Incidental Mutation 'R0480:Ptprk'
| ID |
155847 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ptprk
|
| Ensembl Gene |
ENSMUSG00000019889 |
| Gene Name |
protein tyrosine phosphatase, receptor type, K |
| Synonyms |
RPTPkappa, PTPk |
| MMRRC Submission |
038680-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0480 (G1)
|
| Quality Score |
78 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
28074820-28597397 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 28585948 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Valine
at position 84
(A84V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000151493
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166468]
[ENSMUST00000218276]
[ENSMUST00000218359]
[ENSMUST00000220357]
|
| AlphaFold |
P35822 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166468
AA Change: A1155V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000126279
Gene: ENSMUSG00000019889
AA Change: A1155V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
MAM
|
30 |
193 |
1.61e-73 |
SMART |
|
IG
|
200 |
288 |
2.16e-8 |
SMART |
|
FN3
|
290 |
373 |
1.48e-4 |
SMART |
|
FN3
|
389 |
475 |
4.24e1 |
SMART |
|
FN3
|
491 |
579 |
3.32e-7 |
SMART |
|
transmembrane domain
|
753 |
774 |
N/A |
INTRINSIC |
|
PTPc
|
898 |
1161 |
3.56e-132 |
SMART |
|
PTPc
|
1190 |
1455 |
2.68e-86 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000218276
AA Change: A1169V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000218359
AA Change: A1143V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000220357
AA Change: A84V
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000220404
|
| Meta Mutation Damage Score |
0.7511 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.3%
- 20x: 92.6%
|
| Validation Efficiency |
99% (117/118) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 112 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810021J22Rik |
C |
T |
11: 58,880,186 (GRCm38) |
L165F |
probably damaging |
Het |
| Adamts18 |
A |
G |
8: 113,738,818 (GRCm38) |
V714A |
possibly damaging |
Het |
| Adamtsl1 |
G |
T |
4: 86,252,818 (GRCm38) |
A518S |
probably benign |
Het |
| Adcy2 |
C |
T |
13: 68,732,112 (GRCm38) |
V363M |
probably damaging |
Het |
| Ago4 |
G |
T |
4: 126,526,077 (GRCm38) |
Q36K |
probably benign |
Het |
| Akr1a1 |
A |
G |
4: 116,639,847 (GRCm38) |
V172A |
possibly damaging |
Het |
| Alkbh2 |
T |
A |
5: 114,125,535 (GRCm38) |
N137I |
probably damaging |
Het |
| Ank3 |
T |
A |
10: 69,879,926 (GRCm38) |
S470T |
probably damaging |
Het |
| Ankrd12 |
T |
C |
17: 66,049,828 (GRCm38) |
T65A |
possibly damaging |
Het |
| Aox1 |
A |
T |
1: 58,043,651 (GRCm38) |
|
probably benign |
Het |
| Arhgap11a |
A |
T |
2: 113,839,818 (GRCm38) |
I320N |
probably benign |
Het |
| Arhgap17 |
G |
A |
7: 123,294,644 (GRCm38) |
H518Y |
probably damaging |
Het |
| Ascc3 |
T |
C |
10: 50,735,252 (GRCm38) |
V1563A |
probably damaging |
Het |
| Atf2 |
G |
A |
2: 73,819,156 (GRCm38) |
|
probably benign |
Het |
| Bmpr2 |
C |
T |
1: 59,845,659 (GRCm38) |
T268I |
probably damaging |
Het |
| Bpifb9a |
A |
G |
2: 154,264,688 (GRCm38) |
I380V |
probably benign |
Het |
| C2cd2 |
G |
A |
16: 97,877,148 (GRCm38) |
T363I |
probably benign |
Het |
| Catsperg2 |
T |
G |
7: 29,721,298 (GRCm38) |
N190H |
probably damaging |
Het |
| Ccdc138 |
T |
C |
10: 58,561,967 (GRCm38) |
L543S |
probably damaging |
Het |
| Ccdc170 |
A |
T |
10: 4,518,939 (GRCm38) |
K162N |
probably benign |
Het |
| Cdca5 |
G |
T |
19: 6,090,298 (GRCm38) |
R163L |
probably damaging |
Het |
| Cdh24 |
A |
G |
14: 54,632,597 (GRCm38) |
F239S |
probably benign |
