Incidental Mutation 'R0038:Oog4'
ID15661
Institutional Source Beutler Lab
Gene Symbol Oog4
Ensembl Gene ENSMUSG00000047799
Gene Nameoogenesin 4
Synonyms
MMRRC Submission 038332-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.078) question?
Stock #R0038 (G1)
Quality Score
Status Validated
Chromosome4
Chromosomal Location143437164-143450324 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 143438944 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 211 (D211G)
Ref Sequence ENSEMBL: ENSMUSP00000073325 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061277] [ENSMUST00000073641]
Predicted Effect probably benign
Transcript: ENSMUST00000061277
AA Change: D139G

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000052217
Gene: ENSMUSG00000047799
AA Change: D139G

DomainStartEndE-ValueType
SCOP:d1a4ya_ 195 357 6e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000073641
AA Change: D211G

PolyPhen 2 Score 0.197 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000073325
Gene: ENSMUSG00000047799
AA Change: D211G

DomainStartEndE-ValueType
SCOP:d1a4ya_ 267 429 3e-7 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 83.6%
  • 3x: 76.1%
  • 10x: 58.6%
  • 20x: 40.4%
Validation Efficiency 91% (67/74)
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agfg1 T C 1: 82,886,102 probably benign Het
Ahnak2 T C 12: 112,774,462 T253A probably benign Het
Ankrd28 A T 14: 31,708,035 M892K probably damaging Het
Arhgef25 T C 10: 127,186,865 probably benign Het
Cldn8 A G 16: 88,563,034 M1T probably null Het
Clec11a A G 7: 44,306,482 probably benign Het
Ddx39 T C 8: 83,722,498 L305P probably damaging Het
Depdc5 A G 5: 32,868,853 E60G probably benign Het
Etl4 A T 2: 20,743,574 H39L probably damaging Het
Gramd1b G A 9: 40,317,526 T252M probably damaging Het
Hcrtr2 A T 9: 76,259,681 S125T probably benign Het
Htr2a T G 14: 74,706,247 S422R probably benign Het
Kirrel3 T A 9: 34,911,770 probably null Het
Krtap9-5 G A 11: 99,948,602 C43Y possibly damaging Het
Lama2 T C 10: 26,986,797 D2990G probably benign Het
Ncor1 A G 11: 62,392,551 F437L probably damaging Het
Nlrp1b A G 11: 71,172,171 S685P possibly damaging Het
Pcdh15 A T 10: 74,643,440 E723V possibly damaging Het
Pgm3 A T 9: 86,564,673 probably benign Het
Pnpla5 A G 15: 84,122,513 Y90H probably damaging Het
Polr1b C T 2: 129,115,668 R548* probably null Het
Rnf168 T C 16: 32,298,995 V458A probably benign Het
Rnf32 T C 5: 29,205,654 probably benign Het
Sclt1 T C 3: 41,629,508 probably benign Het
Serpina12 A G 12: 104,037,957 F139L probably damaging Het
Stag3 T A 5: 138,301,036 probably null Het
Stard5 T C 7: 83,636,743 probably benign Het
Suclg1 A G 6: 73,260,503 E77G probably benign Het
Ush2a G T 1: 188,626,612 G2112C probably benign Het
Zfp644 T G 5: 106,635,043 E1155A probably benign Het
Other mutations in Oog4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01580:Oog4 APN 4 143439112 missense probably benign 0.27
IGL02207:Oog4 APN 4 143438940 missense probably benign 0.20
R0038:Oog4 UTSW 4 143438944 missense probably benign 0.20
R0326:Oog4 UTSW 4 143439203 missense probably benign 0.03
R0372:Oog4 UTSW 4 143437689 missense probably damaging 1.00
R1056:Oog4 UTSW 4 143438011 missense possibly damaging 0.72
R1598:Oog4 UTSW 4 143438001 missense probably damaging 0.99
R1712:Oog4 UTSW 4 143439914 missense probably damaging 1.00
R4028:Oog4 UTSW 4 143440200 missense probably benign 0.02
R4029:Oog4 UTSW 4 143440200 missense probably benign 0.02
R4030:Oog4 UTSW 4 143440200 missense probably benign 0.02
R4705:Oog4 UTSW 4 143438875 missense probably benign 0.00
R5260:Oog4 UTSW 4 143437854 missense probably benign 0.00
R5945:Oog4 UTSW 4 143437723 missense probably benign 0.01
R6499:Oog4 UTSW 4 143437978 missense probably damaging 0.96
R6614:Oog4 UTSW 4 143437875 missense possibly damaging 0.66
R6852:Oog4 UTSW 4 143439109 missense possibly damaging 0.72
R7371:Oog4 UTSW 4 143438776 missense possibly damaging 0.47
R7375:Oog4 UTSW 4 143438974 missense possibly damaging 0.72
R7501:Oog4 UTSW 4 143437452 frame shift probably null
R7564:Oog4 UTSW 4 143437452 frame shift probably null
R7678:Oog4 UTSW 4 143437452 frame shift probably null
R7688:Oog4 UTSW 4 143437452 frame shift probably null
R7689:Oog4 UTSW 4 143437452 frame shift probably null
R8219:Oog4 UTSW 4 143439938 missense probably benign 0.00
Z1177:Oog4 UTSW 4 143437574 missense possibly damaging 0.91
Z1177:Oog4 UTSW 4 143437575 missense probably benign 0.06
Posted On2012-12-21