Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01810:Lrrc74b'

155815

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc74b

Ensembl Gene

ENSMUSG00000022759

Gene Name

leucine rich repeat containing 74B

Synonyms

4930451C15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.127) question?

Stock #

IGL01810

Quality Score

Status

Chromosome

Chromosomal Location

17544465-17561247 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 17545558 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 368 (S368P)

Ref Sequence

ENSEMBL: ENSMUSP00000097699 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023442] [ENSMUST00000100123] [ENSMUST00000232637]

AlphaFold

Q14BP6

Predicted Effect

probably benign
Transcript: ENSMUST00000023442
AA Change: S336P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000023442
Gene: ENSMUSG00000022759
AA Change: S336P

Domain	Start	End	E-Value	Type
LRR	71	103	3.9e0	SMART
LRR	104	131	1.04e-3	SMART
LRR	132	159	1.14e1	SMART
LRR	160	187	7.78e-3	SMART
LRR	188	215	3.9e0	SMART
LRR	216	243	7.89e-1	SMART
LRR	244	271	6.78e-3	SMART
LRR	272	299	5.51e-1	SMART
low complexity region	342	355	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000100123
AA Change: S368P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000097699
Gene: ENSMUSG00000022759
AA Change: S368P

Domain	Start	End	E-Value	Type
LRR	71	103	3.9e0	SMART
LRR	104	131	1.04e-3	SMART
LRR	132	159	1.14e1	SMART
LRR	160	187	7.78e-3	SMART
LRR	188	215	3.9e0	SMART
LRR	216	243	7.89e-1	SMART
LRR	244	271	6.78e-3	SMART
LRR	272	299	5.51e-1	SMART
LRR	300	327	4.16e0	SMART
low complexity region	374	387	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138839

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232230

Predicted Effect

probably benign
Transcript: ENSMUST00000232637

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aarsd1	G	T	11: 101,417,359	Y10*	probably null	Het
Aass	C	A	6: 23,107,634	Q383H	probably damaging	Het
Bag1	T	C	4: 40,936,657	D333G	probably damaging	Het
Cap2	A	G	13: 46,639,949		probably benign	Het
Col27a1	G	T	4: 63,225,631	A519S	probably benign	Het
Cr2	A	G	1: 195,159,595	V726A	possibly damaging	Het
Csmd2	A	G	4: 128,480,845		probably benign	Het
Dennd4c	A	G	4: 86,799,551	D595G	possibly damaging	Het
Ercc2	G	T	7: 19,393,449	R340L	probably damaging	Het
Espl1	A	G	15: 102,298,205	T35A	probably benign	Het
Fndc3a	A	G	14: 72,566,141	Y525H	probably benign	Het
Gm4922	T	C	10: 18,784,047	Q309R	probably benign	Het
Gm5263	T	C	1: 146,420,554		noncoding transcript	Het
Gm6563	A	C	19: 23,676,387	R180S	probably damaging	Het
Gpr182	C	A	10: 127,750,864	V73F	probably damaging	Het
Gramd1b	C	T	9: 40,315,773	R179H	probably damaging	Het
Hk1	C	T	10: 62,353,105	A10T	probably benign	Het
Hmgn3	C	A	9: 83,110,384		probably benign	Het
Il1b	C	T	2: 129,369,729	E24K	probably damaging	Het
Itgb6	G	T	2: 60,627,985	Q475K	probably benign	Het
Mfsd2b	T	C	12: 4,866,469	T234A	possibly damaging	Het
Muc6	A	T	7: 141,651,062	Y270N	probably damaging	Het
Naip6	A	G	13: 100,288,095		probably benign	Het
Olfr142	A	T	2: 90,252,132	Y285*	probably null	Het
Pear1	G	A	3: 87,752,301	T742I	probably damaging	Het
Peli2	G	A	14: 48,256,034	V238I	probably benign	Het
Pira2	A	G	7: 3,844,612	L26P	probably damaging	Het
Pot1b	A	G	17: 55,662,521	V549A	possibly damaging	Het
Prdm16	T	C	4: 154,347,927	Y295C	probably benign	Het
Ptprd	A	T	4: 76,140,507		probably benign	Het
Rap1gap	A	T	4: 137,716,155	M145L	probably benign	Het
Setd7	A	T	3: 51,532,967		probably benign	Het
Ssx2ip	T	C	3: 146,428,010	I258T	probably benign	Het
Stard9	T	C	2: 120,699,084	Y1941H	possibly damaging	Het
Stxbp3	T	C	3: 108,800,152	E420G	probably benign	Het
Tpra1	T	C	6: 88,909,342	V101A	probably damaging	Het
Tpx2	G	T	2: 152,884,235	Q373H	probably damaging	Het
Ttn	C	T	2: 76,727,008	R29914Q	probably damaging	Het
Ubr3	T	C	2: 70,003,465		probably null	Het
Usp18	G	A	6: 121,253,771	G53D	probably damaging	Het
Vps13c	A	T	9: 67,955,780	H3026L	probably benign	Het
Zan	T	C	5: 137,463,626	E1097G	unknown	Het

Other mutations in Lrrc74b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02402:Lrrc74b	APN	16	17558164	splice site	probably benign
P0043:Lrrc74b	UTSW	16	17558159	splice site	probably benign
R0131:Lrrc74b	UTSW	16	17553152	missense	probably damaging	1.00
R0131:Lrrc74b	UTSW	16	17553152	missense	probably damaging	1.00
R0132:Lrrc74b	UTSW	16	17553152	missense	probably damaging	1.00
R0829:Lrrc74b	UTSW	16	17558390	splice site	probably benign
R1463:Lrrc74b	UTSW	16	17559873	missense	probably benign	0.00
R1681:Lrrc74b	UTSW	16	17559753	missense	probably damaging	1.00
R1938:Lrrc74b	UTSW	16	17553194	missense	probably benign	0.41
R4790:Lrrc74b	UTSW	16	17549853	missense	probably damaging	1.00
R5428:Lrrc74b	UTSW	16	17558261	missense	probably damaging	0.99
R6198:Lrrc74b	UTSW	16	17548786	missense	probably damaging	0.96
R7910:Lrrc74b	UTSW	16	17558349	nonsense	probably null
R8233:Lrrc74b	UTSW	16	17558225	missense	probably benign	0.00
R8957:Lrrc74b	UTSW	16	17561112	missense	probably benign	0.09
R9030:Lrrc74b	UTSW	16	17549776	critical splice donor site	probably null
X0063:Lrrc74b	UTSW	16	17553208	missense	probably benign	0.05
Z1177:Lrrc74b	UTSW	16	17558168	critical splice donor site	probably null
Z1177:Lrrc74b	UTSW	16	17558172	missense	probably damaging	1.00

Posted On

2014-02-04