Incidental Mutation 'R1305:Or7a37'
ID 157781
Institutional Source Beutler Lab
Gene Symbol Or7a37
Ensembl Gene ENSMUSG00000042774
Gene Name olfactory receptor family 7 subfamily A member 37
Synonyms GA_x6K02T2QGN0-2842591-2841662, Olfr1353, MOR139-2
MMRRC Submission 039371-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R1305 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 78799143-78806446 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 78805933 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 150 (I150T)
Ref Sequence ENSEMBL: ENSMUSP00000145073 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039718] [ENSMUST00000204849] [ENSMUST00000205193]
AlphaFold Q8VGU8
Predicted Effect probably benign
Transcript: ENSMUST00000039718
AA Change: I150T

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000038992
Gene: ENSMUSG00000042774
AA Change: I150T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.9e-6 PFAM
Pfam:7tm_1 41 290 9.3e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204849
AA Change: I150T

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000145454
Gene: ENSMUSG00000042774
AA Change: I150T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.9e-6 PFAM
Pfam:7tm_1 41 290 9.3e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205193
AA Change: I150T

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000145073
Gene: ENSMUSG00000042774
AA Change: I150T

DomainStartEndE-ValueType
Pfam:7tm_4 31 95 5.8e-10 PFAM
Pfam:7tm_1 41 94 3.5e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219714
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.2%
  • 10x: 96.1%
  • 20x: 91.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atxn2 G A 5: 121,887,247 (GRCm39) V306I probably damaging Het
Enc1 T C 13: 97,383,208 (GRCm39) Y573H possibly damaging Het
Gm9869 T C 9: 60,729,168 (GRCm39) probably benign Het
Ifna2 T C 4: 88,601,614 (GRCm39) T135A probably benign Het
Ifngr1 C T 10: 19,482,001 (GRCm39) T197M possibly damaging Het
Kcnj4 A T 15: 79,369,020 (GRCm39) V320E probably damaging Het
Map2 T A 1: 66,464,554 (GRCm39) I1648N probably damaging Het
Map4k1 A T 7: 28,694,890 (GRCm39) M435L probably benign Het
Mark3 T A 12: 111,581,880 (GRCm39) probably null Het
Mex3c T A 18: 73,723,306 (GRCm39) F466L probably benign Het
Msl3l2 T C 10: 55,991,631 (GRCm39) C119R probably damaging Het
Msln T C 17: 25,972,001 (GRCm39) E72G probably benign Het
Nid2 T C 14: 19,818,930 (GRCm39) S475P probably benign Het
Nme8 T A 13: 19,881,077 (GRCm39) N18I possibly damaging Het
Nwd2 G T 5: 63,902,540 (GRCm39) W86L probably damaging Het
Or4p21 A T 2: 88,276,646 (GRCm39) L212* probably null Het
Pard3 T A 8: 128,032,891 (GRCm39) S162T possibly damaging Het
Ppm1a C A 12: 72,830,494 (GRCm39) D6E probably damaging Het
Rcor3 C T 1: 191,800,646 (GRCm39) V312I possibly damaging Het
Rgs20 T A 1: 5,091,262 (GRCm39) probably null Het
Slc11a2 C A 15: 100,307,963 (GRCm39) probably null Het
Snrnp40 C G 4: 130,271,836 (GRCm39) probably null Het
Vmn1r124 C A 7: 20,994,188 (GRCm39) V119F probably benign Het
Zfp827 A G 8: 79,787,523 (GRCm39) T230A possibly damaging Het
Zfp945 T C 17: 23,071,360 (GRCm39) K180E probably damaging Het
Other mutations in Or7a37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02135:Or7a37 APN 10 78,805,940 (GRCm39) missense probably damaging 1.00
IGL02159:Or7a37 APN 10 78,805,735 (GRCm39) missense probably damaging 1.00
R0355:Or7a37 UTSW 10 78,806,267 (GRCm39) missense probably damaging 1.00
R0561:Or7a37 UTSW 10 78,805,729 (GRCm39) nonsense probably null
R1921:Or7a37 UTSW 10 78,805,975 (GRCm39) nonsense probably null
R1922:Or7a37 UTSW 10 78,805,975 (GRCm39) nonsense probably null
R2382:Or7a37 UTSW 10 78,805,990 (GRCm39) missense probably damaging 0.99
R2920:Or7a37 UTSW 10 78,805,846 (GRCm39) missense probably damaging 1.00
R4491:Or7a37 UTSW 10 78,806,151 (GRCm39) missense probably damaging 1.00
R5113:Or7a37 UTSW 10 78,806,037 (GRCm39) missense probably benign
R5305:Or7a37 UTSW 10 78,806,390 (GRCm39) missense possibly damaging 0.68
R5744:Or7a37 UTSW 10 78,806,017 (GRCm39) missense probably damaging 1.00
R5861:Or7a37 UTSW 10 78,805,765 (GRCm39) missense probably damaging 1.00
R6197:Or7a37 UTSW 10 78,805,974 (GRCm39) missense probably damaging 1.00
R6314:Or7a37 UTSW 10 78,806,179 (GRCm39) missense probably benign
R7693:Or7a37 UTSW 10 78,806,137 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAACAAGGTCATCACCTATGCAGGG -3'
(R):5'- GGACATTGCACGTATGGAGGACAC -3'

Sequencing Primer
(F):5'- ACCTATGCAGGGTGCATTAC -3'
(R):5'- CACGTATGGAGGACACTATCTTG -3'
Posted On 2014-02-18