Het |
| Cdkl3 |
T |
C |
11: 52,005,055 (GRCm38) |
V43A |
probably damaging |
Het |
| Cep152 |
G |
T |
2: 125,581,719 (GRCm38) |
Q921K |
possibly damaging |
Het |
| Cftr |
G |
A |
6: 18,274,518 (GRCm38) |
|
probably benign |
Het |
| Chmp5 |
T |
C |
4: 40,948,690 (GRCm38) |
|
probably benign |
Het |
| Cit |
T |
A |
5: 115,933,393 (GRCm38) |
|
probably benign |
Het |
| Cngb3 |
T |
A |
4: 19,309,517 (GRCm38) |
|
probably benign |
Het |
| Cnr2 |
A |
G |
4: 135,917,601 (GRCm38) |
E330G |
probably benign |
Het |
| Cyp21a1 |
A |
T |
17: 34,801,826 (GRCm38) |
L473Q |
probably damaging |
Het |
| Dchs1 |
T |
C |
7: 105,771,489 (GRCm38) |
T575A |
probably benign |
Het |
| Dedd2 |
A |
G |
7: 25,203,625 (GRCm38) |
V303A |
probably damaging |
Het |
| Dmd |
G |
T |
X: 84,425,738 (GRCm38) |
A2370S |
probably benign |
Het |
| Dnah10 |
T |
A |
5: 124,808,851 (GRCm38) |
N3009K |
probably damaging |
Het |
| Dnajc13 |
G |
T |
9: 104,200,509 (GRCm38) |
N934K |
probably damaging |
Het |
| Dock1 |
C |
T |
7: 134,737,718 (GRCm38) |
L106F |
probably damaging |
Het |
| Fat3 |
A |
G |
9: 15,997,729 (GRCm38) |
Y2326H |
probably benign |
Het |
| Fhl5 |
A |
T |
4: 25,207,101 (GRCm38) |
C222* |
probably null |
Het |
| Gnmt |
T |
C |
17: 46,725,928 (GRCm38) |
T252A |
probably benign |
Het |
| Gpi-ps |
A |
G |
8: 5,639,888 (GRCm38) |
|
noncoding transcript |
Het |
| Gsta5 |
C |
T |
9: 78,302,817 (GRCm38) |
A135V |
probably benign |
Het |
| Gtf2f1 |
A |
G |
17: 57,004,307 (GRCm38) |
|
probably null |
Het |
| Gtf3a |
T |
C |
5: 146,953,229 (GRCm38) |
Y187H |
probably damaging |
Het |
| Hdac2 |
A |
G |
10: 36,974,792 (GRCm38) |
Y14C |
probably damaging |
Het |
| Hnrnph1 |
T |
G |
11: 50,385,762 (GRCm38) |
|
probably benign |
Het |
| Homer2 |
T |
C |
7: 81,618,603 (GRCm38) |
D92G |
possibly damaging |
Het |
| Hspg2 |
T |
C |
4: 137,550,024 (GRCm38) |
S2885P |
probably damaging |
Het |
| Insr |
A |
G |
8: 3,161,770 (GRCm38) |
S1084P |
probably damaging |
Het |
| Ints11 |
T |
A |
4: 155,887,624 (GRCm38) |
V362E |
probably damaging |
Het |
| Kank2 |
T |
C |
9: 21,779,899 (GRCm38) |
N513S |
probably damaging |
Het |
| Kl |
T |
G |
5: 150,953,288 (GRCm38) |
V191G |
probably damaging |
Het |
| Krt23 |
A |
G |
11: 99,486,698 (GRCm38) |
|
probably null |
Het |
| Lama3 |
A |
C |
18: 12,450,424 (GRCm38) |
T690P |
possibly damaging |
Het |
| Lamb1 |
G |
A |
12: 31,282,721 (GRCm38) |
A281T |
possibly damaging |
Het |
| Lck |
T |
C |
4: 129,555,640 (GRCm38) |
E299G |
probably damaging |
Het |
| Lonrf1 |
A |
G |
8: 36,222,710 (GRCm38) |
V703A |
probably damaging |
Het |
| Ly6f |
T |
C |
15: 75,271,677 (GRCm38) |
C78R |
probably damaging |
Het |
| Mapkap1 |
C |
T |
2: 34,533,781 (GRCm38) |
|
probably benign |
Het |
| Mast1 |
T |
A |
8: 84,913,089 (GRCm38) |
I1204F |
probably damaging |
Het |
| Mbd6 |
C |
T |
10: 127,285,873 (GRCm38) |
|
probably benign |
Het |
| Mef2c |
A |
T |
13: 83,592,901 (GRCm38) |
T60S |
probably damaging |
Het |
| Mgat4c |
C |
T |
10: 102,389,119 (GRCm38) |
T398I |
probably damaging |
Het |
| Mmp12 |
C |
A |
9: 7,350,016 (GRCm38) |
H102Q |
probably damaging |
Het |
| Mmp20 |
G |
A |
9: 7,645,373 (GRCm38) |
G308E |
probably damaging |
Het |
| Mms19 |
A |
T |
19: 41,954,846 (GRCm38) |
L395Q |
probably damaging |
Het |
| Mus81 |
A |
G |
19: 5,487,931 (GRCm38) |
|
probably benign |
Het |
| Mypn |
C |
T |
10: 63,193,203 (GRCm38) |
R27H |
probably benign |
Het |
| Nav3 |
T |
C |
10: 109,853,300 (GRCm38) |
E372G |
probably damaging |
Het |
| Ncoa1 |
T |
A |
12: 4,339,105 (GRCm38) |
I57F |
probably damaging |
Het |
| Ncstn |
T |
C |
1: 172,082,592 (GRCm38) |
|
