N2E9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000077958
AA Change: V262A

PolyPhen 2 Score 0.679 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000077109
Gene: ENSMUSG00000043897
AA Change: V262A

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	416	4.5e-80	PFAM
Pfam:NCD3G	458	511	8.3e-18	PFAM
Pfam:7tm_3	542	779	1.3e-75	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000177151
AA Change: V346A

PolyPhen 2 Score 0.906 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000135110
Gene: ENSMUSG00000043897
AA Change: V346A

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	83	500	1.6e-84	PFAM
Pfam:NCD3G	542	595	2.6e-17	PFAM
Pfam:7tm_3	628	862	1.9e-47	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	T	C	1: 71,315,342 (GRCm39)	N1860D	probably benign	Het
Abca2	T	A	2: 25,336,637 (GRCm39)	C2248S	probably damaging	Het
Adamts16	G	A	13: 70,949,080 (GRCm39)	Q194*	probably null	Het
Cetn3	A	T	13: 81,932,779 (GRCm39)	K13*	probably null	Het
Cldn18	T	A	9: 99,580,901 (GRCm39)	K116*	probably null	Het
Cntn5	T	A	9: 9,831,542 (GRCm39)	I613F	probably damaging	Het
Cyp46a1	A	G	12: 108,321,745 (GRCm39)	I324V	probably benign	Het
Ddb1	A	C	19: 10,590,382 (GRCm39)	E303A	probably damaging	Het
Dnajc2	A	G	5: 21,962,361 (GRCm39)	V539A	probably damaging	Het
Dock2	T	A	11: 34,212,433 (GRCm39)	Y1236F	probably benign	Het
Dpf1	T	A	7: 29,015,926 (GRCm39)	C383S	probably damaging	Het
Edc4	T	A	8: 106,617,289 (GRCm39)	I1052N	possibly damaging	Het
Ehmt1	A	G	2: 24,681,966 (GRCm39)	L1243P	probably damaging	Het
Exoc6b	A	G	6: 84,885,148 (GRCm39)	S264P	probably damaging	Het
Gbx2	T	C	1: 89,856,703 (GRCm39)	E229G	probably benign	Het
Hip1r	T	A	5: 124,139,613 (GRCm39)		probably null	Het
Lig1	A	G	7: 13,043,131 (GRCm39)	K859E	probably benign	Het
Ly6g6f	T	C	17: 35,300,146 (GRCm39)	D234G	possibly damaging	Het
Mmp11	G	T	10: 75,764,304 (GRCm39)	L54I	probably benign	Het
Naip5	A	T	13: 100,358,092 (GRCm39)	L1048Q	probably damaging	Het
Or4c122	C	A	2: 89,079,566 (GRCm39)	M157I	probably benign	Het
Or6k14	A	G	1: 173,927,401 (GRCm39)	I126V	probably damaging	Het
Or7g12	T	A	9: 18,900,136 (GRCm39)	M284K	probably benign	Het
Or8g17	T	C	9: 38,930,697 (GRCm39)	I47V	probably benign	Het
Pappa2	T	C	1: 158,764,089 (GRCm39)	D474G	probably benign	Het
Plxna1	A	G	6: 89,306,628 (GRCm39)	Y1401H	probably damaging	Het
Prrg4	T	A	2: 104,663,035 (GRCm39)	E190D	probably damaging	Het
Rnf213	T	C	11: 119,333,092 (GRCm39)	F2767S	probably damaging	Het
Scgb1b2	T	A	7: 30,991,155 (GRCm39)		probably benign	Het
Sec31a	A	G	5: 100,523,065 (GRCm39)		probably null	Het
Slc12a4	A	G	8: 106,671,033 (GRCm39)	S1014P	probably damaging	Het
Spns2	A	T	11: 72,348,130 (GRCm39)	I279N	possibly damaging	Het
Spta1	A	T	1: 174,071,746 (GRCm39)	H2242L	probably benign	Het
Tcaf3	T	A	6: 42,574,063 (GRCm39)	I50F	probably damaging	Het
Tnfaip8l1	G	A	17: 56,479,214 (GRCm39)	S168N	probably benign	Het
Trak1	C	T	9: 121,271,751 (GRCm39)		probably benign	Het
Trpv4	A	T	5: 114,782,847 (GRCm39)	N38K	possibly damaging	Het
Ube2o	T	C	11: 116,435,199 (GRCm39)	T530A	probably benign	Het
Vmn2r86	A	C	10: 130,288,858 (GRCm39)	D214E	probably damaging	Het
Wwc1	C	A	11: 35,732,751 (GRCm39)	D986Y	probably damaging	Het
Xdh	T	C	17: 74,199,754 (GRCm39)	D1184G	probably damaging	Het

