Incidental Mutation 'R0019:Mroh7'
ID 15670
Institutional Source Beutler Lab
Gene Symbol Mroh7
Ensembl Gene ENSMUSG00000047502
Gene Name maestro heat-like repeat family member 7
Synonyms Heatr8, Gm1027, LOC381538
MMRRC Submission 038314-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0019 (G1)
Quality Score
Status Validated
Chromosome 4
Chromosomal Location 106537614-106588122 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 106578623 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 18 (I18M)
Ref Sequence ENSEMBL: ENSMUSP00000119211 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106770] [ENSMUST00000145044] [ENSMUST00000148281]
AlphaFold A2AVR2
Predicted Effect probably benign
Transcript: ENSMUST00000106770
AA Change: I18M

PolyPhen 2 Score 0.068 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000102382
Gene: ENSMUSG00000047502
AA Change: I18M

DomainStartEndE-ValueType
low complexity region 39 61 N/A INTRINSIC
low complexity region 318 332 N/A INTRINSIC
low complexity region 563 573 N/A INTRINSIC
SCOP:d1b3ua_ 634 1218 6e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000145044
Predicted Effect probably benign
Transcript: ENSMUST00000148281
AA Change: I18M

PolyPhen 2 Score 0.071 (Sensitivity: 0.94; Specificity: 0.84)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 83.5%
  • 3x: 78.2%
  • 10x: 64.4%
  • 20x: 48.4%
Validation Efficiency 91% (93/102)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd13a T A 5: 114,924,142 (GRCm39) probably benign Het
Arhgef12 A T 9: 42,889,529 (GRCm39) W1029R probably damaging Het
Aunip T A 4: 134,250,823 (GRCm39) L256* probably null Het
Bahcc1 T A 11: 120,180,597 (GRCm39) M2607K probably damaging Het
Bltp3b A G 10: 89,611,831 (GRCm39) T5A probably damaging Het
Cacng6 G T 7: 3,480,384 (GRCm39) M152I possibly damaging Het
Cep120 A G 18: 53,842,119 (GRCm39) probably benign Het
D130043K22Rik T A 13: 25,064,795 (GRCm39) V737D probably damaging Het
Dock10 A G 1: 80,583,642 (GRCm39) S187P probably damaging Het
Eogt C T 6: 97,111,234 (GRCm39) probably benign Het
Fasn A T 11: 120,698,824 (GRCm39) probably benign Het
Frem2 C T 3: 53,431,099 (GRCm39) V2745M probably damaging Het
Fshb T C 2: 106,887,690 (GRCm39) S110G probably benign Het
Gpi1 A G 7: 33,920,324 (GRCm39) Y144H probably damaging Het
Gsap T C 5: 21,475,620 (GRCm39) probably benign Het
Helz2 C A 2: 180,874,552 (GRCm39) G1981C probably damaging Het
Herc3 T C 6: 58,862,050 (GRCm39) probably benign Het
Il1r2 C T 1: 40,164,210 (GRCm39) T359M probably damaging Het
Il6st T C 13: 112,637,682 (GRCm39) C563R possibly damaging Het
Irs1 T A 1: 82,264,977 (GRCm39) K1080* probably null Het
Itpr1 T C 6: 108,331,587 (GRCm39) V182A probably damaging Het
Kalrn C T 16: 34,018,884 (GRCm39) probably benign Het
Kcnj11 G A 7: 45,748,363 (GRCm39) A320V probably benign Het
Lrig1 T A 6: 94,584,330 (GRCm39) R905* probably null Het
Lrrc43 T C 5: 123,639,378 (GRCm39) L469P probably damaging Het
Med29 A T 7: 28,090,501 (GRCm39) probably benign Het
Nalcn A C 14: 123,744,901 (GRCm39) C376G probably benign Het
Ncor2 C T 5: 125,196,545 (GRCm39) probably null Het
