Incidental Mutation 'R1341:Or11m3'
ID 157064
Institutional Source Beutler Lab
Gene Symbol Or11m3
Ensembl Gene ENSMUSG00000054036
Gene Name olfactory receptor family 11 subfamily M member 3
Synonyms Olfr234, GA_x6K02T04SN1-554-3, MOR122-1, GA_x6K02T2NBG7-5241885-5241019, Olfr279
MMRRC Submission 039406-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R1341 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 98390281-98397312 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 98396135 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 261 (V261M)
Ref Sequence ENSEMBL: ENSMUSP00000150851 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050451] [ENSMUST00000205772] [ENSMUST00000216822]
AlphaFold Q8VFD8
Predicted Effect possibly damaging
Transcript: ENSMUST00000050451
AA Change: V261M

PolyPhen 2 Score 0.653 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000061693
Gene: ENSMUSG00000054036
AA Change: V261M

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.9e-50 PFAM
Pfam:7tm_1 41 291 2.3e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205676
Predicted Effect possibly damaging
Transcript: ENSMUST00000205772
AA Change: V261M

PolyPhen 2 Score 0.653 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216822
AA Change: V261M

PolyPhen 2 Score 0.653 (Sensitivity: 0.87; Specificity: 0.91)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.1%
  • 20x: 88.9%
Validation Efficiency 96% (53/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp6v0e2 A G 6: 48,517,045 (GRCm39) Y75C probably benign Het
Bltp3a T C 17: 28,096,393 (GRCm39) probably benign Het
Cacna1g A G 11: 94,324,582 (GRCm39) L1190P probably damaging Het
Ccdc190 A G 1: 169,757,586 (GRCm39) D15G probably damaging Het
Cep126 G T 9: 8,099,777 (GRCm39) P919Q possibly damaging Het
Cfhr4 T A 1: 139,660,131 (GRCm39) T665S probably damaging Het
Chchd6 A G 6: 89,361,623 (GRCm39) V260A probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Cramp1 T C 17: 25,196,514 (GRCm39) K867E probably damaging Het
Dnah6 A T 6: 73,168,602 (GRCm39) N440K probably benign Het
Fbxw15 G A 9: 109,387,314 (GRCm39) S227F probably damaging Het
Gjb3 G A 4: 127,220,224 (GRCm39) R103W probably damaging Het
Gm17421 A T 12: 113,333,334 (GRCm39) noncoding transcript Het
H2bc13 T C 13: 21,900,280 (GRCm39) K12E probably benign Het
Hdac3 A G 18: 38,087,766 (GRCm39) V36A probably damaging Het
Hoxa13 CCG CCGCG 6: 52,237,618 (GRCm39) probably null Het
Itga10 G A 3: 96,559,811 (GRCm39) E489K probably damaging Het
Mgat5b A C 11: 116,869,223 (GRCm39) I589L probably benign Het
Mindy4 A G 6: 55,232,601 (GRCm39) N348S probably benign Het
Mmp15 A G 8: 96,098,931 (GRCm39) D586G probably benign Het
Mmp9 A G 2: 164,791,247 (GRCm39) D139G probably damaging Het
Morc2a C A 11: 3,630,216 (GRCm39) L471I possibly damaging Het
Mycbp2 T A 14: 103,536,303 (GRCm39) probably benign Het
Mylip T A 13: 45,559,412 (GRCm39) S105T probably damaging Het
Nat8f4 A T 6: 85,878,406 (GRCm39) L39Q probably damaging Het
Nrbp1 T A 5: 31,403,157 (GRCm39) I210N probably damaging Het
Obscn T C 11: 58,920,198 (GRCm39) probably benign Het
Or10ak13 T C 4: 118,639,579 (GRCm39) T68A probably benign Het
Or51k2 T A 7: 103,596,589 (GRCm39) V272D possibly damaging Het
Or5t7 T C 2: 86,507,507 (GRCm39) M57V possibly damaging Het
Or9k2 G T 10: 129,999,185 (GRCm39) D3E probably benign Het
Pramel29 T C 4: 143,934,129 (GRCm39) D326G probably damaging Het
Prl2c2 G C 13: 13,176,786 (GRCm39) T47R probably damaging Het
Rab11fip1 G T 8: 27,633,388 (GRCm39) A1106E probably damaging Het
Rfc1 A G 5: 65,448,537 (GRCm39) S363P probably damaging Het
Skint10 A G 4: 112,622,228 (GRCm39) probably benign Het
Spen T C 4: 141,196,711 (GRCm39) N3595D possibly damaging Het
Swsap1 A G 9: 21,868,450 (GRCm39) K241E probably benign Het
Tab1 A G 15: 80,044,315 (GRCm39) T448A possibly damaging Het
Tktl1 G T X: 73,241,289 (GRCm39) G302V probably damaging Het
Usp25 A G 16: 76,912,331 (GRCm39) T1017A probably benign Het
Vmn2r78 T A 7: 86,571,477 (GRCm39) M429K possibly damaging Het
Wdr49 A T 3: 75,336,640 (GRCm39) F356I probably damaging Het
Wnt1 T C 15: 98,689,764 (GRCm39) F184L probably damaging Het
Yy1 T C 12: 108,759,445 (GRCm39) I36T unknown Het
Zbtb39 A G 10: 127,579,369 (GRCm39) I648V possibly damaging Het
Other mutations in Or11m3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01660:Or11m3 APN 15 98,396,076 (GRCm39) missense probably damaging 1.00
R0944:Or11m3 UTSW 15 98,395,565 (GRCm39) missense probably benign 0.39
R1785:Or11m3 UTSW 15 98,395,716 (GRCm39) missense probably damaging 1.00
R4504:Or11m3 UTSW 15 98,396,015 (GRCm39) missense probably benign 0.00
R8099:Or11m3 UTSW 15 98,395,694 (GRCm39) missense probably benign 0.00
R9439:Or11m3 UTSW 15 98,396,247 (GRCm39) missense possibly damaging 0.89
Z1177:Or11m3 UTSW 15 98,396,159 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GGCCATGTCCTATGACCGTTACTTG -3'
(R):5'- AAAAGCTGACCGTGTCCACCTC -3'

Sequencing Primer
(F):5'- ACTTCGCTCCGGTGGTAG -3'
(R):5'- CGTGTCCACCTCAGCGG -3'
Posted On 2014-02-11