Mutagenetix > Incidental Mutations

Incidental Mutation 'R1336:Fcrl6'

156862

Institutional Source

Beutler Lab

Gene Symbol

Fcrl6

Ensembl Gene

ENSMUSG00000070504

Gene Name

Fc receptor-like 6

Synonyms

ENSMUSG00000070504, mIFGP6, moFcRH6, FcRH6

MMRRC Submission

039401-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1336 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

172596642-172602551 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 172599224 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 52 (Q52*)

Ref Sequence

ENSEMBL: ENSMUSP00000091861 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094303]

Predicted Effect

probably null
Transcript: ENSMUST00000094303
AA Change: Q52*

SMART Domains

Protein: ENSMUSP00000091861
Gene: ENSMUSG00000070504
AA Change: Q52*

Domain	Start	End	E-Value	Type
signal peptide	1	16	N/A	INTRINSIC
Pfam:Ig_3	19	91	1.2e-4	PFAM
Pfam:Ig_2	20	106	8e-9	PFAM
Pfam:Ig_3	113	187	1.9e-9	PFAM
transmembrane domain	215	237	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193431

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000193566

Coding Region Coverage

1x: 98.5%
3x: 97.1%
10x: 92.3%
20x: 80.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Asah2	A	G	19: 32,044,941	I231T	probably damaging	Het
Bbs7	A	G	3: 36,604,444	I227T	probably benign	Het
Ccdc141	T	C	2: 77,014,440	T1428A	probably damaging	Het
Chsy1	C	A	7: 66,125,239		probably null	Het
Cox16	T	C	12: 81,472,290	D89G	probably damaging	Het
Dnah17	A	G	11: 118,043,215	I3511T	possibly damaging	Het
Dpy19l4	A	T	4: 11,276,901	Y333N	probably damaging	Het
Fgl2	T	A	5: 21,373,183	L156Q	possibly damaging	Het
Fras1	A	G	5: 96,707,308	D1892G	probably benign	Het
Ogfod1	T	C	8: 94,058,099	C344R	probably damaging	Het
Papss2	T	C	19: 32,638,315	V149A	possibly damaging	Het
Plekhm3	CCTGCTGCTGCTGCTGCTGCTGCTGC	CCTGCTGCTGCTGCTGCTGCTGC	1: 64,937,781		probably benign	Het
Pmfbp1	T	G	8: 109,530,266	I534S	probably damaging	Het
Rif1	T	A	2: 52,078,314	W170R	probably benign	Het
Ros1	G	A	10: 52,168,662	T183I	probably damaging	Het
Snx4	T	C	16: 33,280,680	I234T	probably benign	Het
Sptbn4	A	G	7: 27,417,963	S454P	probably damaging	Het
Stard9	C	A	2: 120,673,636	S221R	probably damaging	Het
Uck1	T	C	2: 32,259,654	D71G	probably damaging	Het
Vcan	C	T	13: 89,693,055	E497K	probably damaging	Het

Other mutations in Fcrl6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00903:Fcrl6	APN	1	172599107	missense	probably benign	0.08
IGL01074:Fcrl6	APN	1	172599113	missense	possibly damaging	0.89
IGL02146:Fcrl6	APN	1	172598697	missense	probably benign	0.01
IGL02277:Fcrl6	APN	1	172599119	missense	probably damaging	1.00
IGL03162:Fcrl6	APN	1	172598253	missense	probably damaging	1.00
IGL03303:Fcrl6	APN	1	172597688	missense	probably damaging	0.99
K3955:Fcrl6	UTSW	1	172597684	missense	probably benign	0.00
R0051:Fcrl6	UTSW	1	172598753	missense	probably benign	0.24
R0051:Fcrl6	UTSW	1	172598753	missense	probably benign	0.24
R2125:Fcrl6	UTSW	1	172599248	missense	probably benign	0.41
R2126:Fcrl6	UTSW	1	172599248	missense	probably benign	0.41
R5376:Fcrl6	UTSW	1	172599280	missense	probably damaging	1.00
R5395:Fcrl6	UTSW	1	172598720	missense	possibly damaging	0.55
R6314:Fcrl6	UTSW	1	172598619	splice site	probably null
R7525:Fcrl6	UTSW	1	172597672	missense	probably benign	0.25
R7690:Fcrl6	UTSW	1	172598656	missense	probably damaging	0.97
R8033:Fcrl6	UTSW	1	172599181	missense	probably benign	0.03
U24488:Fcrl6	UTSW	1	172598870	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- GCTTCATGTTGCAGAGTGAGCACAG -3'
(R):5'- TGCAGAAGATCAGTCCTCAGTCTCC -3'

Sequencing Primer
(F):5'- GCCTGATATCTGGACCCATTAGTAG -3'
(R):5'- CATGTCTCCCCAGAGTTGTT -3'

Posted On

2014-02-11