Incidental Mutation 'IGL01804:Prrg4'
ID155622
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prrg4
Ensembl Gene ENSMUSG00000027171
Gene Nameproline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
Synonyms9930111I18Rik, TMG4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.097) question?
Stock #IGL01804
Quality Score
Status
Chromosome2
Chromosomal Location104830741-104849876 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 104832690 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 190 (E190D)
Ref Sequence ENSEMBL: ENSMUSP00000028593 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028593]
Predicted Effect probably damaging
Transcript: ENSMUST00000028593
AA Change: E190D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000028593
Gene: ENSMUSG00000027171
AA Change: E190D

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
GLA 33 97 1.71e-18 SMART
transmembrane domain 118 140 N/A INTRINSIC
low complexity region 203 210 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,276,183 N1860D probably benign Het
Abca2 T A 2: 25,446,625 C2248S probably damaging Het
Adamts16 G A 13: 70,800,961 Q194* probably null Het
Cetn3 A T 13: 81,784,660 K13* probably null Het
Cldn18 T A 9: 99,698,848 K116* probably null Het
Cntn5 T A 9: 9,831,537 I613F probably damaging Het
Cyp46a1 A G 12: 108,355,486 I324V probably benign Het
Ddb1 A C 19: 10,613,018 E303A probably damaging Het
Dnajc2 A G 5: 21,757,363 V539A probably damaging Het
Dock2 T A 11: 34,262,433 Y1236F probably benign Het
Dpf1 T A 7: 29,316,501 C383S probably damaging Het
Edc4 T A 8: 105,890,657 I1052N possibly damaging Het
Ehmt1 A G 2: 24,791,954 L1243P probably damaging Het
Exoc6b A G 6: 84,908,166 S264P probably damaging Het
Gbx2 T C 1: 89,928,981 E229G probably benign Het
Hip1r T A 5: 124,001,550 probably null Het
Lig1 A G 7: 13,309,206 K859E probably benign Het
Ly6g6f T C 17: 35,081,170 D234G possibly damaging Het
Mmp11 G T 10: 75,928,470 L54I probably benign Het
Naip5 A T 13: 100,221,584 L1048Q probably damaging Het
Olfr1228 C A 2: 89,249,222 M157I probably benign Het
Olfr146 T C 9: 39,019,401 I47V probably benign Het
Olfr427 A G 1: 174,099,835 I126V probably damaging Het
Olfr834 T A 9: 18,988,840 M284K probably benign Het
Pappa2 T C 1: 158,936,519 D474G probably benign Het
Plxna1 A G 6: 89,329,646 Y1401H probably damaging Het
Rnf213 T C 11: 119,442,266 F2767S probably damaging Het
Scgb1b2 T A 7: 31,291,730 probably benign Het
Sec31a A G 5: 100,375,206 probably null Het
Slc12a4 A G 8: 105,944,401 S1014P probably damaging Het
Spns2 A T 11: 72,457,304 I279N possibly damaging Het
Spta1 A T 1: 174,244,180 H2242L probably benign Het
Tcaf3 T A 6: 42,597,129 I50F probably damaging Het
Tnfaip8l1 G A 17: 56,172,214 S168N probably benign Het
Trak1 C T 9: 121,442,685 probably benign Het
Trpv4 A T 5: 114,644,786 N38K possibly damaging Het
Ube2o T C 11: 116,544,373 T530A probably benign Het
Vmn2r2 A G 3: 64,134,256 V346A possibly damaging Het
Vmn2r86 A C 10: 130,452,989 D214E probably damaging Het
Wwc1 C A 11: 35,841,924 D986Y probably damaging Het
Xdh T C 17: 73,892,759 D1184G probably damaging Het
Other mutations in Prrg4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0884:Prrg4 UTSW 2 104839362 missense probably damaging 1.00
R1624:Prrg4 UTSW 2 104832682 missense probably damaging 0.97
R1647:Prrg4 UTSW 2 104832743 missense probably benign 0.00
R1648:Prrg4 UTSW 2 104832743 missense probably benign 0.00
R2151:Prrg4 UTSW 2 104839388 missense probably damaging 1.00
R5592:Prrg4 UTSW 2 104832778 missense probably benign 0.22
R5898:Prrg4 UTSW 2 104845033 missense probably benign 0.00
R7158:Prrg4 UTSW 2 104832613 missense probably damaging 1.00
R7203:Prrg4 UTSW 2 104839442 missense possibly damaging 0.63
R7727:Prrg4 UTSW 2 104839378 missense probably benign 0.00
Posted On2014-02-04