probably benign |
Het |
| Nefm |
C |
T |
14: 68,124,159 (GRCm38) |
D219N |
probably damaging |
Het |
| Notch2 |
C |
T |
3: 98,146,537 (GRCm38) |
T2172I |
possibly damaging |
Het |
| Obscn |
T |
A |
11: 59,133,946 (GRCm38) |
K423* |
probably null |
Het |
| Or51l14 |
A |
G |
7: 103,451,628 (GRCm38) |
N97S |
probably benign |
Het |
| Or5d37 |
A |
C |
2: 88,093,628 (GRCm38) |
S103A |
probably benign |
Het |
| Or5k1 |
T |
C |
16: 58,797,321 (GRCm38) |
N175S |
probably benign |
Het |
| Or9a2 |
A |
T |
6: 41,772,264 (GRCm38) |
C12S |
probably benign |
Het |
| Ostm1 |
T |
A |
10: 42,696,347 (GRCm38) |
M242K |
probably damaging |
Het |
| Oxnad1 |
T |
A |
14: 32,099,480 (GRCm38) |
I154N |
probably damaging |
Het |
| Pcdhb10 |
T |
A |
18: 37,413,099 (GRCm38) |
D409E |
probably damaging |
Het |
| Pdcd11 |
T |
C |
19: 47,125,037 (GRCm38) |
|
probably benign |
Het |
| Peak1 |
C |
A |
9: 56,258,632 (GRCm38) |
V671L |
probably benign |
Het |
| Pex1 |
G |
A |
5: 3,606,444 (GRCm38) |
|
probably null |
Het |
| Plk4 |
T |
A |
3: 40,805,640 (GRCm38) |
F324I |
probably benign |
Het |
| Poglut2 |
C |
T |
1: 44,110,757 (GRCm38) |
W424* |
probably null |
Het |
| Ppfibp1 |
C |
A |
6: 147,019,031 (GRCm38) |
|
probably null |
Het |
| Prcp |
T |
A |
7: 92,919,082 (GRCm38) |
W276R |
probably damaging |
Het |
| Prr14l |
T |
C |
5: 32,829,880 (GRCm38) |
E757G |
probably benign |
Het |
| Prss52 |
T |
A |
14: 64,113,644 (GRCm38) |
Y293N |
probably damaging |
Het |
| Prune2 |
A |
G |
19: 17,006,792 (GRCm38) |
|
probably benign |
Het |
| Rock1 |
A |
G |
18: 10,079,120 (GRCm38) |
L1116P |
possibly damaging |
Het |
| Sdha |
A |
T |
13: 74,327,333 (GRCm38) |
F526Y |
probably benign |
Het |
| Sema4b |
T |
C |
7: 80,220,206 (GRCm38) |
F414S |
probably damaging |
Het |
| Serpina12 |
T |
C |
12: 104,035,701 (GRCm38) |
D252G |
probably damaging |
Het |
| Siglecg |
C |
T |
7: 43,411,126 (GRCm38) |
A310V |
probably benign |
Het |
| Slc30a8 |
A |
G |
15: 52,325,570 (GRCm38) |
I194V |
probably benign |
Het |
| Spred3 |
A |
G |
7: 29,162,975 (GRCm38) |
S148P |
probably damaging |
Het |
| Taf9b |
A |
G |
X: 106,218,408 (GRCm38) |
S58P |
probably damaging |
Het |
| Tgm4 |
A |
T |
9: 123,062,419 (GRCm38) |
Y109F |
probably benign |
Het |
| Tmprss11c |
T |
G |
5: 86,237,609 (GRCm38) |
|
probably benign |
Het |
| Tmtc3 |
A |
T |
10: 100,471,404 (GRCm38) |
V246D |
probably damaging |
Het |
| Tnip1 |
C |
T |
11: 54,937,994 (GRCm38) |
G116R |
probably damaging |
Het |
| Tpr |
A |
G |
1: 150,428,241 (GRCm38) |
E1455G |
possibly damaging |
Het |
| Ttc3 |
T |
A |
16: 94,432,004 (GRCm38) |
L986* |
probably null |
Het |
| Txndc15 |
A |
G |
13: 55,724,623 (GRCm38) |
I275V |
possibly damaging |
Het |
| Ugt2b1 |
T |
A |
5: 86,926,456 (GRCm38) |
I15L |
probably benign |
Het |
| Upf2 |
T |
C |
2: 5,957,634 (GRCm38) |
V49A |
possibly damaging |
Het |
| Vmn1r117 |
G |
A |
7: 20,883,446 (GRCm38) |
P226S |
probably benign |
Het |
| Vmn2r28 |
A |
T |
7: 5,490,457 (GRCm38) |
H163Q |
probably benign |
Het |
| Vstm2a |
T |
A |
11: 16,263,240 (GRCm38) |
S208R |
probably damaging |
Het |
| Zfp346 |
T |
A |
13: 55,113,097 (GRCm38) |
C79* |
probably null |
Het |
| Zfp628 |
A |
T |
7: 4,921,616 (GRCm38) |
T946S |
probably benign |
Het |
|
| Other mutations in Ptprk |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00310:Ptprk
|
APN |
10 |
28,336,510 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL00533:Ptprk
|
APN |
10 |
28,585,975 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL01062:Ptprk
|
APN |
10 |
28,580,418 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01295:Ptprk
|
APN |
10 |
