Incidental Mutation 'R1330:Wap'
ID 156150
Institutional Source Beutler Lab
Gene Symbol Wap
Ensembl Gene ENSMUSG00000000381
Gene Name whey acidic protein
Synonyms
MMRRC Submission 039395-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1330 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 6585482-6588637 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 6586818 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 94 (T94A)
Ref Sequence ENSEMBL: ENSMUSP00000099974 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102910]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000102910
AA Change: T94A
SMART Domains Protein: ENSMUSP00000099974
Gene: ENSMUSG00000000381
AA Change: T94A

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
internal_repeat_1 46 75 4.46e-5 PROSPERO
WAP 79 128 1.96e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127341
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141868
Meta Mutation Damage Score 0.0869 question?
Coding Region Coverage
  • 1x: 98.5%
  • 3x: 97.2%
  • 10x: 92.6%
  • 20x: 82.0%
Validation Efficiency 100% (40/40)
MGI Phenotype PHENOTYPE: Homozygous mutants are phenotypically normal and fertile. Functional differentiation of mammary epithelium is normal and dams produce milk, but pups thrive poorly on milk lacking whey acidic protein. A normal variant determines a one amino acid change inWAP protein in YBR versus other strains. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933421I07Rik T C 7: 42,097,018 (GRCm39) T98A probably benign Het
Adgre4 T A 17: 56,085,814 (GRCm39) C38S probably benign Het
Adgrf3 T A 5: 30,400,093 (GRCm39) T83S probably benign Het
Arhgef40 T C 14: 52,227,613 (GRCm39) V453A probably benign Het
Art4 A T 6: 136,831,339 (GRCm39) probably benign Het
Cdhr2 A G 13: 54,882,081 (GRCm39) K1177R possibly damaging Het
Ddx41 G A 13: 55,682,293 (GRCm39) R205W possibly damaging Het
Ddx6 T C 9: 44,539,070 (GRCm39) probably benign Het
Dolk A T 2: 30,175,112 (GRCm39) V311E probably damaging Het
Dstyk A G 1: 132,377,618 (GRCm39) N408S probably benign Het
Efcab3 A G 11: 104,637,116 (GRCm39) Y1049C possibly damaging Het
Eva1c A C 16: 90,701,284 (GRCm39) E318D probably damaging Het
Frem3 T A 8: 81,395,468 (GRCm39) W1832R probably damaging Het
Jup A T 11: 100,263,502 (GRCm39) I689N probably benign Het
Kcnh7 A G 2: 62,607,755 (GRCm39) S609P possibly damaging Het
Lrch4 G A 5: 137,636,051 (GRCm39) R368Q probably damaging Het
Ncbp1 G A 4: 46,167,354 (GRCm39) V586M probably benign Het
Ncstn C T 1: 171,899,092 (GRCm39) M346I probably damaging Het
Osbpl1a A G 18: 13,015,251 (GRCm39) probably null Het
Pcdh12 A G 18: 38,414,914 (GRCm39) V737A probably benign Het
Pds5b T A 5: 150,684,542 (GRCm39) M600K probably damaging Het
Rbm25 A G 12: 83,724,666 (GRCm39) D805G probably damaging Het
Rfx7 C T 9: 72,524,547 (GRCm39) T579I probably benign Het
Rhod C A 19: 4,476,182 (GRCm39) A190S probably damaging Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Slc22a2 A C 17: 12,805,699 (GRCm39) D150A possibly damaging Het
Spink11 A G 18: 44,329,195 (GRCm39) I17T unknown Het
Tas1r2 A G 4: 139,396,640 (GRCm39) I660V probably benign Het
Utp20 G A 10: 88,637,051 (GRCm39) P720L probably damaging Het
Vmn1r1 A T 1: 181,985,572 (GRCm39) L31H probably damaging Het
Vmn2r23 T C 6: 123,718,963 (GRCm39) L772P probably damaging Het
Wdr47 T C 3: 108,537,069 (GRCm39) S586P probably benign Het
Zfp318 A G 17: 46,724,684 (GRCm39) Y2229C possibly damaging Het
Zfp429 T C 13: 67,544,262 (GRCm39) probably null Het
Other mutations in Wap
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00971:Wap APN 11 6,586,808 (GRCm39) missense probably damaging 0.98
R0899:Wap UTSW 11 6,586,725 (GRCm39) missense probably benign 0.00
R3783:Wap UTSW 11 6,588,550 (GRCm39) nonsense probably null
R3785:Wap UTSW 11 6,588,550 (GRCm39) nonsense probably null
R3786:Wap UTSW 11 6,588,550 (GRCm39) nonsense probably null
R3787:Wap UTSW 11 6,588,550 (GRCm39) nonsense probably null
R5022:Wap UTSW 11 6,587,339 (GRCm39) splice site probably benign
R5065:Wap UTSW 11 6,586,840 (GRCm39) missense probably damaging 0.96
R5664:Wap UTSW 11 6,588,609 (GRCm39) missense possibly damaging 0.86
R8112:Wap UTSW 11 6,586,724 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGGATTGGCTAGGACATTCTCCTCC -3'
(R):5'- GCTGCCTGACCATAAGACAGACTTC -3'

Sequencing Primer
(F):5'- GGTCTCACATTGTATCTGCACTTG -3'
(R):5'- GACTTCAACAAATGCCCCATTC -3'
Posted On 2014-02-11