Incidental Mutation 'R1336:Fcrl6'
| ID |
156862 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fcrl6
|
| Ensembl Gene |
ENSMUSG00000070504 |
| Gene Name |
Fc receptor-like 6 |
| Synonyms |
FcRH6, moFcRH6, mIFGP6, ENSMUSG00000070504 |
| MMRRC Submission |
039401-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1336 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
172424209-172430118 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to A
at 172426791 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 52
(Q52*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000091861
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094303]
|
| AlphaFold |
A1YIY0 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000094303
AA Change: Q52*
|
| SMART Domains |
Protein: ENSMUSP00000091861
Gene: ENSMUSG00000070504
AA Change: Q52*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
16 |
N/A |
INTRINSIC |
|
Pfam:Ig_3
|
19 |
91 |
1.2e-4 |
PFAM |
|
Pfam:Ig_2
|
20 |
106 |
8e-9 |
PFAM |
|
Pfam:Ig_3
|
113 |
187 |
1.9e-9 |
PFAM |
|
transmembrane domain
|
215 |
237 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193431
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193566
|
| Coding Region Coverage |
- 1x: 98.5%
- 3x: 97.1%
- 10x: 92.3%
- 20x: 80.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 20 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Asah2 |
A |
G |
19: 32,022,341 (GRCm39) |
I231T |
probably damaging |
Het |
| Bbs7 |
A |
G |
3: 36,658,593 (GRCm39) |
I227T |
probably benign |
Het |
| Ccdc141 |
T |
C |
2: 76,844,784 (GRCm39) |
T1428A |
probably damaging |
Het |
| Chsy1 |
C |
A |
7: 65,774,987 (GRCm39) |
|
probably null |
Het |
| Cox16 |
T |
C |
12: 81,519,064 (GRCm39) |
D89G |
probably damaging |
Het |
| Dnah17 |
A |
G |
11: 117,934,041 (GRCm39) |
I3511T |
possibly damaging |
Het |
| Dpy19l4 |
A |
T |
4: 11,276,901 (GRCm39) |
Y333N |
probably damaging |
Het |
| Fgl2 |
T |
A |
5: 21,578,181 (GRCm39) |
L156Q |
possibly damaging |
Het |
| Fras1 |
A |
G |
5: 96,855,167 (GRCm39) |
D1892G |
probably benign |
Het |
| Ogfod1 |
T |
C |
8: 94,784,727 (GRCm39) |
C344R |
probably damaging |
Het |
| Papss2 |
T |
C |
19: 32,615,715 (GRCm39) |
V149A |
possibly damaging |
Het |
| Plekhm3 |
CCTGCTGCTGCTGCTGCTGCTGCTGC |
CCTGCTGCTGCTGCTGCTGCTGC |
1: 64,976,940 (GRCm39) |
|
probably benign |
Het |
| Pmfbp1 |
T |
G |
8: 110,256,898 (GRCm39) |
I534S |
probably damaging |
Het |
| Rif1 |
T |
A |
2: 51,968,326 (GRCm39) |
W170R |
probably benign |
Het |
| Ros1 |
G |
A |
10: 52,044,758 (GRCm39) |
T183I |
probably damaging |
Het |
| Snx4 |
T |
C |
16: 33,101,050 (GRCm39) |
I234T |
probably benign |
Het |
| Sptbn4 |
A |
G |
7: 27,117,388 (GRCm39) |
S454P |
probably damaging |
Het |
| Stard9 |
C |
A |
2: 120,504,117 (GRCm39) |
S221R |
probably damaging |
Het |
| Uck1 |
T |
C |
2: 32,149,666 (GRCm39) |
D71G |
probably damaging |
Het |
| Vcan |
C |
T |
13: 89,841,174 (GRCm39) |
E497K |
probably damaging |
Het |
|
| Other mutations in Fcrl6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00903:Fcrl6
|
APN |
1 |
172,426,674 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01074:Fcrl6
|
APN |
1 |
172,426,680 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02146:Fcrl6
|
APN |
1 |
172,426,264 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02277:Fcrl6
|
APN |
1 |
172,426,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03162:Fcrl6
|
APN |
1 |
172,425,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03303:Fcrl6
|
APN |
1 |
172,425,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
K3955:Fcrl6
|
UTSW |
1 |
172,425,251 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0051:Fcrl6
|
UTSW |
1 |
172,426,320 (GRCm39) |
missense |
probably benign |
0.24 |
|
R0051:Fcrl6
|
UTSW |
1 |
172,426,320 (GRCm39) |
missense |
probably benign |
0.24 |
|
R2125:Fcrl6
|
UTSW |
1 |
172,426,815 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2126:Fcrl6
|
UTSW |
1 |
172,426,815 (GRCm39) |
missense |
probably benign |
0.41 |
|
R5376:Fcrl6
|
UTSW |
1 |
172,426,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5395:Fcrl6
|
UTSW |
1 |
172,426,287 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6314:Fcrl6
|
UTSW |
1 |
172,426,186 (GRCm39) |
splice site |
probably null |
|
|
R7525:Fcrl6
|
UTSW |
1 |
172,425,239 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7690:Fcrl6
|
UTSW |
1 |
172,426,223 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8033:Fcrl6
|
UTSW |
1 |
172,426,748 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8894:Fcrl6
|
UTSW |
1 |
172,426,856 (GRCm39) |
missense |
probably benign |
0.05 |
|
U24488:Fcrl6
|
UTSW |
1 |
172,426,437 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTTCATGTTGCAGAGTGAGCACAG -3'
(R):5'- TGCAGAAGATCAGTCCTCAGTCTCC -3'
Sequencing Primer
(F):5'- GCCTGATATCTGGACCCATTAGTAG -3'
(R):5'- CATGTCTCCCCAGAGTTGTT -3'
|
| Posted On |
2014-02-11 |
Incidental Mutation