Incidental Mutation 'R1326:Armc3'
ID 157205
Institutional Source Beutler Lab
Gene Symbol Armc3
Ensembl Gene ENSMUSG00000037683
Gene Name armadillo repeat containing 3
Synonyms 4921513G22Rik
MMRRC Submission 039392-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R1326 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 19204113-19315052 bp(+) (GRCm39)
Type of Mutation makesense
DNA Base Change (assembly) T to C at 19314935 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Stop codon to Glutamine at position 882 (*882Q)
Ref Sequence ENSEMBL: ENSMUSP00000110287 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049255] [ENSMUST00000114640]
AlphaFold A2AU72
Predicted Effect probably null
Transcript: ENSMUST00000049255
AA Change: *870Q
SMART Domains Protein: ENSMUSP00000048784
Gene: ENSMUSG00000037683
AA Change: *870Q

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
ARM 56 96 2.07e-2 SMART
ARM 97 138 9.84e1 SMART
ARM 139 179 7.86e-3 SMART
ARM 180 220 7.63e0 SMART
ARM 221 262 7.76e1 SMART
low complexity region 293 303 N/A INTRINSIC
ARM 305 345 3.91e1 SMART
ARM 346 385 2.93e-2 SMART
ARM 387 427 7.74e-2 SMART
Blast:ARM 428 468 3e-11 BLAST
ARM 469 509 1.45e-1 SMART
low complexity region 544 557 N/A INTRINSIC
low complexity region 583 595 N/A INTRINSIC
low complexity region 620 639 N/A INTRINSIC
low complexity region 675 696 N/A INTRINSIC
Pfam:EDR1 723 857 3.1e-28 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000114640
AA Change: *882Q
SMART Domains Protein: ENSMUSP00000110287
Gene: ENSMUSG00000037683
AA Change: *882Q

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
ARM 56 96 2.07e-2 SMART
ARM 97 138 9.84e1 SMART
ARM 139 179 7.86e-3 SMART
ARM 180 220 7.63e0 SMART
ARM 221 262 7.76e1 SMART
low complexity region 293 303 N/A INTRINSIC
ARM 305 345 3.91e1 SMART
ARM 346 385 2.93e-2 SMART
ARM 387 427 7.74e-2 SMART
Blast:ARM 428 468 3e-11 BLAST
ARM 469 509 1.45e-1 SMART
Pfam:EDR1 549 868 1.4e-41 PFAM
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.8%
  • 10x: 94.7%
  • 20x: 87.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Armadillo/beta-catenin (CTNNB1; MIM 116806)-like (ARM) domains are imperfect 45-amino acid repeats involved in protein-protein interactions. ARM domain-containing proteins, such as ARMC3, function in signal transduction, development, cell adhesion and mobility, and tumor initiation and metastasis (Li et al., 2006 [PubMed 16915934]).[supplied by OMIM, Mar 2008]
Allele List at MGI

All alleles(2) : Targeted(2)

Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap5 G A 12: 52,565,153 (GRCm39) S708N possibly damaging Het
Atp13a3 G A 16: 30,171,128 (GRCm39) L306F probably damaging Het
Cyp2d9 T C 15: 82,339,357 (GRCm39) I130T possibly damaging Het
Ect2l C T 10: 18,041,290 (GRCm39) R296H probably benign Het
Eomes C T 9: 118,313,565 (GRCm39) Q518* probably null Het
Errfi1 T C 4: 150,949,621 (GRCm39) V6A possibly damaging Het
Fezf2 T C 14: 12,342,644 (GRCm38) N407S probably benign Het
Fpgs T C 2: 32,582,592 (GRCm39) probably null Het
Fsbp A G 4: 11,579,891 (GRCm39) Y53C probably damaging Het
Hspd1 T C 1: 55,119,418 (GRCm39) probably null Het
Ifna7 A T 4: 88,734,931 (GRCm39) E156V possibly damaging Het
Map1a C T 2: 121,136,671 (GRCm39) Q2258* probably null Het
Mier2 A G 10: 79,380,543 (GRCm39) F289S probably damaging Het
Mmp16 A G 4: 18,054,517 (GRCm39) N341S possibly damaging Het
Moxd2 T C 6: 40,857,288 (GRCm39) T491A probably benign Het
Narf T A 11: 121,133,379 (GRCm39) L60Q probably damaging Het
Pa2g4 T C 10: 128,395,142 (GRCm39) D341G probably benign Het
Parp1 T A 1: 180,428,023 (GRCm39) V991D probably damaging Het
Rin2 C T 2: 145,702,366 (GRCm39) T354I probably benign Het
Slc1a4 A G 11: 20,282,159 (GRCm39) L105P probably damaging Het
Slc27a2 T A 2: 126,406,690 (GRCm39) Y125N probably damaging Het
Sorl1 A G 9: 41,943,092 (GRCm39) V928A probably benign Het
Spata31e2 G T 1: 26,723,011 (GRCm39) P723H probably damaging Het
Usp31 G C 7: 121,247,525 (GRCm39) S1306C probably damaging Het
Other mutations in Armc3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00535:Armc3 APN 2 19,308,669 (GRCm39) missense possibly damaging 0.48
IGL01123:Armc3 APN 2 19,206,616 (GRCm39) missense possibly damaging 0.87
IGL01142:Armc3 APN 2 19,302,709 (GRCm39) splice site probably benign
IGL01556:Armc3 APN 2 19,273,957 (GRCm39) missense probably damaging 1.00
IGL02145:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02145:Armc3 APN 2 19,301,671 (GRCm39) missense possibly damaging 0.81
IGL02152:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02154:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02243:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02244:Armc3 APN 2 19,290,948 (GRCm39) critical splice donor site probably null
IGL02516:Armc3 APN 2 19,305,317 (GRCm39) missense possibly damaging 0.94
IGL02691:Armc3 APN 2 19,240,295 (GRCm39) missense probably damaging 1.00
IGL03151:Armc3 APN 2 19,243,509 (GRCm39) missense probably damaging 1.00
IGL03190:Armc3 APN 2 19,293,761 (GRCm39) missense probably damaging 0.99
IGL03288:Armc3 APN 2 19,240,293 (GRCm39) missense probably damaging 1.00
IGL03338:Armc3 APN 2 19,253,512 (GRCm39) missense possibly damaging 0.88
R0015:Armc3 UTSW 2 19,301,132 (GRCm39) critical splice acceptor site probably null
R0015:Armc3 UTSW 2 19,301,132 (GRCm39) critical splice acceptor site probably null
R0256:Armc3 UTSW 2 19,274,027 (GRCm39) missense probably damaging 1.00
R0621:Armc3 UTSW 2 19,300,204 (GRCm39) missense probably damaging 0.96
R1470:Armc3 UTSW 2 19,243,547 (GRCm39) missense probably benign
R1470:Armc3 UTSW 2 19,243,547 (GRCm39) missense probably benign
R1489:Armc3 UTSW 2 19,314,858 (GRCm39) missense probably benign 0.01
R1990:Armc3 UTSW 2 19,297,953 (GRCm39) missense probably damaging 0.97
R1991:Armc3 UTSW 2 19,297,953 (GRCm39) missense probably damaging 0.97
R1992:Armc3 UTSW 2 19,297,953 (GRCm39) missense probably damaging 0.97
R2002:Armc3 UTSW 2 19,293,747 (GRCm39) missense probably benign 0.01
R2095:Armc3 UTSW 2 19,293,740 (GRCm39) missense possibly damaging 0.65
R2127:Armc3 UTSW 2 19,206,622 (GRCm39) missense probably damaging 1.00
R2158:Armc3 UTSW 2 19,253,444 (GRCm39) missense probably damaging 0.99
R2697:Armc3 UTSW 2 19,308,746 (GRCm39) missense probably damaging 1.00
R3809:Armc3 UTSW 2 19,305,476 (GRCm39) missense probably damaging 1.00
R3897:Armc3 UTSW 2 19,273,988 (GRCm39) missense probably damaging 1.00
R4107:Armc3 UTSW 2 19,293,720 (GRCm39) missense probably benign 0.13
R4326:Armc3 UTSW 2 19,305,284 (GRCm39) missense probably damaging 0.97
R4464:Armc3 UTSW 2 19,253,470 (GRCm39) missense probably damaging 0.99
R4702:Armc3 UTSW 2 19,314,792 (GRCm39) missense probably damaging 1.00
R4923:Armc3 UTSW 2 19,297,791 (GRCm39) critical splice acceptor site probably null
R5370:Armc3 UTSW 2 19,290,873 (GRCm39) missense probably benign 0.00
R5518:Armc3 UTSW 2 19,302,739 (GRCm39) missense probably benign 0.28
R5718:Armc3 UTSW 2 19,308,610 (GRCm39) nonsense probably null
R5739:Armc3 UTSW 2 19,258,728 (GRCm39) missense possibly damaging 0.67
R5913:Armc3 UTSW 2 19,314,858 (GRCm39) missense possibly damaging 0.65
R6211:Armc3 UTSW 2 19,301,614 (GRCm39) critical splice acceptor site probably null
R6245:Armc3 UTSW 2 19,253,516 (GRCm39) missense probably damaging 1.00
R6841:Armc3 UTSW 2 19,206,630 (GRCm39) splice site probably null
R7003:Armc3 UTSW 2 19,274,839 (GRCm39) missense probably damaging 1.00
R7190:Armc3 UTSW 2 19,297,947 (GRCm39) missense probably damaging 1.00
R7499:Armc3 UTSW 2 19,290,790 (GRCm39) missense probably benign 0.03
R7738:Armc3 UTSW 2 19,293,761 (GRCm39) missense probably damaging 0.99
R7844:Armc3 UTSW 2 19,258,829 (GRCm39) missense possibly damaging 0.90
R7919:Armc3 UTSW 2 19,290,906 (GRCm39) missense probably benign 0.00
R8060:Armc3 UTSW 2 19,293,720 (GRCm39) missense probably benign 0.08
R8111:Armc3 UTSW 2 19,301,674 (GRCm39) missense probably benign
R8406:Armc3 UTSW 2 19,240,365 (GRCm39) missense probably damaging 0.98
R8485:Armc3 UTSW 2 19,297,945 (GRCm39) missense probably damaging 1.00
R8773:Armc3 UTSW 2 19,293,667 (GRCm39) missense probably benign 0.01
R8940:Armc3 UTSW 2 19,240,393 (GRCm39) missense probably damaging 1.00
R9441:Armc3 UTSW 2 19,253,426 (GRCm39) missense possibly damaging 0.89
Z1177:Armc3 UTSW 2 19,290,802 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGCTTGCAAATGACCCTGAGCC -3'
(R):5'- GGAGCATCGCATAGTCACATCCAC -3'

Sequencing Primer
(F):5'- CAGGCACTGGCTGATAAAATC -3'
(R):5'- CACATCCACAGTTTATTTCTACACAG -3'
Posted On 2014-02-18