Incidental Mutation 'IGL01804:Tnfaip8l1'
ID155629
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tnfaip8l1
Ensembl Gene ENSMUSG00000044469
Gene Nametumor necrosis factor, alpha-induced protein 8-like 1
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.078) question?
Stock #IGL01804
Quality Score
Status
Chromosome17
Chromosomal Location56162477-56173955 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 56172214 bp
ZygosityHeterozygous
Amino Acid Change Serine to Asparagine at position 168 (S168N)
Ref Sequence ENSEMBL: ENSMUSP00000076961 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019723] [ENSMUST00000077788]
Predicted Effect probably benign
Transcript: ENSMUST00000019723
SMART Domains Protein: ENSMUSP00000019723
Gene: ENSMUSG00000019579

DomainStartEndE-ValueType
Pfam:UPF0556 11 166 4.8e-82 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000077788
AA Change: S168N

PolyPhen 2 Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000076961
Gene: ENSMUSG00000044469
AA Change: S168N

DomainStartEndE-ValueType
Pfam:DUF758 4 184 5.8e-75 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195950
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,276,183 N1860D probably benign Het
Abca2 T A 2: 25,446,625 C2248S probably damaging Het
Adamts16 G A 13: 70,800,961 Q194* probably null Het
Cetn3 A T 13: 81,784,660 K13* probably null Het
Cldn18 T A 9: 99,698,848 K116* probably null Het
Cntn5 T A 9: 9,831,537 I613F probably damaging Het
Cyp46a1 A G 12: 108,355,486 I324V probably benign Het
Ddb1 A C 19: 10,613,018 E303A probably damaging Het
Dnajc2 A G 5: 21,757,363 V539A probably damaging Het
Dock2 T A 11: 34,262,433 Y1236F probably benign Het
Dpf1 T A 7: 29,316,501 C383S probably damaging Het
Edc4 T A 8: 105,890,657 I1052N possibly damaging Het
Ehmt1 A G 2: 24,791,954 L1243P probably damaging Het
Exoc6b A G 6: 84,908,166 S264P probably damaging Het
Gbx2 T C 1: 89,928,981 E229G probably benign Het
Hip1r T A 5: 124,001,550 probably null Het
Lig1 A G 7: 13,309,206 K859E probably benign Het
Ly6g6f T C 17: 35,081,170 D234G possibly damaging Het
Mmp11 G T 10: 75,928,470 L54I probably benign Het
Naip5 A T 13: 100,221,584 L1048Q probably damaging Het
Olfr1228 C A 2: 89,249,222 M157I probably benign Het
Olfr146 T C 9: 39,019,401 I47V probably benign Het
Olfr427 A G 1: 174,099,835 I126V probably damaging Het
Olfr834 T A 9: 18,988,840 M284K probably benign Het
Pappa2 T C 1: 158,936,519 D474G probably benign Het
Plxna1 A G 6: 89,329,646 Y1401H probably damaging Het
Prrg4 T A 2: 104,832,690 E190D probably damaging Het
Rnf213 T C 11: 119,442,266 F2767S probably damaging Het
Scgb1b2 T A 7: 31,291,730 probably benign Het
Sec31a A G 5: 100,375,206 probably null Het
Slc12a4 A G 8: 105,944,401 S1014P probably damaging Het
Spns2 A T 11: 72,457,304 I279N possibly damaging Het
Spta1 A T 1: 174,244,180 H2242L probably benign Het
Tcaf3 T A 6: 42,597,129 I50F probably damaging Het
Trak1 C T 9: 121,442,685 probably benign Het
Trpv4 A T 5: 114,644,786 N38K possibly damaging Het
Ube2o T C 11: 116,544,373 T530A probably benign Het
Vmn2r2 A G 3: 64,134,256 V346A possibly damaging Het
Vmn2r86 A C 10: 130,452,989 D214E probably damaging Het
Wwc1 C A 11: 35,841,924 D986Y probably damaging Het
Xdh T C 17: 73,892,759 D1184G probably damaging Het
Other mutations in Tnfaip8l1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01710:Tnfaip8l1 APN 17 56171782 missense probably benign 0.38
IGL02323:Tnfaip8l1 APN 17 56172009 missense probably damaging 1.00
R0521:Tnfaip8l1 UTSW 17 56171727 missense probably damaging 1.00
R2426:Tnfaip8l1 UTSW 17 56172030 missense probably benign 0.01
R5737:Tnfaip8l1 UTSW 17 56171950 missense probably benign 0.00
R5966:Tnfaip8l1 UTSW 17 56171799 missense probably benign 0.02
R7366:Tnfaip8l1 UTSW 17 56171897 missense probably damaging 0.98
Posted On2014-02-04