Nek1 T A 8: 61,542,768 (GRCm39) M786K probably benign Het
Nrxn2 A G 19: 6,559,987 (GRCm39) probably benign Het
Nxpe2 T C 9: 48,231,080 (GRCm39) I430V probably benign Het
Pcolce2 A G 9: 95,577,017 (GRCm39) probably null Het
Pdcl A T 2: 37,241,932 (GRCm39) L273M probably damaging Het
Pml A T 9: 58,127,776 (GRCm39) S610R probably damaging Het
Polk C A 13: 96,641,124 (GRCm39) R144S probably damaging Het
Rlf A G 4: 121,003,769 (GRCm39) V1737A possibly damaging Het
Rubcnl T A 14: 75,285,703 (GRCm39) probably benign Het
Scn3a A T 2: 65,292,045 (GRCm39) V1567E probably damaging Het
Scyl2 A G 10: 89,495,183 (GRCm39) I296T probably benign Het
Slc15a3 A G 19: 10,833,404 (GRCm39) I474V probably damaging Het
Sstr1 T C 12: 58,259,935 (GRCm39) L186S probably damaging Het
Tmem108 A T 9: 103,366,539 (GRCm39) V484D possibly damaging Het
Trim69 A T 2: 122,004,958 (GRCm39) probably null Het
Trim80 T G 11: 115,338,768 (GRCm39) Y533D probably damaging Het
Unc13b T C 4: 43,096,990 (GRCm39) I121T possibly damaging Het
Usp40 T C 1: 87,906,133 (GRCm39) T701A probably benign Het
Xpr1 A G 1: 155,208,145 (GRCm39) probably benign Het
Ywhab T A 2: 163,858,090 (GRCm39) I219N probably damaging Het
Zfp219 G T 14: 52,246,485 (GRCm39) T169K probably damaging Het
Other mutations in Mroh7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01722:Mroh7 APN 4 106,560,358 (GRCm39) missense probably benign 0.00
IGL01729:Mroh7 APN 4 106,561,402 (GRCm39) missense possibly damaging 0.66
IGL01834:Mroh7 APN 4 106,538,071 (GRCm39) missense probably benign 0.00
IGL02003:Mroh7 APN 4 106,559,726 (GRCm39) missense probably damaging 0.96
IGL02135:Mroh7 APN 4 106,559,707 (GRCm39) missense probably damaging 1.00
IGL02335:Mroh7 APN 4 106,564,979 (GRCm39) missense probably damaging 1.00
IGL02532:Mroh7 APN 4 106,577,788 (GRCm39) missense probably benign 0.04
IGL02896:Mroh7 APN 4 106,557,013 (GRCm39) missense possibly damaging 0.94
IGL03066:Mroh7 APN 4 106,549,595 (GRCm39) missense possibly damaging 0.85
IGL03298:Mroh7 APN 4 106,571,288 (GRCm39) nonsense probably null
holy UTSW 4 106,567,152 (GRCm39) splice site probably null
moley UTSW 4 106,551,509 (GRCm39) splice site probably null
P0016:Mroh7 UTSW 4 106,565,054 (GRCm39) critical splice acceptor site probably null
R0094:Mroh7 UTSW 4 106,560,381 (GRCm39) missense probably damaging 0.98
R0105:Mroh7 UTSW 4 106,568,467 (GRCm39) missense possibly damaging 0.49
R0105:Mroh7 UTSW 4 106,568,467 (GRCm39) missense possibly damaging 0.49
R0515:Mroh7 UTSW 4 106,548,861 (GRCm39) missense probably benign 0.01
R0828:Mroh7 UTSW 4 106,557,073 (GRCm39) missense probably damaging 0.99
R0831:Mroh7 UTSW 4 106,537,990 (GRCm39) missense possibly damaging 0.92
R1107:Mroh7 UTSW 4 106,564,791 (GRCm39) splice site probably null
R1301:Mroh7 UTSW 4 106,577,692 (GRCm39) missense probably damaging 0.99
R1456:Mroh7 UTSW 4 106,552,338 (GRCm39) splice site probably benign
R1491:Mroh7 UTSW 4 106,560,255 (GRCm39) missense probably benign 0.11
R1540:Mroh7 UTSW 4 106,560,273 (GRCm39) missense probably benign 0.11
R1560:Mroh7 UTSW 4 106,568,451 (GRCm39) missense possibly damaging 0.78
R1645:Mroh7 UTSW 4 106,577,865 (GRCm39) missense probably benign 0.19
