Incidental Mutation 'R1355:Ttc3'
| ID |
156303 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttc3
|
| Ensembl Gene |
ENSMUSG00000040785 |
| Gene Name |
tetratricopeptide repeat domain 3 |
| Synonyms |
2610202A04Rik, D16Ium21, D16Ium21e, TPRD |
| MMRRC Submission |
039420-MU
|
| Accession Numbers |
|
| Is this an essential gene? |
Possibly essential
(E-score: 0.640)
|
| Stock # |
R1355 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
94370618-94469343 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 94418637 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 492
(S492G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000156151
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000117648]
[ENSMUST00000122895]
[ENSMUST00000139513]
[ENSMUST00000141856]
[ENSMUST00000143145]
[ENSMUST00000145883]
[ENSMUST00000147046]
[ENSMUST00000147352]
[ENSMUST00000150097]
[ENSMUST00000150346]
[ENSMUST00000151770]
[ENSMUST00000152117]
[ENSMUST00000153988]
[ENSMUST00000155692]
[ENSMUST00000232395]
[ENSMUST00000232660]
[ENSMUST00000231915]
[ENSMUST00000231850]
[ENSMUST00000231569]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000117648
AA Change: S492G
PolyPhen 2
Score 0.458 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000112801
Gene: ENSMUSG00000040785
AA Change: S492G
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
231 |
264 |
3.61e-2 |
SMART |
|
TPR
|
265 |
298 |
3.32e-1 |
SMART |
|
Blast:TPR
|
300 |
332 |
2e-12 |
BLAST |
|
low complexity region
|
444 |
459 |
N/A |
INTRINSIC |
|
TPR
|
576 |
609 |
2.55e-2 |
SMART |
|
low complexity region
|
720 |
732 |
N/A |
INTRINSIC |
|
coiled coil region
|
765 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1170 |
1190 |
N/A |
INTRINSIC |
|
low complexity region
|
1248 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1278 |
1291 |
N/A |
INTRINSIC |
|
coiled coil region
|
1472 |
1570 |
N/A |
INTRINSIC |
|
low complexity region
|
1876 |
1887 |
N/A |
INTRINSIC |
|
RING
|
1931 |
1970 |
7e-9 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000122895
AA Change: S474G
PolyPhen 2
Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000123037
Gene: ENSMUSG00000040785
AA Change: S474G
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
213 |
246 |
3.61e-2 |
SMART |
|
TPR
|
247 |
280 |
3.32e-1 |
SMART |
|
Blast:TPR
|
282 |
314 |
3e-12 |
BLAST |
|
low complexity region
|
426 |
441 |
N/A |
INTRINSIC |
|
TPR
|
558 |
591 |
2.55e-2 |
SMART |
|
low complexity region
|
702 |
714 |
N/A |
INTRINSIC |
|
coiled coil region
|
747 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000130960
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139513
|
| SMART Domains |
Protein: ENSMUSP00000117881
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
22 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141856
AA Change: S6G
PolyPhen 2
Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000117369
Gene: ENSMUSG00000040785
AA Change: S6G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TPR_1
|
90 |
121 |
1e-6 |
PFAM |
|
Pfam:TPR_2
|
90 |
121 |
