Incidental Mutation 'R1340:Or1l4b'
ID 156982
Institutional Source Beutler Lab
Gene Symbol Or1l4b
Ensembl Gene ENSMUSG00000078198
Gene Name olfactory receptor family 1 subfamily L member 4B
Synonyms MOR138-4P, Olfr364, MOR138-7, GA_x6K02T2NLDC-33831282-33832243
MMRRC Submission 039405-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R1340 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 37036226-37037149 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 37036769 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Valine at position 182 (L182V)
Ref Sequence ENSEMBL: ENSMUSP00000151166 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000104995] [ENSMUST00000214905] [ENSMUST00000217298]
AlphaFold A0A140T8Q2
Predicted Effect probably benign
Transcript: ENSMUST00000104995
AA Change: L182V

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000100611
Gene: ENSMUSG00000078198
AA Change: L182V

DomainStartEndE-ValueType
Pfam:7tm_4 28 303 4.8e-58 PFAM
Pfam:7tm_1 38 287 5e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214905
AA Change: L182V

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000217298
AA Change: L182V

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.4%
  • 20x: 89.9%
Validation Efficiency 100% (52/52)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 A T 6: 142,628,581 (GRCm39) probably benign Het
Acat3 C T 17: 13,148,564 (GRCm39) probably benign Het
Actn1 T C 12: 80,219,918 (GRCm39) probably null Het
Adam8 G A 7: 139,571,290 (GRCm39) S38F probably damaging Het
Aldh9a1 T G 1: 167,184,913 (GRCm39) I275S probably benign Het
Alkbh2 C T 5: 114,262,287 (GRCm39) E148K probably damaging Het
Alms1 G A 6: 85,644,939 (GRCm39) probably null Het
Bltp3a A G 17: 28,113,695 (GRCm39) N1289S probably benign Het
Cacna1d A G 14: 29,794,024 (GRCm39) V1539A probably damaging Het
Cacna1e A G 1: 154,348,403 (GRCm39) L724P probably damaging Het
Ccdc110 A G 8: 46,395,218 (GRCm39) T370A probably benign Het
Ccdc9 G A 7: 16,009,315 (GRCm39) probably benign Het
Cep120 A T 18: 53,857,463 (GRCm39) V334E probably damaging Het
Ces3a C T 8: 105,784,545 (GRCm39) P462L probably damaging Het
Cgref1 A G 5: 31,102,690 (GRCm39) probably benign Het
Cndp1 G A 18: 84,652,777 (GRCm39) probably benign Het
Csrnp3 T A 2: 65,832,740 (GRCm39) F81Y probably damaging Het
Ddr2 T C 1: 169,825,653 (GRCm39) T316A probably benign Het
Dync1h1 G A 12: 110,602,943 (GRCm39) E2195K probably benign Het
Epb41l5 A T 1: 119,476,861 (GRCm39) *740R probably null Het
Gfpt2 A G 11: 49,723,688 (GRCm39) K559E probably damaging Het
Gm2381 A G 7: 42,469,828 (GRCm39) Y99H possibly damaging Het
Gsdma2 T C 11: 98,548,475 (GRCm39) V242A probably damaging Het
Lrp1b T C 2: 40,592,806 (GRCm39) N3771S probably benign Het
Lrriq4 A C 3: 30,704,472 (GRCm39) T167P possibly damaging Het
Mtarc2 T C 1: 184,554,744 (GRCm39) T254A probably benign Het
Naip2 G A 13: 100,325,630 (GRCm39) L93F possibly damaging Het
Nefh G GNNNNNNNNNNNNNNNNNN 11: 4,891,002 (GRCm39) probably benign Het
Nrp1 T C 8: 129,160,836 (GRCm39) S321P probably damaging Het
Nt5c1b T C 12: 10,427,276 (GRCm39) V342A probably damaging Het
Nt5c3 A G 6: 56,860,018 (GRCm39) M273T probably benign Het
Or12j2 A G 7: 139,916,038 (GRCm39) T88A probably benign Het
Or6b1 G A 6: 42,814,943 (GRCm39) V43M probably benign Het
Polr3f A G 2: 144,380,548 (GRCm39) H297R probably benign Het
Ptgs2 T G 1: 149,981,228 (GRCm39) F504V probably damaging Het
Ptpro C T 6: 137,418,079 (GRCm39) P142L possibly damaging Het
Rps17 A G 7: 80,993,481 (GRCm39) probably null Het
