Incidental Mutation 'R1322:Zfp930'
| ID |
157713 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp930
|
| Ensembl Gene |
ENSMUSG00000059897 |
| Gene Name |
zinc finger protein 930 |
| Synonyms |
zinc finger protein, D10627 |
| MMRRC Submission |
039388-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1322 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
69661690-69683188 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 69680820 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 171
(T171A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105845
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000110216]
[ENSMUST00000212312]
[ENSMUST00000212681]
|
| AlphaFold |
A0A1D5RM15 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110216
AA Change: T171A
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000105845
Gene: ENSMUSG00000059897
AA Change: T171A
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
3 |
62 |
1.39e-13 |
SMART |
|
ZnF_C2H2
|
73 |
95 |
1.07e0 |
SMART |
|
ZnF_C2H2
|
101 |
123 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
129 |
151 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
157 |
179 |
2.63e0 |
SMART |
|
ZnF_C2H2
|
185 |
207 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
213 |
235 |
1.22e-4 |
SMART |
|
ZnF_C2H2
|
241 |
263 |
7.49e-5 |
SMART |
|
ZnF_C2H2
|
269 |
291 |
1.13e-4 |
SMART |
|
ZnF_C2H2
|
297 |
319 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
325 |
347 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
353 |
375 |
1.22e-4 |
SMART |
|
ZnF_C2H2
|
381 |
403 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
409 |
431 |
1.72e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000212090
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000212312
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000212681
AA Change: T172A
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.9%
- 20x: 92.5%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 20 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aco2 |
C |
T |
15: 81,779,394 (GRCm39) |
S33L |
probably damaging |
Het |
| Col27a1 |
A |
C |
4: 63,246,803 (GRCm39) |
|
probably benign |
Het |
| Fam184a |
G |
T |
10: 53,528,415 (GRCm39) |
D815E |
probably damaging |
Het |
| Gjb3 |
G |
A |
4: 127,220,224 (GRCm39) |
R103W |
probably damaging |
Het |
| Gpr162 |
G |
T |
6: 124,835,864 (GRCm39) |
T512K |
probably damaging |
Het |
| Hipk1 |
A |
T |
3: 103,651,297 (GRCm39) |
S1155R |
probably damaging |
Het |
| Itih2 |
A |
G |
2: 10,114,333 (GRCm39) |
V417A |
probably damaging |
Het |
| Kmt2a |
A |
G |
9: 44,732,418 (GRCm39) |
|
probably benign |
Het |
| Mecom |
G |
T |
3: 30,011,522 (GRCm39) |
P670Q |
probably damaging |
Het |
| Mgat4d |
A |
G |
8: 84,092,354 (GRCm39) |
T247A |
possibly damaging |
Het |
| Nrbp1 |
T |
A |
5: 31,403,157 (GRCm39) |
I210N |
probably damaging |
Het |
| Or7g18 |
T |
C |
9: 18,786,817 (GRCm39) |
F65L |
possibly damaging |
Het |
| Polr1c |
T |
C |
17: 46,555,089 (GRCm39) |
K327R |
possibly damaging |
Het |
| Prpf39 |
A |
T |
12: 65,089,436 (GRCm39) |
N58I |
possibly damaging |
Het |
| Sh3bp2 |
T |
A |
5: 34,712,837 (GRCm39) |
N92K |
probably damaging |
Het |
| Sppl3 |
TGG |
TG |
5: 115,226,352 (GRCm39) |
|
probably null |
Het |
| Tnc |
C |
T |
4: 63,932,231 (GRCm39) |
V728M |
probably damaging |
Het |
| Trgc3 |
T |
C |
13: 19,445,364 (GRCm39) |
F104S |
probably benign |
Het |
| Vmn2r88 |
T |
G |
14: 51,651,565 (GRCm39) |
I293S |
probably damaging |
Het |
| Zfp251 |
C |
T |
15: 76,738,436 (GRCm39) |
R219Q |
possibly damaging |
Het |
|
| Other mutations in Zfp930 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00429:Zfp930
|
APN |
8 |
69,680,634 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Bodyguard
|
UTSW |
8 |
69,681,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0389:Zfp930
|
UTSW |
8 |
69,680,948 (GRCm39) |
nonsense |
probably null |
|
|
R1275:Zfp930
|
UTSW |
8 |
69,680,631 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1802:Zfp930
|
UTSW |
8 |
69,679,046 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1917:Zfp930
|
UTSW |
8 |
69,681,357 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1918:Zfp930
|
UTSW |
8 |
69,681,357 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1981:Zfp930
|
UTSW |
8 |
69,680,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4492:Zfp930
|
UTSW |
8 |
69,680,898 (GRCm39) |
nonsense |
probably null |
|
|
R4530:Zfp930
|
UTSW |
8 |
69,681,483 (GRCm39) |
nonsense |
probably null |
|
|
R4769:Zfp930
|
UTSW |
8 |
69,679,344 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4906:Zfp930
|
UTSW |
8 |
69,681,597 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5314:Zfp930
|
UTSW |
8 |
69,679,373 (GRCm39) |
missense |
probably benign |
0.27 |
|
R5708:Zfp930
|
UTSW |
8 |
69,679,113 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6004:Zfp930
|
UTSW |
8 |
69,680,556 (GRCm39) |
missense |
probably benign |
|
|
R6385:Zfp930
|
UTSW |
8 |
69,681,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7095:Zfp930
|
UTSW |
8 |
69,681,193 (GRCm39) |
missense |
probably benign |
|
|
R7619:Zfp930
|
UTSW |
8 |
69,661,810 (GRCm39) |
start codon destroyed |
probably null |
0.95 |
|
R7641:Zfp930
|
UTSW |
8 |
69,681,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7674:Zfp930
|
UTSW |
8 |
69,681,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8300:Zfp930
|
UTSW |
8 |
69,680,998 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8905:Zfp930
|
UTSW |
8 |
69,681,351 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8960:Zfp930
|
UTSW |
8 |
69,680,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
|
| Posted On |
2014-02-18 |
Incidental Mutation