7.9e-6 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143145
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145883
AA Change: S6G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000123442
Gene: ENSMUSG00000040785
AA Change: S6G
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
42 |
64 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000147046
AA Change: S91G
PolyPhen 2
Score 0.458 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000119265
Gene: ENSMUSG00000040785
AA Change: S91G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
Pfam:TPR_1
|
175 |
206 |
5.3e-6 |
PFAM |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
low complexity region
|
359 |
382 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147352
AA Change: S474G
PolyPhen 2
Score 0.155 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000116097
Gene: ENSMUSG00000040785
AA Change: S474G
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
213 |
246 |
3.61e-2 |
SMART |
|
TPR
|
247 |
280 |
3.32e-1 |
SMART |
|
Blast:TPR
|
282 |
314 |
3e-12 |
BLAST |
|
low complexity region
|
426 |
441 |
N/A |
INTRINSIC |
|
TPR
|
558 |
591 |
2.55e-2 |
SMART |
|
low complexity region
|
702 |
714 |
N/A |
INTRINSIC |
|
coiled coil region
|
747 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150097
|
| SMART Domains |
Protein: ENSMUSP00000119035
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TPR
|
1 |
22 |
1e-6 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150346
AA Change: S91G
PolyPhen 2
Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000122726
Gene: ENSMUSG00000040785
AA Change: S91G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
Pfam:TPR_1
|
175 |
206 |
9.6e-6 |
PFAM |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
364 |
395 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151770
AA Change: S492G
PolyPhen 2
Score 0.155 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000121349
Gene: ENSMUSG00000040785
AA Change: S492G
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
231 |
264 |
3.61e-2 |
SMART |
|
TPR
|
265 |
298 |
3.32e-1 |
SMART |
|
Blast:TPR
|
300 |
332 |
3e-12 |
BLAST |
|
low complexity region
|
444 |
459 |
N/A |
INTRINSIC |
|
TPR
|
576 |
609 |
2.55e-2 |
SMART |
|
low complexity region
|
720 |
732 |
N/A |
INTRINSIC |
|
coiled coil region
|
765 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1050 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152117
AA Change: S91G
PolyPhen 2
Score 0.056 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000116896
Gene: ENSMUSG00000040785
AA Change: S91G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
SCOP:d1ihga1
|
69 |
201 |
6e-8 |
SMART |
|
Blast:TPR
|
175 |
208 |
1e-14 |
BLAST |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
364 |
395 |
N/A |
INTRINSIC |
|
low complexity region
|
617 |
631 |
N/A |
INTRINSIC |
|
low complexity region
|
635 |
649 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153988
AA Change: S182G
PolyPhen 2
Score 0.087 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000118763
Gene: ENSMUSG00000040785
AA Change: S182G
