Incidental Mutation 'R0041:Olfml1'
ID15604
Institutional Source Beutler Lab
Gene Symbol Olfml1
Ensembl Gene ENSMUSG00000051041
Gene Nameolfactomedin-like 1
SynonymsONT2, mONT2, MVAL564
MMRRC Submission 038335-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.068) question?
Stock #R0041 (G1)
Quality Score
Status Validated
Chromosome7
Chromosomal Location107567446-107591094 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 107590186 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Leucine at position 153 (I153L)
Ref Sequence ENSEMBL: ENSMUSP00000114029 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000120990]
Predicted Effect possibly damaging
Transcript: ENSMUST00000120990
AA Change: I153L

PolyPhen 2 Score 0.813 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000114029
Gene: ENSMUSG00000051041
AA Change: I153L

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
coiled coil region 78 105 N/A INTRINSIC
low complexity region 115 132 N/A INTRINSIC
Pfam:OLF 145 233 5.5e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207374
Meta Mutation Damage Score 0.0910 question?
Coding Region Coverage
  • 1x: 77.6%
  • 3x: 65.6%
  • 10x: 37.8%
  • 20x: 19.1%
Validation Efficiency 90% (47/52)
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700074P13Rik A T 6: 40,926,108 L110* probably null Het
Avpi1 C A 19: 42,123,784 E112* probably null Het
Braf C T 6: 39,640,479 A534T probably damaging Het
Cntnap5c C A 17: 57,876,469 Q57K probably benign Het
Dlk1 G C 12: 109,455,513 G50A probably damaging Het
Dtna C T 18: 23,646,875 probably benign Het
Fancm T A 12: 65,106,443 C1224* probably null Het
Gigyf2 A C 1: 87,378,976 R129S probably damaging Het
Gm10130 A G 2: 150,323,825 I42V possibly damaging Het
Gpr125 A G 5: 49,960,559 Y1216H probably benign Het
Kcnk2 G T 1: 189,295,691 N122K probably benign Het
Lrrc7 G A 3: 158,164,260 probably benign Het
Msto1 A G 3: 88,910,235 S464P probably damaging Het
Myh1 A C 11: 67,209,078 N605H possibly damaging Het
Plekhg1 T A 10: 3,964,074 N1265K probably benign Het
Rlf T A 4: 121,149,929 H618L probably damaging Het
Rock1 T C 18: 10,140,240 D117G probably damaging Het
Serpinb6d A G 13: 33,667,632 D124G probably damaging Het
Slco1a1 A G 6: 141,918,459 probably benign Het
Swap70 A G 7: 110,279,355 K511E probably benign Het
Synb T C 14: 69,510,477 T193A probably damaging Het
Syt11 A G 3: 88,747,903 Y364H probably damaging Het
Vcan T A 13: 89,661,985 H3229L probably damaging Het
Wdr64 G A 1: 175,726,471 W189* probably null Het
Other mutations in Olfml1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Olfml1 APN 7 107590157 missense possibly damaging 0.80
IGL02355:Olfml1 APN 7 107567803 missense probably benign 0.00
IGL02362:Olfml1 APN 7 107567803 missense probably benign 0.00
IGL03218:Olfml1 APN 7 107571269 missense possibly damaging 0.87
IGL03291:Olfml1 APN 7 107590229 missense probably damaging 1.00
R0041:Olfml1 UTSW 7 107590186 missense possibly damaging 0.81
R0081:Olfml1 UTSW 7 107571299 missense probably benign 0.08
R0524:Olfml1 UTSW 7 107590177 missense probably damaging 1.00
R1311:Olfml1 UTSW 7 107567896 critical splice donor site probably null
R1548:Olfml1 UTSW 7 107590375 missense possibly damaging 0.88
R1564:Olfml1 UTSW 7 107571139 missense possibly damaging 0.89
R4347:Olfml1 UTSW 7 107567833 missense probably benign 0.00
R4997:Olfml1 UTSW 7 107571206 missense probably damaging 1.00
R6788:Olfml1 UTSW 7 107567868 missense probably damaging 1.00
R7282:Olfml1 UTSW 7 107590323 missense possibly damaging 0.85
R7703:Olfml1 UTSW 7 107571185 missense probably damaging 1.00
R7922:Olfml1 UTSW 7 107571149 missense probably damaging 1.00
R8324:Olfml1 UTSW 7 107590363 missense probably benign 0.04
Posted On2012-12-21