Incidental Mutation 'R1354:Glod4'
ID 156247
Institutional Source Beutler Lab
Gene Symbol Glod4
Ensembl Gene ENSMUSG00000017286
Gene Name glyoxalase domain containing 4
Synonyms 2700085E05Rik, 1700082G03Rik
MMRRC Submission 039419-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.166) question?
Stock # R1354 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 76111221-76134525 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 76128654 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000131788 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017430] [ENSMUST00000168055] [ENSMUST00000168055] [ENSMUST00000169701] [ENSMUST00000169701] [ENSMUST00000170017] [ENSMUST00000170590] [ENSMUST00000170710]
AlphaFold Q9CPV4
Predicted Effect probably null
Transcript: ENSMUST00000017430
SMART Domains Protein: ENSMUSP00000017430
Gene: ENSMUSG00000017286

DomainStartEndE-ValueType
Pfam:Glyoxalase_2 143 256 1.1e-10 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000164022
SMART Domains Protein: ENSMUSP00000126699
Gene: ENSMUSG00000017286

DomainStartEndE-ValueType
PDB:3ZI1|A 2 212 1e-143 PDB
SCOP:d1mpya1 119 198 4e-7 SMART
Predicted Effect probably null
Transcript: ENSMUST00000164022
SMART Domains Protein: ENSMUSP00000126699
Gene: ENSMUSG00000017286

DomainStartEndE-ValueType
PDB:3ZI1|A 2 212 1e-143 PDB
SCOP:d1mpya1 119 198 4e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000167883
Predicted Effect probably null
Transcript: ENSMUST00000168055
SMART Domains Protein: ENSMUSP00000130675
Gene: ENSMUSG00000017286

DomainStartEndE-ValueType
PDB:3ZI1|A 2 98 3e-61 PDB
Predicted Effect probably null
Transcript: ENSMUST00000168055
SMART Domains Protein: ENSMUSP00000130675
Gene: ENSMUSG00000017286

DomainStartEndE-ValueType
PDB:3ZI1|A 2 98 3e-61 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000169532
Predicted Effect probably null
Transcript: ENSMUST00000169701
SMART Domains Protein: ENSMUSP00000131174
Gene: ENSMUSG00000017286

DomainStartEndE-ValueType
Pfam:Glyoxalase_2 143 256 2.7e-8 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000169701
SMART Domains Protein: ENSMUSP00000131174
Gene: ENSMUSG00000017286

DomainStartEndE-ValueType
Pfam:Glyoxalase_2 143 256 2.7e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000170017
SMART Domains Protein: ENSMUSP00000132496
Gene: ENSMUSG00000017286

DomainStartEndE-ValueType
SCOP:d1qipa_ 1 40 3e-5 SMART
PDB:3ZI1|A 1 47 4e-25 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000170590
SMART Domains Protein: ENSMUSP00000129009
Gene: ENSMUSG00000017286

DomainStartEndE-ValueType
PDB:3ZI1|A 1 47 2e-23 PDB
SCOP:d1mpya2 1 66 1e-6 SMART
Predicted Effect probably null
Transcript: ENSMUST00000170710
SMART Domains Protein: ENSMUSP00000131788
Gene: ENSMUSG00000017286