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TPR
|
1 |
22 |
3e-6 |
BLAST |
|
low complexity region
|
134 |
149 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000155692
AA Change: S511G
PolyPhen 2
Score 0.185 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000122724
Gene: ENSMUSG00000040785
AA Change: S511G
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
250 |
283 |
3.61e-2 |
SMART |
|
TPR
|
284 |
317 |
3.32e-1 |
SMART |
|
Blast:TPR
|
319 |
351 |
3e-12 |
BLAST |
|
low complexity region
|
463 |
478 |
N/A |
INTRINSIC |
|
TPR
|
595 |
628 |
2.55e-2 |
SMART |
|
low complexity region
|
739 |
751 |
N/A |
INTRINSIC |
|
coiled coil region
|
784 |
815 |
N/A |
INTRINSIC |
|
low complexity region
|
1037 |
1051 |
N/A |
INTRINSIC |
|
low complexity region
|
1055 |
1069 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000232395
AA Change: S492G
PolyPhen 2
Score 0.458 (Sensitivity: 0.89; Specificity: 0.90)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000232660
AA Change: S492G
PolyPhen 2
Score 0.458 (Sensitivity: 0.89; Specificity: 0.90)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231915
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231850
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231569
|
| Meta Mutation Damage Score |
0.1107 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.8%
- 20x: 91.4%
|
| Validation Efficiency |
100% (57/57) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 54 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb10 |
C |
T |
8: 123,962,052 |
G495D |
probably damaging |
Het |
| Ankrd52 |
A |
G |
10: 128,388,696 |
D781G |
possibly damaging |
Het |
| Arhgef5 |
T |
A |
6: 43,283,912 |
F1424I |
probably damaging |
Het |
| Atp10b |
G |
A |
11: 43,151,655 |
W14* |
probably null |
Het |
| B4galnt4 |
T |
C |
7: 141,065,395 |
V259A |
probably damaging |
Het |
| Ccdc141 |
A |
T |
2: 77,030,601 |
I944N |
probably damaging |
Het |
| Ccdc146 |
A |
T |
5: 21,321,242 |
D224E |
probably damaging |
Het |
| Ccne1 |
A |
G |
7: 38,106,322 |
I43T |
possibly damaging |
Het |
| Cd226 |
T |
A |
18: 89,247,023 |
S29T |
probably benign |
Het |
| Cebpz |
G |
T |
17: 78,935,324 |
D300E |
probably benign |
Het |
| Cryzl1 |
A |
G |
16: 91,692,658 |
V266A |
possibly damaging |
Het |
| Cyp2c68 |
A |
G |
19: 39,740,956 |
L29P |
probably damaging |
Het |
| Dennd3 |
A |
C |
15: 73,540,854 |
|
probably benign |
Het |
| Dpy19l4 |
C |
T |
4: 11,303,371 |
W183* |
probably null |
Het |
| Eml6 |
T |
G |
11: 29,833,085 |
S599R |
probably benign |
Het |
| Erc1 |
A |
T |
6: 119,743,420 |
L440* |
probably null |
Het |
| Fam71e1 |
A |
G |
7: 44,496,691 |
K2E |
possibly damaging |
Het |
| Frem3 |
A |
G |
8: 80,690,702 |
Y2012C |
probably damaging |
Het |
| Gm10288 |
A |
T |
3: 146,838,993 |
|
noncoding transcript |
Het |
| Gm1110 |
T |
A |
9: 26,883,761 |
K476N |
probably benign |
Het |
| Gm11937 |
A |
T |
11: 99,609,907 |
S95T |
possibly damaging |
Het |
| Hist1h2bl |
T |
A |
13: 21,715,857 |
Q96L |
probably damaging |
Het |
| Hs6st1 |
T |
A |
1: 36,103,576 |
H197Q |
probably damaging |
Het |
| Ism1 |
A |
T |