Other mutations in Vmn2r2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00326:Vmn2r2	APN	3	64,041,319 (GRCm39)	splice site	probably benign
IGL00980:Vmn2r2	APN	3	64,024,601 (GRCm39)	missense	probably benign	0.11
IGL01389:Vmn2r2	APN	3	64,024,430 (GRCm39)	missense	probably damaging	0.97
IGL02750:Vmn2r2	APN	3	64,024,823 (GRCm39)	missense	probably damaging	1.00
IGL02829:Vmn2r2	APN	3	64,026,172 (GRCm39)	splice site	probably benign
IGL03036:Vmn2r2	APN	3	64,024,321 (GRCm39)	missense	probably benign	0.01
IGL03174:Vmn2r2	APN	3	64,024,544 (GRCm39)	nonsense	probably null
PIT4151001:Vmn2r2	UTSW	3	64,024,334 (GRCm39)	missense	possibly damaging	0.67
R0029:Vmn2r2	UTSW	3	64,024,365 (GRCm39)	missense	probably benign	0.00
R0310:Vmn2r2	UTSW	3	64,042,039 (GRCm39)	missense	probably damaging	1.00
R0357:Vmn2r2	UTSW	3	64,041,320 (GRCm39)	splice site	probably null
R0637:Vmn2r2	UTSW	3	64,033,999 (GRCm39)	missense	probably benign	0.00
R1626:Vmn2r2	UTSW	3	64,041,921 (GRCm39)	missense	possibly damaging	0.61
R1662:Vmn2r2	UTSW	3	64,024,551 (GRCm39)	missense	probably benign	0.00
R1710:Vmn2r2	UTSW	3	64,024,820 (GRCm39)	missense	probably benign	0.19
R1797:Vmn2r2	UTSW	3	64,042,128 (GRCm39)	missense	probably benign	0.00
R1862:Vmn2r2	UTSW	3	64,041,942 (GRCm39)	missense	possibly damaging	0.79
R1971:Vmn2r2	UTSW	3	64,034,121 (GRCm39)	missense	probably damaging	1.00
R2051:Vmn2r2	UTSW	3	64,024,766 (GRCm39)	missense	possibly damaging	0.77
R2099:Vmn2r2	UTSW	3	64,024,474 (GRCm39)	missense	probably damaging	1.00
R2275:Vmn2r2	UTSW	3	64,023,930 (GRCm39)	missense	probably benign	0.00
R3078:Vmn2r2	UTSW	3	64,042,053 (GRCm39)	missense	probably benign	0.22
R3418:Vmn2r2	UTSW	3	64,024,320 (GRCm39)	missense	probably benign	0.00
R3419:Vmn2r2	UTSW	3	64,024,320 (GRCm39)	missense	probably benign	0.00
R3959:Vmn2r2	UTSW	3	64,047,947 (GRCm39)	missense	probably benign
R4230:Vmn2r2	UTSW	3	64,041,912 (GRCm39)	missense	probably benign	0.00
R4258:Vmn2r2	UTSW	3	64,042,118 (GRCm39)	missense	probably damaging	1.00
R4810:Vmn2r2	UTSW	3	64,044,883 (GRCm39)	missense	probably damaging	1.00
R4822:Vmn2r2	UTSW	3	64,041,960 (GRCm39)	missense	probably damaging	0.99
R4919:Vmn2r2	UTSW	3	64,024,578 (GRCm39)	missense	possibly damaging	0.56
R4925:Vmn2r2	UTSW	3	64,044,892 (GRCm39)	start codon destroyed	probably null	0.03
R4954:Vmn2r2	UTSW	3	64,047,905 (GRCm39)	missense	probably benign	0.00
R5071:Vmn2r2	UTSW	3	64,024,321 (GRCm39)	missense	probably benign	0.01
