Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01810:Lrrc74b'

155815

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc74b

Ensembl Gene

ENSMUSG00000022759

Gene Name

leucine rich repeat containing 74B

Synonyms

4930451C15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.127) question?

Stock #

IGL01810

Quality Score

Status

Chromosome

Chromosomal Location

17362329-17379111 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 17363422 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 368 (S368P)

Ref Sequence

ENSEMBL: ENSMUSP00000097699 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023442] [ENSMUST00000100123] [ENSMUST00000232637]

AlphaFold

Q14BP6

Predicted Effect

probably benign
Transcript: ENSMUST00000023442
AA Change: S336P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000023442
Gene: ENSMUSG00000022759
AA Change: S336P

Domain	Start	End	E-Value	Type
LRR	71	103	3.9e0	SMART
LRR	104	131	1.04e-3	SMART
LRR	132	159	1.14e1	SMART
LRR	160	187	7.78e-3	SMART
LRR	188	215	3.9e0	SMART
LRR	216	243	7.89e-1	SMART
LRR	244	271	6.78e-3	SMART
LRR	272	299	5.51e-1	SMART
low complexity region	342	355	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000100123
AA Change: S368P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000097699
Gene: ENSMUSG00000022759
AA Change: S368P

Domain	Start	End	E-Value	Type
LRR	71	103	3.9e0	SMART
LRR	104	131	1.04e-3	SMART
LRR	132	159	1.14e1	SMART
LRR	160	187	7.78e-3	SMART
LRR	188	215	3.9e0	SMART
LRR	216	243	7.89e-1	SMART
LRR	244	271	6.78e-3	SMART
LRR	272	299	5.51e-1	SMART
LRR	300	327	4.16e0	SMART
low complexity region	374	387	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138839

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232230

Predicted Effect

probably benign
Transcript: ENSMUST00000232637

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aarsd1	G	T	11: 101,308,185 (GRCm39)	Y10*	probably null	Het
Aass	C	A	6: 23,107,633 (GRCm39)	Q383H	probably damaging	Het
Bag1	T	C	4: 40,936,657 (GRCm39)	D333G	probably damaging	Het
Cap2	A	G	13: 46,793,425 (GRCm39)		probably benign	Het
Col27a1	G	T	4: 63,143,868 (GRCm39)	A519S	probably benign	Het
Cr2	A	G	1: 194,841,903 (GRCm39)	V726A	possibly damaging	Het
Csmd2	A	G	4: 128,374,638 (GRCm39)		probably benign	Het
Dennd4c	A	G	4: 86,717,788 (GRCm39)	D595G	possibly damaging	Het
Ercc2	G	T	7: 19,127,374 (GRCm39)	R340L	probably damaging	Het
Espl1	A	G	15: 102,206,640 (GRCm39)	T35A	probably benign	Het
Fndc3a	A	G	14: 72,803,581 (GRCm39)	Y525H	probably benign	Het
Gm4922	T	C	10: 18,659,795 (GRCm39)	Q309R	probably benign	Het
Gm5263	T	C	1: 146,296,292 (GRCm39)		noncoding transcript	Het
Gm6563	A	C	19: 23,653,751 (GRCm39)	R180S	probably damaging	Het
Gpr182	C	A	10: 127,586,733 (GRCm39)	V73F	probably damaging	Het
Gramd1b	C	T	9: 40,227,069 (GRCm39)	R179H	probably damaging	Het
Hk1	C	T	10: 62,188,884 (GRCm39)	A10T	probably benign	Het
Hmgn3	C	A	9: 82,992,437 (GRCm39)		probably benign	Het
Il1b	C	T	2: 129,211,649 (GRCm39)	E24K	probably damaging	Het
Itgb6	G	T	2: 60,458,329 (GRCm39)	Q475K	probably benign	Het
Mfsd2b	T	C	12: 4,916,469 (GRCm39)	T234A	possibly damaging	Het
Muc6	A	T	7: 141,237,327 (GRCm39)	Y270N	probably damaging	Het
Naip6	A	G	13: 100,424,603 (GRCm39)		probably benign	Het
Or4b13	A	T	2: 90,082,476 (GRCm39)	Y285*	probably null	Het
Pear1	G	A	3: 87,659,608 (GRCm39)	T742I	probably damaging	Het
Peli2	G	A	14: 48,493,491 (GRCm39)	V238I	probably benign	Het
Pira2	A	G	7: 3,847,611 (GRCm39)	L26P	probably damaging	Het
Pot1b	A	G	17: 55,969,521 (GRCm39)	V549A	possibly damaging	Het
Prdm16	T	C	4: 154,432,384 (GRCm39)	Y295C	probably benign	Het
Ptprd	A	T	4: 76,058,744 (GRCm39)		probably benign	Het
Rap1gap	A	T	4: 137,443,466 (GRCm39)	M145L	probably benign	Het
Setd7	A	T	3: 51,440,388 (GRCm39)		probably benign	Het
Ssx2ip	T	C	3: 146,133,765 (GRCm39)	I258T	probably benign	Het
Stard9	T	C	2: 120,529,565 (GRCm39)	Y1941H	possibly damaging	Het
Stxbp3	T	C	3: 108,707,468 (GRCm39)	E420G	probably benign	Het
Tpra1	T	C	6: 88,886,324 (GRCm39)	V101A	probably damaging	Het
Tpx2	G	T	2: 152,726,155 (GRCm39)	Q373H	probably damaging	Het
Ttn	C	T	2: 76,557,352 (GRCm39)	R29914Q	probably damaging	Het
Ubr3	T	C	2: 69,833,809 (GRCm39)		probably null	Het
Usp18	G	A	6: 121,230,730 (GRCm39)	G53D	probably damaging	Het
Vps13c	A	T	9: 67,863,062 (GRCm39)	H3026L	probably benign	Het
Zan	T	C	5: 137,461,888 (GRCm39)	E1097G	unknown	Het

