Mutagenetix > Incidental Mutation

Incidental Mutation 'R0042:Adgrf3'

15656

Institutional Source

Beutler Lab

Gene Symbol

Adgrf3

Ensembl Gene

ENSMUSG00000067642

Gene Name

adhesion G protein-coupled receptor F3

Synonyms

PGR23, LOC381628, Gpr113

MMRRC Submission

038336-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0042 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

30398429-30410720 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 30402426 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 534 (L534P)

Ref Sequence

ENSEMBL: ENSMUSP00000085440 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000088117] [ENSMUST00000125367]

AlphaFold

Q58Y75

Predicted Effect

probably damaging
Transcript: ENSMUST00000088117
AA Change: L534P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000085440
Gene: ENSMUSG00000067642
AA Change: L534P

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
low complexity region	85	97	N/A	INTRINSIC
Blast:IG	163	252	2e-20	BLAST
Blast:CCP	341	399	1e-6	BLAST
low complexity region	403	415	N/A	INTRINSIC
low complexity region	471	483	N/A	INTRINSIC
GPS	632	684	2.68e-17	SMART
Pfam:7tm_2	687	935	1e-30	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000125367

SMART Domains

Protein: ENSMUSP00000120958
Gene: ENSMUSG00000067642

Domain	Start	End	E-Value	Type
transmembrane domain	21	43	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135322

Meta Mutation Damage Score

0.5735

Coding Region Coverage

1x: 81.9%
3x: 73.7%
10x: 53.7%
20x: 34.5%

Validation Efficiency

94% (58/62)

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca1	C	T	4: 53,059,245 (GRCm39)		probably benign	Het
Ank2	T	C	3: 126,730,280 (GRCm39)	D3568G	probably damaging	Het
Atr	T	A	9: 95,809,409 (GRCm39)		probably benign	Het
Ccnb2	A	G	9: 70,326,335 (GRCm39)	V34A	probably benign	Het
Dmxl1	C	A	18: 49,997,102 (GRCm39)	T466K	probably benign	Het
Eya1	T	C	1: 14,254,713 (GRCm39)	D373G	probably damaging	Het
Fam120a	A	G	13: 49,087,490 (GRCm39)	V290A	probably damaging	Het
Gpr179	C	T	11: 97,225,757 (GRCm39)	V2133I	probably benign	Het
Grb10	G	T	11: 11,886,798 (GRCm39)	H435Q	probably damaging	Het
Gzmm	T	C	10: 79,530,399 (GRCm39)	I190T	probably benign	Het
H2-Q3	A	G	17: 35,578,823 (GRCm39)		noncoding transcript	Het
Hspb7	A	G	4: 141,151,245 (GRCm39)	E129G	probably damaging	Het
Il17ra	T	C	6: 120,449,086 (GRCm39)		probably benign	Het
Itgb3	A	G	11: 104,557,966 (GRCm39)	T787A	possibly damaging	Het
Krt4	T	G	15: 101,831,187 (GRCm39)		probably benign	Het
Lgsn	C	T	1: 31,229,534 (GRCm39)	T85I	probably benign	Het
Metap1	C	T	3: 138,177,918 (GRCm39)	V217I	probably benign	Het
Mib2	A	T	4: 155,743,897 (GRCm39)	C48*	probably null	Het
Mroh4	T	A	15: 74,482,154 (GRCm39)	I768F	probably damaging	Het
Npas3	T	A	12: 54,095,624 (GRCm39)	D361E	probably damaging	Het
P4hb	G	A	11: 120,459,092 (GRCm39)	R134C	probably damaging	Het
Prr35	C	A	17: 26,166,956 (GRCm39)	E194*	probably null	Het
Rbl1	A	G	2: 157,017,624 (GRCm39)		probably benign	Het
Rdh10	T	A	1: 16,178,260 (GRCm39)		probably benign	Het
Spata31	A	T	13: 65,070,377 (GRCm39)	I842L	probably benign	Het
Stk32b	A	C	5: 37,874,092 (GRCm39)	D13E	probably benign	Het
Svep1	T	C	4: 58,123,192 (GRCm39)	D708G	possibly damaging	Het
Taar6	T	C	10: 23,861,021 (GRCm39)	D175G	probably benign	Het
Tmod4	T	C	3: 95,037,099 (GRCm39)	D164G	possibly damaging	Het
Ttc23l	A	C	15: 10,551,627 (GRCm39)	L33W	probably damaging	Het
Ttc39d	T	C	17: 80,523,379 (GRCm39)	Y13H	probably benign	Het
Utp18	G	T	11: 93,766,684 (GRCm39)	T309K	probably damaging	Het
Vps11	G	T	9: 44,267,588 (GRCm39)	Y341*	probably null	Het
Vsig8	T	C	1: 172,387,925 (GRCm39)	V5A	possibly damaging	Het

