Incidental Mutation 'IGL01808:Ugt2a3'
ID 155729
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ugt2a3
Ensembl Gene ENSMUSG00000035780
Gene Name UDP glucuronosyltransferase 2 family, polypeptide A3
Synonyms 2010321J07Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # IGL01808
Quality Score
Status
Chromosome 5
Chromosomal Location 87472831-87485054 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87473414 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 501 (V501A)
Ref Sequence ENSEMBL: ENSMUSP00000031195 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031195]
AlphaFold Q8BWQ1
Predicted Effect probably benign
Transcript: ENSMUST00000031195
AA Change: V501A

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000031195
Gene: ENSMUSG00000035780
AA Change: V501A

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:UDPGT 24 526 1.2e-233 PFAM
Pfam:Glyco_tran_28_C 318 454 1.5e-10 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ager A T 17: 34,818,431 (GRCm39) Q266L probably damaging Het
Amz1 A G 5: 140,727,034 (GRCm39) probably benign Het
Ebf2 C T 14: 67,651,932 (GRCm39) A488V probably benign Het
Gm5885 A T 6: 133,508,181 (GRCm39) noncoding transcript Het
Gnas T C 2: 174,140,490 (GRCm39) S220P probably damaging Het
Gpr171 G A 3: 59,005,572 (GRCm39) P68S probably damaging Het
H2ax T C 9: 44,246,246 (GRCm39) I63T possibly damaging Het
H2-M9 A T 17: 36,952,711 (GRCm39) probably null Het
Igsf9 T C 1: 172,312,370 (GRCm39) V27A probably benign Het
Kcnh6 G T 11: 105,914,753 (GRCm39) probably benign Het
Mapkbp1 A G 2: 119,853,650 (GRCm39) probably null Het
Mllt6 C A 11: 97,563,310 (GRCm39) H298N possibly damaging Het
Mtmr3 A G 11: 4,447,404 (GRCm39) I352T probably damaging Het
Mtrr T C 13: 68,714,212 (GRCm39) D509G probably benign Het
Ncan C T 8: 70,560,090 (GRCm39) probably null Het
Or51aa2 T A 7: 103,187,781 (GRCm39) Y220F probably damaging Het
Pcdhb4 T C 18: 37,442,067 (GRCm39) V459A probably damaging Het
Phrf1 C A 7: 140,840,879 (GRCm39) P1274Q probably damaging Het
Slc4a2 T C 5: 24,645,205 (GRCm39) L1125P probably damaging Het
Synpo T C 18: 60,735,280 (GRCm39) I650V probably benign Het
Tsc1 G A 2: 28,552,519 (GRCm39) R86H probably damaging Het
Vmn1r203 T C 13: 22,708,717 (GRCm39) I166T probably benign Het
Vps13a A G 19: 16,687,650 (GRCm39) C933R probably damaging Het
Zfp142 A T 1: 74,615,184 (GRCm39) F342Y probably damaging Het
Other mutations in Ugt2a3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00509:Ugt2a3 APN 5 87,473,514 (GRCm39) missense probably damaging 0.99
IGL00542:Ugt2a3 APN 5 87,484,682 (GRCm39) missense possibly damaging 0.61
IGL01335:Ugt2a3 APN 5 87,484,644 (GRCm39) missense probably damaging 1.00
IGL01369:Ugt2a3 APN 5 87,474,979 (GRCm39) missense probably damaging 1.00
IGL02380:Ugt2a3 APN 5 87,484,658 (GRCm39) missense probably benign 0.09
IGL03245:Ugt2a3 APN 5 87,484,439 (GRCm39) missense probably damaging 1.00
IGL03260:Ugt2a3 APN 5 87,484,439 (GRCm39) missense probably damaging 1.00
IGL03261:Ugt2a3 APN 5 87,484,439 (GRCm39) missense probably damaging 1.00
