Incidental Mutation 'R1337:Larp1b'
ID 156894
Institutional Source Beutler Lab
Gene Symbol Larp1b
Ensembl Gene ENSMUSG00000025762
Gene Name La ribonucleoprotein 1B
Synonyms 4933421B21Rik, Larp2, 1700108L22Rik
MMRRC Submission 039402-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1337 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 40904263-40994669 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 40987837 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 20 (P20S)
Ref Sequence ENSEMBL: ENSMUSP00000096721 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026862] [ENSMUST00000099121]
AlphaFold F6U5V1
Predicted Effect probably benign
Transcript: ENSMUST00000026862
SMART Domains Protein: ENSMUSP00000026862
Gene: ENSMUSG00000025762

DomainStartEndE-ValueType
low complexity region 75 85 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000065411
SMART Domains Protein: ENSMUSP00000066664
Gene: ENSMUSG00000025762

DomainStartEndE-ValueType
Blast:DM15 31 65 1e-16 BLAST
low complexity region 119 129 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000099121
AA Change: P20S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000096721
Gene: ENSMUSG00000025762
AA Change: P20S

DomainStartEndE-ValueType
low complexity region 8 21 N/A INTRINSIC
DM15 52 93 6.61e-18 SMART
DM15 94 132 5.75e-18 SMART
DM15 133 167 2.82e-1 SMART
low complexity region 221 231 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191882
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192456
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194006
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199797
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197214
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730522E02Rik A G 11: 25,719,033 (GRCm39) S37P unknown Het
Abca12 T C 1: 71,333,978 (GRCm39) I1175V probably benign Het
Ager G T 17: 34,819,596 (GRCm39) probably null Het
Amph G A 13: 19,326,198 (GRCm39) V643M probably damaging Het
Cacna1c A G 6: 118,604,416 (GRCm39) I1278T probably damaging Het
Casp8ap2 T C 4: 32,645,721 (GRCm39) V1598A possibly damaging Het
Cdk12 T C 11: 98,136,497 (GRCm39) probably null Het
Ces2g A T 8: 105,690,597 (GRCm39) Y126F possibly damaging Het
Ehbp1l1 A T 19: 5,768,258 (GRCm39) M1015K probably benign Het
Engase A G 11: 118,373,400 (GRCm39) T248A possibly damaging Het
Gsdma C T 11: 98,560,533 (GRCm39) Q162* probably null Het
Hapln3 T C 7: 78,767,824 (GRCm39) E190G probably benign Het
Hdc T C 2: 126,458,196 (GRCm39) Q42R probably benign Het
Macf1 T G 4: 123,370,068 (GRCm39) R1564S probably benign Het
Muc5b A G 7: 141,412,361 (GRCm39) Y1769C unknown Het
Nup88 T A 11: 70,835,716 (GRCm39) Q576L probably damaging Het
Or51f1 T C 7: 102,506,078 (GRCm39) N137S probably benign Het
Or7g21 A G 9: 19,033,099 (GRCm39) I280V probably benign Het
Prune2 C T 19: 17,096,971 (GRCm39) S825L possibly damaging Het
Ryr3 C A 2: 112,610,308 (GRCm39) M2301I possibly damaging Het
Sdk2 A C 11: 113,723,157 (GRCm39) V1278G possibly damaging Het
Sertad3 T C 7: 27,175,866 (GRCm39) L100P probably damaging Het
Slco5a1 T C 1: 13,009,366 (GRCm39) T370A probably benign Het
