Incidental Mutation 'IGL01805:Dpcr1'
ID155641
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dpcr1
Ensembl Gene ENSMUSG00000073408
Gene Namediffuse panbronchiolitis critical region 1 (human)
SynonymsLOC268949
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.050) question?
Stock #IGL01805
Quality Score
Status
Chromosome17
Chromosomal Location35635752-35643695 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 35637643 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 355 (T355S)
Ref Sequence ENSEMBL: ENSMUSP00000093120 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095467] [ENSMUST00000174521]
Predicted Effect possibly damaging
Transcript: ENSMUST00000095467
AA Change: T355S

PolyPhen 2 Score 0.617 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000093120
Gene: ENSMUSG00000073408
AA Change: T355S

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
transmembrane domain 428 450 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000174521
SMART Domains Protein: ENSMUSP00000134221
Gene: ENSMUSG00000090509

DomainStartEndE-ValueType
Pfam:SFTA2 80 117 9.2e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174534
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700019D03Rik T C 1: 52,925,518 D17G possibly damaging Het
Adam28 G T 14: 68,642,091 S169R probably benign Het
Aox1 T C 1: 58,081,513 M855T possibly damaging Het
Apc C A 18: 34,318,218 N2688K probably benign Het
Arhgap23 T A 11: 97,492,602 probably benign Het
Bpifa6 A G 2: 153,984,912 T66A probably benign Het
C1qtnf1 T A 11: 118,448,167 L221Q probably damaging Het
Ccdc175 T A 12: 72,129,229 probably benign Het
Ccl1 C A 11: 82,178,132 M26I possibly damaging Het
D17Wsu92e C T 17: 27,767,906 probably benign Het
Dnah10 T A 5: 124,783,921 F2123I probably damaging Het
Fancm T C 12: 65,113,861 probably null Het
Fstl4 C A 11: 53,186,357 A647E probably damaging Het
Hmgb4 G T 4: 128,260,222 probably benign Het
Hr A T 14: 70,565,297 probably benign Het
Kcna4 G T 2: 107,296,498 V526L probably damaging Het
Mas1 T C 17: 12,842,230 Y102C probably damaging Het
Mul1 C T 4: 138,439,663 P343S possibly damaging Het
Obscn T C 11: 59,132,596 S652G probably damaging Het
Olfr972 T C 9: 39,873,779 F168S probably damaging Het
Pjvk A T 2: 76,657,514 N250I probably benign Het
Pkd2 T C 5: 104,483,093 I461T probably benign Het
Psen2 T C 1: 180,229,838 probably null Het
Ralb T C 1: 119,475,995 E81G probably benign Het
Slc15a4 T C 5: 127,608,836 T261A possibly damaging Het
Vmn2r77 G A 7: 86,811,187 V574M probably benign Het
Xrn2 A G 2: 147,028,143 I251V probably damaging Het
Zfp974 G A 7: 27,912,264 probably benign Het
Other mutations in Dpcr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00476:Dpcr1 APN 17 35638102 missense possibly damaging 0.46
IGL01321:Dpcr1 APN 17 35636866 missense probably damaging 0.98
IGL02320:Dpcr1 APN 17 35637440 missense probably benign 0.00
R1869:Dpcr1 UTSW 17 35638413 missense possibly damaging 0.82
R4570:Dpcr1 UTSW 17 35637991 missense possibly damaging 0.66
R4858:Dpcr1 UTSW 17 35637576 missense possibly damaging 0.74
R5592:Dpcr1 UTSW 17 35643643 missense probably damaging 0.99
R5733:Dpcr1 UTSW 17 35638210 missense probably benign 0.00
R7422:Dpcr1 UTSW 17 35638420 missense probably benign 0.00
R7689:Dpcr1 UTSW 17 35638077 missense possibly damaging 0.83
R7780:Dpcr1 UTSW 17 35636982 missense possibly damaging 0.95
R8079:Dpcr1 UTSW 17 35638192 missense unknown
R8320:Dpcr1 UTSW 17 35643638 missense probably benign 0.22
R8337:Dpcr1 UTSW 17 35637594 missense possibly damaging 0.95
R8867:Dpcr1 UTSW 17 35637980 missense probably benign 0.27
Posted On2014-02-04