Ryr1 A G 7: 28,815,437 (GRCm39) S132P probably damaging Het
Sacs T C 14: 61,441,958 (GRCm39) S1335P probably damaging Het
Senp6 T C 9: 80,029,305 (GRCm39) V383A possibly damaging Het
Skint7 T C 4: 111,837,416 (GRCm39) F65L probably damaging Het
Slc35f1 T C 10: 52,965,550 (GRCm39) Y322H probably damaging Het
Slc38a4 C A 15: 96,908,153 (GRCm39) probably benign Het
Sned1 G A 1: 93,209,376 (GRCm39) V830M possibly damaging Het
Sox15 T A 11: 69,546,373 (GRCm39) S59T probably damaging Het
Srcap T A 7: 127,159,910 (GRCm39) probably benign Het
Txlnb A T 10: 17,718,488 (GRCm39) I440F probably damaging Het
Vmn1r178 A G 7: 23,593,281 (GRCm39) S37G probably benign Het
Vmn2r75 T C 7: 85,797,798 (GRCm39) T672A probably damaging Het
Wscd1 T C 11: 71,659,586 (GRCm39) V222A probably benign Het
Other mutations in Or1l4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00264:Or1l4b APN 2 37,037,079 (GRCm39) missense probably damaging 1.00
IGL01550:Or1l4b APN 2 37,036,986 (GRCm39) missense probably damaging 1.00
IGL01791:Or1l4b APN 2 37,036,548 (GRCm39) missense probably damaging 1.00
IGL01886:Or1l4b APN 2 37,036,521 (GRCm39) missense probably damaging 1.00
IGL02680:Or1l4b APN 2 37,036,427 (GRCm39) missense probably damaging 1.00
IGL03003:Or1l4b APN 2 37,036,464 (GRCm39) missense probably benign 0.00
IGL03289:Or1l4b APN 2 37,036,590 (GRCm39) missense probably damaging 1.00
R0627:Or1l4b UTSW 2 37,036,342 (GRCm39) missense probably damaging 0.96
R1163:Or1l4b UTSW 2 37,037,039 (GRCm39) missense probably damaging 1.00
R1253:Or1l4b UTSW 2 37,036,884 (GRCm39) missense possibly damaging 0.89
R1542:Or1l4b UTSW 2 37,036,978 (GRCm39) missense probably damaging 1.00
R1633:Or1l4b UTSW 2 37,036,983 (GRCm39) missense probably damaging 0.99
R2935:Or1l4b UTSW 2 37,037,123 (GRCm39) missense possibly damaging 0.75
R2982:Or1l4b UTSW 2 37,036,393 (GRCm39) missense probably damaging 0.99
R3855:Or1l4b UTSW 2 37,036,835 (GRCm39) missense possibly damaging 0.95
R4849:Or1l4b UTSW 2 37,036,266 (GRCm39) missense probably damaging 0.97
R4903:Or1l4b UTSW 2 37,036,383 (GRCm39) missense probably benign 0.35
R5160:Or1l4b UTSW 2 37,036,815 (GRCm39) missense probably benign 0.03
R7092:Or1l4b UTSW 2 37,036,623 (GRCm39) missense probably damaging 1.00
R7108:Or1l4b UTSW 2 37,036,272 (GRCm39) missense probably benign 0.00
R7143:Or1l4b UTSW 2 37,036,886 (GRCm39) missense probably benign 0.00
R7278:Or1l4b UTSW 2 37,037,021 (GRCm39) missense probably benign 0.29
R7630:Or1l4b UTSW 2 37,036,371 (GRCm39) missense probably damaging 1.00
R7754:Or1l4b UTSW 2 37,036,858 (GRCm39) missense possibly damaging 0.83
R7888:Or1l4b UTSW 2 37,036,334 (GRCm39) missense probably benign
R8342:Or1l4b UTSW 2 37,036,778 (GRCm39) missense probably damaging 1.00
R8768:Or1l4b UTSW 2 37,037,016 (GRCm39) missense probably benign 0.02
R9063:Or1l4b UTSW 2 37,036,646 (GRCm39) missense probably benign
R9079:Or1l4b UTSW 2 37,036,989 (GRCm39) missense probably damaging 1.00
R9086:Or1l4b UTSW 2 37,036,426 (GRCm39) missense probably damaging 1.00
R9091:Or1l4b UTSW 2 37,037,047 (GRCm39) missense probably benign 0.05
R9270:Or1l4b UTSW 2 37,037,047 (GRCm39) missense probably benign 0.05
R9668:Or1l4b UTSW 2 37,036,518 (GRCm39) missense probably damaging 0.97
Z1088:Or1l4b UTSW 2 37,036,397 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- TGATGTGGTGATGAGGTCACAACG -3'
(R):5'- GAGTGAAGCCTGTCCCTTAACTTCC -3'

Sequencing Primer
(F):5'- ATGAGGTCACAACGCTGCC -3'
(R):5'- TACATAACAGTGGCTATCCGGTC -3'
Posted On 2014-02-11