Incidental Mutation 'R1366:Prl3b1'
ID 156048
Institutional Source Beutler Lab
Gene Symbol Prl3b1
Ensembl Gene ENSMUSG00000038891
Gene Name prolactin family 3, subfamily b, member 1
Synonyms mplII, PL, Pl-2, mPL-II, Pl2, prolactin-like, Csh2
MMRRC Submission 039431-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R1366 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 27426413-27433666 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 27427848 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 53 (A53T)
Ref Sequence ENSEMBL: ENSMUSP00000047680 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035273] [ENSMUST00000225089]
AlphaFold P09586
Predicted Effect probably benign
Transcript: ENSMUST00000035273
AA Change: A53T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000047680
Gene: ENSMUSG00000038891
AA Change: A53T

DomainStartEndE-ValueType
Pfam:Hormone_1 18 222 1e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000225089
AA Change: A53T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.6%
  • 3x: 97.1%
  • 10x: 92.3%
  • 20x: 80.8%
Validation Efficiency 93% (43/46)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aasdh A T 5: 77,036,651 (GRCm39) S297T probably benign Het
Acsm1 T C 7: 119,257,511 (GRCm39) probably benign Het
Ankar T A 1: 72,737,808 (GRCm39) N125Y probably damaging Het
Ccdc121 T A 5: 31,644,861 (GRCm39) C205S probably benign Het
Chd1l T C 3: 97,488,465 (GRCm39) D517G probably damaging Het
Cir1 A T 2: 73,136,757 (GRCm39) probably benign Het
Cpxm1 G A 2: 130,238,042 (GRCm39) R136W probably damaging Het
Dnah10 A T 5: 124,830,390 (GRCm39) E761D probably benign Het
Fam186a T A 15: 99,841,270 (GRCm39) E1658V possibly damaging Het
Fam98a A G 17: 75,846,381 (GRCm39) probably benign Het
Fanca G A 8: 124,031,020 (GRCm39) probably benign Het
Frmd6 T C 12: 70,934,663 (GRCm39) probably benign Het
Gmpr2 T C 14: 55,914,200 (GRCm39) probably benign Het
Hck G A 2: 152,980,215 (GRCm39) G348D probably damaging Het
Ifnab T A 4: 88,609,337 (GRCm39) Q43L possibly damaging Het
Ilkap A G 1: 91,314,937 (GRCm39) I142T possibly damaging Het
Lamc3 T C 2: 31,818,859 (GRCm39) S1206P probably damaging Het
Mfsd13a C T 19: 46,354,943 (GRCm39) T40I probably benign Het
Mid1 A C X: 168,769,090 (GRCm39) N215H probably damaging Het
Mkrn1 T C 6: 39,382,851 (GRCm39) T134A probably benign Het
Mmp9 T A 2: 164,795,262 (GRCm39) V628E probably damaging Het
Msi2 A T 11: 88,607,406 (GRCm39) V67D probably damaging Het
Ncapd3 T A 9: 26,969,236 (GRCm39) V630E probably damaging Het
Nkain1 A G 4: 130,537,316 (GRCm38) V73A probably damaging Het
Nphp4 T A 4: 152,587,383 (GRCm39) D245E probably damaging Het
Or14j3 T C 17: 37,900,655 (GRCm39) I196M probably benign Het
Or7a41 T G 10: 78,870,876 (GRCm39) M82R probably damaging Het
Or9g8 G A 2: 85,607,348 (GRCm39) C140Y probably benign Het
Pkd1l1 T C 11: 8,891,038 (GRCm39) probably benign Het
Plcxd1 A C 5: 110,250,096 (GRCm39) I184L probably damaging Het
Rasl10b G A 11: 83,308,665 (GRCm39) probably null Het
Scube2 A G 7: 109,403,821 (GRCm39) Y890H probably damaging Het
Slco6c1 T A 1: 97,055,928 (GRCm39) probably null Het
Tnfaip2 T G 12: 111,415,756 (GRCm39) F485V probably benign Het
Tpd52 T C 3: 9,028,993 (GRCm39) D17G probably damaging Het
Ube4b T C 4: 149,419,606 (GRCm39) D1034G probably damaging Het
Vmn2r118 G A 17: 55,900,237 (GRCm39) Q556* probably null Het
Zftraf1 T C 15: 76,533,169 (GRCm39) R190G probably damaging Het
Other mutations in Prl3b1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02385:Prl3b1 APN 13 27,433,366 (GRCm39) missense possibly damaging 0.51
IGL02669:Prl3b1 APN 13 27,429,795 (GRCm39) missense probably benign 0.24
IGL03035:Prl3b1 APN 13 27,433,516 (GRCm39) unclassified probably benign
IGL03077:Prl3b1 APN 13 27,429,759 (GRCm39) missense probably benign 0.00
Gabby UTSW 13 27,431,928 (GRCm39) missense probably damaging 1.00
peaches UTSW 13 27,426,473 (GRCm39) start codon destroyed probably null 1.00
Pits UTSW 13 27,431,957 (GRCm39) critical splice donor site probably null
R2014_Prl3b1_632 UTSW 13 27,431,948 (GRCm39) missense probably benign 0.00
R0716:Prl3b1 UTSW 13 27,427,779 (GRCm39) missense probably benign 0.02
R0758:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R0773:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R0774:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R0775:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1364:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1367:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1368:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1530:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1884:Prl3b1 UTSW 13 27,431,886 (GRCm39) missense possibly damaging 0.95
R1990:Prl3b1 UTSW 13 27,429,775 (GRCm39) missense possibly damaging 0.94
R1991:Prl3b1 UTSW 13 27,431,895 (GRCm39) missense possibly damaging 0.60
R2014:Prl3b1 UTSW 13 27,431,948 (GRCm39) missense probably benign 0.00
R2885:Prl3b1 UTSW 13 27,433,505 (GRCm39) missense probably damaging 1.00
R4259:Prl3b1 UTSW 13 27,427,889 (GRCm39) splice site probably null
R4580:Prl3b1 UTSW 13 27,433,450 (GRCm39) missense possibly damaging 0.93
R4913:Prl3b1 UTSW 13 27,433,460 (GRCm39) missense probably damaging 0.99
R5897:Prl3b1 UTSW 13 27,429,858 (GRCm39) missense probably benign 0.08
R6235:Prl3b1 UTSW 13 27,431,928 (GRCm39) missense probably damaging 1.00
R6366:Prl3b1 UTSW 13 27,427,875 (GRCm39) missense probably benign 0.00
R6597:Prl3b1 UTSW 13 27,431,957 (GRCm39) critical splice donor site probably null
R7179:Prl3b1 UTSW 13 27,427,827 (GRCm39) missense probably benign 0.05
R7312:Prl3b1 UTSW 13 27,426,473 (GRCm39) start codon destroyed probably null 1.00
X0026:Prl3b1 UTSW 13 27,431,906 (GRCm39) missense probably benign 0.21
Z1177:Prl3b1 UTSW 13 27,427,742 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- GGACAGACAGTATAGCCTCTACAGTGT -3'
(R):5'- AGGGTTTGATGATTGCTCCATTGGAA -3'

Sequencing Primer
(F):5'- CAGTATAGCCTCTACAGTGTCATTTG -3'
(R):5'- ggaggaggtgagaggtgg -3'
Posted On 2014-02-11