Incidental Mutation 'P0023:Or8b50'
| ID |
15583 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Or8b50
|
| Ensembl Gene |
ENSMUSG00000047050 |
| Gene Name |
olfactory receptor family 8 subfamily B member 50 |
| Synonyms |
Olfr914, MOR165-7, GA_x6K02T2PVTD-32308823-32309773 |
| MMRRC Submission |
038276-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.053)
|
| Stock # |
P0023 (G1)
|
| Quality Score |
|
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
38517763-38518713 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 38517941 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 60
(Y60C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150241
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057755]
[ENSMUST00000217057]
|
| AlphaFold |
E9PW59 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000057755
AA Change: Y60C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000053405
Gene: ENSMUSG00000047050
AA Change: Y60C
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
31 |
310 |
1.1e-48 |
PFAM |
|
Pfam:7tm_1
|
41 |
290 |
5.2e-23 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000217057
AA Change: Y60C
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 85.1%
- 3x: 76.2%
- 10x: 34.8%
- 20x: 2.4%
|
| Validation Efficiency |
97% (62/64) |
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 19 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Actr3 |
A |
T |
1: 125,322,803 (GRCm39) |
|
probably null |
Het |
| Chp2 |
A |
G |
7: 121,821,361 (GRCm39) |
N185S |
probably benign |
Het |
| Cited2 |
A |
G |
10: 17,600,463 (GRCm39) |
D257G |
probably damaging |
Het |
| Clptm1l |
G |
T |
13: 73,753,071 (GRCm39) |
R62L |
possibly damaging |
Het |
| Cmya5 |
C |
T |
13: 93,225,854 (GRCm39) |
S3078N |
probably benign |
Het |
| Dcaf1 |
T |
A |
9: 106,737,650 (GRCm39) |
F1169I |
probably benign |
Het |
| Efhc1 |
G |
A |
1: 21,025,751 (GRCm39) |
V86I |
probably benign |
Het |
| Fanci |
A |
C |
7: 79,052,048 (GRCm39) |
D107A |
probably benign |
Het |
| Fyb1 |
A |
T |
15: 6,681,335 (GRCm39) |
K74M |
probably damaging |
Het |
| Gapvd1 |
A |
G |
2: 34,596,700 (GRCm39) |
|
probably benign |
Het |
| Gm11992 |
T |
C |
11: 9,002,846 (GRCm39) |
Y70H |
probably damaging |
Het |
| Lrba |
A |
G |
3: 86,325,242 (GRCm39) |
E1900G |
probably damaging |
Het |
| Lrpprc |
G |
A |
17: 85,033,766 (GRCm39) |
T1037M |
probably benign |
Het |
| Piezo2 |
A |
G |
18: 63,519,271 (GRCm39) |
|
probably benign |
Het |
| Pld1 |
T |
C |
3: 28,102,274 (GRCm39) |
S342P |
probably damaging |
Het |
| Prkag3 |
A |
G |
1: 74,779,898 (GRCm39) |
L479P |
probably damaging |
Het |
| Rsf1 |
T |
C |
7: 97,311,478 (GRCm39) |
I736T |
probably damaging |
Het |
| Tet2 |
C |
A |
3: 133,192,654 (GRCm39) |
M593I |
probably benign |
Het |
| Ttpal |
T |
C |
2: 163,453,729 (GRCm39) |
Y167H |
probably damaging |
Het |
|
| Other mutations in Or8b50 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01613:Or8b50
|
APN |
9 |
38,517,850 (GRCm39) |
missense |
probably null |
0.00 |
|
IGL01758:Or8b50
|
APN |
9 |
38,518,589 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02003:Or8b50
|
APN |
9 |
38,518,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02203:Or8b50
|
APN |
9 |
38,518,719 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL02233:Or8b50
|
APN |
9 |
38,518,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Or8b50
|
APN |
9 |
38,518,417 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL02882:Or8b50
|
APN |
9 |
38,518,234 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL03081:Or8b50
|
APN |
9 |
38,518,166 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03088:Or8b50
|
APN |
9 |
38,518,597 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03177:Or8b50
|
APN |
9 |
38,517,867 (GRCm39) |
nonsense |
probably null |
|
|
IGL03219:Or8b50
|
APN |
9 |
38,518,247 (GRCm39) |
missense |
probably benign |
0.28 |
|
R0630:Or8b50
|
UTSW |
9 |
38,518,192 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0948:Or8b50
|
UTSW |
9 |
38,517,787 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R1451:Or8b50
|
UTSW |
9 |
38,518,234 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1681:Or8b50
|
UTSW |
9 |
38,518,244 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2402:Or8b50
|
UTSW |
9 |
38,518,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5854:Or8b50
|
UTSW |
9 |
38,517,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6857:Or8b50
|
UTSW |
9 |
38,518,307 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7452:Or8b50
|
UTSW |
9 |
38,518,384 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7838:Or8b50
|
UTSW |
9 |
38,517,708 (GRCm39) |
start gained |
probably benign |
|
|
R8039:Or8b50
|
UTSW |
9 |
38,518,685 (GRCm39) |
missense |
probably benign |
|
|
R8489:Or8b50
|
UTSW |
9 |
38,518,232 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8768:Or8b50
|
UTSW |
9 |
38,518,441 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9373:Or8b50
|
UTSW |
9 |
38,518,142 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9380:Or8b50
|
UTSW |
9 |
38,518,415 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Posted On |
2012-12-21 |
Incidental Mutation