Other mutations in Lrrc74b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02402:Lrrc74b	APN	16	17,376,028 (GRCm39)	splice site	probably benign
P0043:Lrrc74b	UTSW	16	17,376,023 (GRCm39)	splice site	probably benign
R0131:Lrrc74b	UTSW	16	17,371,016 (GRCm39)	missense	probably damaging	1.00
R0131:Lrrc74b	UTSW	16	17,371,016 (GRCm39)	missense	probably damaging	1.00
R0132:Lrrc74b	UTSW	16	17,371,016 (GRCm39)	missense	probably damaging	1.00
R0829:Lrrc74b	UTSW	16	17,376,254 (GRCm39)	splice site	probably benign
R1463:Lrrc74b	UTSW	16	17,377,737 (GRCm39)	missense	probably benign	0.00
R1681:Lrrc74b	UTSW	16	17,377,617 (GRCm39)	missense	probably damaging	1.00
R1938:Lrrc74b	UTSW	16	17,371,058 (GRCm39)	missense	probably benign	0.41
R4790:Lrrc74b	UTSW	16	17,367,717 (GRCm39)	missense	probably damaging	1.00
R5428:Lrrc74b	UTSW	16	17,376,125 (GRCm39)	missense	probably damaging	0.99
R6198:Lrrc74b	UTSW	16	17,366,650 (GRCm39)	missense	probably damaging	0.96
R7910:Lrrc74b	UTSW	16	17,376,213 (GRCm39)	nonsense	probably null
R8233:Lrrc74b	UTSW	16	17,376,089 (GRCm39)	missense	probably benign	0.00
R8957:Lrrc74b	UTSW	16	17,378,976 (GRCm39)	missense	probably benign	0.09
R9030:Lrrc74b	UTSW	16	17,367,640 (GRCm39)	critical splice donor site	probably null
X0063:Lrrc74b	UTSW	16	17,371,072 (GRCm39)	missense	probably benign	0.05
Z1177:Lrrc74b	UTSW	16	17,376,036 (GRCm39)	missense	probably damaging	1.00
Z1177:Lrrc74b	UTSW	16	17,376,032 (GRCm39)	critical splice donor site	probably null

Posted On

2014-02-04