Incidental Mutation 'R0019:Trim69'
ID 15719
Institutional Source Beutler Lab
Gene Symbol Trim69
Ensembl Gene ENSMUSG00000033368
Gene Name tripartite motif-containing 69
Synonyms Rnf36, Trif, 4921519C19Rik
MMRRC Submission 038314-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R0019 (G1)
Quality Score
Status Validated
Chromosome 2
Chromosomal Location 121991189-122009503 bp(+) (GRCm39)
Type of Mutation splice site (3 bp from exon)
DNA Base Change (assembly) A to T at 122004958 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000047627 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028665] [ENSMUST00000036089]
AlphaFold Q80X56
Predicted Effect probably benign
Transcript: ENSMUST00000028665
SMART Domains Protein: ENSMUSP00000028665
Gene: ENSMUSG00000027233

DomainStartEndE-ValueType
low complexity region 33 41 N/A INTRINSIC
low complexity region 143 165 N/A INTRINSIC
low complexity region 215 227 N/A INTRINSIC
Pfam:PAT1 247 490 6.7e-12 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000036089
SMART Domains Protein: ENSMUSP00000047627
Gene: ENSMUSG00000033368

DomainStartEndE-ValueType
RING 42 82 8.48e-8 SMART
low complexity region 95 111 N/A INTRINSIC
PDB:4NQJ|C 144 322 2e-86 PDB
PRY 323 375 9.37e-19 SMART
SPRY 376 500 4.97e-24 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143088
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 83.5%
  • 3x: 78.2%
  • 10x: 64.4%
  • 20x: 48.4%
Validation Efficiency 91% (93/102)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd13a T A 5: 114,924,142 (GRCm39) probably benign Het
Arhgef12 A T 9: 42,889,529 (GRCm39) W1029R probably damaging Het
Aunip T A 4: 134,250,823 (GRCm39) L256* probably null Het
Bahcc1 T A 11: 120,180,597 (GRCm39) M2607K probably damaging Het
Bltp3b A G 10: 89,611,831 (GRCm39) T5A probably damaging Het
Cacng6 G T 7: 3,480,384 (GRCm39) M152I possibly damaging Het
Cep120 A G 18: 53,842,119 (GRCm39) probably benign Het
D130043K22Rik T A 13: 25,064,795 (GRCm39) V737D probably damaging Het
Dock10 A G 1: 80,583,642 (GRCm39) S187P probably damaging Het
Eogt C T 6: 97,111,234 (GRCm39) probably benign Het
Fasn A T 11: 120,698,824 (GRCm39) probably benign Het
Frem2 C T 3: 53,431,099 (GRCm39) V2745M probably damaging Het
Fshb T C 2: 106,887,690 (GRCm39) S110G probably benign Het
Gpi1 A G 7: 33,920,324 (GRCm39) Y144H probably damaging Het
Gsap T C 5: 21,475,620 (GRCm39) probably benign Het
Helz2 C A 2: 180,874,552 (GRCm39) G1981C probably damaging Het
Herc3 T C 6: 58,862,050 (GRCm39) probably benign Het
Il1r2 C T 1: 40,164,210 (GRCm39) T359M probably damaging Het
Il6st T C 13: 112,637,682 (GRCm39) C563R possibly damaging Het
Irs1 T A 1: 82,264,977 (GRCm39) K1080* probably null Het
Itpr1 T C 6: 108,331,587 (GRCm39) V182A probably damaging Het
Kalrn C T 16: 34,018,884 (GRCm39) probably benign Het
Kcnj11 G A 7: 45,748,363 (GRCm39) A320V probably benign Het
Lrig1 T A 6: 94,584,330 (GRCm39) R905* probably null Het
Lrrc43 T C 5: 123,639,378 (GRCm39) L469P probably damaging Het
Med29 A T 7: 28,090,501 (GRCm39) probably benign Het
Mroh7 T C 4: 106,578,623 (GRCm39) I18M probably benign Het
Nalcn A C 14: 123,744,901 (GRCm39) C376G probably benign Het
Ncor2 C T 5: 125,196,545 (GRCm39) probably null Het
Nek1 T A 8: 61,542,768 (GRCm39) M786K probably benign Het
Nrxn2 A G 19: 6,559,987 (GRCm39) probably benign Het
Nxpe2 T C 9: 48,231,080 (GRCm39) I430V probably benign Het
