Incidental Mutation 'R1333:Tmem132d'
ID 156770
Institutional Source Beutler Lab
Gene Symbol Tmem132d
Ensembl Gene ENSMUSG00000034310
Gene Name transmembrane protein 132D
Synonyms C630028F04Rik
MMRRC Submission 039398-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # R1333 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 127860555-128510141 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 127861923 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 733 (M733L)
Ref Sequence ENSEMBL: ENSMUSP00000043633 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044441]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000044441
AA Change: M733L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000043633
Gene: ENSMUSG00000034310
AA Change: M733L

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
Pfam:TMEM132D_N 49 178 1.9e-59 PFAM
Pfam:TMEM132 435 778 3.9e-150 PFAM
Pfam:TMEM132D_C 884 970 1.9e-37 PFAM
low complexity region 998 1011 N/A INTRINSIC
Meta Mutation Damage Score 0.0852 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.2%
  • 20x: 90.3%
Validation Efficiency 98% (41/42)
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts18 A G 8: 114,431,805 (GRCm39) probably benign Het
Amph G A 13: 19,326,198 (GRCm39) V643M probably damaging Het
Amt A G 9: 108,178,296 (GRCm39) D301G probably benign Het
Arhgef26 T C 3: 62,247,744 (GRCm39) V276A probably benign Het
Bid C T 6: 120,874,216 (GRCm39) A110T possibly damaging Het
Ccdc63 T C 5: 122,246,224 (GRCm39) T566A probably benign Het
Cdk5rap1 A G 2: 154,202,574 (GRCm39) S219P probably damaging Het
Col1a2 T A 6: 4,515,684 (GRCm39) probably null Het
Ctns G A 11: 73,075,823 (GRCm39) T342I probably benign Het
Dst G A 1: 34,267,428 (GRCm39) E4957K probably damaging Het
Elp1 C T 4: 56,770,969 (GRCm39) probably benign Het
Fam163b A G 2: 27,003,659 (GRCm39) probably benign Het
Frem2 T C 3: 53,457,152 (GRCm39) T2067A probably benign Het
Gm7353 C T 7: 3,159,066 (GRCm39) noncoding transcript Het
Gm9791 T C 3: 34,059,225 (GRCm39) noncoding transcript Het
Grik2 G T 10: 49,404,087 (GRCm39) T258N probably damaging Het
Herc3 T C 6: 58,864,478 (GRCm39) L704P probably damaging Het
Hjurp A C 1: 88,193,768 (GRCm39) V380G probably damaging Het
Lrrc56 A G 7: 140,778,177 (GRCm39) probably benign Het
Mast3 G A 8: 71,233,938 (GRCm39) P187S probably damaging Het
Mier2 A G 10: 79,380,991 (GRCm39) V231A probably benign Het
Muc5b A G 7: 141,422,144 (GRCm39) T4427A possibly damaging Het
Nox4 A G 7: 86,896,072 (GRCm39) S7G possibly damaging Het
Obscn G C 11: 58,971,143 (GRCm39) Q2457E probably damaging Het
Sh3bgrl2 C T 9: 83,459,684 (GRCm39) probably benign Het
Slc1a1 A G 19: 28,812,611 (GRCm39) probably benign Het
Snrnp40 C G 4: 130,271,836 (GRCm39) probably null Het
Stard9 C A 2: 120,504,117 (GRCm39) S221R probably damaging Het
Stat6 G C 10: 127,487,094 (GRCm39) R200S possibly damaging Het
Stxbp5l C A 16: 37,068,231 (GRCm39) probably null Het
Tanc1 A G 2: 59,673,835 (GRCm39) S1647G probably benign Het
Unc13d A G 11: 115,964,381 (GRCm39) probably benign Het
Usp24 T C 4: 106,199,550 (GRCm39) S165P possibly damaging Het
Vmn1r9 T C 6: 57,048,615 (GRCm39) I230T probably damaging Het
Zscan20 T C 4: 128,481,889 (GRCm39) D591G possibly damaging Het
Other mutations in Tmem132d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Tmem132d APN 5 127,861,896 (GRCm39) missense possibly damaging 0.77
IGL01393:Tmem132d APN 5 127,861,702 (GRCm39) missense probably benign 0.31
IGL01482:Tmem132d APN 5 128,346,270 (GRCm39) missense probably damaging 0.96
IGL01785:Tmem132d APN 5 128,061,379 (GRCm39) missense probably benign 0.00
IGL02409:Tmem132d APN 5 127,861,952 (GRCm39) missense probably damaging 1.00
IGL02539:Tmem132d APN 5 127,861,043 (GRCm39) missense probably benign 0.01
IGL03411:Tmem132d APN 5 128,061,347 (GRCm39) nonsense probably null
R0113:Tmem132d UTSW 5 127,861,657 (GRCm39) missense probably benign 0.11
R0420:Tmem132d UTSW 5 127,941,710 (GRCm39) missense probably benign 0.26
R0437:Tmem132d UTSW 5 127,866,849 (GRCm39) missense probably damaging 0.99
R0468:Tmem132d UTSW 5 128,346,267 (GRCm39) missense probably damaging 1.00
R0564:Tmem132d UTSW 5 127,861,842 (GRCm39) missense probably damaging 1.00