R5315:Vmn2r2	UTSW	3	64,024,377 (GRCm39)	missense	probably benign	0.37
R5450:Vmn2r2	UTSW	3	64,034,011 (GRCm39)	missense	probably benign
R5577:Vmn2r2	UTSW	3	64,024,416 (GRCm39)	missense	probably benign	0.00
R5595:Vmn2r2	UTSW	3	64,034,036 (GRCm39)	missense	possibly damaging	0.74
R5727:Vmn2r2	UTSW	3	64,024,608 (GRCm39)	missense	probably benign	0.41
R5810:Vmn2r2	UTSW	3	64,024,815 (GRCm39)	missense	probably damaging	1.00
R5919:Vmn2r2	UTSW	3	64,044,723 (GRCm39)	missense	probably benign	0.39
R6052:Vmn2r2	UTSW	3	64,024,782 (GRCm39)	missense	possibly damaging	0.56
R6084:Vmn2r2	UTSW	3	64,024,467 (GRCm39)	missense	probably benign	0.01
R6299:Vmn2r2	UTSW	3	64,024,074 (GRCm39)	nonsense	probably null
R6762:Vmn2r2	UTSW	3	64,041,870 (GRCm39)	missense	probably damaging	1.00
R6858:Vmn2r2	UTSW	3	64,044,915 (GRCm39)	missense	probably damaging	1.00
R6889:Vmn2r2	UTSW	3	64,024,688 (GRCm39)	missense	probably damaging	0.99
R6990:Vmn2r2	UTSW	3	64,024,608 (GRCm39)	missense	probably benign	0.02
R7195:Vmn2r2	UTSW	3	64,023,900 (GRCm39)	missense	probably benign	0.01
R7269:Vmn2r2	UTSW	3	64,033,998 (GRCm39)	missense	probably benign	0.32
R7699:Vmn2r2	UTSW	3	64,024,536 (GRCm39)	missense	possibly damaging	0.69
R7717:Vmn2r2	UTSW	3	64,042,019 (GRCm39)	missense	possibly damaging	0.95
R7798:Vmn2r2	UTSW	3	64,041,518 (GRCm39)	missense	possibly damaging	0.60
R7914:Vmn2r2	UTSW	3	64,041,526 (GRCm39)	missense	probably benign	0.20
R7974:Vmn2r2	UTSW	3	64,024,808 (GRCm39)	missense	probably damaging	0.99
R8394:Vmn2r2	UTSW	3	64,044,858 (GRCm39)	missense	probably damaging	1.00
R8478:Vmn2r2	UTSW	3	64,024,257 (GRCm39)	missense	possibly damaging	0.87
R8731:Vmn2r2	UTSW	3	64,024,404 (GRCm39)	missense	probably benign	0.16
R9035:Vmn2r2	UTSW	3	64,024,172 (GRCm39)	missense	probably damaging	1.00
R9182:Vmn2r2	UTSW	3	64,044,802 (GRCm39)	missense	probably damaging	1.00
R9225:Vmn2r2	UTSW	3	64,034,021 (GRCm39)	missense	probably benign	0.00
R9266:Vmn2r2	UTSW	3	64,024,057 (GRCm39)	missense	probably damaging	0.98
R9427:Vmn2r2	UTSW	3	64,041,945 (GRCm39)	missense	probably damaging	1.00
R9659:Vmn2r2	UTSW	3	64,041,942 (GRCm39)	missense	possibly damaging	0.79
R9666:Vmn2r2	UTSW	3	64,023,870 (GRCm39)	missense	probably benign	0.08
R9771:Vmn2r2	UTSW	3	64,042,079 (GRCm39)	missense	possibly damaging	0.88
R9788:Vmn2r2	UTSW	3	64,041,942 (GRCm39)	missense	possibly damaging	0.79
X0024:Vmn2r2	UTSW	3	64,044,707 (GRCm39)	nonsense	probably null

Posted On

2014-02-04