Incidental Mutation 'R1366:Or9g8'
ID 156024
Institutional Source Beutler Lab
Gene Symbol Or9g8
Ensembl Gene ENSMUSG00000059379
Gene Name olfactory receptor family 9 subfamily G member 8
Synonyms MOR213-5, Olfr1014, GA_x6K02T2Q125-47255337-47256254
MMRRC Submission 039431-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R1366 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 85606930-85607847 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 85607348 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 140 (C140Y)
Ref Sequence ENSEMBL: ENSMUSP00000150352 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076250] [ENSMUST00000213453] [ENSMUST00000216397]
AlphaFold Q7TR95
Predicted Effect probably benign
Transcript: ENSMUST00000076250
AA Change: C140Y

PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000075600
Gene: ENSMUSG00000059379
AA Change: C140Y

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 2.7e-50 PFAM
Pfam:7tm_1 40 289 8e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213453
AA Change: C140Y

PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215522
Predicted Effect probably benign
Transcript: ENSMUST00000216397
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.6%
  • 3x: 97.1%
  • 10x: 92.3%
  • 20x: 80.8%
Validation Efficiency 93% (43/46)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh A T 5: 77,036,651 (GRCm39) S297T probably benign Het
Acsm1 T C 7: 119,257,511 (GRCm39) probably benign Het
Ankar T A 1: 72,737,808 (GRCm39) N125Y probably damaging Het
Ccdc121 T A 5: 31,644,861 (GRCm39) C205S probably benign Het
Chd1l T C 3: 97,488,465 (GRCm39) D517G probably damaging Het
Cir1 A T 2: 73,136,757 (GRCm39) probably benign Het
Cpxm1 G A 2: 130,238,042 (GRCm39) R136W probably damaging Het
Dnah10 A T 5: 124,830,390 (GRCm39) E761D probably benign Het
Fam186a T A 15: 99,841,270 (GRCm39) E1658V possibly damaging Het
Fam98a A G 17: 75,846,381 (GRCm39) probably benign Het
Fanca G A 8: 124,031,020 (GRCm39) probably benign Het
Frmd6 T C 12: 70,934,663 (GRCm39) probably benign Het
Gmpr2 T C 14: 55,914,200 (GRCm39) probably benign Het
Hck G A 2: 152,980,215 (GRCm39) G348D probably damaging Het
Ifnab T A 4: 88,609,337 (GRCm39) Q43L possibly damaging Het
Ilkap A G 1: 91,314,937 (GRCm39) I142T possibly damaging Het
Lamc3 T C 2: 31,818,859 (GRCm39) S1206P probably damaging Het
Mfsd13a C T 19: 46,354,943 (GRCm39) T40I probably benign Het
Mid1 A C X: 168,769,090 (GRCm39) N215H probably damaging Het
Mkrn1 T C 6: 39,382,851 (GRCm39) T134A probably benign Het
Mmp9 T A 2: 164,795,262 (GRCm39) V628E probably damaging Het
Msi2 A T 11: 88,607,406 (GRCm39) V67D probably damaging Het
Ncapd3 T A 9: 26,969,236 (GRCm39) V630E probably damaging Het
Nkain1 A G 4: 130,537,316 (GRCm38) V73A probably damaging Het
Nphp4 T A 4: 152,587,383 (GRCm39) D245E probably damaging Het
Or14j3 T C 17: 37,900,655 (GRCm39) I196M probably benign Het
Or7a41 T G 10: 78,870,876 (GRCm39) M82R probably damaging Het
Pkd1l1 T C 11: 8,891,038 (GRCm39) probably benign Het
Plcxd1 A C 5: 110,250,096 (GRCm39) I184L probably damaging Het
Prl3b1 G A 13: 27,427,848 (GRCm39) A53T probably benign Het
Rasl10b G A 11: 83,308,665 (GRCm39) probably null Het
Scube2 A G 7: 109,403,821 (GRCm39) Y890H probably damaging Het
Slco6c1 T A 1: 97,055,928 (GRCm39) probably null Het
Tnfaip2 T G 12: 111,415,756 (GRCm39) F485V probably benign Het
Tpd52 T C 3: 9,028,993 (GRCm39) D17G probably damaging Het
Ube4b T C 4: 149,419,606 (GRCm39) D1034G probably damaging Het
Vmn2r118 G A 17: 55,900,237 (GRCm39) Q556* probably null Het
Zftraf1 T C 15: 76,533,169 (GRCm39) R190G probably damaging Het
Other mutations in Or9g8
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1858:Or9g8 UTSW 2 85,607,582 (GRCm39) missense probably damaging 0.99
R1940:Or9g8 UTSW 2 85,607,515 (GRCm39) missense probably benign
R4868:Or9g8 UTSW 2 85,606,970 (GRCm39) missense possibly damaging 0.62
R4957:Or9g8 UTSW 2 85,607,459 (GRCm39) missense probably damaging 1.00
R5109:Or9g8 UTSW 2 85,607,668 (GRCm39) missense probably damaging 1.00
R5884:Or9g8 UTSW 2 85,607,399 (GRCm39) missense probably damaging 0.99
R7510:Or9g8 UTSW 2 85,607,153 (GRCm39) missense probably damaging 1.00
R8082:Or9g8 UTSW 2 85,607,044 (GRCm39) missense probably benign 0.00
R8964:Or9g8 UTSW 2 85,606,964 (GRCm39) missense probably damaging 0.99
R9097:Or9g8 UTSW 2 85,607,669 (GRCm39) missense probably damaging 1.00
Z1088:Or9g8 UTSW 2 85,607,466 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGCAATGACTCTAGGCTCCATACAC -3'
(R):5'- CTCTATCTAAAGAGTAGCTGGACCGGG -3'

Sequencing Primer
(F):5'- ATCTTAGTGACCTGCATCTCTGAAG -3'
(R):5'- TCCTCAAGATAGTGGCAATGATG -3'
Posted On 2014-02-11