Incidental Mutation 'R0036:Sdr16c6'
ID 15680
Institutional Source Beutler Lab
Gene Symbol Sdr16c6
Ensembl Gene ENSMUSG00000071019
Gene Name short chain dehydrogenase/reductase family 16C, member 6
Synonyms 4833413O15Rik
MMRRC Submission 038330-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.057) question?
Stock # R0036 (G1)
Quality Score
Status Validated
Chromosome 4
Chromosomal Location 4055929-4077522 bp(-) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) C to A at 4063335 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000104020 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095151] [ENSMUST00000108383]
AlphaFold Q05A13
Predicted Effect probably benign
Transcript: ENSMUST00000095151
SMART Domains Protein: ENSMUSP00000092773
Gene: ENSMUSG00000071019

DomainStartEndE-ValueType
Pfam:KR 37 200 1.1e-14 PFAM
Pfam:adh_short 37 235 1.4e-46 PFAM
Pfam:adh_short_C2 43 211 1.7e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108383
SMART Domains Protein: ENSMUSP00000104020
Gene: ENSMUSG00000071019

DomainStartEndE-ValueType
Pfam:adh_short 37 205 2e-32 PFAM
Pfam:KR 38 200 4.4e-15 PFAM
Pfam:adh_short_C2 43 214 4.1e-14 PFAM
low complexity region 235 241 N/A INTRINSIC
Coding Region Coverage
  • 1x: 79.1%
  • 3x: 69.3%
  • 10x: 43.3%
  • 20x: 23.5%
Validation Efficiency 91% (49/54)
Allele List at MGI
Other mutations in this stock
Total: 17 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700028P14Rik A T 19: 23,616,568 probably benign Het
Cfap44 A G 16: 44,439,069 E1098G possibly damaging Het
Ctsq C T 13: 61,037,671 probably null Het
Dock9 C T 14: 121,622,853 V886M probably damaging Het
Eaf2 T C 16: 36,800,658 Y224C probably benign Het
Eif5b T A 1: 38,019,111 S165T probably benign Het
Eln A G 5: 134,711,060 probably null Het
Jakmip1 A G 5: 37,134,304 K514R probably null Het
Myo1e T A 9: 70,341,308 W435R probably damaging Het
Nadsyn1 T C 7: 143,811,291 I226V probably benign Het
Nedd4l T C 18: 65,051,123 probably benign Het
Phrf1 T C 7: 141,261,780 M1435T probably damaging Het
Ppic A T 18: 53,409,192 I148N probably damaging Het
Sgo2a T C 1: 58,015,628 S324P probably benign Het
Slf1 G T 13: 77,100,951 Q373K probably benign Het
Tfg G T 16: 56,690,995 Q324K probably benign Het
Wdr64 G T 1: 175,728,930 G248* probably null Het
Other mutations in Sdr16c6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01463:Sdr16c6 APN 4 4063238 missense probably damaging 1.00
IGL02801:Sdr16c6 APN 4 4076603 missense probably benign 0.00
R1054:Sdr16c6 UTSW 4 4069908 missense probably damaging 1.00
R1778:Sdr16c6 UTSW 4 4058814 missense probably benign 0.00
R1928:Sdr16c6 UTSW 4 4069926 missense probably damaging 0.98
R1930:Sdr16c6 UTSW 4 4058809 missense probably benign 0.02
R2385:Sdr16c6 UTSW 4 4062671 missense probably damaging 0.99
R4865:Sdr16c6 UTSW 4 4058834 missense probably benign
R5342:Sdr16c6 UTSW 4 4069923 missense probably damaging 1.00
R5637:Sdr16c6 UTSW 4 4063232 missense possibly damaging 0.87
R5841:Sdr16c6 UTSW 4 4062728 missense possibly damaging 0.96
R6233:Sdr16c6 UTSW 4 4069984 missense probably damaging 1.00
R6977:Sdr16c6 UTSW 4 4076865 missense probably benign
R7423:Sdr16c6 UTSW 4 4076921 splice site probably benign
R7460:Sdr16c6 UTSW 4 4076575 critical splice donor site probably null
R7623:Sdr16c6 UTSW 4 4058801 missense not run
R8220:Sdr16c6 UTSW 4 4076872 missense probably benign 0.24
R8338:Sdr16c6 UTSW 4 4076620 missense probably damaging 1.00
Z1176:Sdr16c6 UTSW 4 4063308 missense probably damaging 1.00
Posted On 2012-12-21