R0659:Tmem132d UTSW 5 128,061,351 (GRCm39) missense possibly damaging 0.94
R0924:Tmem132d UTSW 5 128,061,503 (GRCm39) splice site probably benign
R1209:Tmem132d UTSW 5 127,861,934 (GRCm39) missense probably damaging 1.00
R1378:Tmem132d UTSW 5 128,346,011 (GRCm39) missense probably benign 0.43
R1741:Tmem132d UTSW 5 127,861,922 (GRCm39) missense probably benign 0.30
R1753:Tmem132d UTSW 5 127,866,919 (GRCm39) missense probably benign 0.02
R1944:Tmem132d UTSW 5 127,860,828 (GRCm39) makesense probably null
R1974:Tmem132d UTSW 5 128,346,263 (GRCm39) missense probably damaging 0.99
R2035:Tmem132d UTSW 5 127,869,522 (GRCm39) missense probably damaging 1.00
R2065:Tmem132d UTSW 5 127,861,505 (GRCm39) missense probably benign
R2074:Tmem132d UTSW 5 128,346,195 (GRCm39) missense probably damaging 1.00
R2276:Tmem132d UTSW 5 127,872,987 (GRCm39) missense probably damaging 1.00
R2297:Tmem132d UTSW 5 128,345,608 (GRCm39) missense possibly damaging 0.69
R2424:Tmem132d UTSW 5 127,941,663 (GRCm39) missense probably benign 0.09
R2902:Tmem132d UTSW 5 127,860,832 (GRCm39) missense probably benign
R3053:Tmem132d UTSW 5 127,869,538 (GRCm39) missense probably benign 0.15
R3836:Tmem132d UTSW 5 127,861,949 (GRCm39) missense probably damaging 1.00
R4127:Tmem132d UTSW 5 128,345,884 (GRCm39) missense probably benign 0.35
R4236:Tmem132d UTSW 5 128,509,389 (GRCm39) missense possibly damaging 0.89
R4358:Tmem132d UTSW 5 128,061,405 (GRCm39) missense possibly damaging 0.92
R4610:Tmem132d UTSW 5 128,061,360 (GRCm39) missense probably benign 0.29
R4686:Tmem132d UTSW 5 127,869,674 (GRCm39) missense possibly damaging 0.55
R4814:Tmem132d UTSW 5 128,061,328 (GRCm39) missense probably benign 0.01
R4883:Tmem132d UTSW 5 128,346,366 (GRCm39) missense possibly damaging 0.79
R4883:Tmem132d UTSW 5 128,346,364 (GRCm39) missense probably damaging 0.99
R4939:Tmem132d UTSW 5 127,873,139 (GRCm39) missense probably damaging 1.00
R5579:Tmem132d UTSW 5 127,873,064 (GRCm39) missense possibly damaging 0.67
R5652:Tmem132d UTSW 5 127,861,859 (GRCm39) missense possibly damaging 0.88
R5801:Tmem132d UTSW 5 127,861,964 (GRCm39) missense possibly damaging 0.50
R5900:Tmem132d UTSW 5 128,346,336 (GRCm39) missense probably damaging 1.00
R5980:Tmem132d UTSW 5 127,861,662 (GRCm39) missense probably benign 0.13
R6048:Tmem132d UTSW 5 128,346,181 (GRCm39) missense probably benign 0.03
R6057:Tmem132d UTSW 5 127,861,934 (GRCm39) missense probably damaging 1.00
R6084:Tmem132d UTSW 5 127,861,164 (GRCm39) missense probably benign 0.06
R6505:Tmem132d UTSW 5 127,861,502 (GRCm39) missense probably benign 0.00
R6522:Tmem132d UTSW 5 127,860,832 (GRCm39) missense probably benign
R6540:Tmem132d UTSW 5 128,345,596 (GRCm39) missense possibly damaging 0.87
R6717:Tmem132d UTSW 5 127,861,485 (GRCm39) missense probably benign
R7158:Tmem132d UTSW 5 128,214,083 (GRCm39) missense possibly damaging 0.81
R7287:Tmem132d UTSW 5 128,061,415 (GRCm39) missense probably damaging 0.96
R7526:Tmem132d UTSW 5 127,861,205 (GRCm39) nonsense probably null
R7826:Tmem132d UTSW 5 127,866,953 (GRCm39) missense probably damaging 1.00
R7864:Tmem132d UTSW 5 127,860,980 (GRCm39) missense probably damaging 1.00
R8124:Tmem132d UTSW 5 127,869,624 (GRCm39) missense probably damaging 1.00
R8543:Tmem132d UTSW 5 128,345,799 (GRCm39) missense probably benign 0.00
R8694:Tmem132d UTSW 5 127,869,495 (GRCm39) missense probably benign 0.06
R8936:Tmem132d UTSW 5 127,869,676 (GRCm39) missense probably damaging 1.00
R9017:Tmem132d UTSW 5 128,346,316 (GRCm39) missense probably benign 0.00
R9017:Tmem132d UTSW 5 127,866,936 (GRCm39) missense probably benign 0.00
R9163:Tmem132d UTSW 5 127,869,570 (GRCm39) missense possibly damaging 0.82
R9257:Tmem132d UTSW 5 127,861,491 (GRCm39) nonsense probably null
R9645:Tmem132d UTSW 5 128,346,075 (GRCm39) missense probably damaging 1.00
R9667:Tmem132d UTSW 5 128,061,375 (GRCm39) missense possibly damaging 0.79
R9711:Tmem132d UTSW 5 127,869,579 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- AGGTGTCCACTCTCACTGCTGTTG -3'
(R):5'- TGGTAAAGCATCTCGTGGCTTTCTC -3'

Sequencing Primer
(F):5'- GTCCAAATTTAACCTTGATGCTGG -3'
(R):5'- cacagacagagacagagacag -3'
Posted On 2014-02-11