28,475,178 (GRCm38) |
missense |
probably benign |
0.14 |
|
IGL01372:Ptprk
|
APN |
10 |
28,569,927 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01452:Ptprk
|
APN |
10 |
28,574,917 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01829:Ptprk
|
APN |
10 |
28,573,387 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01861:Ptprk
|
APN |
10 |
28,383,445 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
IGL01955:Ptprk
|
APN |
10 |
28,595,865 (GRCm38) |
unclassified |
probably benign |
|
|
IGL02263:Ptprk
|
APN |
10 |
28,075,114 (GRCm38) |
missense |
unknown |
|
|
IGL02489:Ptprk
|
APN |
10 |
28,383,472 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02697:Ptprk
|
APN |
10 |
28,575,618 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
IGL02713:Ptprk
|
APN |
10 |
28,592,811 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL02943:Ptprk
|
APN |
10 |
28,475,176 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
IGL03240:Ptprk
|
APN |
10 |
28,492,961 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03373:Ptprk
|
APN |
10 |
28,566,537 (GRCm38) |
missense |
probably damaging |
1.00 |
|
LCD18:Ptprk
|
UTSW |
10 |
28,574,987 (GRCm38) |
intron |
probably benign |
|
|
PIT4366001:Ptprk
|
UTSW |
10 |
28,586,019 (GRCm38) |
missense |
probably benign |
|
|
R0010:Ptprk
|
UTSW |
10 |
28,585,969 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0021:Ptprk
|
UTSW |
10 |
28,592,895 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0021:Ptprk
|
UTSW |
10 |
28,592,895 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0035:Ptprk
|
UTSW |
10 |
28,263,508 (GRCm38) |
nonsense |
probably null |
|
|
R0035:Ptprk
|
UTSW |
10 |
28,263,508 (GRCm38) |
nonsense |
probably null |
|
|
R0053:Ptprk
|
UTSW |
10 |
28,475,109 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0063:Ptprk
|
UTSW |
10 |
28,263,767 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0063:Ptprk
|
UTSW |
10 |
28,263,767 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0244:Ptprk
|
UTSW |
10 |
28,206,225 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R0281:Ptprk
|
UTSW |
10 |
28,573,392 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0387:Ptprk
|
UTSW |
10 |
28,354,629 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R0480:Ptprk
|
UTSW |
10 |
28,585,947 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0585:Ptprk
|
UTSW |
10 |
28,575,668 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0614:Ptprk
|
UTSW |
10 |
28,075,136 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0684:Ptprk
|
UTSW |
10 |
28,483,298 (GRCm38) |
splice site |
probably benign |
|
|
R1073:Ptprk
|
UTSW |
10 |
28,496,947 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1377:Ptprk
|
UTSW |
10 |
28,586,026 (GRCm38) |
missense |
probably benign |
0.42 |
|
R1422:Ptprk
|
UTSW |
10 |
28,475,280 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R1482:Ptprk
|
UTSW |
10 |
28,263,516 (GRCm38) |
missense |
probably benign |
0.24 |
|
R1532:Ptprk
|
UTSW |
10 |
28,585,630 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1576:Ptprk
|
UTSW |
10 |
28,551,651 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1618:Ptprk
|
UTSW |
10 |
28,493,170 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1654:Ptprk
|
UTSW |
10 |
28,383,647 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1701:Ptprk
|
UTSW |
10 |
28,466,058 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1747:Ptprk
|
UTSW |
10 |
28,354,692 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R2033:Ptprk
|
UTSW |
10 |
28,592,767 (GRCm38) |
unclassified |
probably benign |
|
|
R2059:Ptprk
|
