Incidental Mutation 'R1316:Or5b109'
ID 157556
Institutional Source Beutler Lab
Gene Symbol Or5b109
Ensembl Gene ENSMUSG00000096365
Gene Name olfactory receptor family 5 subfamily B member 109
Synonyms Olfr1463, GA_x6K02T2RE5P-3560863-3561795, MOR202-29P
MMRRC Submission 039382-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R1316 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 13211616-13212548 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13211803 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 63 (F63S)
Ref Sequence ENSEMBL: ENSMUSP00000146566 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064102] [ENSMUST00000207246]
AlphaFold Q7TQR3
Predicted Effect probably damaging
Transcript: ENSMUST00000064102
AA Change: F63S

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000070872
Gene: ENSMUSG00000096365
AA Change: F63S

DomainStartEndE-ValueType
Pfam:7tm_4 32 310 1e-51 PFAM
Pfam:7TM_GPCR_Srsx 36 306 3.2e-6 PFAM
Pfam:7tm_1 42 291 1.4e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207246
AA Change: F63S

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.5%
  • 20x: 90.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
C1qtnf12 G A 4: 156,050,331 (GRCm39) E223K probably damaging Het
Cmpk1 A G 4: 114,828,487 (GRCm39) probably benign Het
Col11a1 G A 3: 113,932,619 (GRCm39) probably null Het
Ears2 T C 7: 121,645,905 (GRCm39) T337A probably benign Het
Erbin T C 13: 103,977,742 (GRCm39) K605R possibly damaging Het
Irs3 T C 5: 137,642,703 (GRCm39) E245G probably damaging Het
Limch1 T C 5: 67,156,586 (GRCm39) I223T probably damaging Het
Lrp1b T C 2: 40,592,816 (GRCm39) T3768A probably benign Het
Notch4 G A 17: 34,786,444 (GRCm39) D195N probably damaging Het
Or7g25 T A 9: 19,160,035 (GRCm39) Q220L probably benign Het
Or8b12b T C 9: 37,684,039 (GRCm39) F28S possibly damaging Het
Or8u8 T C 2: 86,011,709 (GRCm39) S249G probably benign Het
Podxl2 A G 6: 88,826,199 (GRCm39) L369P probably benign Het
Rnf149 A G 1: 39,604,401 (GRCm39) *45Q probably null Het
Scart2 T C 7: 139,879,583 (GRCm39) V957A probably benign Het
Slc4a11 T A 2: 130,528,071 (GRCm39) E528V probably benign Het
Slc9a1 A G 4: 133,149,558 (GRCm39) R795G possibly damaging Het
Slco6d1 A T 1: 98,394,518 (GRCm39) M401L probably benign Het
Tiparp T G 3: 65,460,772 (GRCm39) F587C probably damaging Het
Vmn2r120 T C 17: 57,832,939 (GRCm39) Q80R probably benign Het
Other mutations in Or5b109
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01131:Or5b109 APN 19 13,212,103 (GRCm39) missense probably benign 0.01
IGL02596:Or5b109 APN 19 13,211,763 (GRCm39) missense probably damaging 1.00
IGL03030:Or5b109 APN 19 13,212,418 (GRCm39) missense probably damaging 0.98
IGL03232:Or5b109 APN 19 13,212,341 (GRCm39) nonsense probably null
IGL03380:Or5b109 APN 19 13,212,365 (GRCm39) missense probably benign 0.00
PIT4382001:Or5b109 UTSW 19 13,212,259 (GRCm39) missense probably damaging 1.00
PIT4519001:Or5b109 UTSW 19 13,212,216 (GRCm39) missense probably benign 0.00
R0652:Or5b109 UTSW 19 13,211,899 (GRCm39) missense possibly damaging 0.80
R0658:Or5b109 UTSW 19 13,212,424 (GRCm39) missense possibly damaging 0.94
R1181:Or5b109 UTSW 19 13,212,195 (GRCm39) missense probably benign 0.07
R1239:Or5b109 UTSW 19 13,212,040 (GRCm39) missense possibly damaging 0.80
R1465:Or5b109 UTSW 19 13,212,265 (GRCm39) missense possibly damaging 0.61
R1465:Or5b109 UTSW 19 13,212,265 (GRCm39) missense possibly damaging 0.61
R1900:Or5b109 UTSW 19 13,212,277 (GRCm39) missense possibly damaging 0.54
R1927:Or5b109 UTSW 19 13,212,393 (GRCm39) missense probably damaging 1.00
R2239:Or5b109 UTSW 19 13,212,085 (GRCm39) missense probably benign 0.00
R2380:Or5b109 UTSW 19 13,212,085 (GRCm39) missense probably benign 0.00
R3760:Or5b109 UTSW 19 13,212,250 (GRCm39) missense probably damaging 1.00
R3765:Or5b109 UTSW 19 13,211,795 (GRCm39) missense probably damaging 1.00
R3835:Or5b109 UTSW 19 13,212,103 (GRCm39) missense probably benign 0.18
R4690:Or5b109 UTSW 19 13,212,132 (GRCm39) missense possibly damaging 0.91
R4907:Or5b109 UTSW 19 13,212,157 (GRCm39) missense probably damaging 1.00
R5444:Or5b109 UTSW 19 13,212,322 (GRCm39) missense probably benign 0.28
R5465:Or5b109 UTSW 19 13,212,052 (GRCm39) missense probably benign 0.00
R6083:Or5b109 UTSW 19 13,211,889 (GRCm39) missense probably benign 0.01
R6259:Or5b109 UTSW 19 13,211,785 (GRCm39) missense probably damaging 0.98
R6324:Or5b109 UTSW 19 13,212,468 (GRCm39) missense possibly damaging 0.95
R6561:Or5b109 UTSW 19 13,212,394 (GRCm39) missense probably damaging 1.00
R6845:Or5b109 UTSW 19 13,211,997 (GRCm39) missense probably damaging 1.00
R7260:Or5b109 UTSW 19 13,212,388 (GRCm39) missense probably damaging 0.98
R7843:Or5b109 UTSW 19 13,211,901 (GRCm39) missense possibly damaging 0.48
R8560:Or5b109 UTSW 19 13,211,656 (GRCm39) missense possibly damaging 0.91
R8719:Or5b109 UTSW 19 13,211,836 (GRCm39) missense probably damaging 0.97
R9207:Or5b109 UTSW 19 13,212,400 (GRCm39) missense possibly damaging 0.60
R9273:Or5b109 UTSW 19 13,212,268 (GRCm39) missense probably damaging 1.00
R9607:Or5b109 UTSW 19 13,211,953 (GRCm39) missense
X0063:Or5b109 UTSW 19 13,211,999 (GRCm39) missense probably damaging 1.00
X0067:Or5b109 UTSW 19 13,212,061 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- GCACATGAAATTCACATCAGTGTCCAG -3'
(R):5'- TGAGGCCAACAGGTAATTTTCCACAG -3'

Sequencing Primer
(F):5'- CATTGCTGATTTGTTAGATGACACC -3'
(R):5'- CAGGTAATTTTCCACAGTAGCAAAGG -3'
Posted On 2014-02-18