Incidental Mutation 'R1353:Zfp976'
ID 157095
Institutional Source Beutler Lab
Gene Symbol Zfp976
Ensembl Gene ENSMUSG00000074158
Gene Name zinc finger protein 976
Synonyms 9830147E19Rik
MMRRC Submission 039418-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R1353 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 42258950-42292012 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 42265442 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 49 (D49G)
Ref Sequence ENSEMBL: ENSMUSP00000096105 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098503] [ENSMUST00000187616]
AlphaFold E9Q981
Predicted Effect probably damaging
Transcript: ENSMUST00000098503
AA Change: D49G

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000096105
Gene: ENSMUSG00000074158
AA Change: D49G

DomainStartEndE-ValueType
KRAB 4 66 1.73e-18 SMART
ZnF_C2H2 131 153 7.78e-3 SMART
ZnF_C2H2 159 181 1.67e-2 SMART
ZnF_C2H2 187 209 5.9e-3 SMART
ZnF_C2H2 215 237 1.38e-3 SMART
ZnF_C2H2 243 265 8.94e-3 SMART
ZnF_C2H2 271 293 2.24e-3 SMART
ZnF_C2H2 299 321 1.03e-2 SMART
ZnF_C2H2 327 349 1.58e-3 SMART
ZnF_C2H2 355 377 7.9e-4 SMART
ZnF_C2H2 383 405 5.9e-3 SMART
ZnF_C2H2 411 433 2.57e-3 SMART
ZnF_C2H2 439 461 3.16e-3 SMART
ZnF_C2H2 467 489 1.26e-2 SMART
ZnF_C2H2 495 517 8.34e-3 SMART
ZnF_C2H2 523 545 3.63e-3 SMART
ZnF_C2H2 551 573 4.79e-3 SMART
ZnF_C2H2 579 601 9.73e-4 SMART
ZnF_C2H2 607 629 3.63e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000107994
Predicted Effect possibly damaging
Transcript: ENSMUST00000187616
AA Change: D48G

PolyPhen 2 Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000141023
Gene: ENSMUSG00000074158
AA Change: D48G

