Incidental Mutation 'IGL01810:Gpr182'
ID 155790
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr182
Ensembl Gene ENSMUSG00000058396
Gene Name G protein-coupled receptor 182
Synonyms Gpcr17, NOW, G10-D, Admr, AM-R, Gpcr22
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01810
Quality Score
Status
Chromosome 10
Chromosomal Location 127585471-127587667 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 127586733 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Phenylalanine at position 73 (V73F)
Ref Sequence ENSEMBL: ENSMUSP00000100882 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054287] [ENSMUST00000079692]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000054287
SMART Domains Protein: ENSMUSP00000052717
Gene: ENSMUSG00000044617

DomainStartEndE-ValueType
BTB 30 126 9.15e-24 SMART
low complexity region 197 206 N/A INTRINSIC
low complexity region 213 229 N/A INTRINSIC
ZnF_C2H2 372 394 6.4e0 SMART
ZnF_C2H2 400 420 3.21e1 SMART
ZnF_C2H2 451 474 9.31e1 SMART
ZnF_C2H2 480 502 6.92e0 SMART
ZnF_C2H2 508 530 1.79e-2 SMART
ZnF_C2H2 538 560 1.18e-2 SMART
ZnF_C2H2 605 627 2.57e-3 SMART
ZnF_C2H2 633 655 3.78e-1 SMART
ZnF_C2H2 661 683 2.49e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000079692
AA Change: V73F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000100882
Gene: ENSMUSG00000058396
AA Change: V73F

DomainStartEndE-ValueType
Pfam:7tm_1 66 316 1.2e-40 PFAM
low complexity region 340 352 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aarsd1 G T 11: 101,308,185 (GRCm39) Y10* probably null Het
Aass C A 6: 23,107,633 (GRCm39) Q383H probably damaging Het
Bag1 T C 4: 40,936,657 (GRCm39) D333G probably damaging Het
Cap2 A G 13: 46,793,425 (GRCm39) probably benign Het
Col27a1 G T 4: 63,143,868 (GRCm39) A519S probably benign Het
Cr2 A G 1: 194,841,903 (GRCm39) V726A possibly damaging Het
Csmd2 A G 4: 128,374,638 (GRCm39) probably benign Het
Dennd4c A G 4: 86,717,788 (GRCm39) D595G possibly damaging Het
Ercc2 G T 7: 19,127,374 (GRCm39) R340L probably damaging Het
Espl1 A G 15: 102,206,640 (GRCm39) T35A probably benign Het
Fndc3a A G 14: 72,803,581 (GRCm39) Y525H probably benign Het
Gm4922 T C 10: 18,659,795 (GRCm39) Q309R probably benign Het
Gm5263 T C 1: 146,296,292 (GRCm39) noncoding transcript Het
Gm6563 A C 19: 23,653,751 (GRCm39) R180S probably damaging Het
Gramd1b C T 9: 40,227,069 (GRCm39) R179H probably damaging Het
Hk1 C T 10: 62,188,884 (GRCm39) A10T probably benign Het
Hmgn3 C A 9: 82,992,437 (GRCm39) probably benign Het
Il1b C T 2: 129,211,649 (GRCm39) E24K probably damaging Het
Itgb6 G T 2: 60,458,329 (GRCm39) Q475K probably benign Het
Lrrc74b A G 16: 17,363,422 (GRCm39) S368P probably benign Het
Mfsd2b T C 12: 4,916,469 (GRCm39) T234A possibly damaging Het
Muc6 A T 7: 141,237,327 (GRCm39) Y270N probably damaging Het
Naip6 A G 13: 100,424,603 (GRCm39) probably benign Het
Or4b13 A T 2: 90,082,476 (GRCm39) Y285* probably null Het
Pear1 G A 3: 87,659,608 (GRCm39) T742I probably damaging Het
Peli2 G A 14: 48,493,491 (GRCm39) V238I probably benign Het
Pira2 A G 7: 3,847,611 (GRCm39) L26P probably damaging Het
Pot1b A G 17: 55,969,521 (GRCm39) V549A possibly damaging Het
Prdm16 T C 4: 154,432,384 (GRCm39) Y295C probably benign Het
Ptprd A T 4: 76,058,744 (GRCm39) probably benign Het
Rap1gap A T 4: 137,443,466 (GRCm39) M145L probably benign Het
Setd7 A T 3: 51,440,388 (GRCm39) probably benign Het
Ssx2ip T C 3: 146,133,765 (GRCm39) I258T probably benign Het
Stard9 T C 2: 120,529,565 (GRCm39) Y1941H possibly damaging Het
Stxbp3 T C 3: 108,707,468 (GRCm39) E420G probably benign Het
Tpra1 T C 6: 88,886,324 (GRCm39) V101A probably damaging Het
Tpx2 G T 2: 152,726,155 (GRCm39) Q373H probably damaging Het
Ttn C T 2: 76,557,352 (GRCm39) R29914Q probably damaging Het
Ubr3 T C 2: 69,833,809 (GRCm39) probably null Het
Usp18 G A 6: 121,230,730 (GRCm39) G53D probably damaging Het
Vps13c A T 9: 67,863,062 (GRCm39) H3026L probably benign Het
Zan T C 5: 137,461,888 (GRCm39) E1097G unknown Het
Other mutations in Gpr182
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00961:Gpr182 APN 10 127,586,559 (GRCm39) missense probably benign 0.09
IGL00983:Gpr182 APN 10 127,586,657 (GRCm39) missense possibly damaging 0.89
IGL01337:Gpr182 APN 10 127,586,655 (GRCm39) missense possibly damaging 0.95
R0449:Gpr182 UTSW 10 127,586,565 (GRCm39) missense probably damaging 1.00
R0554:Gpr182 UTSW 10 127,586,940 (GRCm39) missense probably benign 0.00
R2229:Gpr182 UTSW 10 127,586,010 (GRCm39) missense possibly damaging 0.91
R2292:Gpr182 UTSW 10 127,586,051 (GRCm39) missense possibly damaging 0.89
R2349:Gpr182 UTSW 10 127,586,806 (GRCm39) missense probably damaging 1.00
R2445:Gpr182 UTSW 10 127,586,496 (GRCm39) missense probably benign 0.01
R5977:Gpr182 UTSW 10 127,586,748 (GRCm39) missense possibly damaging 0.79
R6290:Gpr182 UTSW 10 127,586,893 (GRCm39) missense probably benign 0.00
R6415:Gpr182 UTSW 10 127,586,375 (GRCm39) missense possibly damaging 0.88
R8014:Gpr182 UTSW 10 127,586,874 (GRCm39) missense possibly damaging 0.59
R8093:Gpr182 UTSW 10 127,586,783 (GRCm39) missense probably damaging 1.00
R8333:Gpr182 UTSW 10 127,585,790 (GRCm39) missense probably benign 0.08
R8543:Gpr182 UTSW 10 127,586,861 (GRCm39) missense probably benign 0.43
R8788:Gpr182 UTSW 10 127,586,529 (GRCm39) missense probably benign 0.00
R9047:Gpr182 UTSW 10 127,586,517 (GRCm39) missense probably benign 0.00
Posted On 2014-02-04