Incidental Mutation 'IGL01806:Gm6408'
ID155673
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm6408
Ensembl Gene ENSMUSG00000096344
Gene Namepredicted gene 6408
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL01806
Quality Score
Status
Chromosome5
Chromosomal Location146481965-146484704 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 146482082 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Histidine at position 30 (R30H)
Ref Sequence ENSEMBL: ENSMUSP00000136735 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000179032]
Predicted Effect probably damaging
Transcript: ENSMUST00000179032
AA Change: R30H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000136735
Gene: ENSMUSG00000096344
AA Change: R30H

DomainStartEndE-ValueType
RasGEFN 66 182 4.47e-3 SMART
low complexity region 270 292 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg1 T C 8: 95,012,931 S670P probably damaging Het
Ap5m1 T A 14: 49,080,340 F351L probably damaging Het
Cacnb2 A G 2: 14,614,268 Y38C probably damaging Het
Ccdc28a C T 10: 18,219,514 A151T possibly damaging Het
Cgnl1 T C 9: 71,650,322 E976G probably damaging Het
Cyp2c39 A G 19: 39,536,820 Y189C probably damaging Het
Dbt T C 3: 116,533,305 V101A probably damaging Het
Evc A G 5: 37,320,234 probably null Het
Fastkd5 A G 2: 130,615,612 Y353H probably benign Het
Lhx8 A G 3: 154,322,355 S156P probably damaging Het
Mki67 T C 7: 135,698,957 I1449M probably damaging Het
Mtrr A T 13: 68,580,600 V27E possibly damaging Het
Myh14 A G 7: 44,657,939 V226A probably benign Het
Nek1 T C 8: 61,124,212 S1076P possibly damaging Het
Olfr522 G T 7: 140,162,928 N7K probably benign Het
Olfr619 C T 7: 103,604,341 A229V probably benign Het
Pcdhb7 A G 18: 37,342,495 D228G possibly damaging Het
Pias3 T C 3: 96,703,757 S414P probably benign Het
Plcd4 G A 1: 74,552,033 V196I probably benign Het
Proca1 A G 11: 78,204,911 D123G probably damaging Het
Ptpn3 A G 4: 57,254,915 probably null Het
Ptprq C A 10: 107,699,608 R432L probably damaging Het
Rasgrp4 A G 7: 29,139,050 K108E possibly damaging Het
Siglecg A G 7: 43,411,464 probably null Het
Srpr A G 9: 35,214,905 T465A possibly damaging Het
Tmpo G A 10: 91,163,242 R228C probably benign Het
Zeb1 G A 18: 5,767,867 V793M possibly damaging Het
Other mutations in Gm6408
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01695:Gm6408 APN 5 146482129 splice site probably benign
R0211:Gm6408 UTSW 5 146483060 missense probably benign 0.04
R1763:Gm6408 UTSW 5 146482322 missense probably damaging 1.00
R3745:Gm6408 UTSW 5 146484436 missense probably damaging 1.00
R4393:Gm6408 UTSW 5 146482337 missense probably damaging 1.00
R5586:Gm6408 UTSW 5 146484457 missense possibly damaging 0.71
R5734:Gm6408 UTSW 5 146482382 missense probably benign 0.07
R5999:Gm6408 UTSW 5 146484257 missense possibly damaging 0.86
R6181:Gm6408 UTSW 5 146483772 missense possibly damaging 0.84
R7007:Gm6408 UTSW 5 146483837 missense probably damaging 1.00
R7063:Gm6408 UTSW 5 146483784 missense probably benign 0.01
R7224:Gm6408 UTSW 5 146484370 missense probably benign 0.10
R7734:Gm6408 UTSW 5 146484350 nonsense probably null
R8676:Gm6408 UTSW 5 146482427 missense probably benign 0.02
R8847:Gm6408 UTSW 5 146483792 missense probably benign 0.20
Posted On2014-02-04