2: 139,732,074 |
I115F |
possibly damaging |
Het |
| Itgb8 |
C |
T |
12: 119,171,003 |
G443E |
probably benign |
Het |
| Kalrn |
T |
A |
16: 33,975,584 |
I1274F |
possibly damaging |
Het |
| Lrrcc1 |
G |
T |
3: 14,548,114 |
V299L |
probably benign |
Het |
| Mettl5 |
A |
T |
2: 69,881,420 |
|
probably null |
Het |
| Nlrp2 |
G |
T |
7: 5,327,491 |
N635K |
possibly damaging |
Het |
| Olfr140 |
G |
A |
2: 90,051,613 |
T237I |
probably benign |
Het |
| Olfr1466 |
T |
A |
19: 13,342,518 |
Y253* |
probably null |
Het |
| Olfr1537 |
G |
C |
9: 39,238,251 |
P58A |
probably benign |
Het |
| Olfr198 |
A |
G |
16: 59,201,680 |
S249P |
probably damaging |
Het |
| Plxna1 |
A |
G |
6: 89,320,766 |
|
probably benign |
Het |
| Ppp4r1 |
A |
T |
17: 65,840,987 |
E924D |
probably benign |
Het |
| Prdm2 |
C |
T |
4: 143,131,963 |
V1586I |
probably benign |
Het |
| Pros1 |
A |
G |
16: 62,919,558 |
K457E |
probably benign |
Het |
| Rer1 |
T |
A |
4: 155,075,624 |
M156L |
probably benign |
Het |
| Rgs16 |
A |
T |
1: 153,743,668 |
K140M |
probably damaging |
Het |
| Rgsl1 |
A |
G |
1: 153,807,761 |
M1T |
probably null |
Het |
| Setdb2 |
T |
A |
14: 59,417,441 |
K333N |
probably damaging |
Het |
| Sgo2a |
A |
G |
1: 58,017,965 |
T1103A |
possibly damaging |
Het |
| Sik3 |
C |
T |
9: 46,195,872 |
|
probably benign |
Het |
| Slc44a3 |
C |
A |
3: 121,531,671 |
G47V |
probably damaging |
Het |
| Snrpd1 |
G |
A |
18: 10,627,818 |
G103D |
probably benign |
Het |
| Soga3 |
A |
T |
10: 29,147,322 |
T222S |
probably benign |
Het |
| Sspo |
T |
A |
6: 48,448,626 |
S60R |
probably benign |
Het |
| Susd1 |
C |
T |
4: 59,424,114 |
C37Y |
possibly damaging |
Het |
| Tiam1 |
A |
T |
16: 89,898,221 |
I116N |
probably benign |
Het |
| Uckl1 |
G |
T |
2: 181,573,376 |
T213K |
probably damaging |
Het |
| Usp38 |
T |
C |
8: 80,985,033 |
E791G |
possibly damaging |
Het |
| Vps13b |
C |
T |
15: 35,422,454 |
R187C |
probably damaging |
Het |
| Vwa3a |
A |
G |
7: 120,784,111 |
Y645C |
probably damaging |
Het |
| Wasf3 |
T |
C |
5: 146,470,208 |
|
probably benign |
Het |
|
| Other mutations in Ttc3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Ttc3
|
APN |
16 |
94426761 |
splice site |
probably null |
|
|
IGL00979:Ttc3
|
APN |
16 |
94456718 |
missense |
probably damaging |
1.00 |
|
IGL01520:Ttc3
|
APN |
16 |
94390207 |
missense |
probably benign |
0.04 |
|
IGL01663:Ttc3
|
APN |
16 |
94409731 |
critical splice donor site |
probably null |
|
|
IGL01720:Ttc3
|
APN |
16 |
94385369 |
missense |
probably damaging |
0.99 |
|
IGL01736:Ttc3
|
APN |
16 |
94442527 |
missense |
probably damaging |
0.99 |
|
IGL02045:Ttc3
|
APN |
16 |
94409681 |
splice site |
probably benign |
|
|
IGL02203:Ttc3
|
APN |
16 |
94418598 |
splice site |
probably benign |
|
|
IGL02327:Ttc3
|
APN |
16 |
94448108 |
missense |
probably damaging |
1.00 |
|
IGL02794:Ttc3
|
APN |
16 |
94467926 |
missense |
probably damaging |
1.00 |
|
IGL02898:Ttc3
|
APN |
16 |
94419426 |
missense |
probably damaging |
1.00 |
|
PIT4378001:Ttc3
|
UTSW |
16 |
94410906 |
missense |
probably benign |
0.01 |
|
R0064:Ttc3
|
UTSW |