DomainStartEndE-ValueType
Pfam:Glyoxalase_2 124 237 6.1e-9 PFAM
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.9%
  • 20x: 92.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atoh1 A G 6: 64,706,341 (GRCm39) E12G possibly damaging Het
Ccdc183 T C 2: 25,502,151 (GRCm39) N241S probably benign Het
Cmya5 G A 13: 93,228,566 (GRCm39) T2174I possibly damaging Het
Edem1 A G 6: 108,831,277 (GRCm39) I579M possibly damaging Het
Gimap9 A T 6: 48,654,982 (GRCm39) M190L probably benign Het
Ighv8-6 A T 12: 115,129,700 (GRCm39) S19T probably damaging Het
Lef1 C T 3: 130,988,317 (GRCm39) P267S probably damaging Het
Megf11 A G 9: 64,560,459 (GRCm39) E335G probably benign Het
Muc5ac A G 7: 141,361,114 (GRCm39) N1475S probably damaging Het
Ndst2 C A 14: 20,775,043 (GRCm39) R749L possibly damaging Het
Oas3 C A 5: 120,908,065 (GRCm39) V292L possibly damaging Het
Phactr1 A T 13: 43,210,807 (GRCm39) I210F possibly damaging Het
Plppr5 G A 3: 117,369,496 (GRCm39) R51H possibly damaging Het
Ppp1r12b G A 1: 134,763,721 (GRCm39) T771M probably benign Het
Rasgrf2 G A 13: 92,165,174 (GRCm39) P331S probably damaging Het
Rtl6 C T 15: 84,440,728 (GRCm39) V223M probably damaging Het
Tbc1d9 A C 8: 83,995,610 (GRCm39) probably null Het
Tgm3 T C 2: 129,883,818 (GRCm39) I492T probably benign Het
Trdv1 T A 14: 54,119,375 (GRCm39) probably benign Het
Wdr45b A T 11: 121,226,256 (GRCm39) I191N probably damaging Het
Other mutations in Glod4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00839:Glod4 APN 11 76,124,104 (GRCm39) missense probably benign 0.08
IGL01099:Glod4 APN 11 76,130,376 (GRCm39) nonsense probably null
IGL01761:Glod4 APN 11 76,134,428 (GRCm39) missense probably benign 0.00
FR4548:Glod4 UTSW 11 76,134,136 (GRCm39) start gained probably benign
R1386:Glod4 UTSW 11 76,112,829 (GRCm39) nonsense probably null
R1791:Glod4 UTSW 11 76,128,534 (GRCm39) missense probably damaging 1.00
R2281:Glod4 UTSW 11 76,128,635 (GRCm39) missense possibly damaging 0.74
R2484:Glod4 UTSW 11 76,130,344 (GRCm39) missense probably damaging 1.00
R4515:Glod4 UTSW 11 76,134,397 (GRCm39) missense probably damaging 1.00
R4517:Glod4 UTSW 11 76,134,397 (GRCm39) missense probably damaging 1.00
R4519:Glod4 UTSW 11 76,134,397 (GRCm39) missense probably damaging 1.00
R5945:Glod4 UTSW 11 76,125,297 (GRCm39) missense probably damaging 1.00
R6471:Glod4 UTSW 11 76,124,744 (GRCm39) missense probably damaging 1.00
R6488:Glod4 UTSW 11 76,128,611 (GRCm39) missense probably damaging 0.96
R6976:Glod4 UTSW 11 76,134,406 (GRCm39) missense probably damaging 1.00
R8263:Glod4 UTSW 11 76,125,318 (GRCm39) missense possibly damaging 0.80
R9287:Glod4 UTSW 11 76,128,510 (GRCm39) missense probably benign
R9655:Glod4 UTSW 11 76,125,292 (GRCm39) missense probably benign 0.00
Z1186:Glod4 UTSW 11 76,133,836 (GRCm39) missense probably benign
Z1186:Glod4 UTSW 11 76,133,819 (GRCm39) critical splice donor site probably null
Z1187:Glod4 UTSW 11 76,134,431 (GRCm39) missense probably benign
Z1187:Glod4 UTSW 11 76,133,819 (GRCm39) critical splice donor site probably null
Z1187:Glod4 UTSW 11 76,133,836 (GRCm39) missense probably benign
Z1187:Glod4 UTSW 11 76,134,430 (GRCm39) missense probably benign 0.00
Z1188:Glod4 UTSW 11 76,134,430 (GRCm39) missense probably benign 0.00
Z1188:Glod4 UTSW 11 76,133,836 (GRCm39) missense probably benign
Z1188:Glod4 UTSW 11 76,133,819 (GRCm39) critical splice donor site probably null
Z1188:Glod4 UTSW 11 76,134,431 (GRCm39) missense probably benign
Z1189:Glod4 UTSW 11 76,134,430 (GRCm39) missense probably benign 0.00
Z1189:Glod4 UTSW 11 76,133,836 (GRCm39) missense probably benign
Z1189:Glod4 UTSW 11 76,133,819 (GRCm39) critical splice donor site probably null
Z1189:Glod4 UTSW 11 76,134,431 (GRCm39) missense probably benign
Z1190:Glod4 UTSW 11 76,134,136 (GRCm39) start gained probably benign
Z1190:Glod4 UTSW 11 76,133,836 (GRCm39) missense probably benign
Z1190:Glod4 UTSW 11 76,133,819 (GRCm39) critical splice donor site probably null
Z1190:Glod4 UTSW 11 76,134,431 (GRCm39) missense probably benign
Z1190:Glod4 UTSW 11 76,134,430 (GRCm39) missense probably benign 0.00
Z1192:Glod4 UTSW 11 76,134,430 (GRCm39) missense probably benign 0.00
Z1192:Glod4 UTSW 11 76,133,836 (GRCm39) missense probably benign
Z1192:Glod4 UTSW 11 76,133,819 (GRCm39) critical splice donor site probably null
Z1192:Glod4 UTSW 11 76,134,431 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CAGGCTTTGCCTGGCCTATTGTA -3'
(R):5'- AGTGGATAGCTGACCAGTCCATGT -3'

Sequencing Primer
(F):5'- AGTTACCTGACTGAGATGGGC -3'
(R):5'- accactgagccatttctcc -3'
Posted On 2014-02-11