Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01805:Vmn2r77'

155638

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r77

Ensembl Gene

ENSMUSG00000090949

Gene Name

vomeronasal 2, receptor 77

Synonyms

EG546983

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL01805

Quality Score

Status

Chromosome

Chromosomal Location

86795141-86812032 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 86811187 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 574 (V574M)

Ref Sequence

ENSEMBL: ENSMUSP00000129540 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164996]

AlphaFold

L7N2B7

Predicted Effect

probably benign
Transcript: ENSMUST00000164996
AA Change: V574M

PolyPhen 2 Score 0.178 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000129540
Gene: ENSMUSG00000090949
AA Change: V574M

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	78	467	1.4e-30	PFAM
Pfam:NCD3G	510	562	1e-20	PFAM
Pfam:7tm_3	594	830	2.6e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700019D03Rik	T	C	1: 52,925,518	D17G	possibly damaging	Het
Adam28	G	T	14: 68,642,091	S169R	probably benign	Het
Aox1	T	C	1: 58,081,513	M855T	possibly damaging	Het
Apc	C	A	18: 34,318,218	N2688K	probably benign	Het
Arhgap23	T	A	11: 97,492,602		probably benign	Het
Bpifa6	A	G	2: 153,984,912	T66A	probably benign	Het
C1qtnf1	T	A	11: 118,448,167	L221Q	probably damaging	Het
Ccdc175	T	A	12: 72,129,229		probably benign	Het
Ccl1	C	A	11: 82,178,132	M26I	possibly damaging	Het
D17Wsu92e	C	T	17: 27,767,906		probably benign	Het
Dnah10	T	A	5: 124,783,921	F2123I	probably damaging	Het
Dpcr1	T	A	17: 35,637,643	T355S	possibly damaging	Het
Fancm	T	C	12: 65,113,861		probably null	Het
Fstl4	C	A	11: 53,186,357	A647E	probably damaging	Het
Hmgb4	G	T	4: 128,260,222		probably benign	Het
Hr	A	T	14: 70,565,297		probably benign	Het
Kcna4	G	T	2: 107,296,498	V526L	probably damaging	Het
Mas1	T	C	17: 12,842,230	Y102C	probably damaging	Het
Mul1	C	T	4: 138,439,663	P343S	possibly damaging	Het
Obscn	T	C	11: 59,132,596	S652G	probably damaging	Het
Olfr972	T	C	9: 39,873,779	F168S	probably damaging	Het
Pjvk	A	T	2: 76,657,514	N250I	probably benign	Het
Pkd2	T	C	5: 104,483,093	I461T	probably benign	Het
Psen2	T	C	1: 180,229,838		probably null	Het
Ralb	T	C	1: 119,475,995	E81G	probably benign	Het
Slc15a4	T	C	5: 127,608,836	T261A	possibly damaging	Het
Xrn2	A	G	2: 147,028,143	I251V	probably damaging	Het
Zfp974	G	A	7: 27,912,264		probably benign	Het