Srrm1 A G 4: 135,074,044 (GRCm39) probably null Het
Stk32a A G 18: 43,394,414 (GRCm39) D121G probably benign Het
Ttc7 A T 17: 87,597,724 (GRCm39) R99W probably damaging Het
Xkr9 C A 1: 13,771,348 (GRCm39) S288Y possibly damaging Het
Zfp644 A G 5: 106,785,420 (GRCm39) S376P probably damaging Het
Other mutations in Larp1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01506:Larp1b APN 3 40,987,875 (GRCm39) nonsense probably null
IGL01636:Larp1b APN 3 40,924,913 (GRCm39) missense probably benign 0.35
IGL01845:Larp1b APN 3 40,924,960 (GRCm39) missense probably benign 0.03
IGL02192:Larp1b APN 3 40,921,929 (GRCm39) missense probably benign 0.01
IGL03372:Larp1b APN 3 40,978,962 (GRCm39) missense possibly damaging 0.79
R0396:Larp1b UTSW 3 40,924,996 (GRCm39) missense probably damaging 1.00
R0512:Larp1b UTSW 3 40,924,469 (GRCm39) missense probably benign 0.00
R0975:Larp1b UTSW 3 40,924,925 (GRCm39) missense probably damaging 0.99
R1119:Larp1b UTSW 3 40,987,963 (GRCm39) missense possibly damaging 0.87
R1460:Larp1b UTSW 3 40,916,653 (GRCm39) missense probably benign
R1565:Larp1b UTSW 3 40,926,819 (GRCm39) missense probably damaging 1.00
R1589:Larp1b UTSW 3 40,987,909 (GRCm39) missense probably damaging 1.00
R1640:Larp1b UTSW 3 40,988,507 (GRCm39) start codon destroyed probably null 0.04
R1899:Larp1b UTSW 3 40,918,519 (GRCm39) missense probably benign 0.04
R2133:Larp1b UTSW 3 40,924,970 (GRCm39) missense possibly damaging 0.69
R3054:Larp1b UTSW 3 40,918,535 (GRCm39) missense probably benign 0.10
R4621:Larp1b UTSW 3 40,918,424 (GRCm39) missense possibly damaging 0.71
R4818:Larp1b UTSW 3 40,925,005 (GRCm39) missense probably damaging 1.00
R5023:Larp1b UTSW 3 40,988,420 (GRCm39) missense possibly damaging 0.88
R5166:Larp1b UTSW 3 40,918,487 (GRCm39) nonsense probably null
R5357:Larp1b UTSW 3 40,978,950 (GRCm39) missense probably benign 0.04
R5364:Larp1b UTSW 3 40,931,658 (GRCm39) missense probably damaging 0.99
R5492:Larp1b UTSW 3 40,924,334 (GRCm39) missense probably damaging 0.99
R5495:Larp1b UTSW 3 40,990,257 (GRCm39) missense probably damaging 1.00
R7070:Larp1b UTSW 3 40,931,086 (GRCm39) missense probably damaging 1.00
R7293:Larp1b UTSW 3 40,939,879 (GRCm39) missense
R7615:Larp1b UTSW 3 40,990,251 (GRCm39) missense probably benign 0.01
R7615:Larp1b UTSW 3 40,987,969 (GRCm39) missense possibly damaging 0.79
R7717:Larp1b UTSW 3 40,926,879 (GRCm39) missense probably damaging 0.97
R8060:Larp1b UTSW 3 40,939,837 (GRCm39) missense
R8282:Larp1b UTSW 3 40,991,245 (GRCm39) missense probably damaging 0.99
R8429:Larp1b UTSW 3 40,931,662 (GRCm39) makesense probably null
R8458:Larp1b UTSW 3 40,930,995 (GRCm39) missense probably benign 0.00
R9189:Larp1b UTSW 3 40,925,039 (GRCm39) missense probably damaging 1.00
R9468:Larp1b UTSW 3 40,930,990 (GRCm39) missense probably benign 0.00
R9628:Larp1b UTSW 3 40,916,103 (GRCm39) critical splice donor site probably null
X0021:Larp1b UTSW 3 40,921,929 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GATACTGCGAAGCTGCTAGACAGG -3'
(R):5'- GCACGGGCATCTTACCACTTAGAC -3'

Sequencing Primer
(F):5'- GGATCTTCTGTGTCCACCTCTG -3'
(R):5'- GCATCTTACCACTTAGACTGAGC -3'
Posted On 2014-02-11