Incidental Mutation 'IGL01810:Hmgn3'
ID 155823
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Hmgn3
Ensembl Gene ENSMUSG00000066456
Gene Name high mobility group nucleosomal binding domain 3
Synonyms 6330514M13Rik, HMGN3a, HMGN3b, TRIP7, 1110002A15Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.359) question?
Stock # IGL01810
Quality Score
Status
Chromosome 9
Chromosomal Location 82992001-83028738 bp(-) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) C to A at 82992437 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140247 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000161796] [ENSMUST00000162246] [ENSMUST00000185315] [ENSMUST00000187193] [ENSMUST00000190154]
AlphaFold Q9DCB1
Predicted Effect probably benign
Transcript: ENSMUST00000161796
SMART Domains Protein: ENSMUSP00000125616
Gene: ENSMUSG00000066456

DomainStartEndE-ValueType
HMG17 2 76 3.32e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000162246
SMART Domains Protein: ENSMUSP00000124278
Gene: ENSMUSG00000066456

DomainStartEndE-ValueType
HMG17 2 94 5.21e-40 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000185315
SMART Domains Protein: ENSMUSP00000140356
Gene: ENSMUSG00000066456

DomainStartEndE-ValueType
HMG17 2 94 1.16e-37 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185359
Predicted Effect probably benign
Transcript: ENSMUST00000187193
SMART Domains Protein: ENSMUSP00000140980
Gene: ENSMUSG00000066456

DomainStartEndE-ValueType
HMG17 2 94 5.5e-40 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000189777
Predicted Effect noncoding transcript
Transcript: ENSMUST00000190580
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194697
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191105
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217211
Predicted Effect probably benign
Transcript: ENSMUST00000190154
SMART Domains Protein: ENSMUSP00000140247
Gene: ENSMUSG00000066456

DomainStartEndE-ValueType
HMG17 2 94 1.16e-37 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit impaired glucose tolerance with decreased insulin serum levels and increased glucose serum levels during feeding. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aarsd1 G T 11: 101,308,185 (GRCm39) Y10* probably null Het
Aass C A 6: 23,107,633 (GRCm39) Q383H probably damaging Het
Bag1 T C 4: 40,936,657 (GRCm39) D333G probably damaging Het
Cap2 A G 13: 46,793,425 (GRCm39) probably benign Het
Col27a1 G T 4: 63,143,868 (GRCm39) A519S probably benign Het
Cr2 A G 1: 194,841,903 (GRCm39) V726A possibly damaging Het
Csmd2 A G 4: 128,374,638 (GRCm39) probably benign Het
Dennd4c A G 4: 86,717,788 (GRCm39) D595G possibly damaging Het
Ercc2 G T 7: 19,127,374 (GRCm39) R340L probably damaging Het
Espl1 A G 15: 102,206,640 (GRCm39) T35A probably benign Het
Fndc3a A G 14: 72,803,581 (GRCm39) Y525H probably benign Het
Gm4922 T C 10: 18,659,795 (GRCm39) Q309R probably benign Het
Gm5263 T C 1: 146,296,292 (GRCm39) noncoding transcript Het
Gm6563 A C 19: 23,653,751 (GRCm39) R180S probably damaging Het
Gpr182 C A 10: 127,586,733 (GRCm39) V73F probably damaging Het
Gramd1b C T 9: 40,227,069 (GRCm39) R179H probably damaging Het
Hk1 C T 10: 62,188,884 (GRCm39) A10T probably benign Het
Il1b C T 2: 129,211,649 (GRCm39) E24K probably damaging Het
Itgb6 G T 2: 60,458,329 (GRCm39) Q475K probably benign Het
Lrrc74b A G 16: 17,363,422 (GRCm39) S368P probably benign Het
Mfsd2b T C 12: 4,916,469 (GRCm39) T234A possibly damaging Het
Muc6 A T 7: 141,237,327 (GRCm39) Y270N probably damaging Het
Naip6 A G 13: 100,424,603 (GRCm39) probably benign Het
Or4b13 A T 2: 90,082,476 (GRCm39) Y285* probably null Het
Pear1 G A 3: 87,659,608 (GRCm39) T742I probably damaging Het
Peli2 G A 14: 48,493,491 (GRCm39) V238I probably benign Het
Pira2 A G 7: 3,847,611 (GRCm39) L26P probably damaging Het
Pot1b A G 17: 55,969,521 (GRCm39) V549A possibly damaging Het
Prdm16 T C 4: 154,432,384 (GRCm39) Y295C probably benign Het
Ptprd A T 4: 76,058,744 (GRCm39) probably benign Het
Rap1gap A T 4: 137,443,466 (GRCm39) M145L probably benign Het
Setd7 A T 3: 51,440,388 (GRCm39) probably benign Het
Ssx2ip T C 3: 146,133,765 (GRCm39) I258T probably benign Het
Stard9 T C 2: 120,529,565 (GRCm39) Y1941H possibly damaging Het
Stxbp3 T C 3: 108,707,468 (GRCm39) E420G probably benign Het
Tpra1 T C 6: 88,886,324 (GRCm39) V101A probably damaging Het
Tpx2 G T 2: 152,726,155 (GRCm39) Q373H probably damaging Het
Ttn C T 2: 76,557,352 (GRCm39) R29914Q probably damaging Het
Ubr3 T C 2: 69,833,809 (GRCm39) probably null Het
Usp18 G A 6: 121,230,730 (GRCm39) G53D probably damaging Het
Vps13c A T 9: 67,863,062 (GRCm39) H3026L probably benign Het
Zan T C 5: 137,461,888 (GRCm39) E1097G unknown Het
Other mutations in Hmgn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03142:Hmgn3 APN 9 83,028,482 (GRCm39) critical splice donor site probably benign
R0519:Hmgn3 UTSW 9 82,994,301 (GRCm39) missense probably damaging 1.00
R0601:Hmgn3 UTSW 9 83,028,482 (GRCm39) critical splice donor site probably null
R6008:Hmgn3 UTSW 9 82,994,284 (GRCm39) missense probably damaging 0.99
R8346:Hmgn3 UTSW 9 82,993,159 (GRCm39) missense probably damaging 1.00
Posted On 2014-02-04