UTSW |
10 |
28,566,603 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2076:Ptprk
|
UTSW |
10 |
28,589,368 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2164:Ptprk
|
UTSW |
10 |
28,560,142 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2260:Ptprk
|
UTSW |
10 |
28,206,149 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R2394:Ptprk
|
UTSW |
10 |
28,551,717 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2432:Ptprk
|
UTSW |
10 |
28,592,844 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2437:Ptprk
|
UTSW |
10 |
28,354,713 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2495:Ptprk
|
UTSW |
10 |
28,475,078 (GRCm38) |
splice site |
probably benign |
|
|
R3037:Ptprk
|
UTSW |
10 |
28,580,478 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3162:Ptprk
|
UTSW |
10 |
28,592,826 (GRCm38) |
missense |
probably benign |
|
|
R3162:Ptprk
|
UTSW |
10 |
28,592,826 (GRCm38) |
missense |
probably benign |
|
|
R3687:Ptprk
|
UTSW |
10 |
28,473,043 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3722:Ptprk
|
UTSW |
10 |
28,383,623 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3892:Ptprk
|
UTSW |
10 |
28,263,621 (GRCm38) |
missense |
probably benign |
0.02 |
|
R3963:Ptprk
|
UTSW |
10 |
28,551,665 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4077:Ptprk
|
UTSW |
10 |
28,263,512 (GRCm38) |
missense |
probably benign |
|
|
R4079:Ptprk
|
UTSW |
10 |
28,263,512 (GRCm38) |
missense |
probably benign |
|
|
R4112:Ptprk
|
UTSW |
10 |
28,475,288 (GRCm38) |
critical splice donor site |
probably null |
|
|
R4255:Ptprk
|
UTSW |
10 |
28,206,245 (GRCm38) |
missense |
probably benign |
0.14 |
|
R4523:Ptprk
|
UTSW |
10 |
28,466,052 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4651:Ptprk
|
UTSW |
10 |
28,263,690 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4652:Ptprk
|
UTSW |
10 |
28,263,690 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4828:Ptprk
|
UTSW |
10 |
28,560,054 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4829:Ptprk
|
UTSW |
10 |
28,580,484 (GRCm38) |
nonsense |
probably null |
|
|
R4883:Ptprk
|
UTSW |
10 |
28,588,932 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5004:Ptprk
|
UTSW |
10 |
28,586,063 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5013:Ptprk
|
UTSW |
10 |
28,551,717 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5092:Ptprk
|
UTSW |
10 |
28,592,773 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5126:Ptprk
|
UTSW |
10 |
28,575,644 (GRCm38) |
splice site |
probably null |
|
|
R5183:Ptprk
|
UTSW |
10 |
28,475,236 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5264:Ptprk
|
UTSW |
10 |
28,585,586 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5304:Ptprk
|
UTSW |
10 |
28,592,054 (GRCm38) |
splice site |
probably null |
|
|
R5330:Ptprk
|
UTSW |
10 |
28,587,080 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5474:Ptprk
|
UTSW |
10 |
28,496,930 (GRCm38) |
nonsense |
probably null |
|
|
R5516:Ptprk
|
UTSW |
10 |
28,496,930 (GRCm38) |
nonsense |
probably null |
|
|
R5796:Ptprk
|
UTSW |
10 |
28,383,575 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5843:Ptprk
|
UTSW |
10 |
28,493,064 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5952:Ptprk
|
UTSW |
10 |
28,585,675 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6065:Ptprk
|
UTSW |
10 |
28,475,170 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6226:Ptprk
|
UTSW |
10 |
28,564,103 (GRCm38) |
missense |
probably benign |
0.02 |
|
R6264:Ptprk
|
UTSW |
10 |
28,566,673 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6638:Ptprk
|
UTSW |
10 |