IGL03280:Ugt2a3 APN 5 87,484,439 (GRCm39) missense probably damaging 1.00
IGL03302:Ugt2a3 APN 5 87,484,439 (GRCm39) missense probably damaging 1.00
D4186:Ugt2a3 UTSW 5 87,329,613 (GRCm38) missense probably damaging 1.00
R0051:Ugt2a3 UTSW 5 87,484,865 (GRCm39) missense probably damaging 1.00
R0103:Ugt2a3 UTSW 5 87,484,577 (GRCm39) missense possibly damaging 0.89
R0103:Ugt2a3 UTSW 5 87,484,577 (GRCm39) missense possibly damaging 0.89
R0324:Ugt2a3 UTSW 5 87,474,932 (GRCm39) critical splice donor site probably null
R0401:Ugt2a3 UTSW 5 87,484,349 (GRCm39) missense probably benign 0.03
R0506:Ugt2a3 UTSW 5 87,484,508 (GRCm39) missense possibly damaging 0.78
R0903:Ugt2a3 UTSW 5 87,475,570 (GRCm39) missense probably benign 0.00
R0940:Ugt2a3 UTSW 5 87,475,065 (GRCm39) missense possibly damaging 0.95
R1121:Ugt2a3 UTSW 5 87,475,548 (GRCm39) missense probably damaging 0.99
R1296:Ugt2a3 UTSW 5 87,475,005 (GRCm39) missense probably damaging 0.96
R1527:Ugt2a3 UTSW 5 87,473,457 (GRCm39) missense probably damaging 1.00
R2104:Ugt2a3 UTSW 5 87,477,541 (GRCm39) splice site probably null
R2119:Ugt2a3 UTSW 5 87,484,430 (GRCm39) missense probably damaging 0.98
R2374:Ugt2a3 UTSW 5 87,475,050 (GRCm39) missense probably damaging 1.00
R3082:Ugt2a3 UTSW 5 87,473,534 (GRCm39) missense probably benign 0.05
R3853:Ugt2a3 UTSW 5 87,485,018 (GRCm39) missense
R3894:Ugt2a3 UTSW 5 87,477,449 (GRCm39) missense probably benign 0.09
R4063:Ugt2a3 UTSW 5 87,484,725 (GRCm39) missense probably benign 0.04
R4274:Ugt2a3 UTSW 5 87,475,548 (GRCm39) missense probably damaging 0.99
R4739:Ugt2a3 UTSW 5 87,475,054 (GRCm39) missense probably damaging 0.97
R4879:Ugt2a3 UTSW 5 87,479,144 (GRCm39) missense probably benign 0.06
R5327:Ugt2a3 UTSW 5 87,479,174 (GRCm39) missense probably damaging 1.00
R5508:Ugt2a3 UTSW 5 87,475,059 (GRCm39) missense probably damaging 0.98
R5866:Ugt2a3 UTSW 5 87,484,406 (GRCm39) missense probably damaging 1.00
R6026:Ugt2a3 UTSW 5 87,484,336 (GRCm39) missense probably benign 0.00
R6268:Ugt2a3 UTSW 5 87,477,472 (GRCm39) missense probably damaging 1.00
R6807:Ugt2a3 UTSW 5 87,484,617 (GRCm39) missense probably benign 0.00
R6980:Ugt2a3 UTSW 5 87,473,491 (GRCm39) missense probably damaging 1.00
R7056:Ugt2a3 UTSW 5 87,484,953 (GRCm39) missense probably damaging 0.98
R7133:Ugt2a3 UTSW 5 87,473,393 (GRCm39) missense possibly damaging 0.61
R7477:Ugt2a3 UTSW 5 87,484,479 (GRCm39) missense possibly damaging 0.90
R7485:Ugt2a3 UTSW 5 87,475,539 (GRCm39) critical splice donor site probably null
R7798:Ugt2a3 UTSW 5 87,475,582 (GRCm39) missense probably damaging 1.00
R7957:Ugt2a3 UTSW 5 87,475,050 (GRCm39) missense probably damaging 1.00
R8803:Ugt2a3 UTSW 5 87,484,389 (GRCm39) missense probably damaging 0.98
R8886:Ugt2a3 UTSW 5 87,484,358 (GRCm39) missense probably damaging 1.00
R8944:Ugt2a3 UTSW 5 87,473,417 (GRCm39) missense possibly damaging 0.81
R9387:Ugt2a3 UTSW 5 87,484,832 (GRCm39) missense probably benign 0.38
R9447:Ugt2a3 UTSW 5 87,473,330 (GRCm39) missense probably benign 0.39
R9524:Ugt2a3 UTSW 5 87,485,018 (GRCm39) missense
Posted On 2014-02-04