R1804:Mroh7 UTSW 4 106,551,589 (GRCm39) missense possibly damaging 0.76
R2162:Mroh7 UTSW 4 106,557,378 (GRCm39) missense probably damaging 0.96
R2265:Mroh7 UTSW 4 106,578,124 (GRCm39) missense probably benign 0.01
R2866:Mroh7 UTSW 4 106,548,287 (GRCm39) missense probably damaging 1.00
R3716:Mroh7 UTSW 4 106,561,407 (GRCm39) missense probably benign 0.25
R3718:Mroh7 UTSW 4 106,561,407 (GRCm39) missense probably benign 0.25
R4530:Mroh7 UTSW 4 106,577,634 (GRCm39) missense possibly damaging 0.71
R4661:Mroh7 UTSW 4 106,548,710 (GRCm39) critical splice donor site probably null
R4706:Mroh7 UTSW 4 106,548,821 (GRCm39) missense possibly damaging 0.86
R4910:Mroh7 UTSW 4 106,567,152 (GRCm39) splice site probably null
R4965:Mroh7 UTSW 4 106,548,184 (GRCm39) missense possibly damaging 0.77
R4969:Mroh7 UTSW 4 106,538,070 (GRCm39) missense probably benign
R4971:Mroh7 UTSW 4 106,548,749 (GRCm39) missense probably benign 0.04
R5083:Mroh7 UTSW 4 106,547,515 (GRCm39) missense probably benign 0.03
R5207:Mroh7 UTSW 4 106,578,583 (GRCm39) missense probably damaging 0.97
R5364:Mroh7 UTSW 4 106,548,840 (GRCm39) missense probably benign 0.10
R5392:Mroh7 UTSW 4 106,568,448 (GRCm39) critical splice donor site probably null
R5630:Mroh7 UTSW 4 106,577,764 (GRCm39) missense possibly damaging 0.71
R5691:Mroh7 UTSW 4 106,559,815 (GRCm39) missense probably damaging 0.96
R5703:Mroh7 UTSW 4 106,565,757 (GRCm39) missense possibly damaging 0.77
R5707:Mroh7 UTSW 4 106,539,082 (GRCm39) missense possibly damaging 0.73
R5919:Mroh7 UTSW 4 106,551,509 (GRCm39) splice site probably null
R5979:Mroh7 UTSW 4 106,578,123 (GRCm39) missense probably benign 0.00
R6479:Mroh7 UTSW 4 106,560,385 (GRCm39) missense possibly damaging 0.75
R6520:Mroh7 UTSW 4 106,578,460 (GRCm39) missense probably benign 0.00
R6657:Mroh7 UTSW 4 106,559,697 (GRCm39) nonsense probably null
R6732:Mroh7 UTSW 4 106,537,910 (GRCm39) frame shift probably null
R6817:Mroh7 UTSW 4 106,571,312 (GRCm39) missense probably benign 0.00
R6980:Mroh7 UTSW 4 106,557,434 (GRCm39) missense probably benign 0.05
R7062:Mroh7 UTSW 4 106,541,177 (GRCm39) missense probably damaging 1.00
R7116:Mroh7 UTSW 4 106,568,517 (GRCm39) missense probably benign 0.07
R7134:Mroh7 UTSW 4 106,577,791 (GRCm39) missense probably damaging 0.99
R7169:Mroh7 UTSW 4 106,548,836 (GRCm39) missense probably damaging 0.99
R7419:Mroh7 UTSW 4 106,541,115 (GRCm39) missense probably benign
R7516:Mroh7 UTSW 4 106,548,316 (GRCm39) missense probably benign 0.00
R7525:Mroh7 UTSW 4 106,566,899 (GRCm39) missense probably benign 0.22
R7540:Mroh7 UTSW 4 106,577,595 (GRCm39) missense possibly damaging 0.85
R7849:Mroh7 UTSW 4 106,578,287 (GRCm39) missense probably benign
R7920:Mroh7 UTSW 4 106,564,773 (GRCm39) missense probably benign
R7998:Mroh7 UTSW 4 106,568,478 (GRCm39) missense probably benign 0.02
R8026:Mroh7 UTSW 4 106,578,634 (GRCm39) missense probably benign 0.01
R8122:Mroh7 UTSW 4 106,559,726 (GRCm39) missense probably damaging 0.96
R8249:Mroh7 UTSW 4 106,578,409 (GRCm39) missense probably benign 0.00
R9188:Mroh7 UTSW 4 106,566,789 (GRCm39) missense probably benign 0.01
Posted On 2012-12-21