28,595,811 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6843:Ptprk
|
UTSW |
10 |
28,591,982 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R6860:Ptprk
|
UTSW |
10 |
28,334,484 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6869:Ptprk
|
UTSW |
10 |
28,473,059 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7214:Ptprk
|
UTSW |
10 |
28,574,909 (GRCm38) |
missense |
probably benign |
0.11 |
|
R7307:Ptprk
|
UTSW |
10 |
28,589,008 (GRCm38) |
nonsense |
probably null |
|
|
R7349:Ptprk
|
UTSW |
10 |
28,592,838 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R7442:Ptprk
|
UTSW |
10 |
28,574,819 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7585:Ptprk
|
UTSW |
10 |
28,560,088 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7661:Ptprk
|
UTSW |
10 |
28,466,040 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7694:Ptprk
|
UTSW |
10 |
28,589,370 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R7740:Ptprk
|
UTSW |
10 |
28,496,924 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7810:Ptprk
|
UTSW |
10 |
28,592,857 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7831:Ptprk
|
UTSW |
10 |
28,568,408 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R7836:Ptprk
|
UTSW |
10 |
28,573,389 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8049:Ptprk
|
UTSW |
10 |
28,383,569 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R8235:Ptprk
|
UTSW |
10 |
28,589,041 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R8274:Ptprk
|
UTSW |
10 |
28,580,412 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8286:Ptprk
|
UTSW |
10 |
28,568,327 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8372:Ptprk
|
UTSW |
10 |
28,354,692 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8727:Ptprk
|
UTSW |
10 |
28,566,545 (GRCm38) |
unclassified |
probably benign |
|
|
R8794:Ptprk
|
UTSW |
10 |
28,263,508 (GRCm38) |
nonsense |
probably null |
|
|
R8842:Ptprk
|
UTSW |
10 |
28,566,501 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R8861:Ptprk
|
UTSW |
10 |
28,570,190 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8897:Ptprk
|
UTSW |
10 |
28,591,957 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8910:Ptprk
|
UTSW |
10 |
28,492,997 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R8919:Ptprk
|
UTSW |
10 |
28,483,207 (GRCm38) |
nonsense |
probably null |
|
|
R8976:Ptprk
|
UTSW |
10 |
28,585,673 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8982:Ptprk
|
UTSW |
10 |
28,560,142 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9036:Ptprk
|
UTSW |
10 |
28,585,932 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9135:Ptprk
|
UTSW |
10 |
28,580,417 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9308:Ptprk
|
UTSW |
10 |
28,574,854 (GRCm38) |
missense |
probably benign |
0.15 |
|
R9317:Ptprk
|
UTSW |
10 |
28,354,735 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9475:Ptprk
|
UTSW |
10 |
28,334,480 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
R9585:Ptprk
|
UTSW |
10 |
28,493,151 (GRCm38) |
nonsense |
probably null |
|
|
R9625:Ptprk
|
UTSW |
10 |
28,586,010 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9700:Ptprk
|
UTSW |
10 |
28,580,499 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9745:Ptprk
|
UTSW |
10 |
28,263,612 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
Z1177:Ptprk
|
UTSW |
10 |
28,493,120 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAAAGCCTTACGATCTCGGCG -3'
(R):5'- AAACCTTAGAAGCAGTCTGCACCTG -3'
Sequencing Primer
(F):5'- CTCGGCGCATTAATATGGTACAG -3'
(R):5'- GCAGTCTGCACCTGAAATTC -3'
|
| Posted On |
2014-02-10 |
Incidental Mutation