Incidental Mutation 'R1373:Odad4'
ID 157411
Institutional Source Beutler Lab
Gene Symbol Odad4
Ensembl Gene ENSMUSG00000006784
Gene Name outer dynein arm complex subunit 4
Synonyms 4933404O19Rik, Ttc25
MMRRC Submission 039437-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R1373 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 100436434-100463392 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 100436658 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 11 (F11S)
Ref Sequence ENSEMBL: ENSMUSP00000090355 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006976] [ENSMUST00000092684]
AlphaFold Q9D4B2
Predicted Effect probably damaging
Transcript: ENSMUST00000006976
AA Change: F11S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000006976
Gene: ENSMUSG00000006784
AA Change: F11S

DomainStartEndE-ValueType
TPR 11 44 3.69e1 SMART
TPR 45 78 3.07e1 SMART
TPR 79 112 4.96e0 SMART
low complexity region 147 158 N/A INTRINSIC
low complexity region 191 208 N/A INTRINSIC
TPR 318 351 4.96e0 SMART
TPR 358 391 1.11e1 SMART
Blast:TPR 395 428 7e-14 BLAST
TPR 435 468 2.99e1 SMART
low complexity region 493 505 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000092684
AA Change: F11S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000090355
Gene: ENSMUSG00000006784
AA Change: F11S