Pcolce2 A G 9: 95,577,017 (GRCm39) probably null Het
Pdcl A T 2: 37,241,932 (GRCm39) L273M probably damaging Het
Pml A T 9: 58,127,776 (GRCm39) S610R probably damaging Het
Polk C A 13: 96,641,124 (GRCm39) R144S probably damaging Het
Rlf A G 4: 121,003,769 (GRCm39) V1737A possibly damaging Het
Rubcnl T A 14: 75,285,703 (GRCm39) probably benign Het
Scn3a A T 2: 65,292,045 (GRCm39) V1567E probably damaging Het
Scyl2 A G 10: 89,495,183 (GRCm39) I296T probably benign Het
Slc15a3 A G 19: 10,833,404 (GRCm39) I474V probably damaging Het
Sstr1 T C 12: 58,259,935 (GRCm39) L186S probably damaging Het
Tmem108 A T 9: 103,366,539 (GRCm39) V484D possibly damaging Het
Trim80 T G 11: 115,338,768 (GRCm39) Y533D probably damaging Het
Unc13b T C 4: 43,096,990 (GRCm39) I121T possibly damaging Het
Usp40 T C 1: 87,906,133 (GRCm39) T701A probably benign Het
Xpr1 A G 1: 155,208,145 (GRCm39) probably benign Het
Ywhab T A 2: 163,858,090 (GRCm39) I219N probably damaging Het
Zfp219 G T 14: 52,246,485 (GRCm39) T169K probably damaging Het
Other mutations in Trim69
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00663:Trim69 APN 2 121,998,195 (GRCm39) missense probably benign 0.00
IGL01321:Trim69 APN 2 122,003,765 (GRCm39) missense possibly damaging 0.84
IGL01478:Trim69 APN 2 122,008,924 (GRCm39) missense probably damaging 0.98
IGL01907:Trim69 APN 2 121,998,142 (GRCm39) missense probably benign 0.00
IGL01925:Trim69 APN 2 121,998,397 (GRCm39) missense probably damaging 1.00
IGL03065:Trim69 APN 2 122,009,115 (GRCm39) missense probably damaging 0.98
IGL03121:Trim69 APN 2 121,998,128 (GRCm39) missense probably benign 0.22
IGL03206:Trim69 APN 2 122,003,636 (GRCm39) missense probably benign 0.00
R0019:Trim69 UTSW 2 122,004,958 (GRCm39) splice site probably null
R1956:Trim69 UTSW 2 122,004,956 (GRCm39) critical splice donor site probably null
R1960:Trim69 UTSW 2 121,998,165 (GRCm39) missense probably benign 0.00
R2212:Trim69 UTSW 2 122,009,125 (GRCm39) missense probably benign 0.05
R3412:Trim69 UTSW 2 122,009,125 (GRCm39) missense probably benign 0.05
R3414:Trim69 UTSW 2 122,009,125 (GRCm39) missense probably benign 0.05
R3900:Trim69 UTSW 2 122,009,322 (GRCm39) missense probably benign 0.03
R4470:Trim69 UTSW 2 122,009,080 (GRCm39) missense probably damaging 1.00
R4950:Trim69 UTSW 2 122,009,227 (GRCm39) missense probably damaging 1.00
R5045:Trim69 UTSW 2 122,004,727 (GRCm39) missense probably benign 0.08
R5237:Trim69 UTSW 2 122,003,821 (GRCm39) missense probably benign
R5931:Trim69 UTSW 2 122,009,075 (GRCm39) missense probably damaging 0.98
R6483:Trim69 UTSW 2 121,998,081 (GRCm39) nonsense probably null
R6872:Trim69 UTSW 2 121,998,391 (GRCm39) missense probably damaging 1.00
R7372:Trim69 UTSW 2 122,009,064 (GRCm39) missense possibly damaging 0.94
R7451:Trim69 UTSW 2 121,998,508 (GRCm39) missense probably benign 0.19
R7591:Trim69 UTSW 2 121,998,454 (GRCm39) missense probably benign 0.17
R8353:Trim69 UTSW 2 121,998,490 (GRCm39) missense possibly damaging 0.73
R8551:Trim69 UTSW 2 122,003,810 (GRCm39) missense probably benign 0.00
R9025:Trim69 UTSW 2 122,003,771 (GRCm39) missense probably benign 0.03
R9075:Trim69 UTSW 2 122,009,264 (GRCm39) missense probably benign 0.02
R9413:Trim69 UTSW 2 122,009,083 (GRCm39) nonsense probably null
Z1176:Trim69 UTSW 2 121,998,035 (GRCm39) critical splice acceptor site probably null
Posted On 2012-12-21