DomainStartEndE-ValueType
KRAB 3 65 7.4e-21 SMART
ZnF_C2H2 130 152 3.2e-5 SMART
ZnF_C2H2 158 180 7.1e-5 SMART
ZnF_C2H2 186 208 2.4e-5 SMART
ZnF_C2H2 214 236 5.7e-6 SMART
ZnF_C2H2 242 264 3.8e-5 SMART
ZnF_C2H2 270 292 9.7e-6 SMART
ZnF_C2H2 298 320 4.2e-5 SMART
ZnF_C2H2 326 348 6.6e-6 SMART
ZnF_C2H2 354 376 3.3e-6 SMART
ZnF_C2H2 382 404 2.5e-5 SMART
ZnF_C2H2 410 432 1e-5 SMART
ZnF_C2H2 438 460 1.3e-5 SMART
ZnF_C2H2 466 488 5.2e-5 SMART
ZnF_C2H2 494 516 3.6e-5 SMART
ZnF_C2H2 522 544 1.6e-5 SMART
ZnF_C2H2 550 572 2e-5 SMART
ZnF_C2H2 578 600 4e-6 SMART
ZnF_C2H2 606 628 1.5e-5 SMART
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.6%
  • 10x: 94.1%
  • 20x: 86.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Astn2 T C 4: 66,184,572 (GRCm39) Q175R unknown Het
Capn9 A C 8: 125,332,305 (GRCm39) probably null Het
Car9 G T 4: 43,512,439 (GRCm39) probably null Het
Chd7 A G 4: 8,839,556 (GRCm39) N1364S probably damaging Het
Cmya5 A T 13: 93,178,033 (GRCm39) V3607E probably damaging Het
Crb2 T C 2: 37,677,293 (GRCm39) C262R probably damaging Het
Cyp2t4 A G 7: 26,856,055 (GRCm39) N204S probably benign Het
Epha1 T C 6: 42,338,771 (GRCm39) T676A probably damaging Het
Fancm G A 12: 65,134,944 (GRCm39) V246M probably damaging Het
Fcrl5 T C 3: 87,355,669 (GRCm39) S461P probably damaging Het
Gen1 A T 12: 11,293,220 (GRCm39) L394Q probably benign Het
Hsdl2 G T 4: 59,596,971 (GRCm39) probably null Het
Klri2 C T 6: 129,716,049 (GRCm39) G97S probably damaging Het
Lypla2 T C 4: 135,697,778 (GRCm39) I55V probably null Het
Malrd1 A G 2: 16,132,779 (GRCm39) D1900G unknown Het
Map1b A G 13: 99,563,834 (GRCm39) S2378P unknown Het
Marchf3 A T 18: 56,909,177 (GRCm39) probably null Het
Myom2 G T 8: 15,156,424 (GRCm39) W757L probably damaging Het
Nat10 T A 2: 103,584,418 (GRCm39) M120L possibly damaging Het
Ncam2 T G 16: 80,997,803 (GRCm39) M1R probably null Het
Ncoa4 G T 14: 31,892,815 (GRCm39) G33* probably null Het
Or1j1 C A 2: 36,702,926 (GRCm39) M59I possibly damaging Het
Or1x2 G A 11: 50,917,833 (GRCm39) M1I probably null Het
Or2a20 T A 6: 43,194,624 (GRCm39) M259K probably benign Het
Or4p21 T C 2: 88,276,895 (GRCm39) H129R probably benign Het
Or6c38 C T 10: 128,929,733 (GRCm39) V37I probably benign Het
Or8b41 A C 9: 38,055,024 (GRCm39) I198L probably benign Het
Osbpl8 A G 10: 111,112,340 (GRCm39) N485S probably damaging Het
Pkdrej A T 15: 85,703,119 (GRCm39) V939E probably damaging Het
Plaa T C 4: 94,459,926 (GRCm39) E607G possibly damaging Het
Rtel1 T A 2: 180,991,024 (GRCm39) C285S probably benign Het
Rtl1 A C 12: 109,558,633 (GRCm39) C1069G probably benign Het
Rtn4 C A 11: 29,657,595 (GRCm39) A583E probably damaging Het
Runx1 T A 16: 92,485,939 (GRCm39) R32* probably null Het
Sdcbp A G 4: 6,381,057 (GRCm39) I67M probably damaging Het
Slc22a12 G C 19: 6,587,812 (GRCm39) L259V possibly damaging Het
Sptlc2 A G 12: 87,388,520 (GRCm39) S321P probably damaging Het
Tmem30c C T 16: 57,098,028 (GRCm39) G131D probably damaging Het
Tnfaip2 A T 12: 111,411,403 (GRCm39) Q9L probably damaging Het
Ttn T C 2: 76,576,910 (GRCm39) Y24661C probably damaging Het
Vmn2r77 T G 7: 86,451,394 (GRCm39) F427V probably benign Het
Zcchc4 A G 5: 52,964,419 (GRCm39) I292V probably benign Het
Zfp354b A T 11: 50,814,240 (GRCm39) H228Q probably damaging Het
Zfp84 T A 7: 29,475,600 (GRCm39) N97K probably benign Het
Zgrf1 C T 3: 127,405,452 (GRCm39) T1550I probably damaging Het
Other mutations in Zfp976
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Zfp976 APN 7 42,263,109 (GRCm39) missense unknown
IGL01102:Zfp976 APN 7 42,263,333 (GRCm39) nonsense probably null
IGL01111:Zfp976 APN 7 42,265,711 (GRCm39) missense probably damaging 0.99
IGL01628:Zfp976 APN 7 42,261,935 (GRCm39) missense unknown
IGL02008:Zfp976 APN 7 42,263,656 (GRCm39) splice site probably benign
IGL02548:Zfp976 APN 7 42,261,953 (GRCm39) missense unknown
R0190:Zfp976 UTSW 7 42,291,948 (GRCm39) start gained probably benign
R0685:Zfp976 UTSW 7 42,263,141 (GRCm39) missense probably damaging 0.98
R1310:Zfp976 UTSW 7 42,262,610 (GRCm39) missense probably damaging 1.00
R1447:Zfp976 UTSW 7 42,262,023 (GRCm39) missense possibly damaging 0.79
R1569:Zfp976 UTSW 7 42,262,806 (GRCm39) missense probably damaging 1.00
R1702:Zfp976 UTSW 7 42,265,424 (GRCm39) missense possibly damaging 0.86
R1829:Zfp976 UTSW 7 42,265,735 (GRCm39) missense probably damaging 1.00
R1939:Zfp976 UTSW 7 42,263,105 (GRCm39) missense unknown
R1978:Zfp976 UTSW 7 42,263,265 (GRCm39) missense probably damaging 1.00
R1981:Zfp976 UTSW 7 42,263,046 (GRCm39) missense probably damaging 0.99
R2160:Zfp976 UTSW 7 42,263,354 (GRCm39) missense probably benign
R2192:Zfp976 UTSW 7 42,262,695 (GRCm39) missense probably damaging 1.00
R3121:Zfp976 UTSW 7 42,262,938 (GRCm39) missense probably damaging 1.00
R4210:Zfp976 UTSW 7 42,265,749 (GRCm39) missense probably damaging 0.99
R4724:Zfp976 UTSW 7 42,262,457 (GRCm39) missense possibly damaging 0.91
R4943:Zfp976 UTSW 7 42,261,846 (GRCm39) unclassified probably benign
R5047:Zfp976 UTSW 7 42,262,843 (GRCm39) nonsense probably null
R5071:Zfp976 UTSW 7 42,262,354 (GRCm39) nonsense probably null
R5125:Zfp976 UTSW 7 42,261,925 (GRCm39) splice site probably null
R5178:Zfp976 UTSW 7 42,261,925 (GRCm39) splice site probably null
R5305:Zfp976 UTSW 7 42,262,902 (GRCm39) missense probably benign 0.00
R5777:Zfp976 UTSW 7 42,263,504 (GRCm39) missense probably benign 0.00
R6153:Zfp976 UTSW 7 42,263,610 (GRCm39) missense probably damaging 0.99
R6694:Zfp976 UTSW 7 42,263,610 (GRCm39) missense probably damaging 0.99
R7226:Zfp976 UTSW 7 42,262,684 (GRCm39) nonsense probably null
R7479:Zfp976 UTSW 7 42,262,603 (GRCm39) missense probably benign 0.01
R7561:Zfp976 UTSW 7 42,265,701 (GRCm39) missense probably damaging 1.00
R8178:Zfp976 UTSW 7 42,262,959 (GRCm39) missense probably benign 0.03
R8261:Zfp976 UTSW 7 42,262,125 (GRCm39) missense unknown
R8715:Zfp976 UTSW 7 42,262,869 (GRCm39) missense possibly damaging 0.89
R8921:Zfp976 UTSW 7 42,262,575 (GRCm39) missense possibly damaging 0.57
R9168:Zfp976 UTSW 7 42,263,011 (GRCm39) nonsense probably null
R9575:Zfp976 UTSW 7 42,262,041 (GRCm39) missense unknown
Z1088:Zfp976 UTSW 7 42,262,184 (GRCm39) missense possibly damaging 0.71
Predicted Primers
Posted On 2014-02-11