Other mutations in Adgrf3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03080:Adgrf3	APN	5	30,401,827 (GRCm39)	missense	probably benign	0.02
IGL03171:Adgrf3	APN	5	30,401,292 (GRCm39)	missense	probably damaging	1.00
R0010:Adgrf3	UTSW	5	30,410,607 (GRCm39)	splice site	probably benign
R0140:Adgrf3	UTSW	5	30,401,379 (GRCm39)	missense	probably benign	0.19
R0617:Adgrf3	UTSW	5	30,400,078 (GRCm39)	missense	probably benign	0.25
R0748:Adgrf3	UTSW	5	30,401,874 (GRCm39)	missense	probably damaging	1.00
R1291:Adgrf3	UTSW	5	30,404,532 (GRCm39)	missense	probably damaging	0.99
R1330:Adgrf3	UTSW	5	30,400,093 (GRCm39)	missense	probably benign	0.24
R1468:Adgrf3	UTSW	5	30,407,227 (GRCm39)	splice site	probably benign
R1695:Adgrf3	UTSW	5	30,408,553 (GRCm39)	missense	probably benign	0.05
R1716:Adgrf3	UTSW	5	30,402,549 (GRCm39)	missense	probably benign	0.03
R1844:Adgrf3	UTSW	5	30,404,211 (GRCm39)	missense	probably damaging	0.96
R1935:Adgrf3	UTSW	5	30,407,304 (GRCm39)	missense	probably benign	0.00
R1936:Adgrf3	UTSW	5	30,407,304 (GRCm39)	missense	probably benign	0.00
R2059:Adgrf3	UTSW	5	30,404,489 (GRCm39)	missense	possibly damaging	0.91
R2656:Adgrf3	UTSW	5	30,401,436 (GRCm39)	missense	possibly damaging	0.96
R2913:Adgrf3	UTSW	5	30,401,992 (GRCm39)	missense	probably damaging	1.00
R2914:Adgrf3	UTSW	5	30,401,992 (GRCm39)	missense	probably damaging	1.00
R2987:Adgrf3	UTSW	5	30,402,358 (GRCm39)	missense	probably damaging	1.00
R3797:Adgrf3	UTSW	5	30,401,821 (GRCm39)	missense	possibly damaging	0.49
R3798:Adgrf3	UTSW	5	30,401,821 (GRCm39)	missense	possibly damaging	0.49
R3799:Adgrf3	UTSW	5	30,401,821 (GRCm39)	missense	possibly damaging	0.49
R3934:Adgrf3	UTSW	5	30,405,432 (GRCm39)	unclassified	probably benign
R4043:Adgrf3	UTSW	5	30,409,360 (GRCm39)	missense	probably benign	0.00
R4080:Adgrf3	UTSW	5	30,402,367 (GRCm39)	nonsense	probably null
R4575:Adgrf3	UTSW	5	30,407,255 (GRCm39)	missense	probably benign	0.00
R4754:Adgrf3	UTSW	5	30,402,615 (GRCm39)	critical splice acceptor site	probably null
R4819:Adgrf3	UTSW	5	30,403,442 (GRCm39)	missense	possibly damaging	0.66
R4893:Adgrf3	UTSW	5	30,405,476 (GRCm39)	missense	probably benign	0.00
R4991:Adgrf3	UTSW	5	30,404,146 (GRCm39)	missense	probably benign	0.26
R5686:Adgrf3	UTSW	5	30,402,304 (GRCm39)	missense	probably damaging	1.00
R5965:Adgrf3	UTSW	5	30,410,637 (GRCm39)	missense	probably benign	0.00
R5997:Adgrf3	UTSW	5	30,403,360 (GRCm39)	critical splice donor site	probably null
R6103:Adgrf3	UTSW	5	30,401,265 (GRCm39)	missense	probably damaging	1.00
R6244:Adgrf3	UTSW	5	30,402,531 (GRCm39)	missense	probably benign	0.17
R6409:Adgrf3	UTSW	5	30,402,312 (GRCm39)	missense	probably damaging	0.96
R6575:Adgrf3	UTSW	5	30,401,522 (GRCm39)	missense	possibly damaging	0.72
R6745:Adgrf3	UTSW	5	30,408,601 (GRCm39)	missense	probably benign	0.31
R6790:Adgrf3	UTSW	5	30,401,385 (GRCm39)	missense	probably benign	0.00
R6813:Adgrf3	UTSW	5	30,402,519 (GRCm39)	missense	probably damaging	0.96
R7202:Adgrf3	UTSW	5	30,409,378 (GRCm39)	nonsense	probably null
R7250:Adgrf3	UTSW	5	30,400,680 (GRCm39)	missense	probably damaging	1.00
R7353:Adgrf3	UTSW	5	30,403,495 (GRCm39)	missense	probably damaging	0.98
R7634:Adgrf3	UTSW	5	30,407,245 (GRCm39)	missense	probably benign	0.01
R7658:Adgrf3	UTSW	5	30,402,204 (GRCm39)	missense	probably benign	0.41
R8037:Adgrf3	UTSW	5	30,404,510 (GRCm39)	missense	probably damaging	1.00
R8281:Adgrf3	UTSW	5	30,402,301 (GRCm39)	missense	possibly damaging	0.46
R8717:Adgrf3	UTSW	5	30,403,579 (GRCm39)	unclassified	probably benign
R8857:Adgrf3	UTSW	5	30,402,065 (GRCm39)	nonsense	probably null
R8926:Adgrf3	UTSW	5	30,405,446 (GRCm39)	missense	possibly damaging	0.46
R9391:Adgrf3	UTSW	5	30,400,071 (GRCm39)	missense	possibly damaging	0.94
R9446:Adgrf3	UTSW	5	30,401,957 (GRCm39)	missense	probably benign	0.01
R9522:Adgrf3	UTSW	5	30,404,482 (GRCm39)	missense	possibly damaging	0.90
Z1088:Adgrf3	UTSW	5	30,404,118 (GRCm39)	missense	possibly damaging	0.90

Posted On

2012-12-21