Other mutations in Vmn2r77

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00954:Vmn2r77	APN	7	86800767	missense	probably benign	0.06
IGL01105:Vmn2r77	APN	7	86811664	missense	probably damaging	0.99
IGL01367:Vmn2r77	APN	7	86811916	missense	probably damaging	0.98
IGL01634:Vmn2r77	APN	7	86811649	missense	probably benign
IGL01868:Vmn2r77	APN	7	86803016	missense	probably benign	0.00
IGL01980:Vmn2r77	APN	7	86801470	missense	probably benign	0.14
IGL02055:Vmn2r77	APN	7	86801555	missense	probably benign	0.00
IGL02066:Vmn2r77	APN	7	86803628	nonsense	probably null
IGL02185:Vmn2r77	APN	7	86795152	missense	unknown
IGL02200:Vmn2r77	APN	7	86801979	missense	probably benign	0.04
IGL02336:Vmn2r77	APN	7	86802016	missense	probably damaging	0.99
IGL02445:Vmn2r77	APN	7	86803640	nonsense	probably null
IGL02557:Vmn2r77	APN	7	86795134	unclassified	probably benign
IGL02659:Vmn2r77	APN	7	86800771	missense	probably benign	0.32
IGL02978:Vmn2r77	APN	7	86811347	missense	probably benign
IGL03180:Vmn2r77	APN	7	86801635	missense	possibly damaging	0.85
IGL03255:Vmn2r77	APN	7	86811923	missense	probably benign	0.04
IGL03273:Vmn2r77	APN	7	86811286	missense	probably damaging	0.99
R0046:Vmn2r77	UTSW	7	86801938	missense	possibly damaging	0.73
R0047:Vmn2r77	UTSW	7	86811650	missense	probably benign	0.01
R0066:Vmn2r77	UTSW	7	86800756	missense	probably benign	0.17
R0066:Vmn2r77	UTSW	7	86800756	missense	probably benign	0.17
R0389:Vmn2r77	UTSW	7	86801494	missense	probably benign	0.29
R0635:Vmn2r77	UTSW	7	86811175	missense	probably benign
R0689:Vmn2r77	UTSW	7	86811664	missense	probably damaging	0.99
R0827:Vmn2r77	UTSW	7	86802016	missense	probably damaging	1.00
R1167:Vmn2r77	UTSW	7	86801746	missense	probably benign	0.02
R1228:Vmn2r77	UTSW	7	86801034	critical splice donor site	probably null
R1353:Vmn2r77	UTSW	7	86802186	missense	probably benign	0.29
R1392:Vmn2r77	UTSW	7	86801622	missense	probably benign	0.00
R1392:Vmn2r77	UTSW	7	86801622	missense	probably benign	0.00
R1613:Vmn2r77	UTSW	7	86811148	missense	probably damaging	1.00
R1654:Vmn2r77	UTSW	7	86811915	missense	probably damaging	1.00
R1742:Vmn2r77	UTSW	7	86795335	missense	probably benign	0.35
R1827:Vmn2r77	UTSW	7	86801613	missense	probably damaging	0.99
R1911:Vmn2r77	UTSW	7	86811793	missense	probably damaging	1.00
R1974:Vmn2r77	UTSW	7	86800756	missense	probably benign	0.17
R2008:Vmn2r77	UTSW	7	86801713	missense	probably benign	0.31
R2093:Vmn2r77	UTSW	7	86801494	missense	probably benign	0.29
R2143:Vmn2r77	UTSW	7	86811944	missense	probably damaging	1.00
R2269:Vmn2r77	UTSW	7	86811689	missense	probably benign	0.03
R2972:Vmn2r77	UTSW	7	86803685	missense	probably benign	0.01
R2974:Vmn2r77	UTSW	7	86803685	missense	probably benign	0.01
R3037:Vmn2r77	UTSW	7	86800983	missense	probably benign
R3694:Vmn2r77	UTSW	7	86800836	missense	probably damaging	1.00
R3695:Vmn2r77	UTSW	7	86800836	missense	probably damaging	1.00
R3805:Vmn2r77	UTSW	7	86795160	nonsense	probably null
R3870:Vmn2r77	UTSW	7	86811842	missense	probably damaging	1.00
R4732:Vmn2r77	UTSW	7	86800987	missense	probably benign	0.00
R4733:Vmn2r77	UTSW	7	86800987	missense	probably benign	0.00
R5009:Vmn2r77	UTSW	7	86801807	missense	possibly damaging	0.82
R5201:Vmn2r77	UTSW	7	86811638	missense	probably damaging	0.98
R5218:Vmn2r77	UTSW	7	86802133	missense	probably damaging	0.98
R5469:Vmn2r77	UTSW	7	86802063	missense	probably benign	0.01
R5673:Vmn2r77	UTSW	7	86812006	missense	probably benign	0.05
R5771:Vmn2r77	UTSW	7	86812027	missense	probably benign	0.06
R5832:Vmn2r77	UTSW	7	86811462	nonsense	probably null
R5899:Vmn2r77	UTSW	7	86811716	missense	probably damaging	1.00
R6151:Vmn2r77	UTSW	7	86801670	missense	probably benign	0.00
R6182:Vmn2r77	UTSW	7	86811749	missense	probably damaging	1.00
R6326:Vmn2r77	UTSW	7	86801823	missense	probably benign
R6419:Vmn2r77	UTSW	7	86811559	missense	probably damaging	0.99
R6549:Vmn2r77	UTSW	7	86800857	missense	probably benign	0.06
R6874:Vmn2r77	UTSW	7	86802078	missense	probably benign	0.00
R6972:Vmn2r77	UTSW	7	86802994	missense	probably damaging	1.00
R7056:Vmn2r77	UTSW	7	86801815	missense	probably benign	0.06
R7185:Vmn2r77	UTSW	7	86801827	missense	probably benign	0.00
R7261:Vmn2r77	UTSW	7	86811310	nonsense	probably null
R7298:Vmn2r77	UTSW	7	86800771	missense	probably benign	0.00
R7662:Vmn2r77	UTSW	7	86811284	nonsense	probably null
R8182:Vmn2r77	UTSW	7	86811593	missense	probably damaging	1.00
R8327:Vmn2r77	UTSW	7	86801472	missense	probably benign	0.08
R8387:Vmn2r77	UTSW	7	86801739	missense	probably benign	0.00
R8825:Vmn2r77	UTSW	7	86803647	missense	probably benign
R8898:Vmn2r77	UTSW	7	86795222	missense	probably damaging	1.00
R8973:Vmn2r77	UTSW	7	86802942	missense	possibly damaging	0.93
R9258:Vmn2r77	UTSW	7	86803094	missense	possibly damaging	0.88
R9338:Vmn2r77	UTSW	7	86811786	missense	probably damaging	1.00
R9358:Vmn2r77	UTSW	7	86803028	missense	probably benign	0.00
R9377:Vmn2r77	UTSW	7	86795234	missense	probably benign	0.05
R9404:Vmn2r77	UTSW	7	86802039	missense	probably benign
R9673:Vmn2r77	UTSW	7	86800963	missense	possibly damaging	0.75
R9679:Vmn2r77	UTSW	7	86811533	missense	probably benign	0.07

Posted On

2014-02-04