DomainStartEndE-ValueType
TPR 11 44 3.69e1 SMART
TPR 45 78 3.07e1 SMART
TPR 79 112 4.96e0 SMART
low complexity region 147 158 N/A INTRINSIC
low complexity region 191 208 N/A INTRINSIC
TPR 318 351 4.96e0 SMART
TPR 358 391 1.11e1 SMART
Blast:TPR 395 428 5e-14 BLAST
TPR 435 468 2.99e1 SMART
coiled coil region 528 548 N/A INTRINSIC
low complexity region 556 567 N/A INTRINSIC
coiled coil region 599 624 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127389
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132143
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150331
Meta Mutation Damage Score 0.3053 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 95.2%
Validation Efficiency 94% (34/36)
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele display partial preweaning lethality, impaired ciliary motility, and a variety of left-right body symmetry defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamdec1 G A 14: 68,808,400 (GRCm39) R317C probably damaging Het
Adgrl1 T C 8: 84,664,392 (GRCm39) V1261A probably benign Het
Btla G A 16: 45,044,783 (GRCm39) G23D probably benign Het
Card19 T C 13: 49,357,440 (GRCm39) D110G probably damaging Het
Cbx7 C T 15: 79,803,074 (GRCm39) G160R probably damaging Het
Ccng2 C T 5: 93,418,914 (GRCm39) probably benign Het
Col4a3 G A 1: 82,667,808 (GRCm39) probably benign Het
Colgalt2 A G 1: 152,348,912 (GRCm39) T186A probably damaging Het
Cps1 A G 1: 67,268,583 (GRCm39) N1437S possibly damaging Het
Dcaf1 A G 9: 106,735,079 (GRCm39) I676V probably benign Het
Dnah5 T A 15: 28,314,064 (GRCm39) probably benign Het
Dock1 T C 7: 134,768,904 (GRCm39) S1758P probably benign Het
Furin C T 7: 80,041,932 (GRCm39) probably benign Het
Ice2 G A 9: 69,314,401 (GRCm39) R50H probably benign Het
Ifi207 T A 1: 173,557,913 (GRCm39) D275V unknown Het
Nrxn2 C T 19: 6,522,331 (GRCm39) T190M probably damaging Het
Or14j8 T C 17: 38,263,251 (GRCm39) I221M probably damaging Het
Or2ag17 C T 7: 106,389,963 (GRCm39) V82I probably benign Het
Pcnx3 A G 19: 5,715,544 (GRCm39) L1494P probably damaging Het
Pitrm1 G T 13: 6,620,736 (GRCm39) M739I probably benign Het
Rbm15 G T 3: 107,239,946 (GRCm39) R151S possibly damaging Het
Sfr1 C G 19: 47,723,355 (GRCm39) D286E possibly damaging Het
Slx4 A G 16: 3,803,374 (GRCm39) S1147P probably benign Het
Sry C G Y: 2,662,864 (GRCm39) Q265H unknown Het
Tgfbr3 T C 5: 107,362,809 (GRCm39) I68V probably benign Het
Tpmt A C 13: 47,180,734 (GRCm39) probably null Het
Trpm5 A G 7: 142,640,579 (GRCm39) probably benign Het
Txlnb A G 10: 17,714,695 (GRCm39) T376A probably damaging Het
Usp25 T C 16: 76,859,273 (GRCm39) probably benign Het
Vmn1r11 G A 6: 57,114,963 (GRCm39) C209Y probably benign Het
Vps13c A T 9: 67,834,793 (GRCm39) K1707N probably damaging Het
Other mutations in Odad4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02027:Odad4 APN 11 100,460,728 (GRCm39) missense probably damaging 1.00
IGL02379:Odad4 APN 11 100,457,809 (GRCm39) missense possibly damaging 0.87
IGL03091:Odad4 APN 11 100,441,076 (GRCm39) nonsense probably null
IGL02991:Odad4 UTSW 11 100,444,698 (GRCm39) missense probably benign 0.01
R0044:Odad4 UTSW 11 100,457,827 (GRCm39) missense probably damaging 1.00
R0137:Odad4 UTSW 11 100,454,394 (GRCm39) missense probably damaging 1.00
R0280:Odad4 UTSW 11 100,441,091 (GRCm39) missense probably damaging 1.00
R1793:Odad4 UTSW 11 100,460,679 (GRCm39) splice site probably null
R2097:Odad4 UTSW 11 100,454,408 (GRCm39) missense possibly damaging 0.89
R2121:Odad4 UTSW 11 100,457,837 (GRCm39) critical splice donor site probably null
R2509:Odad4 UTSW 11 100,444,361 (GRCm39) missense probably damaging 0.99
R2655:Odad4 UTSW 11 100,444,405 (GRCm39) missense probably damaging 1.00
R4635:Odad4 UTSW 11 100,442,333 (GRCm39) nonsense probably null
R4773:Odad4 UTSW 11 100,440,742 (GRCm39) missense probably benign 0.05
R4858:Odad4 UTSW 11 100,441,147 (GRCm39) missense probably damaging 0.96
R5164:Odad4 UTSW 11 100,462,346 (GRCm39) nonsense probably null
R5181:Odad4 UTSW 11 100,440,719 (GRCm39) missense probably damaging 1.00
R5707:Odad4 UTSW 11 100,444,887 (GRCm39) missense probably damaging 0.99
R5742:Odad4 UTSW 11 100,436,699 (GRCm39) missense possibly damaging 0.90
R7634:Odad4 UTSW 11 100,452,731 (GRCm39) critical splice donor site probably null
R7851:Odad4 UTSW 11 100,436,655 (GRCm39) missense probably damaging 1.00
R8186:Odad4 UTSW 11 100,454,505 (GRCm39) missense probably benign 0.27
R8194:Odad4 UTSW 11 100,454,502 (GRCm39) missense probably benign 0.06
R8444:Odad4 UTSW 11 100,452,731 (GRCm39) critical splice donor site probably null
R8879:Odad4 UTSW 11 100,457,752 (GRCm39) nonsense probably null
X0018:Odad4 UTSW 11 100,444,424 (GRCm39) missense probably damaging 0.99
X0028:Odad4 UTSW 11 100,436,724 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TTTGTCTGCGAGGCTTTCCACG -3'
(R):5'- GGTTCCATCATTCCAGAGGCCAAC -3'

Sequencing Primer
(F):5'- GCAAACAGCGATCACTCTGG -3'
(R):5'- aggaaagaagagaaaaaaagaagagg -3'
Posted On 2014-02-18