16 |
94422247 |
missense |
possibly damaging |
0.79 |
|
R0098:Ttc3
|
UTSW |
16 |
94390265 |
missense |
probably benign |
0.02 |
|
R0112:Ttc3
|
UTSW |
16 |
94385322 |
splice site |
probably benign |
|
|
R0135:Ttc3
|
UTSW |
16 |
94462268 |
missense |
possibly damaging |
0.92 |
|
R0480:Ttc3
|
UTSW |
16 |
94432004 |
nonsense |
probably null |
|
|
R0513:Ttc3
|
UTSW |
16 |
94426212 |
missense |
probably damaging |
1.00 |
|
R0532:Ttc3
|
UTSW |
16 |
94387330 |
splice site |
probably benign |
|
|
R0607:Ttc3
|
UTSW |
16 |
94456785 |
nonsense |
probably null |
|
|
R0742:Ttc3
|
UTSW |
16 |
94459880 |
missense |
probably benign |
0.23 |
|
R0905:Ttc3
|
UTSW |
16 |
94456789 |
nonsense |
probably null |
|
|
R1118:Ttc3
|
UTSW |
16 |
94416268 |
splice site |
probably benign |
|
|
R1370:Ttc3
|
UTSW |
16 |
94418637 |
missense |
possibly damaging |
0.46 |
|
R1486:Ttc3
|
UTSW |
16 |
94448129 |
missense |
probably damaging |
1.00 |
|
R1598:Ttc3
|
UTSW |
16 |
94422297 |
missense |
probably damaging |
1.00 |
|
R1641:Ttc3
|
UTSW |
16 |
94443317 |
missense |
probably benign |
0.19 |
|
R2092:Ttc3
|
UTSW |
16 |
94442832 |
missense |
probably benign |
0.02 |
|
R2232:Ttc3
|
UTSW |
16 |
94459972 |
missense |
probably benign |
0.00 |
|
R2339:Ttc3
|
UTSW |
16 |
94431998 |
missense |
probably damaging |
1.00 |
|
R2342:Ttc3
|
UTSW |
16 |
94431998 |
missense |
probably damaging |
1.00 |
|
R2842:Ttc3
|
UTSW |
16 |
94431998 |
missense |
probably damaging |
1.00 |
|
R3117:Ttc3
|
UTSW |
16 |
94442563 |
missense |
possibly damaging |
0.51 |
|
R4194:Ttc3
|
UTSW |
16 |
94422277 |
missense |
probably damaging |
0.99 |
|
R4329:Ttc3
|
UTSW |
16 |
94466961 |
missense |
probably damaging |
1.00 |
|
R4431:Ttc3
|
UTSW |
16 |
94410958 |
critical splice donor site |
probably null |
|
|
R4530:Ttc3
|
UTSW |
16 |
94466877 |
intron |
probably benign |
|
|
R4531:Ttc3
|
UTSW |
16 |
94466877 |
intron |
probably benign |
|
|
R4532:Ttc3
|
UTSW |
16 |
94466877 |
intron |
probably benign |
|
|
R4533:Ttc3
|
UTSW |
16 |
94466877 |
intron |
probably benign |
|
|
R4588:Ttc3
|
UTSW |
16 |
94442901 |
missense |
probably benign |
0.01 |
|
R4625:Ttc3
|
UTSW |
16 |
94388272 |
nonsense |
probably null |
|
|
R4676:Ttc3
|
UTSW |
16 |
94442761 |
missense |
probably damaging |
1.00 |
|
R4700:Ttc3
|
UTSW |
16 |
94439241 |
splice site |
probably null |
|
|
R4856:Ttc3
|
UTSW |
16 |
94390283 |
missense |
probably benign |
0.32 |
|
R4867:Ttc3
|
UTSW |
16 |
94454515 |
missense |
probably damaging |
0.96 |
|
R4885:Ttc3
|
UTSW |
16 |
94419465 |
missense |
probably damaging |
1.00 |
|
R4885:Ttc3
|
UTSW |
16 |
94426831 |
critical splice donor site |
probably null |
|
|
R4899:Ttc3
|
UTSW |
16 |
94429455 |
missense |
probably damaging |
1.00 |
|
R4997:Ttc3
|
UTSW |
16 |
94452982 |
missense |
probably damaging |
1.00 |
|
R5023:Ttc3
|
UTSW |
16 |
94429359 |
missense |
probably benign |
0.01 |
|
R5105:Ttc3
|
UTSW |
16 |
94466934 |
missense |
possibly damaging |
0.94 |
|
R5205:Ttc3
|
UTSW |
16 |
94448059 |
missense |
probably benign |
0.07 |
|
R5287:Ttc3
|
UTSW |
16 |
94459844 |
missense |
probably benign |
0.00 |
|
R5338:Ttc3
|
UTSW |
16 |
94384041 |
missense |
probably damaging |
0.99 |
|
R5347:Ttc3
|
UTSW |
16 |
94429620 |
missense |
probably damaging |
1.00 |
|
R5403:Ttc3
|
UTSW |
16 |
94459844 |
missense |
probably benign |
0.00 |
|
R5460:Ttc3
|
UTSW |
16 |
94457382 |
missense |
probably benign |
0.32 |
|
R5739:Ttc3
|
UTSW |
16 |
94439324 |
nonsense |
probably null |
|
|
R6242:Ttc3
|
UTSW |
16 |
94442695 |
missense |
probably benign |
0.04 |
|
R6253:Ttc3
|
UTSW |
16 |
94457413 |
critical splice donor site |
probably null |
|
|
R6455:Ttc3
|
UTSW |
16 |
94418623 |
start codon destroyed |
probably null |
0.83 |
|
R6559:Ttc3
|
UTSW |
16 |
94422349 |
critical splice donor site |
probably null |
|
|
R6564:Ttc3
|
UTSW |
16 |
94442611 |
missense |
probably damaging |
1.00 |
|
R6932:Ttc3
|
UTSW |
16 |
94443453 |
missense |
probably benign |
|
|
R7331:Ttc3
|
UTSW |
16 |
94394359 |
missense |
probably benign |
0.27 |
|
R7497:Ttc3
|
UTSW |
16 |
94418682 |
missense |
possibly damaging |
0.93 |
|
R7610:Ttc3
|
UTSW |
16 |
94427838 |
missense |
probably benign |
0.11 |
|
R7738:Ttc3
|
UTSW |
16 |
94387382 |
missense |
probably benign |
0.00 |
|
R7970:Ttc3
|
UTSW |
16 |
94457364 |
missense |
probably damaging |
1.00 |
|
R8052:Ttc3
|
UTSW |
16 |
94467989 |
missense |
probably benign |
0.09 |
|
R8087:Ttc3
|
UTSW |
16 |
94442953 |
missense |
probably benign |
0.00 |
|
R8309:Ttc3
|
UTSW |
16 |
94466979 |
missense |
probably damaging |
1.00 |
|
R8320:Ttc3
|
UTSW |
16 |
94418676 |
missense |
probably damaging |
1.00 |
|
R8322:Ttc3
|
UTSW |
16 |
94454492 |
missense |
probably damaging |
1.00 |
|
R8518:Ttc3
|
UTSW |
16 |
94457379 |
missense |
probably benign |
0.21 |
|
R8670:Ttc3
|
UTSW |
16 |
94390208 |
missense |
probably damaging |
0.99 |
|
R8826:Ttc3
|
UTSW |
16 |
94431970 |
missense |
possibly damaging |
0.85 |
|
R8868:Ttc3
|
UTSW |
16 |
94451143 |
missense |
probably benign |
0.00 |
|
R8873:Ttc3
|
UTSW |
16 |
94442983 |
missense |
probably damaging |
0.97 |
|
R8940:Ttc3
|
UTSW |
16 |
94429499 |
missense |
possibly damaging |
0.94 |
|
R8993:Ttc3
|
UTSW |
16 |
94427808 |
missense |
possibly damaging |
0.85 |
|
R9068:Ttc3
|
UTSW |
16 |
94403360 |
missense |
probably damaging |
1.00 |
|
R9119:Ttc3
|
UTSW |
16 |
94392091 |
missense |
probably damaging |
0.98 |
|
R9124:Ttc3
|
UTSW |
16 |
94435530 |
missense |
probably benign |
0.00 |
|
R9129:Ttc3
|
UTSW |
16 |
94384349 |
missense |
probably benign |
0.02 |
|
R9189:Ttc3
|
UTSW |
16 |
94467972 |
missense |
possibly damaging |
0.62 |
|
R9217:Ttc3
|
UTSW |
16 |
94429608 |
missense |
possibly damaging |
0.80 |
|
R9490:Ttc3
|
UTSW |
16 |
94444501 |
missense |
probably benign |
|
|
R9564:Ttc3
|
UTSW |
16 |
94448059 |
missense |
probably benign |
0.07 |
|
X0022:Ttc3
|
UTSW |
16 |
94442525 |
missense |
probably benign |
0.00 |
|
Y5378:Ttc3
|
UTSW |
16 |
94412129 |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATTCCTATAATGACAGTTGCACCCACC -3'
(R):5'- ACAAACTGGGAGCACTACTTGCC -3'
Sequencing Primer
(F):5'- AGTTGCACCCACCTACATAC -3'
(R):5'- gctcacaaatgtctaagttctgttc -3'
|
| Posted On |
2014-02-11 |
Incidental Mutation